SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1zbs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMA_B_NCAB700_0
(EXOTOXIN A)		 1zbs HYPOTHETICAL PROTEIN
PG1100
(Porphyromonas
gingivalis) 		4 / 6 GLY A 100
TYR A  64
ALA A  95
GLU A  93
 None
 0.82A 1dmaB-1zbsA:
undetectable		 1dmaB-1zbsA:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FML_A_RTLA401_0
(RETINOL DEHYDRATASE)		 1zbs HYPOTHETICAL PROTEIN
PG1100
(Porphyromonas
gingivalis) 		5 / 12 LEU A 150
LEU A 153
SER A 219
LEU A 207
ILE A 203
 None
 1.41A 1fmlA-1zbsA:
undetectable		 1fmlA-1zbsA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_R_TRPR81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1zbs HYPOTHETICAL PROTEIN
PG1100
(Porphyromonas
gingivalis) 		5 / 9 GLY A  30
ALA A  44
THR A  28
ILE A  31
SER A  47
 None
 1.46A 1gtnR-1zbsA:
undetectable
1gtnS-1zbsA:
undetectable		 1gtnR-1zbsA:
12.33
1gtnS-1zbsA:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TV8_A_SAMA1501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 1zbs HYPOTHETICAL PROTEIN
PG1100
(Porphyromonas
gingivalis) 		4 / 7 THR A  28
THR A  12
VAL A  94
MET A  77
 None
 0.89A 1tv8A-1zbsA:
undetectable		 1tv8A-1zbsA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TV8_B_SAMB2501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 1zbs HYPOTHETICAL PROTEIN
PG1100
(Porphyromonas
gingivalis) 		4 / 7 THR A  28
THR A  12
VAL A  94
MET A  77
 None
 0.97A 1tv8B-1zbsA:
undetectable		 1tv8B-1zbsA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BJF_A_DXCA330_0
(CHOLOYLGLYCINE
HYDROLASE)		 1zbs HYPOTHETICAL PROTEIN
PG1100
(Porphyromonas
gingivalis) 		5 / 12 CYH A  70
PHE A  26
ILE A  53
ILE A  16
LEU A  82
 None
 1.28A 2bjfA-1zbsA:
undetectable		 2bjfA-1zbsA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_B_GBNB914_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 1zbs HYPOTHETICAL PROTEIN
PG1100
(Porphyromonas
gingivalis) 		5 / 10 PHE A 171
TYR A 175
GLY A 198
GLY A 147
ALA A 148
 None
 1.08A 2ej3B-1zbsA:
undetectable		 2ej3B-1zbsA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FB2_A_SAMA501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 1zbs HYPOTHETICAL PROTEIN
PG1100
(Porphyromonas
gingivalis) 		4 / 8 THR A  28
THR A  12
VAL A  94
MET A  77
 None
 0.92A 2fb2A-1zbsA:
undetectable		 2fb2A-1zbsA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FB2_B_SAMB501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 1zbs HYPOTHETICAL PROTEIN
PG1100
(Porphyromonas
gingivalis) 		4 / 7 THR A  28
THR A  12
VAL A  94
MET A  77
 None
 0.90A 2fb2B-1zbsA:
undetectable		 2fb2B-1zbsA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_GLYA333_0
(CHOLOYLGLYCINE
HYDROLASE)		 1zbs HYPOTHETICAL PROTEIN
PG1100
(Porphyromonas
gingivalis) 		3 / 3 ASN A 280
ASN A 281
ARG A 128
 None
 0.87A 2rlcA-1zbsA:
undetectable		 2rlcA-1zbsA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXP_A_CLMA1211_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 1zbs HYPOTHETICAL PROTEIN
PG1100
(Porphyromonas
gingivalis) 		5 / 8 ALA A  44
LEU A  45
LEU A  82
VAL A  63
ILE A  60
 None
 1.24A 2uxpA-1zbsA:
undetectable		 2uxpA-1zbsA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN0_A_TDZA501_1
(CYTOCHROME P450 2C8)		 1zbs HYPOTHETICAL PROTEIN
PG1100
(Porphyromonas
gingivalis) 		5 / 12 ILE A  31
THR A  12
LEU A  78
ASN A  79
ILE A  92
 None
 1.23A 2vn0A-1zbsA:
undetectable		 2vn0A-1zbsA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_B_H3PB552_1
(GLUTAMATE
DEHYDROGENASE)		 1zbs HYPOTHETICAL PROTEIN
PG1100
(Porphyromonas
gingivalis) 		3 / 3 TYR A 187
TYR A 139
ILE A 140
 None
 0.79A 3eteA-1zbsA:
undetectable
3eteB-1zbsA:
undetectable		 3eteA-1zbsA:
20.63
3eteB-1zbsA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_E_TOPE200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 1zbs HYPOTHETICAL PROTEIN
PG1100
(Porphyromonas
gingivalis) 		5 / 10 LEU A  78
LEU A  45
VAL A  49
LEU A  86
THR A  12
 None
 1.07A 3fl9E-1zbsA:
undetectable		 3fl9E-1zbsA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HLW_B_CE3B302_2
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 1zbs HYPOTHETICAL PROTEIN
PG1100
(Porphyromonas
gingivalis) 		3 / 3 CYH A 123
PRO A 136
ASP A  97
 None
 1.01A 3hlwB-1zbsA:
undetectable		 3hlwB-1zbsA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_A_SAMA300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1zbs HYPOTHETICAL PROTEIN
PG1100
(Porphyromonas
gingivalis) 		5 / 12 LEU A 274
ALA A  95
GLY A  67
GLY A 100
ALA A  75
 None
 1.14A 3ou6A-1zbsA:
undetectable		 3ou6A-1zbsA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_B_SAMB300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1zbs HYPOTHETICAL PROTEIN
PG1100
(Porphyromonas
gingivalis) 		5 / 12 LEU A 274
ALA A  95
GLY A  67
GLY A 100
ALA A  75
 None
 1.14A 3ou6B-1zbsA:
undetectable		 3ou6B-1zbsA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_B_SAMB300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1zbs HYPOTHETICAL PROTEIN
PG1100
(Porphyromonas
gingivalis) 		5 / 12 LEU A 274
ALA A  95
GLY A  67
GLY A 100
ALA A  75
 None
 1.15A 3ou7B-1zbsA:
undetectable		 3ou7B-1zbsA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXC_A_ROCA401_3
(PROTEASE)		 1zbs HYPOTHETICAL PROTEIN
PG1100
(Porphyromonas
gingivalis) 		5 / 12 LEU A  86
GLY A  54
GLY A  24
VAL A  63
ILE A  60
 None
 0.89A 3oxcB-1zbsA:
undetectable		 3oxcB-1zbsA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_B_SAMB300_0
(PUTATIVE
METHYLTRANSFERASE)		 1zbs HYPOTHETICAL PROTEIN
PG1100
(Porphyromonas
gingivalis) 		5 / 12 GLY A  67
GLY A  96
ASP A  97
SER A   9
ASN A  32
 None
 1.34A 3t7sB-1zbsA:
undetectable		 3t7sB-1zbsA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_A_NCAA1201_0
(TANKYRASE-2)		 1zbs HYPOTHETICAL PROTEIN
PG1100
(Porphyromonas
gingivalis) 		4 / 7 GLY A 100
TYR A  64
ALA A  95
GLU A  93
 None
 0.90A 4hyfA-1zbsA:
undetectable		 4hyfA-1zbsA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_B_NCAB1201_0
(TANKYRASE-2)		 1zbs HYPOTHETICAL PROTEIN
PG1100
(Porphyromonas
gingivalis) 		4 / 8 GLY A 100
TYR A  64
ALA A  95
GLU A  93
 None
 0.90A 4hyfB-1zbsA:
undetectable		 4hyfB-1zbsA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_C_NCAC1201_0
(TANKYRASE-2)		 1zbs HYPOTHETICAL PROTEIN
PG1100
(Porphyromonas
gingivalis) 		4 / 8 GLY A 100
TYR A  64
ALA A  95
GLU A  93
 None
 0.91A 4hyfC-1zbsA:
undetectable		 4hyfC-1zbsA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV0_B_SAMB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 1zbs HYPOTHETICAL PROTEIN
PG1100
(Porphyromonas
gingivalis) 		5 / 12 TYR A 248
GLY A 117
GLY A 147
ILE A 115
SER A 243
 None
 1.09A 4iv0B-1zbsA:
undetectable		 4iv0B-1zbsA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 1zbs HYPOTHETICAL PROTEIN
PG1100
(Porphyromonas
gingivalis) 		5 / 12 TYR A 248
GLY A 117
GLY A 147
ILE A 115
SER A 243
 None
 1.07A 4mwzA-1zbsA:
undetectable		 4mwzA-1zbsA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_C_SAMC601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 1zbs HYPOTHETICAL PROTEIN
PG1100
(Porphyromonas
gingivalis) 		5 / 12 GLY A 145
ASP A 222
ILE A 115
ASN A 121
GLY A 242
 None
 1.19A 4obwC-1zbsA:
undetectable		 4obwC-1zbsA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_G_SAMG301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 1zbs HYPOTHETICAL PROTEIN
PG1100
(Porphyromonas
gingivalis) 		5 / 12 ALA A  95
GLY A  96
GLY A  69
ALA A 102
ARG A 103
 None
 0.87A 5c0oG-1zbsA:
undetectable		 5c0oG-1zbsA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MXB_A_ML1A220_1
(CLASS 10 PLANT
PATHOGENESIS-RELATED
PROTEIN)		 1zbs HYPOTHETICAL PROTEIN
PG1100
(Porphyromonas
gingivalis) 		5 / 9 LEU A 116
VAL A 244
LEU A 153
TYR A 248
VAL A 255
 None
 1.32A 5mxbA-1zbsA:
0.0		 5mxbA-1zbsA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_A_RITA602_1
(CYTOCHROME P450 3A5)		 1zbs HYPOTHETICAL PROTEIN
PG1100
(Porphyromonas
gingivalis) 		5 / 12 LEU A 261
ILE A 112
ALA A 113
ALA A 245
GLY A 145
 None
 1.11A 5veuA-1zbsA:
undetectable		 5veuA-1zbsA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_B_RITB602_1
(CYTOCHROME P450 3A5)		 1zbs HYPOTHETICAL PROTEIN
PG1100
(Porphyromonas
gingivalis) 		5 / 12 LEU A 215
PHE A 171
ILE A 203
PHE A 202
GLY A 166
 None
 0.96A 5veuB-1zbsA:
undetectable		 5veuB-1zbsA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_D_HISD402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 1zbs HYPOTHETICAL PROTEIN
PG1100
(Porphyromonas
gingivalis) 		4 / 8 GLY A 260
LEU A 261
VAL A 225
LEU A 229
 None
 0.84A 6czmD-1zbsA:
undetectable
6czmF-1zbsA:
undetectable		 6czmD-1zbsA:
24.75
6czmF-1zbsA:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_F_HISF402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 1zbs HYPOTHETICAL PROTEIN
PG1100
(Porphyromonas
gingivalis) 		5 / 10 VAL A 225
VAL A 255
LEU A 229
GLY A 260
LEU A 261
 None
 1.12A 6czmE-1zbsA:
undetectable
6czmF-1zbsA:
undetectable		 6czmE-1zbsA:
24.75
6czmF-1zbsA:
24.75