SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1zbu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JTV_A_TESA500_1
(17
BETA-HYDROXYSTEROID
DEHYDROGENASE TYPE 1)
1zbu 3'-5' EXONUCLEASE
ERI1

(Homo
sapiens)
4 / 8 VAL A 330
TYR A 127
SER A 226
GLU A 337
None
0.90A 1jtvA-1zbuA:
undetectable
1jtvA-1zbuA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOS_A_VIAA1_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)
1zbu 3'-5' EXONUCLEASE
ERI1

(Homo
sapiens)
5 / 12 MET A 235
LEU A 227
MET A 344
SER A 246
ILE A 133
None
1.17A 1xosA-1zbuA:
undetectable
1xosA-1zbuA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_4
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)
1zbu 3'-5' EXONUCLEASE
ERI1

(Homo
sapiens)
4 / 5 ALA A 137
ALA A 200
GLN A 242
VAL A 206
AMP  A1002 (-3.7A)
None
None
None
0.94A 2nyrB-1zbuA:
undetectable
2nyrB-1zbuA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)
1zbu 3'-5' EXONUCLEASE
ERI1

(Homo
sapiens)
4 / 7 LEU A 239
GLN A 343
VAL A 210
LEU A 227
None
0.83A 3g8iA-1zbuA:
undetectable
3g8iA-1zbuA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_A_CELA682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)
1zbu 3'-5' EXONUCLEASE
ERI1

(Homo
sapiens)
4 / 8 ARG A 348
LEU A 239
ILE A 151
PHE A 203
None
0.76A 3ln1A-1zbuA:
undetectable
3ln1A-1zbuA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_B_CELB682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)
1zbu 3'-5' EXONUCLEASE
ERI1

(Homo
sapiens)
4 / 7 ARG A 348
LEU A 239
ILE A 151
PHE A 203
None
0.76A 3ln1B-1zbuA:
undetectable
3ln1B-1zbuA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZE_A_BAXA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
1zbu 3'-5' EXONUCLEASE
ERI1

(Homo
sapiens)
5 / 8 VAL A 157
VAL A 156
ILE A 132
ASP A 134
PHE A 135
None
None
None
MG  A1001 (-2.6A)
None
1.19A 3wzeA-1zbuA:
undetectable
3wzeA-1zbuA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UYM_B_VORB590_1
(14-ALPHA STEROL
DEMETHYLASE)
1zbu 3'-5' EXONUCLEASE
ERI1

(Homo
sapiens)
4 / 7 PHE A 253
TYR A 250
ILE A 151
PHE A 154
None
0.91A 4uymB-1zbuA:
undetectable
4uymB-1zbuA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_G_SAMG301_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)
1zbu 3'-5' EXONUCLEASE
ERI1

(Homo
sapiens)
3 / 3 GLU A 136
HIS A 293
ASP A 230
AMP  A1002 ( 2.7A)
AMP  A1002 (-4.0A)
None
0.79A 5c0oG-1zbuA:
undetectable
5c0oG-1zbuA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FCT_A_C2FA402_0
(THYMIDYLATE SYNTHASE)
1zbu 3'-5' EXONUCLEASE
ERI1

(Homo
sapiens)
5 / 11 PHE A 154
LEU A 277
ASP A 297
LEU A 296
GLY A 295
None
None
None
None
MG  A1001 ( 4.1A)
1.31A 5fctA-1zbuA:
undetectable
5fctA-1zbuA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUM_A_Z80A201_1
(BETA-LACTOGLOBULIN)
1zbu 3'-5' EXONUCLEASE
ERI1

(Homo
sapiens)
5 / 8 ILE A 132
ILE A 302
ILE A 260
ASN A 259
SER A 236
None
1.32A 5numA-1zbuA:
undetectable
5numA-1zbuA:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_E_D16E402_1
(THYMIDYLATE SYNTHASE)
1zbu 3'-5' EXONUCLEASE
ERI1

(Homo
sapiens)
4 / 6 PHE A 154
ASP A 297
LEU A 296
GLY A 295
None
None
None
MG  A1001 ( 4.1A)
1.01A 5x5qE-1zbuA:
undetectable
5x5qE-1zbuA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_B_FFOB403_0
(THYMIDYLATE SYNTHASE)
1zbu 3'-5' EXONUCLEASE
ERI1

(Homo
sapiens)
5 / 10 PHE A 154
LEU A 277
ASP A 297
LEU A 296
GLY A 295
None
None
None
None
MG  A1001 ( 4.1A)
1.31A 6r2eB-1zbuA:
undetectable
6r2eB-1zbuA:
23.90