SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1z9l'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2ZD1_A_T27A557_1 (REVERSE TRANSCRIPTASE/RIBONU CLEASE H)	1z9l	VESICLE-ASSOCIATED MEMBRANE PROTEIN-ASSOCIATED PROTEIN A (Rattus norvegicus)	5 / 12	LEU A 119 VAL A 71 VAL A 44 TYR A 52 PHE A 18	None	1.39A	2zd1A-1z9lA: 0.7	2zd1A-1z9lA: 12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3CR5_X_PNTX94_0 (PROTEIN S100-B)	1z9l	VESICLE-ASSOCIATED MEMBRANE PROTEIN-ASSOCIATED PROTEIN A (Rattus norvegicus)	3 / 3	PHE A 88 CYH A 121 PHE A 18	None	0.86A	3cr5X-1z9lA: undetectable	3cr5X-1z9lA: 18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4G1Q_A_T27A601_1 (REVERSE TRANSCRIPTASE/RIBONU CLEASE H)	1z9l	VESICLE-ASSOCIATED MEMBRANE PROTEIN-ASSOCIATED PROTEIN A (Rattus norvegicus)	5 / 12	LEU A 119 VAL A 71 VAL A 44 TYR A 52 PHE A 18	None	1.41A	4g1qA-1z9lA: 0.5	4g1qA-1z9lA: 12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ICL_A_T27A601_1 (REVERSE TRANSCRIPTASE/RIBONU CLEASE H)	1z9l	VESICLE-ASSOCIATED MEMBRANE PROTEIN-ASSOCIATED PROTEIN A (Rattus norvegicus)	5 / 12	LEU A 119 VAL A 71 VAL A 44 TYR A 52 PHE A 18	None	1.39A	4iclA-1z9lA: 0.0	4iclA-1z9lA: 12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ID5_A_T27A601_1 (REVERSE TRANSCRIPTASE/RIBONU CLEASE H)	1z9l	VESICLE-ASSOCIATED MEMBRANE PROTEIN-ASSOCIATED PROTEIN A (Rattus norvegicus)	5 / 12	LEU A 119 VAL A 71 VAL A 44 TYR A 52 PHE A 18	None	1.39A	4id5A-1z9lA: undetectable	4id5A-1z9lA: 12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4IDK_A_T27A601_1 (REVERSE TRANSCRIPTASE/RIBONU CLEASE H)	1z9l	VESICLE-ASSOCIATED MEMBRANE PROTEIN-ASSOCIATED PROTEIN A (Rattus norvegicus)	5 / 12	LEU A 119 VAL A 71 VAL A 44 TYR A 52 PHE A 18	None	1.39A	4idkA-1z9lA: 0.0	4idkA-1z9lA: 12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4IFV_A_T27A601_1 (EXORIBONUCLEASE H, P66 RT)	1z9l	VESICLE-ASSOCIATED MEMBRANE PROTEIN-ASSOCIATED PROTEIN A (Rattus norvegicus)	5 / 12	LEU A 119 VAL A 71 VAL A 44 TYR A 52 PHE A 18	None	1.39A	4ifvA-1z9lA: 0.0	4ifvA-1z9lA: 12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4IFY_A_T27A601_1 (REVERSE TRANSCRIPTASE/RIBONU CLEASE H)	1z9l	VESICLE-ASSOCIATED MEMBRANE PROTEIN-ASSOCIATED PROTEIN A (Rattus norvegicus)	5 / 12	LEU A 119 VAL A 71 VAL A 44 TYR A 52 PHE A 18	None	1.38A	4ifyA-1z9lA: undetectable	4ifyA-1z9lA: 12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4IG3_A_T27A601_1 (REVERSE TRANSCRIPTASE/RIBONU CLEASE H)	1z9l	VESICLE-ASSOCIATED MEMBRANE PROTEIN-ASSOCIATED PROTEIN A (Rattus norvegicus)	5 / 12	LEU A 119 VAL A 71 VAL A 44 TYR A 52 PHE A 18	None	1.39A	4ig3A-1z9lA: 0.5	4ig3A-1z9lA: 12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4KFB_A_T27A607_1 (REVERSE TRANSCRIPTASE/RIBONU CLEASE H, EXORIBONUCLEA P66 RT)	1z9l	VESICLE-ASSOCIATED MEMBRANE PROTEIN-ASSOCIATED PROTEIN A (Rattus norvegicus)	5 / 12	LEU A 119 VAL A 71 VAL A 44 TYR A 52 PHE A 18	None	1.39A	4kfbA-1z9lA: 0.0	4kfbA-1z9lA: 12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4YOA_A_017A100_1 (HIV-1 PROTEASE)	1z9l	VESICLE-ASSOCIATED MEMBRANE PROTEIN-ASSOCIATED PROTEIN A (Rattus norvegicus)	4 / 6	ASN A 34 ASP A 37 THR A 92 VAL A 40	None	1.11A	4yoaA-1z9lA: undetectable	4yoaA-1z9lA: 24.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5CYM_A_T27A601_1 (HIV-1 REVERSE TRANSCRIPTASE, P66 SUBUNIT)	1z9l	VESICLE-ASSOCIATED MEMBRANE PROTEIN-ASSOCIATED PROTEIN A (Rattus norvegicus)	5 / 12	LEU A 119 VAL A 71 VAL A 44 TYR A 52 PHE A 18	None	1.40A	5cymA-1z9lA: undetectable	5cymA-1z9lA: 12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5CYQ_A_T27A601_1 (HIV-1 REVERSE TRANSCRIPTASE, P66 SUBUNIT)	1z9l	VESICLE-ASSOCIATED MEMBRANE PROTEIN-ASSOCIATED PROTEIN A (Rattus norvegicus)	5 / 12	LEU A 119 VAL A 71 VAL A 44 TYR A 52 PHE A 18	None	1.40A	5cyqA-1z9lA: undetectable	5cyqA-1z9lA: 12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6ELI_A_T27A701_1 (REVERSE TRANSCRIPTASE)	1z9l	VESICLE-ASSOCIATED MEMBRANE PROTEIN-ASSOCIATED PROTEIN A (Rattus norvegicus)	5 / 12	LEU A 119 VAL A 71 VAL A 44 TYR A 52 PHE A 18	None	1.40A	6eliA-1z9lA: undetectable	6eliA-1z9lA: 19.38

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2ZD1_A_T27A557_1","REVERSE TRANSCRIPTASE\/RIBONUCLEASE H","1z9l","VESICLE-ASSOCIATED MEMBRANE PROTEIN-ASSOCIATED PROTEIN A","Rattus norvegicus",5,"LEU A 119;VAL A  71;VAL A  44;TYR A  52;PHE A  18","None","1.39A","2zd1A-1z9lA:0.7","2zd1A-1z9lA:12.03"],["3CR5_X_PNTX94_0","PROTEIN S100-B","1z9l","VESICLE-ASSOCIATED MEMBRANE PROTEIN-ASSOCIATED PROTEIN A","Rattus norvegicus",3,"PHE A  88;CYH A 121;PHE A  18","None","0.86A","3cr5X-1z9lA:undetectable","3cr5X-1z9lA:18.75"],["4G1Q_A_T27A601_1","REVERSE TRANSCRIPTASE\/RIBONUCLEASE H","1z9l","VESICLE-ASSOCIATED MEMBRANE PROTEIN-ASSOCIATED PROTEIN A","Rattus norvegicus",5,"LEU A 119;VAL A  71;VAL A  44;TYR A  52;PHE A  18","None","1.41A","4g1qA-1z9lA:0.5","4g1qA-1z9lA:12.03"],["4ICL_A_T27A601_1","REVERSE TRANSCRIPTASE\/RIBONUCLEASE H","1z9l","VESICLE-ASSOCIATED MEMBRANE PROTEIN-ASSOCIATED PROTEIN A","Rattus norvegicus",5,"LEU A 119;VAL A  71;VAL A  44;TYR A  52;PHE A  18","None","1.39A","4iclA-1z9lA:0.0","4iclA-1z9lA:12.03"],["4ID5_A_T27A601_1","REVERSE TRANSCRIPTASE\/RIBONUCLEASE H","1z9l","VESICLE-ASSOCIATED MEMBRANE PROTEIN-ASSOCIATED PROTEIN A","Rattus norvegicus",5,"LEU A 119;VAL A  71;VAL A  44;TYR A  52;PHE A  18","None","1.39A","4id5A-1z9lA:undetectable","4id5A-1z9lA:12.03"],["4IDK_A_T27A601_1","REVERSE TRANSCRIPTASE\/RIBONUCLEASE H","1z9l","VESICLE-ASSOCIATED MEMBRANE PROTEIN-ASSOCIATED PROTEIN A","Rattus norvegicus",5,"LEU A 119;VAL A  71;VAL A  44;TYR A  52;PHE A  18","None","1.39A","4idkA-1z9lA:0.0","4idkA-1z9lA:12.03"],["4IFV_A_T27A601_1","EXORIBONUCLEASE H, P66 RT","1z9l","VESICLE-ASSOCIATED MEMBRANE PROTEIN-ASSOCIATED PROTEIN A","Rattus norvegicus",5,"LEU A 119;VAL A  71;VAL A  44;TYR A  52;PHE A  18","None","1.39A","4ifvA-1z9lA:0.0","4ifvA-1z9lA:12.03"],["4IFY_A_T27A601_1","REVERSE TRANSCRIPTASE\/RIBONUCLEASE H","1z9l","VESICLE-ASSOCIATED MEMBRANE PROTEIN-ASSOCIATED PROTEIN A","Rattus norvegicus",5,"LEU A 119;VAL A  71;VAL A  44;TYR A  52;PHE A  18","None","1.38A","4ifyA-1z9lA:undetectable","4ifyA-1z9lA:12.03"],["4IG3_A_T27A601_1","REVERSE TRANSCRIPTASE\/RIBONUCLEASE H","1z9l","VESICLE-ASSOCIATED MEMBRANE PROTEIN-ASSOCIATED PROTEIN A","Rattus norvegicus",5,"LEU A 119;VAL A  71;VAL A  44;TYR A  52;PHE A  18","None","1.39A","4ig3A-1z9lA:0.5","4ig3A-1z9lA:12.03"],["4KFB_A_T27A607_1","REVERSE TRANSCRIPTASE\/RIBONUCLEASE H, EXORIBONUCLEA P66 RT","1z9l","VESICLE-ASSOCIATED MEMBRANE PROTEIN-ASSOCIATED PROTEIN A","Rattus norvegicus",5,"LEU A 119;VAL A  71;VAL A  44;TYR A  52;PHE A  18","None","1.39A","4kfbA-1z9lA:0.0","4kfbA-1z9lA:12.03"],["4YOA_A_017A100_1","HIV-1 PROTEASE","1z9l","VESICLE-ASSOCIATED MEMBRANE PROTEIN-ASSOCIATED PROTEIN A","Rattus norvegicus",4,"ASN A  34;ASP A  37;THR A  92;VAL A  40","None","1.11A","4yoaA-1z9lA:undetectable","4yoaA-1z9lA:24.63"],["5CYM_A_T27A601_1","HIV-1 REVERSE TRANSCRIPTASE, P66 SUBUNIT","1z9l","VESICLE-ASSOCIATED MEMBRANE PROTEIN-ASSOCIATED PROTEIN A","Rattus norvegicus",5,"LEU A 119;VAL A  71;VAL A  44;TYR A  52;PHE A  18","None","1.40A","5cymA-1z9lA:undetectable","5cymA-1z9lA:12.03"],["5CYQ_A_T27A601_1","HIV-1 REVERSE TRANSCRIPTASE, P66 SUBUNIT","1z9l","VESICLE-ASSOCIATED MEMBRANE PROTEIN-ASSOCIATED PROTEIN A","Rattus norvegicus",5,"LEU A 119;VAL A  71;VAL A  44;TYR A  52;PHE A  18","None","1.40A","5cyqA-1z9lA:undetectable","5cyqA-1z9lA:12.03"],["6ELI_A_T27A701_1","REVERSE TRANSCRIPTASE","1z9l","VESICLE-ASSOCIATED MEMBRANE PROTEIN-ASSOCIATED PROTEIN A","Rattus norvegicus",5,"LEU A 119;VAL A  71;VAL A  44;TYR A  52;PHE A  18","None","1.40A","6eliA-1z9lA:undetectable","6eliA-1z9lA:19.38"]]