SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1za4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BU5_B_RBFB302_1
(PROTEIN (FLAVODOXIN))		 1za4 THROMBOSPONDIN 1
(Homo
sapiens) 		4 / 8 THR A 109
THR A  82
GLY A  84
ASP A 188
 None
 1.02A 1bu5B-1za4A:
undetectable		 1bu5B-1za4A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DDW_B_PXLB1005_1
(PYRIDOXINE KINASE)		 1za4 THROMBOSPONDIN 1
(Homo
sapiens) 		4 / 7 SER A 100
LEU A 114
THR A 115
GLY A  96
 None
 1.05A 2ddwB-1za4A:
undetectable		 2ddwB-1za4A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_W_CHDW1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1za4 THROMBOSPONDIN 1
(Homo
sapiens) 		4 / 7 LEU A 173
PHE A  57
LEU A  89
PHE A  99
 None
 1.04A 2eimP-1za4A:
undetectable
2eimW-1za4A:
undetectable		 2eimP-1za4A:
20.43
2eimW-1za4A:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		 1za4 THROMBOSPONDIN 1
(Homo
sapiens) 		3 / 3 LEU A  89
LEU A  72
PHE A  57
 None
 0.68A 2pgrA-1za4A:
undetectable		 2pgrA-1za4A:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V1N_A_BEZA288_0
(2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE)		 1za4 THROMBOSPONDIN 1
(Homo
sapiens) 		5 / 8 GLY A 105
GLY A 108
SER A 103
ILE A 151
LEU A 149
 None
 1.11A 3v1nA-1za4A:
undetectable		 3v1nA-1za4A:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1za4 THROMBOSPONDIN 1
(Homo
sapiens) 		4 / 8 ARG A 180
ILE A  49
ASN A 189
ASP A  45
 None
 0.88A 4d33A-1za4A:
undetectable		 4d33A-1za4A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1za4 THROMBOSPONDIN 1
(Homo
sapiens) 		4 / 7 ARG A 180
ILE A  49
ASN A 189
ASP A  45
 None
 0.89A 4d33B-1za4A:
undetectable		 4d33B-1za4A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1za4 THROMBOSPONDIN 1
(Homo
sapiens) 		4 / 8 ARG A 180
ILE A  49
ASN A 189
ASP A  45
 None
 0.97A 4d39A-1za4A:
undetectable		 4d39A-1za4A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1za4 THROMBOSPONDIN 1
(Homo
sapiens) 		4 / 7 ARG A 180
ILE A  49
ASN A 189
ASP A  45
 None
 1.06A 4d39B-1za4A:
undetectable		 4d39B-1za4A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G24_A_ACAA1004_1
(PENTATRICOPEPTIDE
REPEAT-CONTAINING
PROTEIN AT2G32230,
MITOCHONDRIAL)		 1za4 THROMBOSPONDIN 1
(Homo
sapiens) 		4 / 6 ALA A 159
VAL A 142
ASP A 145
GLU A 144
 None
 0.95A 4g24A-1za4A:
undetectable		 4g24A-1za4A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_F_FOLF301_1
(FOLATE RECEPTOR
ALPHA)		 1za4 THROMBOSPONDIN 1
(Homo
sapiens) 		3 / 3 ASP A  14
TRP A 135
SER A  38
 None
 1.02A 4lrhF-1za4A:
undetectable		 4lrhF-1za4A:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1za4 THROMBOSPONDIN 1
(Homo
sapiens) 		4 / 5 LEU A 173
PHE A  57
LEU A  89
PHE A  99
 None
 1.04A 5x19C-1za4A:
undetectable
5x19J-1za4A:
undetectable		 5x19C-1za4A:
20.43
5x19J-1za4A:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1za4 THROMBOSPONDIN 1
(Homo
sapiens) 		4 / 7 LEU A 173
PHE A  57
LEU A  89
PHE A  99
 None
 0.94A 5z85C-1za4A:
undetectable
5z85J-1za4A:
undetectable		 5z85C-1za4A:
20.43
5z85J-1za4A:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1za4 THROMBOSPONDIN 1
(Homo
sapiens) 		4 / 7 LEU A 173
PHE A  57
LEU A  89
PHE A  99
 None
 0.96A 5zcqP-1za4A:
undetectable
5zcqW-1za4A:
undetectable		 5zcqP-1za4A:
20.43
5zcqW-1za4A:
14.66