SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1zcj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_A_ESTA351_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 1zcj PEROXISOMAL
BIFUNCTIONAL ENZYME
(Rattus
norvegicus) 		6 / 12 SER A 521
VAL A 520
LEU A 484
PRO A 517
PHE A 492
LEU A 623
 None
 1.48A 1fduA-1zcjA:
7.0		 1fduA-1zcjA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7H_A_BCZA801_0
(NEURAMINIDASE)		 1zcj PEROXISOMAL
BIFUNCTIONAL ENZYME
(Rattus
norvegicus) 		5 / 12 ARG A 552
ILE A 688
GLU A 497
GLU A 496
TYR A 602
 None
 1.30A 1l7hA-1zcjA:
undetectable		 1l7hA-1zcjA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_D_THAD4_2
(LIVER
CARBOXYLESTERASE I)		 1zcj PEROXISOMAL
BIFUNCTIONAL ENZYME
(Rattus
norvegicus) 		3 / 3 PHE A 511
LEU A 623
MET A 483
 None
 0.88A 1mx1D-1zcjA:
2.0		 1mx1D-1zcjA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_2
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1zcj PEROXISOMAL
BIFUNCTIONAL ENZYME
(Rattus
norvegicus) 		3 / 3 LEU A 671
VAL A 674
LEU A 678
 None
 0.50A 1mz9B-1zcjA:
undetectable		 1mz9B-1zcjA:
6.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TDR_A_MTXA170_1
(TELLUROMETHIONYL
DIHYDROFOLATE
REDUCTASE)		 1zcj PEROXISOMAL
BIFUNCTIONAL ENZYME
(Rattus
norvegicus) 		5 / 12 ILE A 465
ALA A 436
PHE A 315
THR A 430
LEU A 376
 None
 1.14A 1tdrA-1zcjA:
undetectable		 1tdrA-1zcjA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA130_1
(FATTY ACID-BINDING
PROTEIN)		 1zcj PEROXISOMAL
BIFUNCTIONAL ENZYME
(Rattus
norvegicus) 		3 / 3 TYR A 649
ARG A 632
GLN A 690
 None
 1.00A 1tw4A-1zcjA:
undetectable		 1tw4A-1zcjA:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CDQ_A_SAMA1500_0
(ASPARTOKINASE)		 1zcj PEROXISOMAL
BIFUNCTIONAL ENZYME
(Rattus
norvegicus) 		4 / 8 ILE A 320
SER A 297
ASP A 375
LEU A 461
 None
 0.95A 2cdqA-1zcjA:
2.1		 2cdqA-1zcjA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PRG_A_BRLA1_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 1zcj PEROXISOMAL
BIFUNCTIONAL ENZYME
(Rattus
norvegicus) 		3 / 3 ILE A 633
ILE A 648
LEU A 678
 None
 0.49A 2prgA-1zcjA:
undetectable		 2prgA-1zcjA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_C_DVAC8_0
(GRAMICIDIN A)		 1zcj PEROXISOMAL
BIFUNCTIONAL ENZYME
(Rattus
norvegicus) 		3 / 3 VAL A 470
TRP A 288
TRP A 280
 None
 1.14A 2xdcC-1zcjA:
undetectable
2xdcD-1zcjA:
undetectable		 2xdcC-1zcjA:
3.14
2xdcD-1zcjA:
3.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 1zcj PEROXISOMAL
BIFUNCTIONAL ENZYME
(Rattus
norvegicus) 		5 / 12 LEU A 708
ALA A 630
ALA A 667
PHE A 511
LEU A 508
 None
 1.29A 3b0wB-1zcjA:
undetectable		 3b0wB-1zcjA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB1_A_IMNA701_1
(LACTOTRANSFERRIN)		 1zcj PEROXISOMAL
BIFUNCTIONAL ENZYME
(Rattus
norvegicus) 		4 / 4 PRO A 283
THR A 282
GLY A 429
THR A 407
 None
 1.16A 3ib1A-1zcjA:
2.3		 3ib1A-1zcjA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 1zcj PEROXISOMAL
BIFUNCTIONAL ENZYME
(Rattus
norvegicus) 		5 / 12 ILE A 313
GLY A 310
ALA A 380
PRO A 435
ALA A 335
 None
 0.89A 3jb2A-1zcjA:
3.1		 3jb2A-1zcjA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB3_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 1zcj PEROXISOMAL
BIFUNCTIONAL ENZYME
(Rattus
norvegicus) 		5 / 12 ILE A 313
GLY A 310
ALA A 380
PRO A 435
ALA A 335
 None
 1.01A 3jb3A-1zcjA:
undetectable		 3jb3A-1zcjA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TPX_E_ACTE204_0
(E3 UBIQUITIN-PROTEIN
LIGASE MDM2)		 1zcj PEROXISOMAL
BIFUNCTIONAL ENZYME
(Rattus
norvegicus) 		3 / 3 LYS A 583
PRO A 584
LEU A 585
 None
 0.82A 3tpxE-1zcjA:
undetectable		 3tpxE-1zcjA:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WXO_A_NIZA802_1
(CATALASE-PEROXIDASE)		 1zcj PEROXISOMAL
BIFUNCTIONAL ENZYME
(Rattus
norvegicus) 		4 / 8 LEU A 634
ILE A 633
GLY A 480
ILE A 648
 None
 0.87A 3wxoA-1zcjA:
undetectable		 3wxoA-1zcjA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQ8_A_DVAA8_0
(VAL-GRAMICIDIN A)		 1zcj PEROXISOMAL
BIFUNCTIONAL ENZYME
(Rattus
norvegicus) 		3 / 3 VAL A 470
TRP A 288
TRP A 280
 None
 1.11A 3zq8A-1zcjA:
undetectable
3zq8B-1zcjA:
undetectable		 3zq8A-1zcjA:
3.14
3zq8B-1zcjA:
3.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FR0_A_SAMA401_0
(ARSENIC
METHYLTRANSFERASE)		 1zcj PEROXISOMAL
BIFUNCTIONAL ENZYME
(Rattus
norvegicus) 		6 / 12 GLY A 303
GLY A 305
GLN A 331
GLU A 394
ASN A 408
LEU A 387
 None
 1.39A 4fr0A-1zcjA:
6.1		 4fr0A-1zcjA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G5J_A_0WMA1102_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 1zcj PEROXISOMAL
BIFUNCTIONAL ENZYME
(Rattus
norvegicus) 		4 / 7 TYR A 602
HIS A 606
ILE A 608
PRO A 559
 None
 1.02A 4g5jA-1zcjA:
0.0		 4g5jA-1zcjA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HOJ_A_ACTA303_0
(REGF PROTEIN)		 1zcj PEROXISOMAL
BIFUNCTIONAL ENZYME
(Rattus
norvegicus) 		4 / 5 VAL A 479
ARG A 482
MET A 483
GLU A 629
 None
 1.17A 4hojA-1zcjA:
undetectable		 4hojA-1zcjA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_A_OBNA1104_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 1zcj PEROXISOMAL
BIFUNCTIONAL ENZYME
(Rattus
norvegicus) 		4 / 5 PRO A 662
ASP A 646
ILE A 633
VAL A 470
 None
 1.20A 4hytA-1zcjA:
3.5		 4hytA-1zcjA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I90_A_ACTA500_0
(1-PHOSPHATIDYLINOSIT
OL PHOSPHODIESTERASE)		 1zcj PEROXISOMAL
BIFUNCTIONAL ENZYME
(Rattus
norvegicus) 		3 / 3 LYS A 576
ARG A 569
TRP A 594
 None
 1.06A 4i90A-1zcjA:
1.8		 4i90A-1zcjA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWV_A_BCZA513_0
(NEURAMINIDASE)		 1zcj PEROXISOMAL
BIFUNCTIONAL ENZYME
(Rattus
norvegicus) 		5 / 12 ARG A 552
ILE A 688
GLU A 497
GLU A 496
TYR A 602
 None
 1.28A 4mwvA-1zcjA:
undetectable		 4mwvA-1zcjA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PFJ_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1zcj PEROXISOMAL
BIFUNCTIONAL ENZYME
(Rattus
norvegicus) 		4 / 7 GLU A 496
LEU A 691
ASN A 685
SER A 499
 None
 0.99A 4pfjA-1zcjA:
3.7		 4pfjA-1zcjA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWD_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 1zcj PEROXISOMAL
BIFUNCTIONAL ENZYME
(Rattus
norvegicus) 		4 / 8 PRO A 501
LEU A 595
TYR A 579
LEU A 564
 None
 0.90A 4pwdA-1zcjA:
undetectable		 4pwdA-1zcjA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA409_0
(FAD:PROTEIN FMN
TRANSFERASE)		 1zcj PEROXISOMAL
BIFUNCTIONAL ENZYME
(Rattus
norvegicus) 		4 / 5 ILE A 648
VAL A 470
ILE A 468
VAL A 647
 None
 0.76A 4xdtA-1zcjA:
undetectable		 4xdtA-1zcjA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DBY_A_ACTA610_0
(SERUM ALBUMIN)		 1zcj PEROXISOMAL
BIFUNCTIONAL ENZYME
(Rattus
norvegicus) 		3 / 3 TYR A 681
LYS A 677
LYS A 680
 None
 1.36A 5dbyA-1zcjA:
undetectable		 5dbyA-1zcjA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5P9I_A_1E8A701_2
(TYROSINE-PROTEIN
KINASE BTK)		 1zcj PEROXISOMAL
BIFUNCTIONAL ENZYME
(Rattus
norvegicus) 		4 / 5 LEU A 484
TYR A 649
CYH A 622
ASP A 505
 None
 1.36A 5p9iA-1zcjA:
undetectable		 5p9iA-1zcjA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA902_0
(MRNA CAPPING ENZYME
P5)		 1zcj PEROXISOMAL
BIFUNCTIONAL ENZYME
(Rattus
norvegicus) 		5 / 12 LEU A 691
GLY A 491
PRO A 486
PRO A 517
VAL A 507
 None
 1.31A 5x6yA-1zcjA:
3.1		 5x6yA-1zcjA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9M_A_NIOA401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 1zcj PEROXISOMAL
BIFUNCTIONAL ENZYME
(Rattus
norvegicus) 		4 / 8 LEU A 376
VAL A 299
VAL A 296
ILE A 465
 None
 0.77A 5y9mA-1zcjA:
undetectable		 5y9mA-1zcjA:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_A_TLFA300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		 1zcj PEROXISOMAL
BIFUNCTIONAL ENZYME
(Rattus
norvegicus) 		5 / 12 VAL A 325
PHE A 315
ILE A 320
VAL A 296
VAL A 323
 None
 1.27A 6ap6A-1zcjA:
undetectable		 6ap6A-1zcjA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_B_TLFB300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		 1zcj PEROXISOMAL
BIFUNCTIONAL ENZYME
(Rattus
norvegicus) 		5 / 12 VAL A 325
PHE A 315
ILE A 320
VAL A 296
VAL A 323
 None
 1.26A 6ap6B-1zcjA:
undetectable		 6ap6B-1zcjA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FK2_A_SORA302_0
(GALECTIN-3)		 1zcj PEROXISOMAL
BIFUNCTIONAL ENZYME
(Rattus
norvegicus) 		4 / 4 ARG A 621
GLU A 617
GLU A 497
ARG A 611
 None
 1.14A 6fk2A-1zcjA:
undetectable		 6fk2A-1zcjA:
16.92