SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1zb1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_D_DVAD8_0
(GRAMICIDIN A)		 1zb1 BRO1 PROTEIN
(Saccharomyces
cerevisiae) 		3 / 3 TRP A 291
VAL A 243
TRP A 239
 None
 1.30A 1gmkC-1zb1A:
undetectable
1gmkD-1zb1A:
undetectable		 1gmkC-1zb1A:
2.55
1gmkD-1zb1A:
2.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_A_URFA1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 1zb1 BRO1 PROTEIN
(Saccharomyces
cerevisiae) 		4 / 6 ILE A 124
ASN A  67
ASN A  55
THR A  13
 None
 1.27A 1h7xA-1zb1A:
undetectable		 1h7xA-1zb1A:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_B_URFB1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 1zb1 BRO1 PROTEIN
(Saccharomyces
cerevisiae) 		4 / 6 ILE A 124
ASN A  67
ASN A  55
THR A  13
 None
 1.27A 1h7xB-1zb1A:
undetectable		 1h7xB-1zb1A:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_C_URFC1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 1zb1 BRO1 PROTEIN
(Saccharomyces
cerevisiae) 		4 / 6 ILE A 124
ASN A  67
ASN A  55
THR A  13
 None
 1.27A 1h7xC-1zb1A:
undetectable		 1h7xC-1zb1A:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_D_URFD1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 1zb1 BRO1 PROTEIN
(Saccharomyces
cerevisiae) 		4 / 6 ILE A 124
ASN A  67
ASN A  55
THR A  13
 None
 1.27A 1h7xD-1zb1A:
undetectable		 1h7xD-1zb1A:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKN_A_RALA600_2
(ESTROGEN RECEPTOR
BETA)		 1zb1 BRO1 PROTEIN
(Saccharomyces
cerevisiae) 		3 / 3 ASP A  48
LEU A  47
HIS A 111
 None
 0.67A 1qknA-1zb1A:
undetectable		 1qknA-1zb1A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_A_ZMRA1478_1
(NEURAMINIDASE)		 1zb1 BRO1 PROTEIN
(Saccharomyces
cerevisiae) 		4 / 7 SER A 166
ASP A 168
SER A 164
GLN A 110
 None
 1.15A 2cmlA-1zb1A:
undetectable		 2cmlA-1zb1A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_A_SAMA238_0
(N,N-DIMETHYLTRANSFER
ASE)		 1zb1 BRO1 PROTEIN
(Saccharomyces
cerevisiae) 		5 / 12 GLY A  82
LEU A  88
SER A  86
PHE A  79
LEU A 362
 None
 1.35A 3bxoA-1zb1A:
undetectable		 3bxoA-1zb1A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR4_X_PNTX101_0
(PROTEIN S100-B)		 1zb1 BRO1 PROTEIN
(Saccharomyces
cerevisiae) 		3 / 3 CYH A 245
HIS A 248
PHE A 288
 None
 1.09A 3cr4X-1zb1A:
0.0		 3cr4X-1zb1A:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UG8_A_IMNA2001_2
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 1zb1 BRO1 PROTEIN
(Saccharomyces
cerevisiae) 		3 / 3 TYR A 351
GLU A 345
TYR A 156
 None
 0.95A 3ug8A-1zb1A:
undetectable		 3ug8A-1zb1A:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VN2_A_TLSA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1zb1 BRO1 PROTEIN
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 366
TYR A  25
LEU A  22
LEU A  16
MET A  90
 None
 1.45A 3vn2A-1zb1A:
0.0		 3vn2A-1zb1A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW7_A_VPXA2001_1
(PROTEINASE-ACTIVATED
RECEPTOR 1, LYSOZYME)		 1zb1 BRO1 PROTEIN
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 292
LEU A 191
PHE A   6
LEU A 216
ALA A 212
 None
 1.07A 3vw7A-1zb1A:
2.4		 3vw7A-1zb1A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_C_SPMC201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 1zb1 BRO1 PROTEIN
(Saccharomyces
cerevisiae) 		4 / 7 TYR A  71
GLU A 345
GLU A  75
TYR A  78
 None
 1.29A 4mi4A-1zb1A:
undetectable
4mi4C-1zb1A:
undetectable		 4mi4A-1zb1A:
19.59
4mi4C-1zb1A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_B_9CRB501_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1zb1 BRO1 PROTEIN
(Saccharomyces
cerevisiae) 		3 / 3 GLN A 130
ILE A 339
HIS A 182
 None
 0.69A 5z12B-1zb1A:
undetectable		 5z12B-1zb1A:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKU_A_ZMRA901_2
(SIALIDASE)		 1zb1 BRO1 PROTEIN
(Saccharomyces
cerevisiae) 		4 / 6 ASP A  96
ASN A 123
LEU A 157
SER A 118
 None
 1.17A 6ekuA-1zb1A:
undetectable		 6ekuA-1zb1A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EU9_B_REAB601_1
(RETINOIC ACID
RECEPTOR)		 1zb1 BRO1 PROTEIN
(Saccharomyces
cerevisiae) 		5 / 10 VAL A 167
LEU A 169
SER A 166
PHE A 122
GLY A 235
 None
 1.21A 6eu9B-1zb1A:
undetectable		 6eu9B-1zb1A:
15.12