SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1zao'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		 1zao RIO2 SERINE KINASE
(Archaeoglobus
fulgidus) 		3 / 3 ASN A 194
PHE A 262
VAL A 198
 None
 0.86A 1kijA-1zaoA:
undetectable		 1kijA-1zaoA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TDN_A_LEUA487_0
(L-AMINO ACID OXIDASE)		 1zao RIO2 SERINE KINASE
(Archaeoglobus
fulgidus) 		4 / 7 ASN A 223
HIS A 216
PHE A 236
ILE A 202
 MN  A 283 (-2.8A)
None
None
None
 1.30A 1tdnA-1zaoA:
undetectable		 1tdnA-1zaoA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7A_A_BEZA1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 1zao RIO2 SERINE KINASE
(Archaeoglobus
fulgidus) 		5 / 9 LEU A 199
LEU A 187
ILE A 231
LEU A 219
ILE A 258
 None
 1.29A 2f7aA-1zaoA:
undetectable		 2f7aA-1zaoA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q83_A_ADNA1_1
(YTAA PROTEIN)		 1zao RIO2 SERINE KINASE
(Archaeoglobus
fulgidus) 		4 / 7 PRO A 167
ILE A 182
LEU A 225
ILE A 234
 ATP  A 286 ( 4.7A)
ATP  A 286 (-4.2A)
None
ATP  A 286 (-4.5A)
 0.63A 2q83A-1zaoA:
8.8		 2q83A-1zaoA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_L_ASDL1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1zao RIO2 SERINE KINASE
(Archaeoglobus
fulgidus) 		4 / 7 PHE A 107
ALA A 105
PHE A 121
PHE A  74
 None
 1.02A 2vcvL-1zaoA:
undetectable		 2vcvL-1zaoA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEG_A_BAXA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 1zao RIO2 SERINE KINASE
(Archaeoglobus
fulgidus) 		4 / 6 VAL A 166
ILE A 214
HIS A 216
ILE A 233
 EDO  A 287 (-4.9A)
None
None
None
 0.62A 3hegA-1zaoA:
8.3		 3hegA-1zaoA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB3_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 1zao RIO2 SERINE KINASE
(Archaeoglobus
fulgidus) 		5 / 12 ASN A 153
SER A 239
ILE A 234
ASN A 223
GLU A 186
 None
None
ATP  A 286 (-4.5A)
MN  A 283 (-2.8A)
ATP  A 286 (-3.5A)
 1.46A 3jb3A-1zaoA:
undetectable		 3jb3A-1zaoA:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WAR_A_NIOA401_1
(CASEIN KINASE II
SUBUNIT ALPHA)		 1zao RIO2 SERINE KINASE
(Archaeoglobus
fulgidus) 		5 / 8 VAL A 106
VAL A 118
LYS A 120
ILE A 234
ASP A 235
 ATP  A 286 (-4.6A)
ATP  A 286 (-4.9A)
ATP  A 286 (-2.6A)
ATP  A 286 (-4.5A)
ATP  A 286 ( 2.5A)
 0.60A 3warA-1zaoA:
6.1		 3warA-1zaoA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAJ_B_0HKB2000_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR M3,
LYSOZYME)		 1zao RIO2 SERINE KINASE
(Archaeoglobus
fulgidus) 		3 / 3 ASN A  24
LEU A  51
PHE A  22
 None
 0.81A 4dajB-1zaoA:
undetectable		 4dajB-1zaoA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DT8_A_ADNA401_1
(APH(2'')-ID)		 1zao RIO2 SERINE KINASE
(Archaeoglobus
fulgidus) 		5 / 11 LYS A 120
PRO A 167
ILE A 182
LEU A 225
ILE A 234
 ATP  A 286 (-2.6A)
ATP  A 286 ( 4.7A)
ATP  A 286 (-4.2A)
None
ATP  A 286 (-4.5A)
 1.00A 4dt8A-1zaoA:
10.4		 4dt8A-1zaoA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTA_A_ADNA401_1
(APH(2'')-ID)		 1zao RIO2 SERINE KINASE
(Archaeoglobus
fulgidus) 		5 / 10 LYS A 120
PRO A 167
ILE A 182
LEU A 225
ILE A 234
 ATP  A 286 (-2.6A)
ATP  A 286 ( 4.7A)
ATP  A 286 (-4.2A)
None
ATP  A 286 (-4.5A)
 0.93A 4dtaA-1zaoA:
10.6		 4dtaA-1zaoA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTA_B_ADNB401_1
(APH(2'')-ID)		 1zao RIO2 SERINE KINASE
(Archaeoglobus
fulgidus) 		4 / 8 PRO A 167
ILE A 182
LEU A 225
ILE A 234
 ATP  A 286 ( 4.7A)
ATP  A 286 (-4.2A)
None
ATP  A 286 (-4.5A)
 0.57A 4dtaB-1zaoA:
10.9		 4dtaB-1zaoA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAA_A_RTZA401_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 1zao RIO2 SERINE KINASE
(Archaeoglobus
fulgidus) 		5 / 11 VAL A 106
LYS A 120
LEU A 225
ILE A 234
ASP A 235
 ATP  A 286 (-4.6A)
ATP  A 286 (-2.6A)
None
ATP  A 286 (-4.5A)
ATP  A 286 ( 2.5A)
 0.67A 4iaaA-1zaoA:
12.4		 4iaaA-1zaoA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAR_A_ERMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 1zao RIO2 SERINE KINASE
(Archaeoglobus
fulgidus) 		4 / 7 ILE A 148
VAL A 124
SER A  81
ASP A 235
 None
None
None
ATP  A 286 ( 2.5A)
 1.20A 4iarA-1zaoA:
undetectable		 4iarA-1zaoA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LA0_A_198A601_1
(SERUM ALBUMIN)		 1zao RIO2 SERINE KINASE
(Archaeoglobus
fulgidus) 		5 / 10 LEU A 225
PRO A 167
ALA A 157
PHE A 236
PHE A 209
 None
ATP  A 286 ( 4.7A)
None
None
None
 1.39A 4la0A-1zaoA:
2.5		 4la0A-1zaoA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LA0_B_198B601_1
(SERUM ALBUMIN)		 1zao RIO2 SERINE KINASE
(Archaeoglobus
fulgidus) 		5 / 9 LEU A 225
PRO A 167
ALA A 157
PHE A 236
PHE A 209
 None
ATP  A 286 ( 4.7A)
None
None
None
 1.41A 4la0B-1zaoA:
2.8		 4la0B-1zaoA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PO0_A_NPSA602_1
(SERUM ALBUMIN)		 1zao RIO2 SERINE KINASE
(Archaeoglobus
fulgidus) 		4 / 8 LYS A  46
ALA A  47
LEU A  51
LEU A  33
 None
 0.50A 4po0A-1zaoA:
undetectable		 4po0A-1zaoA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DLV_B_5D5B927_1
(ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 2)		 1zao RIO2 SERINE KINASE
(Archaeoglobus
fulgidus) 		4 / 7 SER A  81
TYR A  80
PHE A  22
HIS A  39
 None
 1.34A 5dlvB-1zaoA:
3.0		 5dlvB-1zaoA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_E_ASCE1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 1zao RIO2 SERINE KINASE
(Archaeoglobus
fulgidus) 		4 / 7 HIS A 216
ILE A 214
VAL A 215
GLN A 238
 None
 0.94A 5kkzC-1zaoA:
undetectable
5kkzE-1zaoA:
undetectable		 5kkzC-1zaoA:
20.21
5kkzE-1zaoA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_K_ASCK1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 1zao RIO2 SERINE KINASE
(Archaeoglobus
fulgidus) 		4 / 7 HIS A 216
ILE A 214
VAL A 215
GLN A 238
 None
 0.91A 5kkzK-1zaoA:
undetectable
5kkzQ-1zaoA:
undetectable		 5kkzK-1zaoA:
20.62
5kkzQ-1zaoA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_O_ASCO1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 1zao RIO2 SERINE KINASE
(Archaeoglobus
fulgidus) 		4 / 7 HIS A 216
ILE A 214
VAL A 215
GLN A 238
 None
 0.98A 5kkzM-1zaoA:
undetectable
5kkzO-1zaoA:
undetectable		 5kkzM-1zaoA:
20.21
5kkzO-1zaoA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWW_A_ACAA18_1
(SCRFP-TAG,GP41)		 1zao RIO2 SERINE KINASE
(Archaeoglobus
fulgidus) 		5 / 12 GLY A  11
SER A  14
LYS A  12
ASN A  49
LEU A  57
 None
 1.08A 5nwwA-1zaoA:
undetectable		 5nwwA-1zaoA:
9.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_C_SAMC501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 1zao RIO2 SERINE KINASE
(Archaeoglobus
fulgidus) 		4 / 7 LEU A  85
GLY A  89
SER A  81
ALA A 171
 None
 0.76A 5o96C-1zaoA:
undetectable		 5o96C-1zaoA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9M_A_NIOA401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 1zao RIO2 SERINE KINASE
(Archaeoglobus
fulgidus) 		5 / 8 VAL A 106
VAL A 118
LYS A 120
ILE A 234
ASP A 235
 ATP  A 286 (-4.6A)
ATP  A 286 (-4.9A)
ATP  A 286 (-2.6A)
ATP  A 286 (-4.5A)
ATP  A 286 ( 2.5A)
 0.49A 5y9mA-1zaoA:
9.8		 5y9mA-1zaoA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9M_X_NIOX401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 1zao RIO2 SERINE KINASE
(Archaeoglobus
fulgidus) 		5 / 8 VAL A 106
VAL A 118
LYS A 120
ILE A 234
ASP A 235
 ATP  A 286 (-4.6A)
ATP  A 286 (-4.9A)
ATP  A 286 (-2.6A)
ATP  A 286 (-4.5A)
ATP  A 286 ( 2.5A)
 0.47A 5y9mX-1zaoA:
4.8		 5y9mX-1zaoA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF9_B_NIOB401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 1zao RIO2 SERINE KINASE
(Archaeoglobus
fulgidus) 		5 / 7 VAL A 106
VAL A 118
LYS A 120
ILE A 234
ASP A 235
 ATP  A 286 (-4.6A)
ATP  A 286 (-4.9A)
ATP  A 286 (-2.6A)
ATP  A 286 (-4.5A)
ATP  A 286 ( 2.5A)
 0.59A 5yf9B-1zaoA:
6.8		 5yf9B-1zaoA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF9_X_NIOX401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 1zao RIO2 SERINE KINASE
(Archaeoglobus
fulgidus) 		5 / 9 VAL A 106
VAL A 118
LYS A 120
ILE A 234
ASP A 235
 ATP  A 286 (-4.6A)
ATP  A 286 (-4.9A)
ATP  A 286 (-2.6A)
ATP  A 286 (-4.5A)
ATP  A 286 ( 2.5A)
 0.61A 5yf9X-1zaoA:
10.9		 5yf9X-1zaoA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YWM_X_NIOX403_0
(CASEIN KINASE II
SUBUNIT ALPHA')		 1zao RIO2 SERINE KINASE
(Archaeoglobus
fulgidus) 		5 / 7 VAL A 106
VAL A 118
LYS A 120
ILE A 234
ASP A 235
 ATP  A 286 (-4.6A)
ATP  A 286 (-4.9A)
ATP  A 286 (-2.6A)
ATP  A 286 (-4.5A)
ATP  A 286 ( 2.5A)
 0.63A 5ywmX-1zaoA:
10.9		 5ywmX-1zaoA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_A_ZOTA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 1zao RIO2 SERINE KINASE
(Archaeoglobus
fulgidus) 		5 / 12 LEU A  85
VAL A  91
GLY A  89
PHE A 114
VAL A 169
 None
 1.22A 6a94A-1zaoA:
undetectable		 6a94A-1zaoA:
22.22