SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1zcw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DY5_B_ACTB602_0
(RIBONUCLEASE A)		 1zcw AROMATIC
PRENYLTRANSFERASE
(Streptomyces
sp.
CL190) 		4 / 4 SER A 214
TYR A 175
GLN A 161
MET A 162
 None
GPP  A 401 (-4.7A)
None
GPP  A 401 ( 4.7A)
 1.40A 1dy5B-1zcwA:
0.0		 1dy5B-1zcwA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_B_SAMB1293_1
(GLYCINE
N-METHYLTRANSFERASE)		 1zcw AROMATIC
PRENYLTRANSFERASE
(Streptomyces
sp.
CL190) 		4 / 5 ARG A 228
ASP A 110
SER A  64
SER A 164
 GPP  A 401 (-4.2A)
MG  A 501 ( 4.5A)
GPP  A 401 ( 4.2A)
GPP  A 401 ( 4.1A)
 1.23A 1kiaB-1zcwA:
undetectable		 1kiaB-1zcwA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_C_SAMC2293_1
(GLYCINE
N-METHYLTRANSFERASE)		 1zcw AROMATIC
PRENYLTRANSFERASE
(Streptomyces
sp.
CL190) 		4 / 6 ARG A 228
ASP A 110
SER A  64
SER A 164
 GPP  A 401 (-4.2A)
MG  A 501 ( 4.5A)
GPP  A 401 ( 4.2A)
GPP  A 401 ( 4.1A)
 1.23A 1kiaC-1zcwA:
1.0		 1kiaC-1zcwA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O76_B_CAMB1420_0
(CYTOCHROME P450-CAM)		 1zcw AROMATIC
PRENYLTRANSFERASE
(Streptomyces
sp.
CL190) 		4 / 8 THR A  98
LEU A  94
VAL A 172
VAL A 160
 None
 1.09A 1o76B-1zcwA:
undetectable		 1o76B-1zcwA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OG5_A_SWFA502_1
(CYTOCHROME P450 2C9)		 1zcw AROMATIC
PRENYLTRANSFERASE
(Streptomyces
sp.
CL190) 		5 / 12 ALA A 122
PHE A 124
LEU A  94
THR A 218
LEU A 174
 None
 1.20A 1og5A-1zcwA:
undetectable		 1og5A-1zcwA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UYU_B_CAMB1416_0
(CYTOCHROME P450-CAM)		 1zcw AROMATIC
PRENYLTRANSFERASE
(Streptomyces
sp.
CL190) 		4 / 8 THR A  98
LEU A  94
VAL A 172
VAL A 160
 None
 1.11A 1uyuB-1zcwA:
undetectable		 1uyuB-1zcwA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_D_MIXD3539_2
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 1zcw AROMATIC
PRENYLTRANSFERASE
(Streptomyces
sp.
CL190) 		3 / 3 VAL A 160
VAL A 215
ASP A 110
 None
None
MG  A 501 ( 4.5A)
 0.74A 2fumD-1zcwA:
undetectable		 2fumD-1zcwA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WA2_B_SAMB1267_0
(NON-STRUCTURAL
PROTEIN 5)		 1zcw AROMATIC
PRENYLTRANSFERASE
(Streptomyces
sp.
CL190) 		5 / 12 GLY A 116
VAL A  78
THR A  77
ASP A 110
ILE A 109
 None
None
None
MG  A 501 ( 4.5A)
None
 0.92A 2wa2B-1zcwA:
undetectable		 2wa2B-1zcwA:
24.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_B_STIB1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 1zcw AROMATIC
PRENYLTRANSFERASE
(Streptomyces
sp.
CL190) 		4 / 7 TYR A 255
VAL A 113
MET A  14
ARG A  56
 None
 1.01A 3mssB-1zcwA:
undetectable		 3mssB-1zcwA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FIM_A_CELA711_1
(LACTOTRANSFERRIN)		 1zcw AROMATIC
PRENYLTRANSFERASE
(Streptomyces
sp.
CL190) 		5 / 9 GLY A 205
PRO A 242
TYR A 283
GLY A 273
TYR A 272
 None
 1.29A 4fimA-1zcwA:
undetectable		 4fimA-1zcwA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1zcw AROMATIC
PRENYLTRANSFERASE
(Streptomyces
sp.
CL190) 		3 / 3 VAL A  49
LEU A  95
MET A 165
 None
 0.65A 5ikrA-1zcwA:
undetectable		 5ikrA-1zcwA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M50_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 1zcw AROMATIC
PRENYLTRANSFERASE
(Streptomyces
sp.
CL190) 		5 / 12 GLU A 266
GLN A 161
ARG A 296
GLY A 297
LEU A 298
 None
None
NO3  A 601 ( 4.7A)
None
None
 1.33A 5m50B-1zcwA:
undetectable		 5m50B-1zcwA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_D_ERMD1201_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 1zcw AROMATIC
PRENYLTRANSFERASE
(Streptomyces
sp.
CL190) 		4 / 6 LEU A  95
VAL A  91
LEU A  83
GLU A  80
 None
 0.98A 5tudD-1zcwA:
undetectable		 5tudD-1zcwA:
20.75