SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1zap'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOF_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 1zap SECRETED ASPARTIC
PROTEINASE
(Candida
albicans) 		4 / 5 LEU A 216
ASP A 218
ALA A 303
ILE A 305
 None
A70  A 500 ( 2.3A)
A70  A 500 ( 3.8A)
A70  A 500 (-4.8A)
 0.81A 2aofB-1zapA:
6.8		 2aofB-1zapA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOH_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 1zap SECRETED ASPARTIC
PROTEINASE
(Candida
albicans) 		4 / 5 LEU A 216
ASP A 218
ALA A 303
ILE A 305
 None
A70  A 500 ( 2.3A)
A70  A 500 ( 3.8A)
A70  A 500 (-4.8A)
 0.80A 2aohB-1zapA:
7.0		 2aohB-1zapA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVS_B_MK1B902_1
(POL POLYPROTEIN)		 1zap SECRETED ASPARTIC
PROTEINASE
(Candida
albicans) 		5 / 12 ASP A  32
GLY A  34
ASP A  37
GLY A  83
ILE A 123
 A70  A 500 ( 2.7A)
A70  A 500 (-3.8A)
None
None
A70  A 500 (-4.8A)
 0.63A 2avsA-1zapA:
7.5		 2avsA-1zapA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVS_B_MK1B902_3
(POL POLYPROTEIN)		 1zap SECRETED ASPARTIC
PROTEINASE
(Candida
albicans) 		5 / 12 GLY A 125
ILE A 119
GLY A 122
VAL A  40
ILE A  82
 None
A70  A 500 (-3.9A)
None
None
None
 1.06A 2avsB-1zapA:
7.3		 2avsB-1zapA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_A_MK1A901_1
(POL POLYPROTEIN)		 1zap SECRETED ASPARTIC
PROTEINASE
(Candida
albicans) 		5 / 12 ASP A  32
GLY A  34
ASP A  37
GLY A  83
ILE A 123
 A70  A 500 ( 2.7A)
A70  A 500 (-3.8A)
None
None
A70  A 500 (-4.8A)
 0.63A 2avvA-1zapA:
7.2		 2avvA-1zapA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_1
(POL POLYPROTEIN)		 1zap SECRETED ASPARTIC
PROTEINASE
(Candida
albicans) 		5 / 12 ASP A  32
GLY A  34
ASP A  37
GLY A  83
ILE A 123
 A70  A 500 ( 2.7A)
A70  A 500 (-3.8A)
None
None
A70  A 500 (-4.8A)
 0.65A 2avvD-1zapA:
7.0		 2avvD-1zapA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_2
(POL POLYPROTEIN)		 1zap SECRETED ASPARTIC
PROTEINASE
(Candida
albicans) 		3 / 3 ASP A 115
ILE A  82
VAL A  29
 None
 0.70A 2avvD-1zapA:
7.0		 2avvD-1zapA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_B_BEZB1004_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 1zap SECRETED ASPARTIC
PROTEINASE
(Candida
albicans) 		4 / 7 VAL A 188
SER A 190
LEU A 320
THR A 130
 None
 1.14A 2f78B-1zapA:
undetectable		 2f78B-1zapA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F80_B_017B301_1
(POL POLYPROTEIN)		 1zap SECRETED ASPARTIC
PROTEINASE
(Candida
albicans) 		5 / 12 LEU A 216
ASP A 218
GLY A 220
ASN A 309
ILE A 305
 None
A70  A 500 ( 2.3A)
A70  A 500 (-3.3A)
None
A70  A 500 (-4.8A)
 0.92A 2f80A-1zapA:
7.7		 2f80A-1zapA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IDW_B_017B401_2
(PROTEASE)		 1zap SECRETED ASPARTIC
PROTEINASE
(Candida
albicans) 		5 / 9 ASP A  32
GLY A  34
ASP A  37
GLY A  83
ILE A 123
 A70  A 500 ( 2.7A)
A70  A 500 (-3.8A)
None
None
A70  A 500 (-4.8A)
 0.76A 2idwB-1zapA:
6.5		 2idwB-1zapA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMY_A_ROCA401_1
(PROTEASE)		 1zap SECRETED ASPARTIC
PROTEINASE
(Candida
albicans) 		5 / 12 ASP A  32
GLY A  34
ASP A  37
GLY A  83
ILE A 123
 A70  A 500 ( 2.7A)
A70  A 500 (-3.8A)
None
None
A70  A 500 (-4.8A)
 0.85A 2nmyA-1zapA:
6.8		 2nmyA-1zapA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMZ_B_ROCB401_1
(PROTEASE)		 1zap SECRETED ASPARTIC
PROTEINASE
(Candida
albicans) 		5 / 12 ASP A  32
GLY A  34
ASP A  37
GLY A  83
ILE A 123
 A70  A 500 ( 2.7A)
A70  A 500 (-3.8A)
None
None
A70  A 500 (-4.8A)
 0.84A 2nmzA-1zapA:
7.5		 2nmzA-1zapA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMZ_B_ROCB401_1
(PROTEASE)		 1zap SECRETED ASPARTIC
PROTEINASE
(Candida
albicans) 		5 / 12 LEU A 216
ASP A 218
GLY A 220
ALA A 303
ILE A 305
 None
A70  A 500 ( 2.3A)
A70  A 500 (-3.3A)
A70  A 500 ( 3.8A)
A70  A 500 (-4.8A)
 0.79A 2nmzA-1zapA:
7.5		 2nmzA-1zapA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMZ_B_ROCB401_3
(PROTEASE)		 1zap SECRETED ASPARTIC
PROTEINASE
(Candida
albicans) 		5 / 12 ASP A  32
GLY A  34
ASP A  37
GLY A  83
ILE A 123
 A70  A 500 ( 2.7A)
A70  A 500 (-3.8A)
None
None
A70  A 500 (-4.8A)
 0.82A 2nmzB-1zapA:
7.8		 2nmzB-1zapA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMZ_B_ROCB401_3
(PROTEASE)		 1zap SECRETED ASPARTIC
PROTEINASE
(Candida
albicans) 		5 / 12 LEU A 216
ASP A 218
GLY A 220
ALA A 303
ILE A 305
 None
A70  A 500 ( 2.3A)
A70  A 500 (-3.3A)
A70  A 500 ( 3.8A)
A70  A 500 (-4.8A)
 0.80A 2nmzB-1zapA:
7.8		 2nmzB-1zapA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RKF_A_AB1A501_1
(PROTEASE RETROPEPSIN)		 1zap SECRETED ASPARTIC
PROTEINASE
(Candida
albicans) 		5 / 12 LEU A 216
ASP A 218
GLY A 220
ALA A 303
ILE A 305
 None
A70  A 500 ( 2.3A)
A70  A 500 (-3.3A)
A70  A 500 ( 3.8A)
A70  A 500 (-4.8A)
 0.75A 2rkfA-1zapA:
7.3		 2rkfA-1zapA:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RKF_A_AB1A501_2
(PROTEASE RETROPEPSIN)		 1zap SECRETED ASPARTIC
PROTEINASE
(Candida
albicans) 		5 / 12 LEU A 216
ASP A 218
GLY A 220
ALA A 303
ILE A 305
 None
A70  A 500 ( 2.3A)
A70  A 500 (-3.3A)
A70  A 500 ( 3.8A)
A70  A 500 (-4.8A)
 0.72A 2rkfB-1zapA:
7.8		 2rkfB-1zapA:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_C_C41C1328_1
(RENIN)		 1zap SECRETED ASPARTIC
PROTEINASE
(Candida
albicans) 		6 / 12 ASP A  32
GLY A  34
SER A  35
TYR A  84
ASP A 218
GLY A 220
 A70  A 500 ( 2.7A)
A70  A 500 (-3.8A)
A70  A 500 ( 4.5A)
A70  A 500 (-3.8A)
A70  A 500 ( 2.3A)
A70  A 500 (-3.3A)
 0.32A 2v0zC-1zapA:
35.7		 2v0zC-1zapA:
27.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_C_C41C1328_1
(RENIN)		 1zap SECRETED ASPARTIC
PROTEINASE
(Candida
albicans) 		5 / 12 ASP A 218
GLY A 220
ASP A  32
GLY A  34
SER A  36
 A70  A 500 ( 2.3A)
A70  A 500 (-3.3A)
A70  A 500 ( 2.7A)
A70  A 500 (-3.8A)
None
 0.90A 2v0zC-1zapA:
35.7		 2v0zC-1zapA:
27.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_1
(RENIN)		 1zap SECRETED ASPARTIC
PROTEINASE
(Candida
albicans) 		6 / 12 ASP A 218
GLY A 220
ASP A  32
GLY A  34
SER A  36
ILE A 119
 A70  A 500 ( 2.3A)
A70  A 500 (-3.3A)
A70  A 500 ( 2.7A)
A70  A 500 (-3.8A)
None
A70  A 500 (-3.9A)
 1.05A 2v0zO-1zapA:
35.6		 2v0zO-1zapA:
27.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W1B_A_DXCA2034_0
(ACRIFLAVIN
RESISTANCE PROTEIN B)		 1zap SECRETED ASPARTIC
PROTEINASE
(Candida
albicans) 		3 / 3 PHE A 279
SER A 313
LEU A 311
 None
 0.79A 2w1bA-1zapA:
undetectable		 2w1bA-1zapA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BUF_A_AEGA394_0
(BETA-SECRETASE 1)		 1zap SECRETED ASPARTIC
PROTEINASE
(Candida
albicans) 		4 / 5 LEU A 216
ASP A 218
ILE A 305
GLY A  34
 None
A70  A 500 ( 2.3A)
A70  A 500 (-4.8A)
A70  A 500 (-3.8A)
 0.46A 3bufA-1zapA:
31.9		 3bufA-1zapA:
26.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_3
(HIV-1 PROTEASE)		 1zap SECRETED ASPARTIC
PROTEINASE
(Candida
albicans) 		5 / 12 ASP A  32
GLY A  34
ASP A  37
GLY A  83
ILE A 123
 A70  A 500 ( 2.7A)
A70  A 500 (-3.8A)
None
None
A70  A 500 (-4.8A)
 0.64A 3cyxB-1zapA:
7.2		 3cyxB-1zapA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKQ_A_ROCA100_1
(PROTEASE)		 1zap SECRETED ASPARTIC
PROTEINASE
(Candida
albicans) 		5 / 12 ASP A  32
GLY A  34
ASP A  37
GLY A  83
ILE A 123
 A70  A 500 ( 2.7A)
A70  A 500 (-3.8A)
None
None
A70  A 500 (-4.8A)
 0.84A 3ekqA-1zapA:
7.5		 3ekqA-1zapA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL0_A_1UNA201_1
(PROTEASE)		 1zap SECRETED ASPARTIC
PROTEINASE
(Candida
albicans) 		4 / 8 ASP A  32
GLY A  34
ASP A  37
ILE A 123
 A70  A 500 ( 2.7A)
A70  A 500 (-3.8A)
None
A70  A 500 (-4.8A)
 0.52A 3el0A-1zapA:
6.4		 3el0A-1zapA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_B_ERYB195_0
(REPRESSOR PROTEIN
MPHR(A))		 1zap SECRETED ASPARTIC
PROTEINASE
(Candida
albicans) 		5 / 12 THR A 338
GLY A 172
LEU A 124
VAL A 140
ILE A  18
 None
 1.04A 3frqB-1zapA:
undetectable		 3frqB-1zapA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_B_EPAB3_2
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 1zap SECRETED ASPARTIC
PROTEINASE
(Candida
albicans) 		5 / 12 GLN A 168
VAL A 126
VAL A 140
LEU A 144
ILE A 150
 None
 1.08A 3gwxB-1zapA:
undetectable		 3gwxB-1zapA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_1
(HIV-1 PROTEASE)		 1zap SECRETED ASPARTIC
PROTEINASE
(Candida
albicans) 		5 / 12 ASP A  32
GLY A  34
ASP A  37
GLY A  83
ILE A 123
 A70  A 500 ( 2.7A)
A70  A 500 (-3.8A)
None
None
A70  A 500 (-4.8A)
 0.80A 3k4vA-1zapA:
7.3		 3k4vA-1zapA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_3
(HIV-1 PROTEASE)		 1zap SECRETED ASPARTIC
PROTEINASE
(Candida
albicans) 		5 / 12 ASP A  32
GLY A  34
ASP A  37
GLY A  83
ILE A 123
 A70  A 500 ( 2.7A)
A70  A 500 (-3.8A)
None
None
A70  A 500 (-4.8A)
 0.77A 3k4vB-1zapA:
7.8		 3k4vB-1zapA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_A_CELA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1zap SECRETED ASPARTIC
PROTEINASE
(Candida
albicans) 		5 / 12 TYR A 315
LEU A 183
SER A 336
ILE A 170
GLY A 172
 None
 1.04A 3kk6A-1zapA:
undetectable		 3kk6A-1zapA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_B_CELB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1zap SECRETED ASPARTIC
PROTEINASE
(Candida
albicans) 		5 / 12 TYR A 315
LEU A 183
SER A 336
ILE A 170
GLY A 172
 None
 0.99A 3kk6B-1zapA:
undetectable		 3kk6B-1zapA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LCV_B_SAMB301_0
(SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM)		 1zap SECRETED ASPARTIC
PROTEINASE
(Candida
albicans) 		5 / 12 ARG A 195
TYR A 225
PHE A 298
ILE A 305
LEU A 217
 None
A70  A 500 ( 4.0A)
None
A70  A 500 (-4.8A)
None
 1.26A 3lcvB-1zapA:
undetectable		 3lcvB-1zapA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_A_ROCA101_1
(PROTEASE)		 1zap SECRETED ASPARTIC
PROTEINASE
(Candida
albicans) 		5 / 12 ASP A  32
GLY A  34
ASP A  37
GLY A  83
ILE A 123
 A70  A 500 ( 2.7A)
A70  A 500 (-3.8A)
None
None
A70  A 500 (-4.8A)
 0.77A 3ndtA-1zapA:
7.7		 3ndtA-1zapA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDX_A_RITA100_2
(PROTEASE)		 1zap SECRETED ASPARTIC
PROTEINASE
(Candida
albicans) 		5 / 11 ASP A  32
GLY A  34
ASP A  37
GLY A  83
ILE A 123
 A70  A 500 ( 2.7A)
A70  A 500 (-3.8A)
None
None
A70  A 500 (-4.8A)
 0.78A 3ndxB-1zapA:
7.2		 3ndxB-1zapA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU5_B_478B401_1
(PROTEASE)		 1zap SECRETED ASPARTIC
PROTEINASE
(Candida
albicans) 		5 / 12 ASP A  32
GLY A  34
ASP A  37
GLY A  85
ILE A 123
 A70  A 500 ( 2.7A)
A70  A 500 (-3.8A)
None
A70  A 500 (-3.5A)
A70  A 500 (-4.8A)
 0.83A 3nu5A-1zapA:
7.7		 3nu5A-1zapA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_B_478B200_1
(HIV-1 PROTEASE)		 1zap SECRETED ASPARTIC
PROTEINASE
(Candida
albicans) 		5 / 9 ASP A  32
GLY A  34
ASP A  37
GLY A  83
ILE A 123
 A70  A 500 ( 2.7A)
A70  A 500 (-3.8A)
None
None
A70  A 500 (-4.8A)
 0.82A 3oxvA-1zapA:
7.1		 3oxvA-1zapA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PRS_A_RITA1001_2
(ENDOTHIAPEPSIN)		 1zap SECRETED ASPARTIC
PROTEINASE
(Candida
albicans) 		9 / 12 ASP A  32
GLY A  34
GLY A  85
ASP A  86
ASP A 120
ASP A 218
THR A 221
TYR A 225
ILE A 305
 A70  A 500 ( 2.7A)
A70  A 500 (-3.8A)
A70  A 500 (-3.5A)
A70  A 500 (-3.1A)
None
A70  A 500 ( 2.3A)
A70  A 500 (-3.6A)
A70  A 500 ( 4.0A)
A70  A 500 (-4.8A)
 0.83A 3prsA-1zapA:
36.4		 3prsA-1zapA:
29.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWW_A_ROCA1001_1
(ENDOTHIAPEPSIN)		 1zap SECRETED ASPARTIC
PROTEINASE
(Candida
albicans) 		5 / 12 ASP A  32
GLY A  85
THR A 221
TYR A 225
ILE A 305
 A70  A 500 ( 2.7A)
A70  A 500 (-3.5A)
A70  A 500 (-3.6A)
A70  A 500 ( 4.0A)
A70  A 500 (-4.8A)
 0.45A 3pwwA-1zapA:
36.2		 3pwwA-1zapA:
29.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWW_A_ROCA1001_2
(ENDOTHIAPEPSIN)		 1zap SECRETED ASPARTIC
PROTEINASE
(Candida
albicans) 		7 / 8 GLY A  34
SER A  35
ILE A  82
TYR A  84
ASP A  86
ASP A 218
THR A 222
 A70  A 500 (-3.8A)
A70  A 500 ( 4.5A)
None
A70  A 500 (-3.8A)
A70  A 500 (-3.1A)
A70  A 500 ( 2.3A)
A70  A 500 (-4.0A)
 0.33A 3pwwA-1zapA:
36.2		 3pwwA-1zapA:
29.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWW_A_ROCA1001_2
(ENDOTHIAPEPSIN)		 1zap SECRETED ASPARTIC
PROTEINASE
(Candida
albicans) 		7 / 8 GLY A  34
SER A  35
TYR A  84
ASP A  86
SER A  88
ASP A 218
THR A 222
 A70  A 500 (-3.8A)
A70  A 500 ( 4.5A)
A70  A 500 (-3.8A)
A70  A 500 (-3.1A)
A70  A 500 ( 4.2A)
A70  A 500 ( 2.3A)
A70  A 500 (-4.0A)
 0.48A 3pwwA-1zapA:
36.2		 3pwwA-1zapA:
29.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3Q70_A_RITA2001_1
(CANDIDAPEPSIN-2)		 1zap SECRETED ASPARTIC
PROTEINASE
(Candida
albicans) 		12 / 12 ILE A  30
ASP A  32
GLY A  34
GLY A  85
SER A  88
ILE A 119
ASN A 131
GLU A 193
ASP A 218
THR A 221
TYR A 225
ILE A 305
 A70  A 500 (-4.3A)
A70  A 500 ( 2.7A)
A70  A 500 (-3.8A)
A70  A 500 (-3.5A)
A70  A 500 ( 4.2A)
A70  A 500 (-3.9A)
A70  A 500 (-3.8A)
A70  A 500 (-4.4A)
A70  A 500 ( 2.3A)
A70  A 500 (-3.6A)
A70  A 500 ( 4.0A)
A70  A 500 (-4.8A)
 0.48A 3q70A-1zapA:
54.1		 3q70A-1zapA:
97.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3Q70_A_RITA2001_1
(CANDIDAPEPSIN-2)		 1zap SECRETED ASPARTIC
PROTEINASE
(Candida
albicans) 		10 / 12 ILE A 123
ASP A  32
GLY A  34
GLY A  85
ILE A 119
GLU A 193
ASP A 218
THR A 221
TYR A 225
ILE A 305
 A70  A 500 (-4.8A)
A70  A 500 ( 2.7A)
A70  A 500 (-3.8A)
A70  A 500 (-3.5A)
A70  A 500 (-3.9A)
A70  A 500 (-4.4A)
A70  A 500 ( 2.3A)
A70  A 500 (-3.6A)
A70  A 500 ( 4.0A)
A70  A 500 (-4.8A)
 1.19A 3q70A-1zapA:
54.1		 3q70A-1zapA:
97.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3Q70_A_RITA2001_2
(CANDIDAPEPSIN-2)		 1zap SECRETED ASPARTIC
PROTEINASE
(Candida
albicans) 		6 / 6 THR A  13
SER A  35
ILE A  82
TYR A  84
ASP A 120
THR A 222
 A70  A 500 (-3.5A)
A70  A 500 ( 4.5A)
None
A70  A 500 (-3.8A)
None
A70  A 500 (-4.0A)
 0.34A 3q70A-1zapA:
54.1		 3q70A-1zapA:
97.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S54_B_017B201_2
(PROTEASE)		 1zap SECRETED ASPARTIC
PROTEINASE
(Candida
albicans) 		5 / 12 ASP A  32
GLY A  34
ASP A  37
GLY A  83
ILE A 123
 A70  A 500 ( 2.7A)
A70  A 500 (-3.8A)
None
None
A70  A 500 (-4.8A)
 0.82A 3s54B-1zapA:
7.4		 3s54B-1zapA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_1
(PROTEASE)		 1zap SECRETED ASPARTIC
PROTEINASE
(Candida
albicans) 		5 / 12 ASP A  32
GLY A  34
ASP A  37
GLY A  83
ILE A 123
 A70  A 500 ( 2.7A)
A70  A 500 (-3.8A)
None
None
A70  A 500 (-4.8A)
 0.84A 3tl9A-1zapA:
7.7		 3tl9A-1zapA:
17.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TNE_A_RITA401_1
(SECRETED ASPARTIC
PROTEASE)		 1zap SECRETED ASPARTIC
PROTEINASE
(Candida
albicans) 		11 / 12 ILE A  30
ASP A  32
GLY A  34
ILE A  82
GLY A  85
ASP A  86
SER A  88
ASN A 131
ASP A 218
TYR A 225
ILE A 305
 A70  A 500 (-4.3A)
A70  A 500 ( 2.7A)
A70  A 500 (-3.8A)
None
A70  A 500 (-3.5A)
A70  A 500 (-3.1A)
A70  A 500 ( 4.2A)
A70  A 500 (-3.8A)
A70  A 500 ( 2.3A)
A70  A 500 ( 4.0A)
A70  A 500 (-4.8A)
 0.60A 3tneA-1zapA:
47.9		 3tneA-1zapA:
51.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TNE_A_RITA401_1
(SECRETED ASPARTIC
PROTEASE)		 1zap SECRETED ASPARTIC
PROTEINASE
(Candida
albicans) 		11 / 12 ILE A  30
ASP A  32
GLY A  34
ILE A  82
GLY A  85
SER A  88
ASP A 120
ASN A 131
ASP A 218
TYR A 225
ILE A 305
 A70  A 500 (-4.3A)
A70  A 500 ( 2.7A)
A70  A 500 (-3.8A)
None
A70  A 500 (-3.5A)
A70  A 500 ( 4.2A)
None
A70  A 500 (-3.8A)
A70  A 500 ( 2.3A)
A70  A 500 ( 4.0A)
A70  A 500 (-4.8A)
 0.73A 3tneA-1zapA:
47.9		 3tneA-1zapA:
51.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TNE_A_RITA401_1
(SECRETED ASPARTIC
PROTEASE)		 1zap SECRETED ASPARTIC
PROTEINASE
(Candida
albicans) 		9 / 12 ILE A 123
ASP A  32
GLY A  34
GLY A  85
ASP A  86
SER A  88
ASP A 218
TYR A 225
ILE A 305
 A70  A 500 (-4.8A)
A70  A 500 ( 2.7A)
A70  A 500 (-3.8A)
A70  A 500 (-3.5A)
A70  A 500 (-3.1A)
A70  A 500 ( 4.2A)
A70  A 500 ( 2.3A)
A70  A 500 ( 4.0A)
A70  A 500 (-4.8A)
 1.20A 3tneA-1zapA:
47.9		 3tneA-1zapA:
51.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TNE_A_RITA401_1
(SECRETED ASPARTIC
PROTEASE)		 1zap SECRETED ASPARTIC
PROTEINASE
(Candida
albicans) 		9 / 12 ILE A 123
ASP A  32
GLY A  34
GLY A  85
SER A  88
ASP A 120
ASP A 218
TYR A 225
ILE A 305
 A70  A 500 (-4.8A)
A70  A 500 ( 2.7A)
A70  A 500 (-3.8A)
A70  A 500 (-3.5A)
A70  A 500 ( 4.2A)
None
A70  A 500 ( 2.3A)
A70  A 500 ( 4.0A)
A70  A 500 (-4.8A)
 1.37A 3tneA-1zapA:
47.9		 3tneA-1zapA:
51.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TNE_A_RITA401_2
(SECRETED ASPARTIC
PROTEASE)		 1zap SECRETED ASPARTIC
PROTEINASE
(Candida
albicans) 		4 / 6 SER A  35
TYR A  84
THR A 221
THR A 222
 A70  A 500 ( 4.5A)
A70  A 500 (-3.8A)
A70  A 500 (-3.6A)
A70  A 500 (-4.0A)
 0.31A 3tneA-1zapA:
47.9		 3tneA-1zapA:
51.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TNE_B_RITB401_1
(SECRETED ASPARTIC
PROTEASE)		 1zap SECRETED ASPARTIC
PROTEINASE
(Candida
albicans) 		9 / 12 ILE A  30
ASP A  32
GLY A  34
GLY A  85
ASP A  86
SER A  88
ASN A 131
ASP A 218
ILE A 305
 A70  A 500 (-4.3A)
A70  A 500 ( 2.7A)
A70  A 500 (-3.8A)
A70  A 500 (-3.5A)
A70  A 500 (-3.1A)
A70  A 500 ( 4.2A)
A70  A 500 (-3.8A)
A70  A 500 ( 2.3A)
A70  A 500 (-4.8A)
 0.60A 3tneB-1zapA:
48.1		 3tneB-1zapA:
51.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TNE_B_RITB401_1
(SECRETED ASPARTIC
PROTEASE)		 1zap SECRETED ASPARTIC
PROTEINASE
(Candida
albicans) 		9 / 12 ILE A  30
ASP A  32
GLY A  34
GLY A  85
SER A  88
ASP A 120
ASN A 131
ASP A 218
ILE A 305
 A70  A 500 (-4.3A)
A70  A 500 ( 2.7A)
A70  A 500 (-3.8A)
A70  A 500 (-3.5A)
A70  A 500 ( 4.2A)
None
A70  A 500 (-3.8A)
A70  A 500 ( 2.3A)
A70  A 500 (-4.8A)
 0.74A 3tneB-1zapA:
48.1		 3tneB-1zapA:
51.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TNE_B_RITB401_1
(SECRETED ASPARTIC
PROTEASE)		 1zap SECRETED ASPARTIC
PROTEINASE
(Candida
albicans) 		9 / 12 ILE A  30
ASP A  32
GLY A  34
ILE A  82
GLY A  85
ASP A  86
ASN A 131
ASP A 218
ILE A 305
 A70  A 500 (-4.3A)
A70  A 500 ( 2.7A)
A70  A 500 (-3.8A)
None
A70  A 500 (-3.5A)
A70  A 500 (-3.1A)
A70  A 500 (-3.8A)
A70  A 500 ( 2.3A)
A70  A 500 (-4.8A)
 0.47A 3tneB-1zapA:
48.1		 3tneB-1zapA:
51.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TNE_B_RITB401_1
(SECRETED ASPARTIC
PROTEASE)		 1zap SECRETED ASPARTIC
PROTEINASE
(Candida
albicans) 		9 / 12 ILE A  30
ASP A  32
GLY A  34
ILE A  82
GLY A  85
ASP A 120
ASN A 131
ASP A 218
ILE A 305
 A70  A 500 (-4.3A)
A70  A 500 ( 2.7A)
A70  A 500 (-3.8A)
None
A70  A 500 (-3.5A)
None
A70  A 500 (-3.8A)
A70  A 500 ( 2.3A)
A70  A 500 (-4.8A)
 0.56A 3tneB-1zapA:
48.1		 3tneB-1zapA:
51.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TNE_B_RITB401_1
(SECRETED ASPARTIC
PROTEASE)		 1zap SECRETED ASPARTIC
PROTEINASE
(Candida
albicans) 		8 / 12 ILE A 123
ASP A  32
GLY A  34
GLY A  85
ASP A  86
SER A  88
ASP A 218
ILE A 305
 A70  A 500 (-4.8A)
A70  A 500 ( 2.7A)
A70  A 500 (-3.8A)
A70  A 500 (-3.5A)
A70  A 500 (-3.1A)
A70  A 500 ( 4.2A)
A70  A 500 ( 2.3A)
A70  A 500 (-4.8A)
 1.23A 3tneB-1zapA:
48.1		 3tneB-1zapA:
51.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TNE_B_RITB401_1
(SECRETED ASPARTIC
PROTEASE)		 1zap SECRETED ASPARTIC
PROTEINASE
(Candida
albicans) 		8 / 12 ILE A 123
ASP A  32
GLY A  34
GLY A  85
SER A  88
ASP A 120
ASP A 218
ILE A 305
 A70  A 500 (-4.8A)
A70  A 500 ( 2.7A)
A70  A 500 (-3.8A)
A70  A 500 (-3.5A)
A70  A 500 ( 4.2A)
None
A70  A 500 ( 2.3A)
A70  A 500 (-4.8A)
 1.37A 3tneB-1zapA:
48.1		 3tneB-1zapA:
51.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TNE_B_RITB401_2
(SECRETED ASPARTIC
PROTEASE)		 1zap SECRETED ASPARTIC
PROTEINASE
(Candida
albicans) 		6 / 7 SER A  35
TYR A  84
ILE A 123
THR A 221
THR A 222
TYR A 225
 A70  A 500 ( 4.5A)
A70  A 500 (-3.8A)
A70  A 500 (-4.8A)
A70  A 500 (-3.6A)
A70  A 500 (-4.0A)
A70  A 500 ( 4.0A)
 0.41A 3tneB-1zapA:
48.1		 3tneB-1zapA:
51.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_B_SAMB401_0
(MNMC2)		 1zap SECRETED ASPARTIC
PROTEINASE
(Candida
albicans) 		5 / 12 GLY A 127
GLY A 125
LEU A  38
ASN A 153
LEU A 320
 None
 1.25A 3vywB-1zapA:
undetectable		 3vywB-1zapA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1475_0
(MJ0495-LIKE PROTEIN)		 1zap SECRETED ASPARTIC
PROTEINASE
(Candida
albicans) 		5 / 8 ASP A  17
ILE A  18
SER A  73
GLN A  25
GLY A  21
 None
 1.33A 4ac9C-1zapA:
undetectable		 4ac9C-1zapA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQF_B_017B101_2
(ASPARTYL PROTEASE)		 1zap SECRETED ASPARTIC
PROTEINASE
(Candida
albicans) 		5 / 10 ASP A  32
GLY A  34
ASP A  37
GLY A  83
ILE A 123
 A70  A 500 ( 2.7A)
A70  A 500 (-3.8A)
None
None
A70  A 500 (-4.8A)
 0.75A 4dqfB-1zapA:
7.4		 4dqfB-1zapA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX5_B_MIYB1103_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 1zap SECRETED ASPARTIC
PROTEINASE
(Candida
albicans) 		5 / 12 ASN A  28
ASP A  17
ILE A  18
VAL A  99
PHE A 101
 None
 1.19A 4dx5B-1zapA:
undetectable		 4dx5B-1zapA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX5_B_MIYB1103_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 1zap SECRETED ASPARTIC
PROTEINASE
(Candida
albicans) 		5 / 12 GLY A 122
ASN A  28
ASP A  17
VAL A  99
PHE A 101
 None
 1.12A 4dx5B-1zapA:
undetectable		 4dx5B-1zapA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ECK_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1zap SECRETED ASPARTIC
PROTEINASE
(Candida
albicans) 		5 / 12 VAL A 274
ALA A 314
LEU A 217
PHE A 266
PHE A 264
 None
 1.23A 4eckA-1zapA:
undetectable		 4eckA-1zapA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTV_A_ADNA403_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1zap SECRETED ASPARTIC
PROTEINASE
(Candida
albicans) 		5 / 12 SER A  88
ASP A  32
ILE A  30
ASP A 120
ILE A 119
 A70  A 500 ( 4.2A)
A70  A 500 ( 2.7A)
A70  A 500 (-4.3A)
None
A70  A 500 (-3.9A)
 1.36A 4ktvA-1zapA:
0.0
4ktvB-1zapA:
undetectable		 4ktvA-1zapA:
24.76
4ktvB-1zapA:
24.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 2)		 1zap SECRETED ASPARTIC
PROTEINASE
(Candida
albicans) 		5 / 12 ILE A 327
TYR A 155
VAL A 126
LEU A   7
LEU A 159
 None
 1.48A 4qztA-1zapA:
undetectable		 4qztA-1zapA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WH5_A_3QBA204_1
(LINCOSAMIDE
RESISTANCE PROTEIN)		 1zap SECRETED ASPARTIC
PROTEINASE
(Candida
albicans) 		5 / 12 ASP A 261
PHE A 266
ILE A 272
ALA A 314
GLN A 329
 None
 1.37A 4wh5A-1zapA:
undetectable		 4wh5A-1zapA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y4J_A_LNRA412_1
(ENDOTHIAPEPSIN)		 1zap SECRETED ASPARTIC
PROTEINASE
(Candida
albicans) 		5 / 9 ASP A  32
TYR A  84
ASP A  86
SER A  88
ASP A 120
 A70  A 500 ( 2.7A)
A70  A 500 (-3.8A)
A70  A 500 (-3.1A)
A70  A 500 ( 4.2A)
None
 1.15A 4y4jA-1zapA:
36.4		 4y4jA-1zapA:
29.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y4J_A_LNRA412_1
(ENDOTHIAPEPSIN)		 1zap SECRETED ASPARTIC
PROTEINASE
(Candida
albicans) 		5 / 9 ASP A  32
TYR A  84
SER A  88
SER A 118
ASP A 120
 A70  A 500 ( 2.7A)
A70  A 500 (-3.8A)
A70  A 500 ( 4.2A)
None
None
 1.45A 4y4jA-1zapA:
36.4		 4y4jA-1zapA:
29.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_A_STRA604_1
(CYTOCHROME P450
21-HYDROXYLASE)		 1zap SECRETED ASPARTIC
PROTEINASE
(Candida
albicans) 		5 / 12 VAL A  29
ILE A  18
GLY A 100
VAL A   3
LEU A 144
 None
 0.84A 4y8wA-1zapA:
undetectable		 4y8wA-1zapA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_B_STRB603_1
(CYTOCHROME P450
21-HYDROXYLASE)		 1zap SECRETED ASPARTIC
PROTEINASE
(Candida
albicans) 		5 / 12 VAL A  29
ILE A  18
GLY A 100
VAL A   3
LEU A 144
 None
 0.86A 4y8wB-1zapA:
undetectable		 4y8wB-1zapA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_C_STRC603_1
(CYTOCHROME P450
21-HYDROXYLASE)		 1zap SECRETED ASPARTIC
PROTEINASE
(Candida
albicans) 		5 / 12 VAL A  29
ILE A  18
GLY A 100
VAL A   3
LEU A 144
 None
 0.84A 4y8wC-1zapA:
undetectable		 4y8wC-1zapA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESE_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1zap SECRETED ASPARTIC
PROTEINASE
(Candida
albicans) 		4 / 8 TYR A  14
LEU A   7
ILE A  30
LEU A 311
 None
None
A70  A 500 (-4.3A)
None
 0.87A 5eseA-1zapA:
undetectable		 5eseA-1zapA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FXT_A_0LAA1376_1
(DNA POLYMERASE III
SUBUNIT BETA)		 1zap SECRETED ASPARTIC
PROTEINASE
(Candida
albicans) 		4 / 7 LEU A 306
THR A 224
ILE A 234
LEU A 296
 None
 0.77A 5fxtA-1zapA:
undetectable		 5fxtA-1zapA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M50_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 1zap SECRETED ASPARTIC
PROTEINASE
(Candida
albicans) 		5 / 12 VAL A 114
ASP A 113
SER A  90
THR A  55
GLY A  63
 None
None
None
ZN  A 400 ( 4.7A)
None
 1.37A 5m50B-1zapA:
undetectable		 5m50B-1zapA:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUI_B_CTCB405_0
(TETRACYCLINE
DESTRUCTASE TET(50))		 1zap SECRETED ASPARTIC
PROTEINASE
(Candida
albicans) 		5 / 12 PHE A 298
LEU A 306
PRO A 275
VAL A 203
ILE A 234
 None
 1.06A 5tuiB-1zapA:
undetectable		 5tuiB-1zapA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBP_B_ADNB404_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1zap SECRETED ASPARTIC
PROTEINASE
(Candida
albicans) 		5 / 12 ASP A  32
ILE A  30
ASP A 120
ILE A 119
SER A  88
 A70  A 500 ( 2.7A)
A70  A 500 (-4.3A)
None
A70  A 500 (-3.9A)
A70  A 500 ( 4.2A)
 1.21A 6fbpA-1zapA:
undetectable
6fbpB-1zapA:
undetectable		 6fbpA-1zapA:
13.21
6fbpB-1zapA:
13.21