SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1zau'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1L2I_B_CCSB417_0 (ESTROGEN RECEPTOR)	1zau	DNA LIGASE (Mycobacterium tuberculosis)	4 / 6	PRO A 174 PHE A 244 GLU A 242 VAL A 178	None	1.42A	1l2iB-1zauA: undetectable	1l2iB-1zauA: 22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3MBG_C_ACTC800_0 (FAD-LINKED SULFHYDRYL OXIDASE ALR)	1zau	DNA LIGASE (Mycobacterium tuberculosis)	3 / 3	ASP A 162 ARG A 232 ALA A 161	None	0.63A	3mbgC-1zauA: 0.0	3mbgC-1zauA: 18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3QWU_B_ADNB501_1 (DNA LIGASE)	1zau	DNA LIGASE (Mycobacterium tuberculosis)	5 / 11	GLU A 121 LYS A 123 ARG A 144 GLU A 184 LYS A 300	AMP A 400 (-4.3A) AMP A 400 (-2.7A) AMP A 400 ( 4.0A) AMP A 400 (-2.7A) AMP A 400 (-2.7A)	1.20A	3qwuB-1zauA: 4.6	3qwuB-1zauA: 22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3QWU_B_ADNB501_1 (DNA LIGASE)	1zau	DNA LIGASE (Mycobacterium tuberculosis)	5 / 11	GLU A 121 LYS A 123 GLU A 184 VAL A 298 LYS A 300	AMP A 400 (-4.3A) AMP A 400 (-2.7A) AMP A 400 (-2.7A) None AMP A 400 (-2.7A)	0.83A	3qwuB-1zauA: 4.6	3qwuB-1zauA: 22.83

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1L2I_B_CCSB417_0","ESTROGEN RECEPTOR","1zau","DNA LIGASE","Mycobacterium tuberculosis",4,"PRO A 174;PHE A 244;GLU A 242;VAL A 178","None","1.42A","1l2iB-1zauA:undetectable","1l2iB-1zauA:22.96"],["3MBG_C_ACTC800_0","FAD-LINKED SULFHYDRYL OXIDASE ALR","1zau","DNA LIGASE","Mycobacterium tuberculosis",3,"ASP A 162;ARG A 232;ALA A 161","None","0.63A","3mbgC-1zauA:0.0","3mbgC-1zauA:18.02"],["3QWU_B_ADNB501_1","DNA LIGASE","1zau","DNA LIGASE","Mycobacterium tuberculosis",5,"GLU A 121;LYS A 123;ARG A 144;GLU A 184;LYS A 300","AMP A 400 (-4.3A);AMP A 400 (-2.7A);AMP A 400 ( 4.0A);AMP A 400 (-2.7A);AMP A 400 (-2.7A)","1.20A","3qwuB-1zauA:4.6","3qwuB-1zauA:22.83"],["3QWU_B_ADNB501_1","DNA LIGASE","1zau","DNA LIGASE","Mycobacterium tuberculosis",5,"GLU A 121;LYS A 123;GLU A 184;VAL A 298;LYS A 300","AMP A 400 (-4.3A);AMP A 400 (-2.7A);AMP A 400 (-2.7A);None;AMP A 400 (-2.7A)","0.83A","3qwuB-1zauA:4.6","3qwuB-1zauA:22.83"]]