SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1zbh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_B_SAMB801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 1zbh 3'-5' EXONUCLEASE
ERI1
(Homo
sapiens) 		4 / 8 ILE A 318
ASN A 259
SER A 232
SER A 329
 None
None
None
C  F  20 ( 3.3A)
 1.09A 2zw9B-1zbhA:
undetectable		 2zw9B-1zbhA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3REM_A_SALA301_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 1zbh 3'-5' EXONUCLEASE
ERI1
(Homo
sapiens) 		4 / 8 VAL A 206
ARG A 175
VAL A 197
GLN A 172
 None
 1.03A 3remA-1zbhA:
2.8		 3remA-1zbhA:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZE_A_BAXA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 1zbh 3'-5' EXONUCLEASE
ERI1
(Homo
sapiens) 		4 / 8 VAL A 157
ILE A 132
ASP A 134
PHE A 135
 None
None
MG  A1000 (-2.5A)
None
 0.59A 3wzeA-1zbhA:
undetectable		 3wzeA-1zbhA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UYM_B_VORB590_1
(14-ALPHA STEROL
DEMETHYLASE)		 1zbh 3'-5' EXONUCLEASE
ERI1
(Homo
sapiens) 		4 / 7 PHE A 253
TYR A 250
ILE A 151
PHE A 154
 None
 0.95A 4uymB-1zbhA:
undetectable		 4uymB-1zbhA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUE_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 1zbh 3'-5' EXONUCLEASE
ERI1
(Homo
sapiens) 		4 / 5 GLY A 231
TYR A 264
GLU A 320
ASP A 230
 None
 1.33A 4xueA-1zbhA:
undetectable		 4xueA-1zbhA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI2_A_BAXA801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1zbh 3'-5' EXONUCLEASE
ERI1
(Homo
sapiens) 		5 / 8 ILE A 152
ILE A 132
ILE A 166
ILE A 302
ASP A 297
 None
 1.45A 5hi2A-1zbhA:
undetectable		 5hi2A-1zbhA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUM_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 1zbh 3'-5' EXONUCLEASE
ERI1
(Homo
sapiens) 		5 / 8 ILE A 132
ILE A 302
ILE A 260
ASN A 259
SER A 236
 None
 1.28A 5numA-1zbhA:
undetectable		 5numA-1zbhA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_E_D16E402_1
(THYMIDYLATE SYNTHASE)		 1zbh 3'-5' EXONUCLEASE
ERI1
(Homo
sapiens) 		4 / 6 PHE A 154
ASP A 297
LEU A 296
GLY A 295
 None
None
None
MG  A1001 ( 4.3A)
 1.00A 5x5qE-1zbhA:
undetectable		 5x5qE-1zbhA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_B_FFOB403_0
(THYMIDYLATE SYNTHASE)		 1zbh 3'-5' EXONUCLEASE
ERI1
(Homo
sapiens) 		5 / 10 PHE A 154
LEU A 277
ASP A 297
LEU A 296
GLY A 295
 None
None
None
None
MG  A1001 ( 4.3A)
 1.31A 6r2eB-1zbhA:
0.0		 6r2eB-1zbhA:
23.33