SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1zcz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A29_A_TFPA153_1
(CALMODULIN)		 1zcz BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Thermotoga
maritima) 		5 / 8 ILE A   4
LEU A  21
GLU A 125
ALA A 123
VAL A  82
 None
 1.22A 1a29A-1zczA:
undetectable		 1a29A-1zczA:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQG_A_IBPA701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 1zcz BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Thermotoga
maritima) 		5 / 9 VAL A 240
LEU A 256
ALA A 267
SER A 269
LEU A 270
 None
 1.13A 1eqgA-1zczA:
undetectable		 1eqgA-1zczA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQG_B_IBPB1701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 1zcz BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Thermotoga
maritima) 		5 / 11 VAL A 240
LEU A 256
ALA A 267
SER A 269
LEU A 270
 None
 1.14A 1eqgB-1zczA:
undetectable		 1eqgB-1zczA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FXH_B_PACB1001_0
(PENICILLIN ACYLASE)		 1zcz BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Thermotoga
maritima) 		4 / 7 PHE A 442
PHE A 402
ALA A 435
ILE A 440
 None
 0.97A 1fxhA-1zczA:
undetectable
1fxhB-1zczA:
undetectable		 1fxhA-1zczA:
18.63
1fxhB-1zczA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EFJ_A_37TA502_1
(3,7-DIMETHYLXANTHINE
METHYLTRANSFERASE)		 1zcz BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Thermotoga
maritima) 		5 / 12 LEU A  38
TRP A  26
ILE A  17
ILE A 124
ILE A   4
 None
 1.07A 2efjA-1zczA:
undetectable		 2efjA-1zczA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QK8_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 1zcz BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Thermotoga
maritima) 		5 / 12 ALA A  45
LEU A   8
VAL A   6
ILE A  17
LEU A 120
 None
 1.06A 2qk8A-1zczA:
undetectable		 2qk8A-1zczA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFB_A_ACTA501_0
(METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER)		 1zcz BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Thermotoga
maritima) 		4 / 7 ASP A  92
VAL A  98
ILE A  95
TYR A 146
 None
 1.08A 2yfbA-1zczA:
0.5		 2yfbA-1zczA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFB_B_ACTB501_0
(METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER)		 1zcz BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Thermotoga
maritima) 		4 / 6 ASP A  92
VAL A  98
ILE A  95
TYR A 146
 None
 1.12A 2yfbB-1zczA:
undetectable		 2yfbB-1zczA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AV6_A_SAMA1_0
(DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1)		 1zcz BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Thermotoga
maritima) 		5 / 12 PHE A  84
GLY A  96
TRP A  80
LEU A 120
VAL A  98
 None
 1.05A 3av6A-1zczA:
undetectable		 3av6A-1zczA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_A_TMQA611_1
(DHFR-TS)		 1zcz BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Thermotoga
maritima) 		5 / 11 ALA A  45
ILE A  43
ILE A  17
LEU A 120
ILE A   4
 None
 1.01A 3clbA-1zczA:
undetectable		 3clbA-1zczA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DAT_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 1zcz BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Thermotoga
maritima) 		5 / 12 ALA A  45
LEU A   8
VAL A   6
ILE A  17
LEU A 120
 None
 1.12A 3datA-1zczA:
undetectable		 3datA-1zczA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_A_TMQA611_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1zcz BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Thermotoga
maritima) 		5 / 10 ALA A  45
ILE A  43
ILE A  17
LEU A 120
ILE A   4
 None
 1.01A 3hbbA-1zczA:
undetectable		 3hbbA-1zczA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_C_TMQC613_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1zcz BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Thermotoga
maritima) 		5 / 11 ALA A  45
ILE A  43
ILE A  17
LEU A 120
ILE A   4
 None
 0.94A 3hbbC-1zczA:
undetectable		 3hbbC-1zczA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW5_B_TOPB208_1
(DIHYDROFOLATE
REDUCTASE)		 1zcz BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Thermotoga
maritima) 		5 / 10 ALA A  45
LEU A   8
VAL A   6
ILE A  17
LEU A 120
 None
 1.13A 3jw5B-1zczA:
undetectable		 3jw5B-1zczA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		 1zcz BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Thermotoga
maritima) 		4 / 6 LEU A 408
PHE A 402
ALA A 380
THR A 384
 None
 1.08A 3mdrA-1zczA:
undetectable		 3mdrA-1zczA:
26.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_B_GJZB506_1
(CHOLESTEROL
24-HYDROXYLASE)		 1zcz BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Thermotoga
maritima) 		4 / 6 PHE A 402
ALA A 380
THR A 384
ALA A 414
 None
 0.90A 3mdrB-1zczA:
undetectable		 3mdrB-1zczA:
26.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J14_A_X2NA602_1
(CHOLESTEROL
24-HYDROXYLASE)		 1zcz BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Thermotoga
maritima) 		6 / 10 ALA A 435
LEU A 408
PHE A 402
ALA A 380
THR A 384
ALA A 414
 None
 1.33A 4j14A-1zczA:
undetectable		 4j14A-1zczA:
26.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1zcz BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Thermotoga
maritima) 		4 / 8 PRO A 227
SER A 226
VAL A 367
GLY A 368
 None
 0.97A 4klrB-1zczA:
undetectable		 4klrB-1zczA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_B_MXMB606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1zcz BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Thermotoga
maritima) 		5 / 12 ILE A 244
VAL A 240
LEU A 256
ALA A 267
SER A 269
 None
 1.03A 4m11B-1zczA:
undetectable		 4m11B-1zczA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_B_MXMB807_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1zcz BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Thermotoga
maritima) 		5 / 12 ILE A 244
VAL A 240
LEU A 256
ALA A 267
SER A 269
 None
 1.01A 4o1zB-1zczA:
undetectable		 4o1zB-1zczA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_A_SORA1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1zcz BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Thermotoga
maritima) 		4 / 7 ILE A 255
LEU A 274
GLY A 253
GLY A 254
 None
 0.78A 5a06A-1zczA:
4.4		 5a06A-1zczA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_B_SORB1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1zcz BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Thermotoga
maritima) 		4 / 7 ILE A 255
LEU A 274
GLY A 253
GLY A 254
 None
 0.76A 5a06B-1zczA:
4.4		 5a06B-1zczA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_C_SORC1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1zcz BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Thermotoga
maritima) 		4 / 7 ILE A 255
LEU A 274
GLY A 253
GLY A 254
 None
 0.76A 5a06C-1zczA:
4.4		 5a06C-1zczA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_E_SORE1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1zcz BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Thermotoga
maritima) 		4 / 7 ILE A 255
LEU A 274
GLY A 253
GLY A 254
 None
 0.78A 5a06E-1zczA:
4.4		 5a06E-1zczA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_F_SORF1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1zcz BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Thermotoga
maritima) 		4 / 7 ILE A 255
LEU A 274
GLY A 253
GLY A 254
 None
 0.81A 5a06F-1zczA:
4.5		 5a06F-1zczA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB5_A_010A609_0
(HNL ISOENZYME 5)		 1zcz BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Thermotoga
maritima) 		5 / 11 ALA A 123
ALA A 114
LEU A 120
LEU A  21
VAL A   6
 None
 1.27A 5eb5A-1zczA:
undetectable		 5eb5A-1zczA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNZ_B_TA1B902_2
(TUBULIN BETA-2B
CHAIN)		 1zcz BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Thermotoga
maritima) 		3 / 3 LEU A   8
LEU A  18
ARG A  79
 None
 0.64A 5hnzB-1zczA:
undetectable		 5hnzB-1zczA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1zcz BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Thermotoga
maritima) 		3 / 3 TYR A 273
TYR A 171
SER A 197
 None
 0.99A 5iktB-1zczA:
undetectable		 5iktB-1zczA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB6_B_ADNB401_1
(ADENOSINE KINASE)		 1zcz BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Thermotoga
maritima) 		5 / 12 GLY A  97
VAL A  85
ALA A 103
ALA A 104
ILE A  73
 None
 0.94A 5kb6B-1zczA:
undetectable		 5kb6B-1zczA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		 1zcz BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Thermotoga
maritima) 		4 / 8 SER A 398
ASP A 399
PHE A 450
SER A 425
 None
K  A 453 (-3.7A)
None
None
 1.09A 5l1fA-1zczA:
undetectable
5l1fB-1zczA:
undetectable		 5l1fA-1zczA:
21.81
5l1fB-1zczA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OSP_A_ACTA403_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 1zcz BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Thermotoga
maritima) 		4 / 7 VAL A 358
ILE A 360
VAL A 419
ALA A 396
 None
 0.75A 5ospA-1zczA:
undetectable		 5ospA-1zczA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIY_A_OAQA302_0
(SULFOTRANSFERASE)		 1zcz BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Thermotoga
maritima) 		5 / 11 MET A 262
ASP A 263
VAL A 237
SER A 269
MET A 217
 None
 1.45A 5tiyA-1zczA:
0.6		 5tiyA-1zczA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z3J_A_NCAA302_0
(ABRIN A-CHAIN)		 1zcz BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Thermotoga
maritima) 		4 / 6 VAL A 330
ILE A 432
GLU A 433
ARG A 436
 None
 0.98A 5z3jA-1zczA:
undetectable		 5z3jA-1zczA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEO_A_DHIA4_0
((DPR)PY(DHI)PKDL(DGN
))		 1zcz BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Thermotoga
maritima) 		3 / 3 TYR A 322
PRO A 215
LEU A 214
 None
 0.85A 6beoA-1zczA:
undetectable		 6beoA-1zczA:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		 1zcz BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Thermotoga
maritima) 		5 / 11 ALA A 243
VAL A 240
ALA A 279
ALA A 207
LEU A 256
 None
 1.17A 6h1lB-1zczA:
undetectable		 6h1lB-1zczA:
22.82