SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1zbx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1MJL_A_SAMA200_0 (METHIONINE REPRESSOR PROTEIN METJ)	1zbx	ORIGIN RECOGNITION COMPLEX SUBUNIT 1 (Saccharomyces cerevisiae)	5 / 11	ALA A 204 GLU A 73 ARG A 75 ALA A 87 LEU A 138	None	1.08A	1mjlA-1zbxA: undetectable 1mjlB-1zbxA: undetectable	1mjlA-1zbxA: 22.22 1mjlB-1zbxA: 22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2ZIF_B_SAMB298_1 (PUTATIVE MODIFICATION METHYLASE)	1zbx	ORIGIN RECOGNITION COMPLEX SUBUNIT 1 (Saccharomyces cerevisiae)	3 / 3	ASP A 154 THR A 126 GLU A 131	None	0.59A	2zifB-1zbxA: undetectable	2zifB-1zbxA: 21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4XR4_B_AG2B511_1 (HOMOSPERMIDINE SYNTHASE)	1zbx	ORIGIN RECOGNITION COMPLEX SUBUNIT 1 (Saccharomyces cerevisiae)	3 / 3	VAL A 96 PHE A 105 ARG A 174	None	0.88A	4xr4B-1zbxA: undetectable	4xr4B-1zbxA: 19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Y4D_A_CFFA411_1 (ENDOTHIAPEPSIN)	1zbx	ORIGIN RECOGNITION COMPLEX SUBUNIT 1 (Saccharomyces cerevisiae)	4 / 6	LEU A 141 LEU A 50 ILE A 147 PHE A 146	None	1.27A	4y4dA-1zbxA: undetectable	4y4dA-1zbxA: 21.66

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1MJL_A_SAMA200_0","METHIONINE REPRESSOR PROTEIN METJ","1zbx","ORIGIN RECOGNITION COMPLEX SUBUNIT 1","Saccharomyces cerevisiae",5,"ALA A 204;GLU A  73;ARG A  75;ALA A  87;LEU A 138","None","1.08A","1mjlA-1zbxA:undetectable;1mjlB-1zbxA:undetectable","1mjlA-1zbxA:22.22;1mjlB-1zbxA:22.22"],["2ZIF_B_SAMB298_1","PUTATIVE MODIFICATION METHYLASE","1zbx","ORIGIN RECOGNITION COMPLEX SUBUNIT 1","Saccharomyces cerevisiae",3,"ASP A 154;THR A 126;GLU A 131","None","0.59A","2zifB-1zbxA:undetectable","2zifB-1zbxA:21.59"],["4XR4_B_AG2B511_1","HOMOSPERMIDINE SYNTHASE","1zbx","ORIGIN RECOGNITION COMPLEX SUBUNIT 1","Saccharomyces cerevisiae",3,"VAL A  96;PHE A 105;ARG A 174","None","0.88A","4xr4B-1zbxA:undetectable","4xr4B-1zbxA:19.24"],["4Y4D_A_CFFA411_1","ENDOTHIAPEPSIN","1zbx","ORIGIN RECOGNITION COMPLEX SUBUNIT 1","Saccharomyces cerevisiae",4,"LEU A 141;LEU A  50;ILE A 147;PHE A 146","None","1.27A","4y4dA-1zbxA:undetectable","4y4dA-1zbxA:21.66"]]