SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1zca'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F5L_A_AMRA301_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 1zca G ALPHA I/12
(Mus
musculus) 		4 / 8 SER A  66
SER A  69
GLY A 228
GLY A  62
 GDP  A 382 (-2.9A)
MG  A 383 ( 2.1A)
ALF  A 384 (-3.3A)
None
 0.65A 1f5lA-1zcaA:
undetectable		 1f5lA-1zcaA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TNL_A_TPAA900_1
(TRYPSIN)		 1zca G ALPHA I/12
(Mus
musculus) 		4 / 6 SER A  66
SER A  69
GLY A 228
GLY A  62
 GDP  A 382 (-2.9A)
MG  A 383 ( 2.1A)
ALF  A 384 (-3.3A)
None
 0.77A 1tnlA-1zcaA:
undetectable		 1tnlA-1zcaA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZP4_C_C2FC997_0
(5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE)		 1zca G ALPHA I/12
(Mus
musculus) 		5 / 10 ASP A 318
GLN A 331
PHE A 315
TYR A 255
LEU A 329
 None
 1.28A 1zp4C-1zcaA:
3.2		 1zp4C-1zcaA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTV_A_NCAA1301_0
(CATIONIC TRYPSIN)		 1zca G ALPHA I/12
(Mus
musculus) 		4 / 6 SER A  66
SER A  69
GLY A 228
GLY A  62
 GDP  A 382 (-2.9A)
MG  A 383 ( 2.1A)
ALF  A 384 (-3.3A)
None
 0.73A 2otvA-1zcaA:
undetectable		 2otvA-1zcaA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1501_1
(CYTOCHROME P450 3A4)		 1zca G ALPHA I/12
(Mus
musculus) 		5 / 10 ASP A 334
ARG A 337
SER A 245
ILE A 246
ILE A  58
 None
 1.17A 2v0mA-1zcaA:
undetectable		 2v0mA-1zcaA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VIN_A_505A1247_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR CHAIN B)		 1zca G ALPHA I/12
(Mus
musculus) 		4 / 8 SER A  66
SER A  69
GLY A 228
GLY A  62
 GDP  A 382 (-2.9A)
MG  A 383 ( 2.1A)
ALF  A 384 (-3.3A)
None
 0.71A 2vinA-1zcaA:
undetectable		 2vinA-1zcaA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YDO_A_ADNA400_1
(ADENOSINE RECEPTOR
A2A)		 1zca G ALPHA I/12
(Mus
musculus) 		5 / 12 PHE A 361
MET A  75
LEU A 247
ILE A 290
SER A 245
 None
 1.37A 2ydoA-1zcaA:
0.0		 2ydoA-1zcaA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZI9_A_CL9A401_2
(DEOXYCYTIDINE KINASE)		 1zca G ALPHA I/12
(Mus
musculus) 		3 / 3 ASP A  93
PHE A  96
LEU A 100
 None
 0.30A 2zi9A-1zcaA:
6.1		 2zi9A-1zcaA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_B_TMQB612_1
(DHFR-TS)		 1zca G ALPHA I/12
(Mus
musculus) 		5 / 12 ALA A 363
ILE A 290
PHE A 361
SER A 245
ILE A  58
 None
 1.08A 3clbB-1zcaA:
undetectable		 3clbB-1zcaA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N61_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE)		 1zca G ALPHA I/12
(Mus
musculus) 		4 / 7 PHE A 165
SER A 103
VAL A 105
VAL A 177
 None
 1.25A 3n61A-1zcaA:
undetectable
3n61B-1zcaA:
undetectable		 3n61A-1zcaA:
21.25
3n61B-1zcaA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RXF_A_4APA9_1
(CATIONIC TRYPSIN)		 1zca G ALPHA I/12
(Mus
musculus) 		4 / 6 SER A  66
SER A  69
GLY A 228
GLY A  62
 GDP  A 382 (-2.9A)
MG  A 383 ( 2.1A)
ALF  A 384 (-3.3A)
None
 0.64A 3rxfA-1zcaA:
undetectable		 3rxfA-1zcaA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ6_A_SAMA300_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 1zca G ALPHA I/12
(Mus
musculus) 		5 / 12 LEU A 181
ILE A  95
ILE A 187
ASP A  97
LEU A 129
 None
 0.95A 3uj6A-1zcaA:
2.5		 3uj6A-1zcaA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I13_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 1zca G ALPHA I/12
(Mus
musculus) 		3 / 3 ASP A 297
ARG A 168
THR A 350
 GDP  A 382 (-3.1A)
None
GDP  A 382 (-3.7A)
 0.89A 4i13A-1zcaA:
undetectable		 4i13A-1zcaA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWX_A_ZMRA513_2
(NEURAMINIDASE)		 1zca G ALPHA I/12
(Mus
musculus) 		3 / 3 ARG A 233
TRP A 236
ILE A 274
 None
 1.01A 4mwxA-1zcaA:
undetectable		 4mwxA-1zcaA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3R_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 1zca G ALPHA I/12
(Mus
musculus) 		3 / 3 ASP A 297
ARG A 168
THR A 350
 GDP  A 382 (-3.1A)
None
GDP  A 382 (-3.7A)
 0.88A 4p3rA-1zcaA:
undetectable		 4p3rA-1zcaA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB201_0
(HYDROXYNITRILE LYASE)		 1zca G ALPHA I/12
(Mus
musculus) 		5 / 11 VAL A 149
PHE A 145
ILE A  95
ILE A 187
LEU A 181
 None
 1.09A 5e4dB-1zcaA:
undetectable		 5e4dB-1zcaA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERS_A_ACTA803_0
(GEPHYRIN)		 1zca G ALPHA I/12
(Mus
musculus) 		3 / 3 THR A  94
ALA A 202
ASN A  98
 None
 0.48A 5ersA-1zcaA:
2.6		 5ersA-1zcaA:
23.36