SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1zch'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_C_MK1C402_2
(HIV-II PROTEASE)		 1zch HYPOTHETICAL
OXIDOREDUCTASE YCND
(Bacillus
subtilis) 		5 / 8 ALA A  73
GLY A 131
ILE A  14
PRO A 134
ILE A 135
 None
None
None
FMN  A 301 (-4.0A)
FMN  A 301 (-3.8A)
 1.25A 1hshD-1zchA:
undetectable		 1hshD-1zchA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PN0_A_IPHA6012_0
(PHENOL
2-MONOOXYGENASE)		 1zch HYPOTHETICAL
OXIDOREDUCTASE YCND
(Bacillus
subtilis) 		5 / 10 GLY A 110
GLN A  45
VAL A 109
MET A  98
ILE A 100
 None
 1.34A 1pn0A-1zchA:
undetectable		 1pn0A-1zchA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PN0_B_IPHB6022_0
(PHENOL
2-MONOOXYGENASE)		 1zch HYPOTHETICAL
OXIDOREDUCTASE YCND
(Bacillus
subtilis) 		5 / 10 GLY A 110
GLN A  45
VAL A 109
MET A  98
ILE A 100
 None
 1.35A 1pn0B-1zchA:
undetectable		 1pn0B-1zchA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SV9_A_DIFA701_1
(PHOSPHOLIPASE A2)		 1zch HYPOTHETICAL
OXIDOREDUCTASE YCND
(Bacillus
subtilis) 		5 / 8 LEU A 161
ALA A 125
ILE A  30
GLY A 119
HIS A  11
 None
None
None
None
FMN  A 301 (-4.1A)
 1.32A 1sv9A-1zchA:
undetectable		 1sv9A-1zchA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B17_A_DIFA701_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 1zch HYPOTHETICAL
OXIDOREDUCTASE YCND
(Bacillus
subtilis) 		5 / 10 LEU A 161
ALA A 125
ILE A  30
GLY A 119
HIS A  11
 None
None
None
None
FMN  A 301 (-4.1A)
 1.33A 2b17A-1zchA:
undetectable		 2b17A-1zchA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXF_B_DZPB2001_1
(SERUM ALBUMIN)		 1zch HYPOTHETICAL
OXIDOREDUCTASE YCND
(Bacillus
subtilis) 		5 / 12 ILE A  49
LEU A  63
CYH A  80
LEU A 148
ARG A  56
 None
 1.28A 2bxfB-1zchA:
undetectable		 2bxfB-1zchA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6F_C_010C6_0
(INFECTIOUS
BRONCHITIS VIRUS
(IBV) MAIN PROTEASE
N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE)		 1zch HYPOTHETICAL
OXIDOREDUCTASE YCND
(Bacillus
subtilis) 		3 / 3 ASN A 189
LEU A 193
HIS A 183
 None
 0.82A 2q6fB-1zchA:
0.0		 2q6fB-1zchA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5Q_B_1UNB900_2
(PROTEASE)		 1zch HYPOTHETICAL
OXIDOREDUCTASE YCND
(Bacillus
subtilis) 		5 / 11 GLY A  65
ALA A  64
ILE A  60
VAL A 133
ILE A 135
 None
None
None
None
FMN  A 301 (-3.8A)
 0.87A 2r5qB-1zchA:
undetectable		 2r5qB-1zchA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_B_CELB1701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1zch HYPOTHETICAL
OXIDOREDUCTASE YCND
(Bacillus
subtilis) 		4 / 6 VAL A   4
LEU A 161
ALA A 123
LEU A   8
 None
 0.76A 3kk6B-1zchA:
undetectable		 3kk6B-1zchA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDV_B_CL6B506_1
(CHOLESTEROL
24-HYDROXYLASE)		 1zch HYPOTHETICAL
OXIDOREDUCTASE YCND
(Bacillus
subtilis) 		6 / 12 LEU A 161
VAL A  48
LEU A 130
THR A  50
ALA A  33
ALA A 125
 None
 1.39A 3mdvB-1zchA:
undetectable		 3mdvB-1zchA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_A_CGEA501_1
(CYTOCHROME P450 2B4)		 1zch HYPOTHETICAL
OXIDOREDUCTASE YCND
(Bacillus
subtilis) 		5 / 10 VAL A  48
PHE A  79
ILE A  31
ALA A 125
VAL A  75
 None
 1.03A 3me6A-1zchA:
undetectable		 3me6A-1zchA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_C_CGEC501_1
(CYTOCHROME P450 2B4)		 1zch HYPOTHETICAL
OXIDOREDUCTASE YCND
(Bacillus
subtilis) 		5 / 9 VAL A  48
PHE A  79
ILE A  31
ALA A 125
VAL A  75
 None
 1.05A 3me6C-1zchA:
undetectable		 3me6C-1zchA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_D_CGED501_1
(CYTOCHROME P450 2B4)		 1zch HYPOTHETICAL
OXIDOREDUCTASE YCND
(Bacillus
subtilis) 		5 / 9 VAL A  48
PHE A  79
ILE A  31
ALA A 125
VAL A  75
 None
 1.03A 3me6D-1zchA:
undetectable		 3me6D-1zchA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_K_BO2K1402_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 1zch HYPOTHETICAL
OXIDOREDUCTASE YCND
(Bacillus
subtilis) 		6 / 11 ALA A 121
THR A 122
ALA A 124
ALA A 114
GLY A 115
SER A 159
 None
None
None
None
None
FMN  A 301 ( 3.9A)
 1.26A 3mg0K-1zchA:
undetectable
3mg0L-1zchA:
undetectable		 3mg0K-1zchA:
21.32
3mg0L-1zchA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_Y_BO2Y1403_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 1zch HYPOTHETICAL
OXIDOREDUCTASE YCND
(Bacillus
subtilis) 		6 / 12 ALA A 121
THR A 122
ALA A 123
ALA A 114
GLY A 115
SER A 159
 None
None
None
None
None
FMN  A 301 ( 3.9A)
 1.47A 3mg0Y-1zchA:
undetectable
3mg0Z-1zchA:
undetectable		 3mg0Y-1zchA:
21.32
3mg0Z-1zchA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_Y_BO2Y1403_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 1zch HYPOTHETICAL
OXIDOREDUCTASE YCND
(Bacillus
subtilis) 		6 / 12 ALA A 121
THR A 122
ALA A 124
ALA A 114
GLY A 115
SER A 159
 None
None
None
None
None
FMN  A 301 ( 3.9A)
 1.31A 3mg0Y-1zchA:
undetectable
3mg0Z-1zchA:
undetectable		 3mg0Y-1zchA:
21.32
3mg0Z-1zchA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_B_SAMB201_0
(YAEB-LIKE PROTEIN
RPA0152)		 1zch HYPOTHETICAL
OXIDOREDUCTASE YCND
(Bacillus
subtilis) 		3 / 3 LYS A 249
ARG A 237
LYS A 153
 None
 1.05A 3okxA-1zchA:
undetectable		 3okxA-1zchA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HAJ_A_DXCA75_0
(PPCA)		 1zch HYPOTHETICAL
OXIDOREDUCTASE YCND
(Bacillus
subtilis) 		4 / 7 ILE A 236
LEU A 240
PHE A 156
GLY A 110
 None
 0.90A 4hajA-1zchA:
undetectable		 4hajA-1zchA:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HB6_A_DXCA75_0
(PPCA)		 1zch HYPOTHETICAL
OXIDOREDUCTASE YCND
(Bacillus
subtilis) 		4 / 8 ILE A 236
LEU A 240
PHE A 156
GLY A 110
 None
 0.81A 4hb6A-1zchA:
undetectable		 4hb6A-1zchA:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6C_B_STRB503_1
(CYTOCHROME P450
MONOOXYGENASE)		 1zch HYPOTHETICAL
OXIDOREDUCTASE YCND
(Bacillus
subtilis) 		5 / 10 ALA A 121
ALA A 124
ALA A 125
VAL A  22
GLN A  26
 None
 1.16A 4j6cB-1zchA:
undetectable		 4j6cB-1zchA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JBT_A_ASDA501_1
(CYTOCHROME P450
MONOOXYGENASE)		 1zch HYPOTHETICAL
OXIDOREDUCTASE YCND
(Bacillus
subtilis) 		5 / 12 ALA A 121
ALA A 124
ALA A 125
VAL A  22
GLN A  26
 None
 1.12A 4jbtA-1zchA:
undetectable		 4jbtA-1zchA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JBT_B_ASDB502_1
(CYTOCHROME P450
MONOOXYGENASE)		 1zch HYPOTHETICAL
OXIDOREDUCTASE YCND
(Bacillus
subtilis) 		5 / 11 ALA A 121
ALA A 124
ALA A 125
VAL A  22
GLN A  26
 None
 1.12A 4jbtB-1zchA:
undetectable		 4jbtB-1zchA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		 1zch HYPOTHETICAL
OXIDOREDUCTASE YCND
(Bacillus
subtilis) 		4 / 6 LEU A 128
ALA A 124
LEU A 130
VAL A  34
 None
 1.11A 5a6iA-1zchA:
undetectable		 5a6iA-1zchA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_B_ACTB404_0
(D-ALANINE--D-ALANINE
LIGASE)		 1zch HYPOTHETICAL
OXIDOREDUCTASE YCND
(Bacillus
subtilis) 		4 / 7 ARG A 139
GLY A 136
SER A 159
LEU A 158
 None
FMN  A 301 (-3.5A)
FMN  A 301 ( 3.9A)
None
 0.96A 5bphB-1zchA:
undetectable		 5bphB-1zchA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_D_ACTD403_0
(D-ALANINE--D-ALANINE
LIGASE)		 1zch HYPOTHETICAL
OXIDOREDUCTASE YCND
(Bacillus
subtilis) 		4 / 6 ARG A 139
GLY A 136
SER A 159
LEU A 158
 None
FMN  A 301 (-3.5A)
FMN  A 301 ( 3.9A)
None
 0.94A 5bphD-1zchA:
undetectable		 5bphD-1zchA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB3_A_UEGA202_1
(YFIR)		 1zch HYPOTHETICAL
OXIDOREDUCTASE YCND
(Bacillus
subtilis) 		4 / 4 LEU A 240
ILE A 236
PRO A 157
LEU A 158
 None
 1.22A 5eb3A-1zchA:
undetectable		 5eb3A-1zchA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECL_D_ILED602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 1zch HYPOTHETICAL
OXIDOREDUCTASE YCND
(Bacillus
subtilis) 		4 / 6 ILE A 116
ALA A 121
THR A 120
VAL A  46
 None
 0.88A 5eclD-1zchA:
0.7		 5eclD-1zchA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JVZ_A_FLPA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1zch HYPOTHETICAL
OXIDOREDUCTASE YCND
(Bacillus
subtilis) 		5 / 12 LEU A 240
VAL A 247
GLY A 103
SER A 106
LEU A 108
 None
 1.00A 5jvzA-1zchA:
undetectable		 5jvzA-1zchA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YN6_A_SAMA401_0
(NSP16 PROTEIN)		 1zch HYPOTHETICAL
OXIDOREDUCTASE YCND
(Bacillus
subtilis) 		5 / 12 TYR A 233
GLY A 136
PRO A 142
GLY A 140
LEU A 161
 None
FMN  A 301 (-3.5A)
None
None
None
 1.13A 5yn6A-1zchA:
undetectable		 5yn6A-1zchA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YNI_A_SAMA401_0
(NSP16 PROTEIN)		 1zch HYPOTHETICAL
OXIDOREDUCTASE YCND
(Bacillus
subtilis) 		5 / 12 TYR A 233
GLY A 136
PRO A 142
GLY A 140
LEU A 161
 None
FMN  A 301 (-3.5A)
None
None
None
 1.14A 5yniA-1zchA:
undetectable		 5yniA-1zchA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YNM_A_SAMA401_0
(NSP16 PROTEIN)		 1zch HYPOTHETICAL
OXIDOREDUCTASE YCND
(Bacillus
subtilis) 		5 / 12 TYR A 233
GLY A 136
PRO A 142
GLY A 140
LEU A 161
 None
FMN  A 301 (-3.5A)
None
None
None
 1.14A 5ynmA-1zchA:
undetectable		 5ynmA-1zchA:
21.45