SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1z9a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I18_A_RBFA98_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 1z9a NAD(P)H-DEPENDENT
D-XYLOSE REDUCTASE
([Candida]
tenuis) 		5 / 10 LEU A 110
LEU A 112
ILE A 214
THR A 215
ILE A   8
 None
 1.41A 1i18A-1z9aA:
undetectable
1i18B-1z9aA:
undetectable		 1i18A-1z9aA:
14.52
1i18B-1z9aA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I18_B_RBFB99_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 1z9a NAD(P)H-DEPENDENT
D-XYLOSE REDUCTASE
([Candida]
tenuis) 		5 / 10 ILE A   8
LEU A 110
LEU A 112
ILE A 214
THR A 215
 None
 1.42A 1i18A-1z9aA:
undetectable
1i18B-1z9aA:
undetectable		 1i18A-1z9aA:
14.52
1i18B-1z9aA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QVT_A_PRLA311_0
(TRANSCRIPTIONAL
REGULATOR QACR)		 1z9a NAD(P)H-DEPENDENT
D-XYLOSE REDUCTASE
([Candida]
tenuis) 		4 / 8 GLU A 299
GLU A 295
ILE A 248
TYR A 252
 None
 1.02A 1qvtA-1z9aA:
0.0		 1qvtA-1z9aA:
21.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1S2A_A_IMNA2001_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 1z9a NAD(P)H-DEPENDENT
D-XYLOSE REDUCTASE
([Candida]
tenuis) 		5 / 12 TRP A  83
HIS A 114
GLU A 193
TYR A 217
SER A 218
 None
NAD  A1350 (-4.4A)
None
NAD  A1350 (-3.2A)
NAD  A1350 (-3.5A)
 0.30A 1s2aA-1z9aA:
41.5		 1s2aA-1z9aA:
39.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UUJ_B_ACTB1077_0
(PLATELET-ACTIVATING
FACTOR
ACETYLHYDROLASE IB
ALPHA SUBUNIT)		 1z9a NAD(P)H-DEPENDENT
D-XYLOSE REDUCTASE
([Candida]
tenuis) 		3 / 3 ARG A  64
TYR A  36
LYS A  40
 None
 0.72A 1uujB-1z9aA:
undetectable		 1uujB-1z9aA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		 1z9a NAD(P)H-DEPENDENT
D-XYLOSE REDUCTASE
([Candida]
tenuis) 		3 / 3 LEU A  26
LEU A 103
PHE A  21
 None
 0.72A 2pgrA-1z9aA:
5.7		 2pgrA-1z9aA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1160_1
(ALLERGEN ARG R 1)		 1z9a NAD(P)H-DEPENDENT
D-XYLOSE REDUCTASE
([Candida]
tenuis) 		4 / 7 TYR A 107
VAL A 105
ILE A  76
ASP A 109
 None
 1.13A 2x45B-1z9aA:
undetectable		 2x45B-1z9aA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1160_1
(ALLERGEN ARG R 1)		 1z9a NAD(P)H-DEPENDENT
D-XYLOSE REDUCTASE
([Candida]
tenuis) 		4 / 7 TYR A 107
VAL A 105
ILE A  76
ASP A 109
 None
 1.11A 2x45C-1z9aA:
undetectable		 2x45C-1z9aA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XTK_A_AZMA1339_1
(CLASS III CHITINASE
CHIA1)		 1z9a NAD(P)H-DEPENDENT
D-XYLOSE REDUCTASE
([Candida]
tenuis) 		5 / 11 GLY A  48
ALA A  49
ASP A  47
GLN A 191
ASN A 170
 None
None
NAD  A1350 (-4.0A)
NAD  A1350 (-3.7A)
NAD  A1350 (-3.3A)
 0.80A 2xtkA-1z9aA:
9.1		 2xtkA-1z9aA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BPX_B_SALB258_1
(TRANSCRIPTIONAL
REGULATOR)		 1z9a NAD(P)H-DEPENDENT
D-XYLOSE REDUCTASE
([Candida]
tenuis) 		5 / 11 ALA A 265
LEU A 261
ILE A 272
PRO A 273
SER A  18
 None
None
NAD  A1350 (-4.2A)
NAD  A1350 (-4.8A)
None
 1.49A 3bpxA-1z9aA:
1.2
3bpxB-1z9aA:
undetectable		 3bpxA-1z9aA:
18.79
3bpxB-1z9aA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BU1_A_HSMA301_1
(LIPOCALIN)		 1z9a NAD(P)H-DEPENDENT
D-XYLOSE REDUCTASE
([Candida]
tenuis) 		4 / 7 TYR A 107
VAL A 105
ILE A  76
ASP A 109
 None
 1.05A 3bu1A-1z9aA:
undetectable		 3bu1A-1z9aA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DOU_A_SAMA1_1
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 1z9a NAD(P)H-DEPENDENT
D-XYLOSE REDUCTASE
([Candida]
tenuis) 		3 / 3 ASP A  60
ASP A  67
ASP A 102
 None
 0.76A 3douA-1z9aA:
undetectable		 3douA-1z9aA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_D_MTXD164_2
(DIHYDROFOLATE
REDUCTASE)		 1z9a NAD(P)H-DEPENDENT
D-XYLOSE REDUCTASE
([Candida]
tenuis) 		3 / 3 ARG A 267
ILE A 245
THR A 236
 None
 0.60A 3ia4D-1z9aA:
0.2		 3ia4D-1z9aA:
18.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R43_A_ID8A332_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 1z9a NAD(P)H-DEPENDENT
D-XYLOSE REDUCTASE
([Candida]
tenuis) 		5 / 12 TYR A  52
TRP A  83
HIS A 114
ASN A 170
TYR A 217
 None
None
NAD  A1350 (-4.4A)
NAD  A1350 (-3.3A)
NAD  A1350 (-3.2A)
 0.23A 3r43A-1z9aA:
41.3		 3r43A-1z9aA:
39.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R6I_A_JMSA332_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 1z9a NAD(P)H-DEPENDENT
D-XYLOSE REDUCTASE
([Candida]
tenuis) 		5 / 12 TYR A  52
TRP A  83
HIS A 114
ASN A 170
TYR A 217
 None
None
NAD  A1350 (-4.4A)
NAD  A1350 (-3.3A)
NAD  A1350 (-3.2A)
 0.24A 3r6iA-1z9aA:
40.5		 3r6iA-1z9aA:
39.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3S3G_A_TLTA317_1
(ALDOSE REDUCTASE)		 1z9a NAD(P)H-DEPENDENT
D-XYLOSE REDUCTASE
([Candida]
tenuis) 		4 / 7 TRP A  24
TYR A  52
HIS A 114
PHE A 132
 NAD  A1350 (-4.7A)
None
NAD  A1350 (-4.4A)
None
 0.60A 3s3gA-1z9aA:
43.4		 3s3gA-1z9aA:
40.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UG8_A_IMNA2001_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 1z9a NAD(P)H-DEPENDENT
D-XYLOSE REDUCTASE
([Candida]
tenuis) 		5 / 12 TRP A  83
HIS A 114
ASN A 170
TYR A 217
SER A 224
 None
NAD  A1350 (-4.4A)
NAD  A1350 (-3.3A)
NAD  A1350 (-3.2A)
NAD  A1350 (-2.8A)
 0.98A 3ug8A-1z9aA:
40.5		 3ug8A-1z9aA:
39.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UG8_A_IMNA2001_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 1z9a NAD(P)H-DEPENDENT
D-XYLOSE REDUCTASE
([Candida]
tenuis) 		6 / 12 TYR A  52
TRP A  83
HIS A 114
ASN A 170
TYR A 217
SER A 218
 None
None
NAD  A1350 (-4.4A)
NAD  A1350 (-3.3A)
NAD  A1350 (-3.2A)
NAD  A1350 (-3.5A)
 0.19A 3ug8A-1z9aA:
40.5		 3ug8A-1z9aA:
39.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 1z9a NAD(P)H-DEPENDENT
D-XYLOSE REDUCTASE
([Candida]
tenuis) 		5 / 12 ILE A 147
ILE A 166
ILE A 113
ARG A 181
ALA A 183
 None
 0.92A 3uj7A-1z9aA:
0.4		 3uj7A-1z9aA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_B_SAMB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 1z9a NAD(P)H-DEPENDENT
D-XYLOSE REDUCTASE
([Candida]
tenuis) 		5 / 12 ILE A 147
ILE A 166
ILE A 113
ARG A 181
ALA A 183
 None
 0.96A 3uj7B-1z9aA:
undetectable		 3uj7B-1z9aA:
21.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3V35_A_NTIA317_1
(ALDOSE REDUCTASE)		 1z9a NAD(P)H-DEPENDENT
D-XYLOSE REDUCTASE
([Candida]
tenuis) 		4 / 8 TRP A  24
TRP A  83
HIS A 114
PHE A 132
 NAD  A1350 (-4.7A)
None
NAD  A1350 (-4.4A)
None
 0.66A 3v35A-1z9aA:
43.3		 3v35A-1z9aA:
40.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW7_A_VPXA2001_1
(PROTEINASE-ACTIVATED
RECEPTOR 1, LYSOZYME)		 1z9a NAD(P)H-DEPENDENT
D-XYLOSE REDUCTASE
([Candida]
tenuis) 		5 / 12 LEU A 154
LEU A 180
LEU A 179
ALA A 207
ALA A 210
 None
 1.13A 3vw7A-1z9aA:
undetectable		 3vw7A-1z9aA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7A_A_RGZA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 1z9a NAD(P)H-DEPENDENT
D-XYLOSE REDUCTASE
([Candida]
tenuis) 		5 / 11 TYR A 217
LEU A 154
GLN A 191
ILE A 113
TYR A  52
 NAD  A1350 (-3.2A)
None
NAD  A1350 (-3.7A)
None
None
 1.19A 4a7aA-1z9aA:
undetectable		 4a7aA-1z9aA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_B_SAMB601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 1z9a NAD(P)H-DEPENDENT
D-XYLOSE REDUCTASE
([Candida]
tenuis) 		4 / 5 ASN A  28
GLY A  53
ASP A 109
ASP A 102
 None
 1.11A 4n48B-1z9aA:
undetectable		 4n48B-1z9aA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N49_A_SAMA601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 1z9a NAD(P)H-DEPENDENT
D-XYLOSE REDUCTASE
([Candida]
tenuis) 		4 / 4 ASN A  28
GLY A  53
ASP A 109
ASP A 102
 None
 1.09A 4n49A-1z9aA:
undetectable		 4n49A-1z9aA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_A_GCSA301_1
(CHITOSANASE)		 1z9a NAD(P)H-DEPENDENT
D-XYLOSE REDUCTASE
([Candida]
tenuis) 		3 / 3 TYR A 197
GLY A 221
PRO A 222
 None
 0.71A 4qwpA-1z9aA:
undetectable		 4qwpA-1z9aA:
22.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YVV_A_GBMA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 1z9a NAD(P)H-DEPENDENT
D-XYLOSE REDUCTASE
([Candida]
tenuis) 		5 / 9 TYR A  52
TRP A  83
HIS A 114
ASN A 170
TYR A 217
 None
None
NAD  A1350 (-4.4A)
NAD  A1350 (-3.3A)
NAD  A1350 (-3.2A)
 0.22A 4yvvA-1z9aA:
41.7		 4yvvA-1z9aA:
39.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBS_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 1z9a NAD(P)H-DEPENDENT
D-XYLOSE REDUCTASE
([Candida]
tenuis) 		4 / 8 LEU A 260
LEU A 303
THR A 236
GLN A 230
 None
 1.17A 5hbsA-1z9aA:
undetectable		 5hbsA-1z9aA:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_B_FK5B201_1
(FK506-BINDING
PROTEIN 1)		 1z9a NAD(P)H-DEPENDENT
D-XYLOSE REDUCTASE
([Candida]
tenuis) 		5 / 11 ASP A 314
ARG A 232
PHE A 225
ILE A 320
ILE A 318
 None
 1.21A 5hw8B-1z9aA:
undetectable		 5hw8B-1z9aA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_E_CVIE301_1
(REGULATORY PROTEIN
TETR)		 1z9a NAD(P)H-DEPENDENT
D-XYLOSE REDUCTASE
([Candida]
tenuis) 		4 / 7 GLN A 223
GLY A 221
TYR A  52
ASP A 310
 NAD  A1350 (-4.7A)
None
None
NAD  A1350 (-4.6A)
 1.06A 5vlmE-1z9aA:
0.0		 5vlmE-1z9aA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_C_DAHC60_1
(PUTATIVE CYTOCHROME
C)		 1z9a NAD(P)H-DEPENDENT
D-XYLOSE REDUCTASE
([Candida]
tenuis) 		4 / 6 HIS A  87
ASN A 170
VAL A 168
LEU A 154
 None
NAD  A1350 (-3.3A)
None
None
 1.15A 5xdhA-1z9aA:
0.0
5xdhC-1z9aA:
0.0		 5xdhA-1z9aA:
16.67
5xdhC-1z9aA:
16.67