SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1za0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A7Y_B_DVAB8_0
(ACTINOMYCIN D)		 1za0 POSSIBLE
ACYL-[ACYL-CARRIER
PROTEIN] DESATURASE
DESA2 (ACYL-[ACP]
DESATURASE)
(STEAROYL-ACP
DESATURASE)
(Mycobacterium
tuberculosis) 		3 / 3 THR A  64
THR A  66
PRO A  62
 None
 0.87A 1a7yB-1za0A:
undetectable		 1a7yB-1za0A:
3.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDR_B_MTXB200_1
(DIHYDROFOLATE
REDUCTASE)		 1za0 POSSIBLE
ACYL-[ACYL-CARRIER
PROTEIN] DESATURASE
DESA2 (ACYL-[ACP]
DESATURASE)
(STEAROYL-ACP
DESATURASE)
(Mycobacterium
tuberculosis) 		5 / 12 ILE A 177
LEU A 118
ILE A  65
ARG A  63
LEU A  61
 None
 1.21A 1ddrB-1za0A:
undetectable		 1ddrB-1za0A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QVU_A_PRLA196_0
(TRANSCRIPTIONAL
REGULATOR QACR)		 1za0 POSSIBLE
ACYL-[ACYL-CARRIER
PROTEIN] DESATURASE
DESA2 (ACYL-[ACP]
DESATURASE)
(STEAROYL-ACP
DESATURASE)
(Mycobacterium
tuberculosis) 		4 / 6 LEU A  14
GLU A  15
TRP A  95
THR A  23
 None
 0.99A 1qvuA-1za0A:
1.3		 1qvuA-1za0A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RNR_A_DAHA208_1
(RIBONUCLEOTIDE
REDUCTASE R1 PROTEIN)		 1za0 POSSIBLE
ACYL-[ACYL-CARRIER
PROTEIN] DESATURASE
DESA2 (ACYL-[ACP]
DESATURASE)
(STEAROYL-ACP
DESATURASE)
(Mycobacterium
tuberculosis) 		5 / 11 GLU A 107
HIS A 110
GLU A 159
ILE A 185
GLU A 189
 MN  A 888 (-2.7A)
None
MN  A 888 (-2.0A)
None
MN  A 888 (-2.6A)
 0.80A 1rnrA-1za0A:
13.8		 1rnrA-1za0A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RNR_B_DAHB208_1
(RIBONUCLEOTIDE
REDUCTASE R1 PROTEIN)		 1za0 POSSIBLE
ACYL-[ACYL-CARRIER
PROTEIN] DESATURASE
DESA2 (ACYL-[ACP]
DESATURASE)
(STEAROYL-ACP
DESATURASE)
(Mycobacterium
tuberculosis) 		5 / 12 GLU A 107
HIS A 110
GLU A 159
ILE A 185
GLU A 189
 MN  A 888 (-2.7A)
None
MN  A 888 (-2.0A)
None
MN  A 888 (-2.6A)
 0.82A 1rnrB-1za0A:
13.7		 1rnrB-1za0A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JLG_B_SAMB401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 1za0 POSSIBLE
ACYL-[ACYL-CARRIER
PROTEIN] DESATURASE
DESA2 (ACYL-[ACP]
DESATURASE)
(STEAROYL-ACP
DESATURASE)
(Mycobacterium
tuberculosis) 		5 / 11 ILE A 112
ALA A  34
GLY A 180
HIS A 110
TRP A  32
 None
None
None
None
EDO  A 980 (-4.3A)
 1.35A 4jlgB-1za0A:
undetectable		 4jlgB-1za0A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGF_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1za0 POSSIBLE
ACYL-[ACYL-CARRIER
PROTEIN] DESATURASE
DESA2 (ACYL-[ACP]
DESATURASE)
(STEAROYL-ACP
DESATURASE)
(Mycobacterium
tuberculosis) 		4 / 6 THR A 207
GLU A 210
THR A 211
LEU A  10
 None
 1.08A 4pgfA-1za0A:
undetectable		 4pgfA-1za0A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPU_C_IPHC101_0
(INSULIN, CHAIN A
INSULIN, CHAIN B)		 1za0 POSSIBLE
ACYL-[ACYL-CARRIER
PROTEIN] DESATURASE
DESA2 (ACYL-[ACP]
DESATURASE)
(STEAROYL-ACP
DESATURASE)
(Mycobacterium
tuberculosis) 		4 / 6 CYH A  69
LEU A 178
HIS A 110
LEU A 114
 None
 1.16A 5hpuC-1za0A:
undetectable
5hpuD-1za0A:
undetectable		 5hpuC-1za0A:
5.95
5hpuD-1za0A:
9.49