SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1zbt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK1_A_T44A3003_1
(SERUM ALBUMIN)		 1zbt PEPTIDE CHAIN
RELEASE FACTOR 1
(Streptococcus
mutans) 		5 / 6 ILE A 114
LYS A 273
LYS A 270
ALA A 271
VAL A 165
 None
 1.44A 1hk1A-1zbtA:
3.2		 1hk1A-1zbtA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0A_A_GLYA73_0
(NONSTRUCTURAL
PROTEIN 1)		 1zbt PEPTIDE CHAIN
RELEASE FACTOR 1
(Streptococcus
mutans) 		4 / 5 GLN A  64
ALA A  61
GLN A  58
ILE A  60
 None
 1.23A 2z0aA-1zbtA:
4.2		 2z0aA-1zbtA:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_J_ZPCJ1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1zbt PEPTIDE CHAIN
RELEASE FACTOR 1
(Streptococcus
mutans) 		4 / 5 GLU A 152
GLU A 257
TYR A 228
HIS A 229
 None
 1.40A 4a97J-1zbtA:
0.0		 4a97J-1zbtA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYZ_B_CCSB109_0
(CELLULOSOME-RELATED
PROTEIN MODULE FROM
RUMINOCOCCUS
FLAVEFACIENS THAT
RESEMBLES
PAPAIN-LIKE CYSTEINE
PEPTIDASES)		 1zbt PEPTIDE CHAIN
RELEASE FACTOR 1
(Streptococcus
mutans) 		4 / 8 ASN A 108
VAL A 173
ILE A 113
ALA A 277
 None
 1.02A 4eyzB-1zbtA:
undetectable		 4eyzB-1zbtA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_C_377C401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1zbt PEPTIDE CHAIN
RELEASE FACTOR 1
(Streptococcus
mutans) 		4 / 6 ASN A   2
GLU A  95
TYR A  53
LEU A   7
 None
 1.17A 4twdB-1zbtA:
2.8
4twdC-1zbtA:
2.8		 4twdB-1zbtA:
20.05
4twdC-1zbtA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE3_A_CL6A502_1
(CYTOCHROME P-450)		 1zbt PEPTIDE CHAIN
RELEASE FACTOR 1
(Streptococcus
mutans) 		4 / 5 LEU A 338
ALA A 141
VAL A 207
ILE A 113
 None
 0.98A 4xe3A-1zbtA:
undetectable		 4xe3A-1zbtA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXE_A_ESTA1000_1
(ESTROGEN RECEPTOR)		 1zbt PEPTIDE CHAIN
RELEASE FACTOR 1
(Streptococcus
mutans) 		4 / 8 LEU A 338
GLU A 340
LEU A 327
HIS A 184
 None
 1.19A 5dxeA-1zbtA:
undetectable		 5dxeA-1zbtA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESG_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1zbt PEPTIDE CHAIN
RELEASE FACTOR 1
(Streptococcus
mutans) 		4 / 4 LEU A 206
TYR A 216
PRO A 209
ILE A 113
 None
 1.22A 5esgA-1zbtA:
undetectable		 5esgA-1zbtA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I9Y_A_1N1A1001_2
(EPHRIN TYPE-A
RECEPTOR 2)		 1zbt PEPTIDE CHAIN
RELEASE FACTOR 1
(Streptococcus
mutans) 		3 / 3 ILE A 274
ILE A 254
MET A 258
 None
 0.70A 5i9yA-1zbtA:
undetectable		 5i9yA-1zbtA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZMQ_I_PACI1_0
(SERINE PROTEASE NS3
SERINE PROTEASE
SUBUNIT NS2B
PEPTIDE
PAC-DLY-DLY-DAR)		 1zbt PEPTIDE CHAIN
RELEASE FACTOR 1
(Streptococcus
mutans) 		3 / 3 VAL A 186
TYR A 311
GLU A 125
 None
 0.86A 5zmqD-1zbtA:
undetectable
5zmqE-1zbtA:
undetectable		 5zmqD-1zbtA:
18.82
5zmqE-1zbtA:
8.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBZ_A_ESTA601_1
(ESTROGEN RECEPTOR)		 1zbt PEPTIDE CHAIN
RELEASE FACTOR 1
(Streptococcus
mutans) 		4 / 8 LEU A 338
GLU A 340
LEU A 327
HIS A 184
 None
 1.16A 6cbzA-1zbtA:
undetectable		 6cbzA-1zbtA:
11.11