SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1z9d'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3V_A_TOPA1169_1
(DIHYDROFOLATE
REDUCTASE)		 1z9d URIDYLATE KINASE
(Streptococcus
pyogenes) 		6 / 12 VAL A 228
ILE A 159
PHE A 217
LEU A  14
ILE A 225
THR A 237
 None
 1.48A 2w3vA-1z9dA:
undetectable		 2w3vA-1z9dA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WX2_A_TPFA1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 1z9d URIDYLATE KINASE
(Streptococcus
pyogenes) 		4 / 7 MET A 219
ALA A  34
ALA A  36
LEU A  51
 None
 0.80A 2wx2A-1z9dA:
undetectable		 2wx2A-1z9dA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WX2_B_TPFB1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 1z9d URIDYLATE KINASE
(Streptococcus
pyogenes) 		4 / 8 MET A 219
ALA A  34
ALA A  36
LEU A  51
 None
 0.88A 2wx2B-1z9dA:
undetectable		 2wx2B-1z9dA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADX_B_IMNB3_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1z9d URIDYLATE KINASE
(Streptococcus
pyogenes) 		5 / 12 LEU A 214
GLY A  54
ALA A 162
ILE A  12
LEU A  11
 None
SO4  A1007 (-3.1A)
None
None
None
 1.03A 3adxB-1z9dA:
undetectable		 3adxB-1z9dA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC505_2
(PHOSPHOLIPASE A2)		 1z9d URIDYLATE KINASE
(Streptococcus
pyogenes) 		4 / 5 VAL A 216
VAL A 215
PHE A 183
ARG A 227
 None
 1.36A 3bjwH-1z9dA:
undetectable		 3bjwH-1z9dA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC507_2
(PHOSPHOLIPASE A2)		 1z9d URIDYLATE KINASE
(Streptococcus
pyogenes) 		4 / 6 VAL A 216
VAL A 215
PHE A 183
ARG A 227
 None
 1.19A 3bjwF-1z9dA:
undetectable		 3bjwF-1z9dA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6W_A_SAMA465_0
(RRNA METHYLASE)		 1z9d URIDYLATE KINASE
(Streptococcus
pyogenes) 		5 / 12 ALA A 147
GLY A 135
GLY A 133
ASP A 200
VAL A 216
 None
 1.06A 3m6wA-1z9dA:
undetectable		 3m6wA-1z9dA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9T_A_BEZA264_0
(ECHA1_1)		 1z9d URIDYLATE KINASE
(Streptococcus
pyogenes) 		4 / 8 ALA A 162
ILE A  12
ALA A  18
MET A  89
 None
 0.69A 3r9tA-1z9dA:
undetectable		 3r9tA-1z9dA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UT5_D_LOCD502_1
(TUBULIN BETA CHAIN)		 1z9d URIDYLATE KINASE
(Streptococcus
pyogenes) 		5 / 12 LEU A  11
LEU A  51
MET A  89
ALA A 162
ILE A  39
 None
 1.11A 3ut5D-1z9dA:
undetectable		 3ut5D-1z9dA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_B_ECNB403_1
(FLAVOHEMOGLOBIN)		 1z9d URIDYLATE KINASE
(Streptococcus
pyogenes) 		5 / 11 ILE A  53
ALA A  20
LEU A  19
THR A  31
VAL A  32
 None
 0.89A 4g1bB-1z9dA:
2.5		 4g1bB-1z9dA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_D_LOCD502_1
(TUBULIN BETA CHAIN)		 1z9d URIDYLATE KINASE
(Streptococcus
pyogenes) 		5 / 12 LEU A  11
LEU A  51
MET A  89
ALA A 162
ILE A  39
 None
 1.06A 4x1iD-1z9dA:
undetectable		 4x1iD-1z9dA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1Y_D_LOCD502_2
(TUBULIN BETA CHAIN)		 1z9d URIDYLATE KINASE
(Streptococcus
pyogenes) 		5 / 12 LEU A  11
LEU A  51
MET A  89
ALA A 162
ILE A  39
 None
 1.05A 4x1yD-1z9dA:
undetectable		 4x1yD-1z9dA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDR_A_ADNA402_1
(FAD:PROTEIN FMN
TRANSFERASE)		 1z9d URIDYLATE KINASE
(Streptococcus
pyogenes) 		5 / 12 GLY A  97
HIS A  43
ILE A  39
THR A 100
VAL A 131
 None
 1.00A 4xdrA-1z9dA:
undetectable		 4xdrA-1z9dA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDR_A_ADNA402_1
(FAD:PROTEIN FMN
TRANSFERASE)		 1z9d URIDYLATE KINASE
(Streptococcus
pyogenes) 		5 / 12 GLY A  97
HIS A  43
ILE A 129
THR A 100
VAL A 131
 None
 0.96A 4xdrA-1z9dA:
undetectable		 4xdrA-1z9dA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 1z9d URIDYLATE KINASE
(Streptococcus
pyogenes) 		5 / 12 ILE A 198
LEU A 196
THR A 236
GLY A 168
GLY A 231
 None
 1.05A 5d4uA-1z9dA:
undetectable		 5d4uA-1z9dA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_B_SAMB301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 1z9d URIDYLATE KINASE
(Streptococcus
pyogenes) 		5 / 12 ILE A 198
LEU A 196
THR A 236
GLY A 168
GLY A 231
 None
 1.08A 5d4uB-1z9dA:
undetectable		 5d4uB-1z9dA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_D_SAMD301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 1z9d URIDYLATE KINASE
(Streptococcus
pyogenes) 		5 / 12 ILE A 198
LEU A 196
THR A 236
GLY A 168
GLY A 231
 None
 0.99A 5d4uD-1z9dA:
undetectable		 5d4uD-1z9dA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECN_D_LEUD602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 1z9d URIDYLATE KINASE
(Streptococcus
pyogenes) 		4 / 8 ILE A  53
ALA A  36
VAL A  32
VAL A 131
 None
 0.80A 5ecnD-1z9dA:
undetectable		 5ecnD-1z9dA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_A_PFLA510_1
(PROTON-GATED ION
CHANNEL)		 1z9d URIDYLATE KINASE
(Streptococcus
pyogenes) 		5 / 9 ILE A  10
ILE A  12
ILE A 129
ALA A  50
LEU A  51
 None
 1.08A 5mvmA-1z9dA:
undetectable
5mvmE-1z9dA:
undetectable		 5mvmA-1z9dA:
15.00
5mvmE-1z9dA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NM5_B_LOCB502_2
(TUBULIN BETA-2B
CHAIN)		 1z9d URIDYLATE KINASE
(Streptococcus
pyogenes) 		5 / 12 LEU A  51
MET A  89
ILE A 225
ALA A 162
ILE A  39
 None
 1.27A 5nm5B-1z9dA:
undetectable		 5nm5B-1z9dA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA312_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 1z9d URIDYLATE KINASE
(Streptococcus
pyogenes) 		3 / 3 ILE A  10
VAL A 229
PRO A   5
 None
 0.69A 5uunA-1z9dA:
undetectable		 5uunA-1z9dA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_B_8LXB501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1z9d URIDYLATE KINASE
(Streptococcus
pyogenes) 		5 / 12 LEU A  58
ILE A  27
TYR A  96
LEU A  93
ILE A  53
 None
 1.21A 5y2tB-1z9dA:
undetectable		 5y2tB-1z9dA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZMQ_K_PACK1_0
(SERINE PROTEASE NS3
PEPTIDE
PAC-DLY-DLY-DAR)		 1z9d URIDYLATE KINASE
(Streptococcus
pyogenes) 		3 / 3 ALA A 156
VAL A 229
TYR A   7
 None
 0.66A 5zmqH-1z9dA:
undetectable		 5zmqH-1z9dA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_D_AQ4D602_0
(CYTOCHROME P450 1A1)		 1z9d URIDYLATE KINASE
(Streptococcus
pyogenes) 		5 / 12 SER A  15
GLY A  21
ALA A  20
ASP A  28
ILE A  53
 SO4  A1004 ( 3.1A)
None
None
None
None
 1.09A 6dwnD-1z9dA:
undetectable		 6dwnD-1z9dA:
15.66