SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1zc6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVT_A_FLPA125_1
(TRANSTHYRETIN)		 1zc6 PROBABLE
N-ACETYLGLUCOSAMINE
KINASE
(Chromobacterium
violaceum) 		4 / 8 LEU A  35
LEU A  27
LEU A  81
THR A  23
 None
 0.83A 1dvtA-1zc6A:
undetectable
1dvtB-1zc6A:
undetectable		 1dvtA-1zc6A:
15.49
1dvtB-1zc6A:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETB_2_T442129_1
(TRANSTHYRETIN)		 1zc6 PROBABLE
N-ACETYLGLUCOSAMINE
KINASE
(Chromobacterium
violaceum) 		4 / 6 LEU A 231
GLU A 227
ALA A 167
LEU A 163
 None
 1.23A 1etb2-1zc6A:
undetectable		 1etb2-1zc6A:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETB_2_T442129_1
(TRANSTHYRETIN)		 1zc6 PROBABLE
N-ACETYLGLUCOSAMINE
KINASE
(Chromobacterium
violaceum) 		4 / 6 LEU A 231
GLU A 227
THR A 185
LEU A 163
 None
 1.02A 1etb2-1zc6A:
undetectable		 1etb2-1zc6A:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_5
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1zc6 PROBABLE
N-ACETYLGLUCOSAMINE
KINASE
(Chromobacterium
violaceum) 		3 / 3 THR A 185
LEU A 189
VAL A 192
 None
 0.49A 1mz9E-1zc6A:
undetectable		 1mz9E-1zc6A:
9.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT6_B_DESB128_1
(TRANSTHYRETIN)		 1zc6 PROBABLE
N-ACETYLGLUCOSAMINE
KINASE
(Chromobacterium
violaceum) 		4 / 5 LEU A  81
ALA A 108
LEU A  83
SER A  84
 None
 1.12A 1tt6B-1zc6A:
undetectable		 1tt6B-1zc6A:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXQ_A_IMNA2001_1
(SERUM ALBUMIN)		 1zc6 PROBABLE
N-ACETYLGLUCOSAMINE
KINASE
(Chromobacterium
violaceum) 		5 / 10 LYS A   8
ALA A  74
ALA A  78
LEU A 291
LEU A  13
 None
 1.11A 2bxqA-1zc6A:
undetectable		 2bxqA-1zc6A:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_C_GBNC1414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 1zc6 PROBABLE
N-ACETYLGLUCOSAMINE
KINASE
(Chromobacterium
violaceum) 		4 / 8 GLY A 151
GLY A 132
THR A 131
ALA A 161
 None
 0.57A 2ej3C-1zc6A:
undetectable		 2ej3C-1zc6A:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HMA_A_SAMA375_0
(PROBABLE TRNA
(5-METHYLAMINOMETHYL
-2-THIOURIDYLATE)-ME
THYLTRANSFERASE)		 1zc6 PROBABLE
N-ACETYLGLUCOSAMINE
KINASE
(Chromobacterium
violaceum) 		5 / 11 GLY A 149
SER A 133
GLY A 155
GLN A 165
PHE A 211
 None
 1.48A 2hmaA-1zc6A:
undetectable		 2hmaA-1zc6A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMY_A_ROCA401_2
(PROTEASE)		 1zc6 PROBABLE
N-ACETYLGLUCOSAMINE
KINASE
(Chromobacterium
violaceum) 		5 / 12 LEU A  60
GLY A  80
ASP A  17
ALA A  63
ILE A  25
 None
 0.92A 2nmyB-1zc6A:
undetectable		 2nmyB-1zc6A:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA502_0
(CHORISMATE SYNTHASE)		 1zc6 PROBABLE
N-ACETYLGLUCOSAMINE
KINASE
(Chromobacterium
violaceum) 		3 / 3 GLY A 111
ASP A 110
SER A 283
 None
 0.70A 2qhfA-1zc6A:
undetectable		 2qhfA-1zc6A:
25.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_A_SAMA801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 1zc6 PROBABLE
N-ACETYLGLUCOSAMINE
KINASE
(Chromobacterium
violaceum) 		5 / 12 ILE A  79
SER A  52
GLY A  82
GLY A  18
LEU A 290
 None
 0.96A 2zw9A-1zc6A:
undetectable		 2zw9A-1zc6A:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC10_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 1zc6 PROBABLE
N-ACETYLGLUCOSAMINE
KINASE
(Chromobacterium
violaceum) 		3 / 3 GLY A 281
GLY A 286
GLY A 117
 None
 0.43A 3bogC-1zc6A:
undetectable		 3bogC-1zc6A:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC10_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 1zc6 PROBABLE
N-ACETYLGLUCOSAMINE
KINASE
(Chromobacterium
violaceum) 		3 / 3 GLY A 286
GLY A 120
GLY A 117
 None
 0.41A 3bogC-1zc6A:
undetectable		 3bogC-1zc6A:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DHID8_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 1zc6 PROBABLE
N-ACETYLGLUCOSAMINE
KINASE
(Chromobacterium
violaceum) 		4 / 4 SER A 133
GLY A 132
GLY A 148
GLY A 155
 None
 0.84A 3bogB-1zc6A:
0.0
3bogD-1zc6A:
0.0		 3bogB-1zc6A:
undetectable
3bogD-1zc6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DVAD10_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 1zc6 PROBABLE
N-ACETYLGLUCOSAMINE
KINASE
(Chromobacterium
violaceum) 		3 / 3 GLY A 286
GLY A 120
GLY A 117
 None
 0.35A 3bogD-1zc6A:
undetectable		 3bogD-1zc6A:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_A_THHA642_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 1zc6 PROBABLE
N-ACETYLGLUCOSAMINE
KINASE
(Chromobacterium
violaceum) 		5 / 12 GLY A 130
ASP A 110
VAL A  86
GLY A 149
ILE A 134
 None
 1.17A 3k13A-1zc6A:
undetectable		 3k13A-1zc6A:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_B_THHB643_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 1zc6 PROBABLE
N-ACETYLGLUCOSAMINE
KINASE
(Chromobacterium
violaceum) 		5 / 12 GLY A 130
ASP A 110
VAL A  86
GLY A 149
ILE A 134
 None
 1.18A 3k13B-1zc6A:
undetectable		 3k13B-1zc6A:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_C_THHC643_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 1zc6 PROBABLE
N-ACETYLGLUCOSAMINE
KINASE
(Chromobacterium
violaceum) 		5 / 12 GLY A 130
ASP A 110
VAL A  86
GLY A 149
ILE A 134
 None
 1.18A 3k13C-1zc6A:
undetectable		 3k13C-1zc6A:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_B_ADNB402_1
(PROBABLE SUGAR
KINASE PROTEIN)		 1zc6 PROBABLE
N-ACETYLGLUCOSAMINE
KINASE
(Chromobacterium
violaceum) 		5 / 9 ILE A  14
VAL A  16
ALA A  38
ALA A  63
ILE A  25
 None
 1.08A 4lbgB-1zc6A:
undetectable		 4lbgB-1zc6A:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_B_CQAB303_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 1zc6 PROBABLE
N-ACETYLGLUCOSAMINE
KINASE
(Chromobacterium
violaceum) 		4 / 8 GLY A  82
GLY A  15
LEU A 288
LEU A 289
 None
 0.82A 4mwzB-1zc6A:
undetectable		 4mwzB-1zc6A:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 1zc6 PROBABLE
N-ACETYLGLUCOSAMINE
KINASE
(Chromobacterium
violaceum) 		5 / 9 THR A  59
ALA A 284
GLY A  41
GLY A  22
ASP A 110
 None
 1.07A 4qwuY-1zc6A:
undetectable
4qwuZ-1zc6A:
undetectable		 4qwuY-1zc6A:
20.71
4qwuZ-1zc6A:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 1zc6 PROBABLE
N-ACETYLGLUCOSAMINE
KINASE
(Chromobacterium
violaceum) 		5 / 8 LEU A 163
GLY A 164
ALA A 235
LEU A 264
GLY A 130
 None
 1.20A 4zauA-1zc6A:
undetectable		 4zauA-1zc6A:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 1zc6 PROBABLE
N-ACETYLGLUCOSAMINE
KINASE
(Chromobacterium
violaceum) 		5 / 8 LEU A 260
GLY A 259
ALA A 215
LEU A 163
GLY A 132
 None
 0.91A 4zauA-1zc6A:
undetectable		 4zauA-1zc6A:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWX_A_SAMA301_0
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 1zc6 PROBABLE
N-ACETYLGLUCOSAMINE
KINASE
(Chromobacterium
violaceum) 		5 / 12 ALA A 284
GLY A 286
GLY A  80
HIS A  28
LEU A  27
 None
 1.11A 5gwxA-1zc6A:
undetectable		 5gwxA-1zc6A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_G_IPHG101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 1zc6 PROBABLE
N-ACETYLGLUCOSAMINE
KINASE
(Chromobacterium
violaceum) 		4 / 6 LEU A 288
CYH A  77
HIS A  28
LEU A  27
 None
 1.11A 5hrqD-1zc6A:
undetectable
5hrqG-1zc6A:
undetectable
5hrqH-1zc6A:
undetectable		 5hrqD-1zc6A:
6.76
5hrqG-1zc6A:
5.21
5hrqH-1zc6A:
6.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MFX_A_ACTA701_0
(GENOME POLYPROTEIN)		 1zc6 PROBABLE
N-ACETYLGLUCOSAMINE
KINASE
(Chromobacterium
violaceum) 		4 / 5 THR A  33
HIS A  28
ALA A  29
ASP A  31
 None
 1.33A 5mfxA-1zc6A:
undetectable		 5mfxA-1zc6A:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA901_0
(MRNA CAPPING ENZYME
P5)		 1zc6 PROBABLE
N-ACETYLGLUCOSAMINE
KINASE
(Chromobacterium
violaceum) 		5 / 11 VAL A 127
GLY A 135
ASP A 238
ALA A 239
LEU A 129
 None
 1.11A 5x6yA-1zc6A:
undetectable		 5x6yA-1zc6A:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_A_HISA402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 1zc6 PROBABLE
N-ACETYLGLUCOSAMINE
KINASE
(Chromobacterium
violaceum) 		5 / 10 GLY A 236
LEU A 264
VAL A 218
ALA A 222
LEU A 163
 None
 1.15A 6czmA-1zc6A:
undetectable
6czmC-1zc6A:
undetectable		 6czmA-1zc6A:
24.00
6czmC-1zc6A:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_B_TA1B501_1
(TUBULIN BETA CHAIN)		 1zc6 PROBABLE
N-ACETYLGLUCOSAMINE
KINASE
(Chromobacterium
violaceum) 		5 / 12 ASP A 229
LEU A 256
LEU A 276
LEU A 129
LEU A 219
 None
 1.11A 6ew0B-1zc6A:
undetectable		 6ew0B-1zc6A:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_D_TA1D501_1
(TUBULIN BETA CHAIN)		 1zc6 PROBABLE
N-ACETYLGLUCOSAMINE
KINASE
(Chromobacterium
violaceum) 		5 / 12 ASP A 229
LEU A 256
LEU A 276
LEU A 129
LEU A 219
 None
 1.11A 6ew0D-1zc6A:
undetectable		 6ew0D-1zc6A:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_H_TA1H501_1
(TUBULIN BETA CHAIN)		 1zc6 PROBABLE
N-ACETYLGLUCOSAMINE
KINASE
(Chromobacterium
violaceum) 		5 / 12 ASP A 229
LEU A 256
LEU A 276
LEU A 129
LEU A 219
 None
 1.12A 6ew0H-1zc6A:
undetectable		 6ew0H-1zc6A:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_I_TA1I501_1
(TUBULIN BETA CHAIN)		 1zc6 PROBABLE
N-ACETYLGLUCOSAMINE
KINASE
(Chromobacterium
violaceum) 		5 / 12 ASP A 229
LEU A 256
LEU A 276
LEU A 129
LEU A 219
 None
 1.11A 6ew0I-1zc6A:
undetectable		 6ew0I-1zc6A:
14.14