SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1zcn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1EI6_D_PPFD412_1 (PHOSPHONOACETATE HYDROLASE)	1zcn	PEPTIDYL-PROLYL CIS-TRANS ISOMERASE NIMA-INTERACTING 1 (Homo sapiens)	4 / 8	PHE A 151 THR A 152 ILE A 156 HIS A 59	None 1PE A 400 ( 4.6A) None 1PE A 400 ( 4.4A)	0.83A	1ei6D-1zcnA: undetectable	1ei6D-1zcnA: 16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2XRZ_A_ACTA1467_0 (DEOXYRIBODIPYRIMIDIN E PHOTOLYASE)	1zcn	PEPTIDYL-PROLYL CIS-TRANS ISOMERASE NIMA-INTERACTING 1 (Homo sapiens)	4 / 5	ARG A 127 ASP A 136 ILE A 28 GLU A 51	None	1.40A	2xrzA-1zcnA: undetectable 2xrzB-1zcnA: undetectable	2xrzA-1zcnA: 16.82 2xrzB-1zcnA: 16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3JZJ_A_ACRA405_2 (ACARBOSE/MALTOSE BINDING PROTEIN GACH)	1zcn	PEPTIDYL-PROLYL CIS-TRANS ISOMERASE NIMA-INTERACTING 1 (Homo sapiens)	4 / 6	ASN A 17 TYR A 24 TRP A 11 TRP A 34	None None None 1PE A 300 (-3.6A)	1.49A	3jzjA-1zcnA: 0.0	3jzjA-1zcnA: 16.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4TNS_A_REAA201_1 (PEPTIDYL-PROLYL CIS-TRANS ISOMERASE NIMA-INTERACTING 1)	1zcn	PEPTIDYL-PROLYL CIS-TRANS ISOMERASE NIMA-INTERACTING 1 (Homo sapiens)	8 / 9	HIS A 59 LYS A 63 ARG A 68 MET A 130 GLN A 131 PHE A 134 SER A 154 HIS A 157	1PE A 400 ( 4.4A) PO4 A 321 (-2.6A) PO4 A 321 (-3.8A) 1PE A 400 (-3.8A) 1PE A 400 (-4.5A) 1PE A 400 (-3.7A) PO4 A 321 (-2.7A) 1PE A 400 ( 4.7A)	0.28A	4tnsA-1zcnA: 24.7	4tnsA-1zcnA: 77.64

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1EI6_D_PPFD412_1","PHOSPHONOACETATE HYDROLASE","1zcn","PEPTIDYL-PROLYL CIS-TRANS ISOMERASE NIMA-INTERACTING 1","Homo sapiens",4,"PHE A 151;THR A 152;ILE A 156;HIS A  59","None;1PE A 400 ( 4.6A);None;1PE A 400 ( 4.4A)","0.83A","1ei6D-1zcnA:undetectable","1ei6D-1zcnA:16.87"],["2XRZ_A_ACTA1467_0","DEOXYRIBODIPYRIMIDINE PHOTOLYASE","1zcn","PEPTIDYL-PROLYL CIS-TRANS ISOMERASE NIMA-INTERACTING 1","Homo sapiens",4,"ARG A 127;ASP A 136;ILE A  28;GLU A  51","None","1.40A","2xrzA-1zcnA:undetectable;2xrzB-1zcnA:undetectable","2xrzA-1zcnA:16.82;2xrzB-1zcnA:16.82"],["3JZJ_A_ACRA405_2","ACARBOSE\/MALTOSE BINDING PROTEIN GACH","1zcn","PEPTIDYL-PROLYL CIS-TRANS ISOMERASE NIMA-INTERACTING 1","Homo sapiens",4,"ASN A  17;TYR A  24;TRP A  11;TRP A  34","None;None;None;1PE A 300 (-3.6A)","1.49A","3jzjA-1zcnA:0.0","3jzjA-1zcnA:16.91"],["4TNS_A_REAA201_1","PEPTIDYL-PROLYL CIS-TRANS ISOMERASE NIMA-INTERACTING 1","1zcn","PEPTIDYL-PROLYL CIS-TRANS ISOMERASE NIMA-INTERACTING 1","Homo sapiens",8,"HIS A  59;LYS A  63;ARG A  68;MET A 130;GLN A 131;PHE A 134;SER A 154;HIS A 157","1PE A 400 ( 4.4A);PO4 A 321 (-2.6A);PO4 A 321 (-3.8A);1PE A 400 (-3.8A);1PE A 400 (-4.5A);1PE A 400 (-3.7A);PO4 A 321 (-2.7A);1PE A 400 ( 4.7A)","0.28A","4tnsA-1zcnA:24.7","4tnsA-1zcnA:77.64"]]