SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1zc1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1ICU_D_NIOD223_1 (OXYGEN-INSENSITIVE NAD(P)H NITROREDUCTASE)	1zc1	UBIQUITIN FUSION DEGRADATION PROTEIN 1 (Saccharomyces cerevisiae)	4 / 5	PHE A 151 GLY A 45 SER A 163 THR A 168	None	1.25A	1icuC-1zc1A: undetectable 1icuD-1zc1A: undetectable	1icuC-1zc1A: 18.83 1icuD-1zc1A: 18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1ICV_B_NIOB702_1 (OXYGEN-INSENSITIVE NAD(P)H NITROREDUCTASE)	1zc1	UBIQUITIN FUSION DEGRADATION PROTEIN 1 (Saccharomyces cerevisiae)	4 / 5	PHE A 151 GLY A 45 SER A 163 THR A 168	None	1.23A	1icvA-1zc1A: undetectable 1icvB-1zc1A: undetectable	1icvA-1zc1A: 18.83 1icvB-1zc1A: 18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2VAV_F_CSCF1383_2 (ACETYL-COA--DEACETYL CEPHALOSPORIN C ACETYLTRANSFERASE)	1zc1	UBIQUITIN FUSION DEGRADATION PROTEIN 1 (Saccharomyces cerevisiae)	3 / 3	LEU A 58 MET A 67 MET A 17	None	1.06A	2vavF-1zc1A: undetectable	2vavF-1zc1A: 18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3U88_A_CHDA611_0 (MENIN)	1zc1	UBIQUITIN FUSION DEGRADATION PROTEIN 1 (Saccharomyces cerevisiae)	3 / 3	SER A 163 PHE A 169 LYS A 170	None	0.88A	3u88A-1zc1A: undetectable	3u88A-1zc1A: 16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5IEN_A_VDYA201_1 (CDL2.2)	1zc1	UBIQUITIN FUSION DEGRADATION PROTEIN 1 (Saccharomyces cerevisiae)	5 / 12	LEU A 96 MET A 100 ILE A 114 ALA A 89 LEU A 50	None	1.27A	5ienA-1zc1A: undetectable	5ienA-1zc1A: 20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5LG3_G_Z80G401_1 (GAMMA-AMINOBUTYRIC-A CID RECEPTOR SUBUNIT BETA-1)	1zc1	UBIQUITIN FUSION DEGRADATION PROTEIN 1 (Saccharomyces cerevisiae)	5 / 10	ILE A 173 ILE A 160 PHE A 151 VAL A 125 THR A 194	None	1.14A	5lg3G-1zc1A: undetectable	5lg3G-1zc1A: 21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5LG3_H_Z80H401_1 (GAMMA-AMINOBUTYRIC-A CID RECEPTOR SUBUNIT BETA-1)	1zc1	UBIQUITIN FUSION DEGRADATION PROTEIN 1 (Saccharomyces cerevisiae)	5 / 10	ILE A 173 ILE A 160 PHE A 151 VAL A 125 THR A 194	None	1.15A	5lg3H-1zc1A: undetectable	5lg3H-1zc1A: 21.21

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1ICU_D_NIOD223_1","OXYGEN-INSENSITIVE NAD(P)H NITROREDUCTASE;OXYGEN-INSENSITIVE NAD(P)H NITROREDUCTASE","1zc1","UBIQUITIN FUSION DEGRADATION PROTEIN 1","Saccharomyces cerevisiae",4,"PHE A 151;GLY A  45;SER A 163;THR A 168","None","1.25A","1icuC-1zc1A:undetectable;1icuD-1zc1A:undetectable","1icuC-1zc1A:18.83;1icuD-1zc1A:18.83"],["1ICV_B_NIOB702_1","OXYGEN-INSENSITIVE NAD(P)H NITROREDUCTASE;OXYGEN-INSENSITIVE NAD(P)H NITROREDUCTASE","1zc1","UBIQUITIN FUSION DEGRADATION PROTEIN 1","Saccharomyces cerevisiae",4,"PHE A 151;GLY A  45;SER A 163;THR A 168","None","1.23A","1icvA-1zc1A:undetectable;1icvB-1zc1A:undetectable","1icvA-1zc1A:18.83;1icvB-1zc1A:18.83"],["2VAV_F_CSCF1383_2","ACETYL-COA--DEACETYLCEPHALOSPORIN C ACETYLTRANSFERASE","1zc1","UBIQUITIN FUSION DEGRADATION PROTEIN 1","Saccharomyces cerevisiae",3,"LEU A  58;MET A  67;MET A  17","None","1.06A","2vavF-1zc1A:undetectable","2vavF-1zc1A:18.36"],["3U88_A_CHDA611_0","MENIN","1zc1","UBIQUITIN FUSION DEGRADATION PROTEIN 1","Saccharomyces cerevisiae",3,"SER A 163;PHE A 169;LYS A 170","None","0.88A","3u88A-1zc1A:undetectable","3u88A-1zc1A:16.82"],["5IEN_A_VDYA201_1","CDL2.2","1zc1","UBIQUITIN FUSION DEGRADATION PROTEIN 1","Saccharomyces cerevisiae",5,"LEU A  96;MET A 100;ILE A 114;ALA A  89;LEU A  50","None","1.27A","5ienA-1zc1A:undetectable","5ienA-1zc1A:20.27"],["5LG3_G_Z80G401_1","GAMMA-AMINOBUTYRIC-ACID RECEPTOR SUBUNIT BETA-1","1zc1","UBIQUITIN FUSION DEGRADATION PROTEIN 1","Saccharomyces cerevisiae",5,"ILE A 173;ILE A 160;PHE A 151;VAL A 125;THR A 194","None","1.14A","5lg3G-1zc1A:undetectable","5lg3G-1zc1A:21.21"],["5LG3_H_Z80H401_1","GAMMA-AMINOBUTYRIC-ACID RECEPTOR SUBUNIT BETA-1","1zc1","UBIQUITIN FUSION DEGRADATION PROTEIN 1","Saccharomyces cerevisiae",5,"ILE A 173;ILE A 160;PHE A 151;VAL A 125;THR A 194","None","1.15A","5lg3H-1zc1A:undetectable","5lg3H-1zc1A:21.21"]]