SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1zdr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AO8_A_MTXA170_1
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		7 / 12 ALA A   7
ASP A  27
LEU A  28
PHE A  31
THR A  46
LEU A  54
ARG A  57
 None
None
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.1A)
SO4  A3483 (-3.5A)
SO4  A3486 (-4.2A)
SO4  A3484 (-3.3A)
 0.85A 1ao8A-1zdrA:
22.0		 1ao8A-1zdrA:
38.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AO8_A_MTXA170_1
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		7 / 12 ALA A   7
ASP A  27
LEU A  28
PHE A  31
THR A  46
LEU A  54
THR A 115
 None
None
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.1A)
SO4  A3483 (-3.5A)
SO4  A3486 (-4.2A)
None
 0.79A 1ao8A-1zdrA:
22.0		 1ao8A-1zdrA:
38.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1BZF_A_TMQA170_1
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		5 / 12 ALA A   7
ASP A  27
PHE A  31
THR A  46
LEU A  54
 None
None
SO4  A3486 (-4.1A)
SO4  A3483 (-3.5A)
SO4  A3486 (-4.2A)
 0.68A 1bzfA-1zdrA:
21.8		 1bzfA-1zdrA:
38.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1BZF_A_TMQA170_1
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		6 / 12 ALA A   7
LEU A  20
ASP A  27
LEU A  28
PHE A  31
THR A  46
 None
None
None
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.1A)
SO4  A3483 (-3.5A)
 0.81A 1bzfA-1zdrA:
21.8		 1bzfA-1zdrA:
38.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1BZF_A_TMQA170_1
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		6 / 12 ALA A   7
LEU A  20
ASP A  27
LEU A  28
THR A  46
THR A 115
 None
None
None
SO4  A3486 ( 4.8A)
SO4  A3483 (-3.5A)
None
 0.80A 1bzfA-1zdrA:
21.8		 1bzfA-1zdrA:
38.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CD2_A_FOLA307_0
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		9 / 12 ILE A   5
ALA A   7
LEU A  20
PHE A  31
LYS A  32
THR A  46
LEU A  54
ILE A  96
THR A 115
 None
None
None
SO4  A3486 (-4.1A)
SO4  A3484 (-3.1A)
SO4  A3483 (-3.5A)
SO4  A3486 (-4.2A)
None
None
 0.64A 1cd2A-1zdrA:
19.4		 1cd2A-1zdrA:
34.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1D1G_A_MTXA171_1
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		7 / 12 ALA A   7
ASP A  27
ILE A  50
LEU A  54
ARG A  57
ILE A  96
THR A 115
 None
None
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
SO4  A3484 (-3.3A)
None
None
 0.44A 1d1gA-1zdrA:
19.1		 1d1gA-1zdrA:
32.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1D1G_B_MTXB171_1
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		7 / 12 ALA A   7
ASP A  27
ILE A  50
LEU A  54
ARG A  57
ILE A  96
THR A 115
 None
None
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
SO4  A3484 (-3.3A)
None
None
 0.48A 1d1gB-1zdrA:
19.2		 1d1gB-1zdrA:
32.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DDR_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		9 / 12 ILE A   5
ALA A   7
ASP A  27
LEU A  28
LYS A  32
THR A  46
ILE A  50
LEU A  54
ARG A  57
 None
None
None
SO4  A3486 ( 4.8A)
SO4  A3484 (-3.1A)
SO4  A3483 (-3.5A)
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
SO4  A3484 (-3.3A)
 0.69A 1ddrA-1zdrA:
23.7		 1ddrA-1zdrA:
40.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DDR_B_MTXB200_1
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		9 / 12 ILE A   5
ALA A   7
ASP A  27
LEU A  28
PHE A  31
ILE A  50
LEU A  54
ARG A  57
THR A 115
 None
None
None
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.1A)
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
SO4  A3484 (-3.3A)
None
 0.57A 1ddrB-1zdrA:
24.0		 1ddrB-1zdrA:
40.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DDR_B_MTXB200_1
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		9 / 12 ILE A   5
ALA A   7
ASP A  27
LEU A  28
PHE A  31
LYS A  32
ILE A  50
LEU A  54
THR A 115
 None
None
None
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.1A)
SO4  A3484 (-3.1A)
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
None
 0.68A 1ddrB-1zdrA:
24.0		 1ddrB-1zdrA:
40.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DDS_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		10 / 12 ILE A   5
ALA A   7
ASP A  27
LEU A  28
LYS A  32
THR A  46
ILE A  50
LEU A  54
ARG A  57
THR A 115
 None
None
None
SO4  A3486 ( 4.8A)
SO4  A3484 (-3.1A)
SO4  A3483 (-3.5A)
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
SO4  A3484 (-3.3A)
None
 0.64A 1ddsA-1zdrA:
24.0		 1ddsA-1zdrA:
40.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DDS_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		8 / 12 ILE A   5
ALA A   7
ASP A  27
LEU A  28
LYS A  32
LEU A  54
ARG A  57
THR A 115
 None
None
None
SO4  A3486 ( 4.8A)
SO4  A3484 (-3.1A)
SO4  A3486 (-4.2A)
SO4  A3484 (-3.3A)
None
 0.69A 1ddsB-1zdrA:
24.3		 1ddsB-1zdrA:
40.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DDS_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		8 / 12 ILE A   5
ALA A   7
ASP A  27
LYS A  32
ILE A  50
LEU A  54
ARG A  57
THR A 115
 None
None
None
SO4  A3484 (-3.1A)
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
SO4  A3484 (-3.3A)
None
 0.70A 1ddsB-1zdrA:
24.3		 1ddsB-1zdrA:
40.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DF7_A_MTXA501_1
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		6 / 12 ILE A   5
ALA A   7
ASP A  27
LEU A  54
ARG A  57
ILE A  96
 None
None
None
SO4  A3486 (-4.2A)
SO4  A3484 (-3.3A)
None
 0.39A 1df7A-1zdrA:
22.6		 1df7A-1zdrA:
34.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DG5_A_TOPA201_1
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		5 / 11 ILE A   5
ALA A   7
ASP A  27
PHE A  31
ILE A  96
 None
None
None
SO4  A3486 (-4.1A)
None
 0.54A 1dg5A-1zdrA:
22.6		 1dg5A-1zdrA:
34.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DHF_A_FOLA187_0
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		7 / 12 ILE A   5
ALA A   7
PHE A  31
THR A  46
ILE A  50
LEU A  54
THR A 115
 None
None
SO4  A3486 (-4.1A)
SO4  A3483 (-3.5A)
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
None
 0.53A 1dhfA-1zdrA:
20.7		 1dhfA-1zdrA:
33.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DHF_B_FOLB187_0
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		8 / 12 ILE A   5
ALA A   7
PHE A  31
THR A  46
ILE A  50
LEU A  54
ARG A  57
THR A 115
 None
None
SO4  A3486 (-4.1A)
SO4  A3483 (-3.5A)
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
SO4  A3484 (-3.3A)
None
 0.57A 1dhfB-1zdrA:
20.7		 1dhfB-1zdrA:
33.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DHI_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		9 / 12 ILE A   5
ALA A   7
LEU A  28
LYS A  32
ILE A  50
LEU A  54
ARG A  57
ILE A  96
THR A 115
 None
None
SO4  A3486 ( 4.8A)
SO4  A3484 (-3.1A)
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
SO4  A3484 (-3.3A)
None
None
 0.63A 1dhiA-1zdrA:
23.9		 1dhiA-1zdrA:
39.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DHI_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		9 / 11 ILE A   5
ALA A   7
LEU A  28
LYS A  32
ILE A  50
LEU A  54
ARG A  57
ILE A  96
THR A 115
 None
None
SO4  A3486 ( 4.8A)
SO4  A3484 (-3.1A)
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
SO4  A3484 (-3.3A)
None
None
 0.60A 1dhiB-1zdrA:
24.5		 1dhiB-1zdrA:
39.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DHJ_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		9 / 12 ILE A   5
ALA A   7
LEU A  28
LYS A  32
ILE A  50
LEU A  54
ARG A  57
ILE A  96
THR A 115
 None
None
SO4  A3486 ( 4.8A)
SO4  A3484 (-3.1A)
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
SO4  A3484 (-3.3A)
None
None
 0.64A 1dhjA-1zdrA:
23.9		 1dhjA-1zdrA:
40.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DHJ_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		9 / 12 ILE A   5
ALA A   7
LEU A  28
LYS A  32
LEU A  54
PRO A  55
ARG A  57
ILE A  96
THR A 115
 None
None
SO4  A3486 ( 4.8A)
SO4  A3484 (-3.1A)
SO4  A3486 (-4.2A)
SO4  A3484 ( 4.4A)
SO4  A3484 (-3.3A)
None
None
 0.66A 1dhjB-1zdrA:
24.5		 1dhjB-1zdrA:
40.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DHJ_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		9 / 12 ILE A   5
ALA A   7
LYS A  32
ILE A  50
LEU A  54
PRO A  55
ARG A  57
ILE A  96
THR A 115
 None
None
SO4  A3484 (-3.1A)
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
SO4  A3484 ( 4.4A)
SO4  A3484 (-3.3A)
None
None
 0.72A 1dhjB-1zdrA:
24.5		 1dhjB-1zdrA:
40.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DLS_A_MTXA188_1
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		5 / 12 ILE A   5
ALA A   7
ILE A  50
LEU A  54
ARG A  57
 None
None
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
SO4  A3484 (-3.3A)
 0.58A 1dlsA-1zdrA:
20.5		 1dlsA-1zdrA:
32.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DRA_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		8 / 12 ILE A   5
ALA A   7
LEU A  28
LYS A  32
ILE A  50
LEU A  54
ARG A  57
ILE A  96
 None
None
SO4  A3486 ( 4.8A)
SO4  A3484 (-3.1A)
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
SO4  A3484 (-3.3A)
None
 0.65A 1draA-1zdrA:
24.0		 1draA-1zdrA:
39.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DRA_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		9 / 12 ILE A   5
ALA A   7
LEU A  28
LYS A  32
ILE A  50
LEU A  54
ARG A  57
ILE A  96
THR A 115
 None
None
SO4  A3486 ( 4.8A)
SO4  A3484 (-3.1A)
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
SO4  A3484 (-3.3A)
None
None
 0.63A 1draB-1zdrA:
24.5		 1draB-1zdrA:
39.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DRB_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		9 / 12 ILE A   5
ALA A   7
LEU A  28
LYS A  32
ILE A  50
LEU A  54
ARG A  57
ILE A  96
THR A 115
 None
None
SO4  A3486 ( 4.8A)
SO4  A3484 (-3.1A)
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
SO4  A3484 (-3.3A)
None
None
 0.66A 1drbA-1zdrA:
23.9		 1drbA-1zdrA:
39.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DRB_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		10 / 12 ILE A   5
ALA A   7
LEU A  28
PHE A  31
LYS A  32
ILE A  50
LEU A  54
ARG A  57
ILE A  96
THR A 115
 None
None
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.1A)
SO4  A3484 (-3.1A)
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
SO4  A3484 (-3.3A)
None
None
 0.64A 1drbB-1zdrA:
24.4		 1drbB-1zdrA:
39.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DRE_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		8 / 12 ALA A   7
ASP A  27
LEU A  28
PHE A  31
LYS A  32
ILE A  50
LEU A  54
ARG A  57
 None
None
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.1A)
SO4  A3484 (-3.1A)
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
SO4  A3484 (-3.3A)
 0.69A 1dreA-1zdrA:
25.2		 1dreA-1zdrA:
40.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DRF_A_FOLA187_0
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		6 / 12 ILE A   5
ALA A   7
LEU A  20
PHE A  31
ILE A  50
LEU A  54
 None
None
None
SO4  A3486 (-4.1A)
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
 0.62A 1drfA-1zdrA:
20.4		 1drfA-1zdrA:
33.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DYI_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		10 / 12 ILE A   5
ALA A   7
ASP A  27
LEU A  28
PHE A  31
LYS A  32
THR A  46
ILE A  50
LEU A  54
THR A 115
 None
None
None
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.1A)
SO4  A3484 (-3.1A)
SO4  A3483 (-3.5A)
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
None
 0.55A 1dyiA-1zdrA:
24.1		 1dyiA-1zdrA:
40.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DYI_B_FOLB161_0
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		10 / 12 ILE A   5
ALA A   7
ASP A  27
LEU A  28
PHE A  31
LYS A  32
THR A  46
ILE A  50
LEU A  54
THR A 115
 None
None
None
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.1A)
SO4  A3484 (-3.1A)
SO4  A3483 (-3.5A)
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
None
 0.51A 1dyiB-1zdrA:
24.5		 1dyiB-1zdrA:
40.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DYR_A_TOPA407_1
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		7 / 11 ILE A   5
ALA A   7
LEU A  20
PHE A  31
ILE A  50
ILE A  96
THR A 115
 None
None
None
SO4  A3486 (-4.1A)
SO4  A3486 ( 4.8A)
None
None
 0.49A 1dyrA-1zdrA:
19.5		 1dyrA-1zdrA:
34.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J3J_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		7 / 10 ILE A   5
ALA A   7
ASP A  27
PHE A  31
ILE A  50
ILE A  96
THR A 115
 None
None
None
SO4  A3486 (-4.1A)
SO4  A3486 ( 4.8A)
None
None
 0.46A 1j3jA-1zdrA:
20.6		 1j3jA-1zdrA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J3J_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		6 / 9 ALA A   7
ASP A  27
PHE A  31
ILE A  50
ILE A  96
THR A 115
 None
None
SO4  A3486 (-4.1A)
SO4  A3486 ( 4.8A)
None
None
 0.30A 1j3jB-1zdrA:
20.3		 1j3jB-1zdrA:
22.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JOL_A_FFOA161_0
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		9 / 12 ILE A   5
ALA A   7
ASP A  27
LEU A  28
PHE A  31
LYS A  32
ILE A  50
LEU A  54
THR A 115
 None
None
None
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.1A)
SO4  A3484 (-3.1A)
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
None
 0.61A 1jolA-1zdrA:
24.0		 1jolA-1zdrA:
40.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JOL_B_FFOB361_0
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		9 / 12 ILE A   5
ALA A   7
ASP A  27
LEU A  28
PHE A  31
LYS A  32
LEU A  54
PRO A  55
THR A 115
 None
None
None
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.1A)
SO4  A3484 (-3.1A)
SO4  A3486 (-4.2A)
SO4  A3484 ( 4.4A)
None
 0.66A 1jolB-1zdrA:
24.5		 1jolB-1zdrA:
40.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JOL_B_FFOB361_0
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		9 / 12 ILE A   5
ALA A   7
ASP A  27
PHE A  31
LYS A  32
ILE A  50
LEU A  54
PRO A  55
THR A 115
 None
None
None
SO4  A3486 (-4.1A)
SO4  A3484 (-3.1A)
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
SO4  A3484 ( 4.4A)
None
 0.67A 1jolB-1zdrA:
24.5		 1jolB-1zdrA:
40.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JOM_A_FFOA161_0
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		9 / 11 ALA A   7
ASP A  27
LEU A  28
PHE A  31
LYS A  32
ILE A  50
LEU A  54
ARG A  57
THR A 115
 None
None
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.1A)
SO4  A3484 (-3.1A)
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
SO4  A3484 (-3.3A)
None
 0.55A 1jomA-1zdrA:
23.9		 1jomA-1zdrA:
40.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_A_FOLA605_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		9 / 12 ALA A   7
LEU A  20
ASP A  27
LEU A  28
THR A  46
ILE A  50
LEU A  54
ARG A  57
THR A 115
 None
None
None
SO4  A3486 ( 4.8A)
SO4  A3483 (-3.5A)
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
SO4  A3484 (-3.3A)
None
 0.61A 1qzfA-1zdrA:
13.0		 1qzfA-1zdrA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_B_FOLB609_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		9 / 12 ALA A   7
LEU A  20
ASP A  27
LEU A  28
THR A  46
ILE A  50
LEU A  54
ARG A  57
THR A 115
 None
None
None
SO4  A3486 ( 4.8A)
SO4  A3483 (-3.5A)
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
SO4  A3484 (-3.3A)
None
 0.60A 1qzfB-1zdrA:
20.0		 1qzfB-1zdrA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_C_FOLC613_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		9 / 12 ALA A   7
LEU A  20
ASP A  27
LEU A  28
THR A  46
ILE A  50
LEU A  54
ARG A  57
THR A 115
 None
None
None
SO4  A3486 ( 4.8A)
SO4  A3483 (-3.5A)
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
SO4  A3484 (-3.3A)
None
 0.61A 1qzfC-1zdrA:
13.6		 1qzfC-1zdrA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_D_FOLD617_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		9 / 12 ALA A   7
LEU A  20
ASP A  27
LEU A  28
THR A  46
ILE A  50
LEU A  54
ARG A  57
THR A 115
 None
None
None
SO4  A3486 ( 4.8A)
SO4  A3483 (-3.5A)
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
SO4  A3484 (-3.3A)
None
 0.62A 1qzfD-1zdrA:
13.0		 1qzfD-1zdrA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_E_FOLE621_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		9 / 12 ALA A   7
LEU A  20
ASP A  27
LEU A  28
THR A  46
ILE A  50
LEU A  54
ARG A  57
THR A 115
 None
None
None
SO4  A3486 ( 4.8A)
SO4  A3483 (-3.5A)
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
SO4  A3484 (-3.3A)
None
 0.61A 1qzfE-1zdrA:
13.1		 1qzfE-1zdrA:
16.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RA2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		10 / 12 ILE A   5
ALA A   7
ASP A  27
LEU A  28
PHE A  31
LYS A  32
ILE A  50
LEU A  54
ILE A  96
THR A 115
 None
None
None
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.1A)
SO4  A3484 (-3.1A)
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
None
None
 0.54A 1ra2A-1zdrA:
24.4		 1ra2A-1zdrA:
40.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RA3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		9 / 12 ILE A   5
ALA A   7
ASP A  27
LEU A  28
LYS A  32
LEU A  54
ARG A  57
ILE A  96
THR A 115
 None
None
None
SO4  A3486 ( 4.8A)
SO4  A3484 (-3.1A)
SO4  A3486 (-4.2A)
SO4  A3484 (-3.3A)
None
None
 0.52A 1ra3A-1zdrA:
24.4		 1ra3A-1zdrA:
40.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RA3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		9 / 12 ILE A   5
ALA A   7
ASP A  27
LYS A  32
ILE A  50
LEU A  54
ARG A  57
ILE A  96
THR A 115
 None
None
None
SO4  A3484 (-3.1A)
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
SO4  A3484 (-3.3A)
None
None
 0.57A 1ra3A-1zdrA:
24.4		 1ra3A-1zdrA:
40.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RA8_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		9 / 12 ILE A   5
ALA A   7
LEU A  28
PHE A  31
THR A  46
ILE A  50
LEU A  54
ILE A  96
THR A 115
 None
None
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.1A)
SO4  A3483 (-3.5A)
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
None
None
 0.52A 1ra8A-1zdrA:
24.3		 1ra8A-1zdrA:
40.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RA8_A_FOLA161_1
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		3 / 3 ASP A  27
LYS A  32
ARG A  57
 None
SO4  A3484 (-3.1A)
SO4  A3484 (-3.3A)
 0.72A 1ra8A-1zdrA:
24.3		 1ra8A-1zdrA:
40.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RB2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		10 / 12 ILE A   5
ALA A   7
ASP A  27
LEU A  28
PHE A  31
LYS A  32
ILE A  50
LEU A  54
ILE A  96
THR A 115
 None
None
None
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.1A)
SO4  A3484 (-3.1A)
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
None
None
 0.47A 1rb2A-1zdrA:
24.6		 1rb2A-1zdrA:
40.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RB2_B_FOLB161_0
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		10 / 12 ILE A   5
ALA A   7
ASP A  27
LEU A  28
PHE A  31
LYS A  32
LEU A  54
ARG A  57
ILE A  96
THR A 115
 None
None
None
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.1A)
SO4  A3484 (-3.1A)
SO4  A3486 (-4.2A)
SO4  A3484 (-3.3A)
None
None
 0.58A 1rb2B-1zdrA:
24.3		 1rb2B-1zdrA:
40.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RB3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		9 / 10 ILE A   5
ALA A   7
ASP A  27
LEU A  28
LYS A  32
ILE A  50
ARG A  57
ILE A  96
THR A 115
 None
None
None
SO4  A3486 ( 4.8A)
SO4  A3484 (-3.1A)
SO4  A3486 ( 4.8A)
SO4  A3484 (-3.3A)
None
None
 0.57A 1rb3A-1zdrA:
24.5		 1rb3A-1zdrA:
40.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RB3_B_MTXB161_1
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		10 / 12 ILE A   5
ALA A   7
ASP A  27
LEU A  28
LYS A  32
ILE A  50
LEU A  54
ARG A  57
ILE A  96
THR A 115
 None
None
None
SO4  A3486 ( 4.8A)
SO4  A3484 (-3.1A)
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
SO4  A3484 (-3.3A)
None
None
 0.95A 1rb3B-1zdrA:
24.4		 1rb3B-1zdrA:
40.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RD7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		10 / 12 ILE A   5
ALA A   7
LEU A  28
PHE A  31
LYS A  32
THR A  46
ILE A  50
LEU A  54
ILE A  96
THR A 115
 None
None
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.1A)
SO4  A3484 (-3.1A)
SO4  A3483 (-3.5A)
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
None
None
 0.46A 1rd7A-1zdrA:
24.0		 1rd7A-1zdrA:
40.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RD7_B_FOLB361_0
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		10 / 12 ILE A   5
ALA A   7
ASP A  27
LEU A  28
LYS A  32
THR A  46
ILE A  50
LEU A  54
ILE A  96
THR A 115
 None
None
None
SO4  A3486 ( 4.8A)
SO4  A3484 (-3.1A)
SO4  A3483 (-3.5A)
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
None
None
 0.46A 1rd7B-1zdrA:
23.8		 1rd7B-1zdrA:
40.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RE7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		10 / 12 ILE A   5
ALA A   7
ASP A  27
LEU A  28
PHE A  31
LYS A  32
THR A  46
ILE A  50
ILE A  96
THR A 115
 None
None
None
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.1A)
SO4  A3484 (-3.1A)
SO4  A3483 (-3.5A)
SO4  A3486 ( 4.8A)
None
None
 0.53A 1re7A-1zdrA:
24.2		 1re7A-1zdrA:
40.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RE7_B_FOLB361_0
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		10 / 12 ILE A   5
ALA A   7
ASP A  27
LEU A  28
PHE A  31
LYS A  32
LEU A  54
PRO A  55
ILE A  96
THR A 115
 None
None
None
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.1A)
SO4  A3484 (-3.1A)
SO4  A3486 (-4.2A)
SO4  A3484 ( 4.4A)
None
None
 0.45A 1re7B-1zdrA:
23.8		 1re7B-1zdrA:
40.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RE7_B_FOLB361_0
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		10 / 12 ILE A   5
ALA A   7
ASP A  27
PHE A  31
LYS A  32
ILE A  50
LEU A  54
PRO A  55
ILE A  96
THR A 115
 None
None
None
SO4  A3486 (-4.1A)
SO4  A3484 (-3.1A)
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
SO4  A3484 ( 4.4A)
None
None
 0.43A 1re7B-1zdrA:
23.8		 1re7B-1zdrA:
40.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RG7_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		6 / 12 ALA A   7
ASP A  27
LEU A  28
LYS A  32
LEU A  54
ARG A  57
 None
None
SO4  A3486 ( 4.8A)
SO4  A3484 (-3.1A)
SO4  A3486 (-4.2A)
SO4  A3484 (-3.3A)
 1.08A 1rg7A-1zdrA:
22.9		 1rg7A-1zdrA:
40.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RG7_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		7 / 12 ALA A   7
ASP A  27
LEU A  28
LYS A  32
THR A  46
LEU A  54
ARG A  57
 None
None
SO4  A3486 ( 4.8A)
SO4  A3484 (-3.1A)
SO4  A3483 (-3.5A)
SO4  A3486 (-4.2A)
SO4  A3484 (-3.3A)
 0.68A 1rg7A-1zdrA:
22.9		 1rg7A-1zdrA:
40.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RG7_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		7 / 12 ALA A   7
ASP A  27
LYS A  32
THR A  46
ILE A  50
LEU A  54
ARG A  57
 None
None
SO4  A3484 (-3.1A)
SO4  A3483 (-3.5A)
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
SO4  A3484 (-3.3A)
 0.62A 1rg7A-1zdrA:
22.9		 1rg7A-1zdrA:
40.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RG7_A_MTXA161_2
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		3 / 3 ILE A   5
ILE A  96
THR A 115
 None
 0.11A 1rg7A-1zdrA:
22.9		 1rg7A-1zdrA:
40.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RH3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		8 / 12 ILE A   5
ASP A  27
LEU A  28
PHE A  31
LYS A  32
ILE A  50
LEU A  54
ARG A  57
 None
None
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.1A)
SO4  A3484 (-3.1A)
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
SO4  A3484 (-3.3A)
 0.64A 1rh3A-1zdrA:
25.1		 1rh3A-1zdrA:
40.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RX2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		9 / 12 ILE A   5
ALA A   7
LEU A  28
PHE A  31
LYS A  32
ILE A  50
LEU A  54
ILE A  96
THR A 115
 None
None
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.1A)
SO4  A3484 (-3.1A)
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
None
None
 0.78A 1rx2A-1zdrA:
25.5		 1rx2A-1zdrA:
40.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RX3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		8 / 12 ILE A   5
ALA A   7
ASP A  27
LEU A  28
PHE A  31
ILE A  50
LEU A  54
ARG A  57
 None
None
None
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.1A)
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
SO4  A3484 (-3.3A)
 0.63A 1rx3A-1zdrA:
25.5		 1rx3A-1zdrA:
40.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RX3_A_MTXA161_2
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		3 / 3 LYS A  32
ILE A  96
THR A 115
 SO4  A3484 (-3.1A)
None
None
 0.33A 1rx3A-1zdrA:
25.5		 1rx3A-1zdrA:
40.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RX7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		11 / 12 ILE A   5
ALA A   7
ASP A  27
LEU A  28
PHE A  31
LYS A  32
THR A  46
ILE A  50
LEU A  54
ILE A  96
THR A 115
 None
None
None
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.1A)
SO4  A3484 (-3.1A)
SO4  A3483 (-3.5A)
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
None
None
 0.53A 1rx7A-1zdrA:
23.6		 1rx7A-1zdrA:
40.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RX8_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		8 / 12 ILE A   5
ALA A   7
LEU A  28
LYS A  32
ILE A  50
LEU A  54
PRO A  55
THR A 115
 None
None
SO4  A3486 ( 4.8A)
SO4  A3484 (-3.1A)
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
SO4  A3484 ( 4.4A)
None
 0.75A 1rx8A-1zdrA:
25.3		 1rx8A-1zdrA:
40.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RX8_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		8 / 12 ILE A   5
ALA A   7
LEU A  28
PHE A  31
ILE A  50
LEU A  54
PRO A  55
THR A 115
 None
None
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.1A)
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
SO4  A3484 ( 4.4A)
None
 0.55A 1rx8A-1zdrA:
25.3		 1rx8A-1zdrA:
40.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TDR_A_MTXA170_1
(TELLUROMETHIONYL
DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		10 / 12 ILE A   5
ALA A   7
ASP A  27
LEU A  28
PHE A  31
LYS A  32
THR A  46
ILE A  50
LEU A  54
ARG A  57
 None
None
None
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.1A)
SO4  A3484 (-3.1A)
SO4  A3483 (-3.5A)
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
SO4  A3484 (-3.3A)
 0.75A 1tdrA-1zdrA:
24.0		 1tdrA-1zdrA:
40.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TDR_B_MTXB170_1
(TELLUROMETHIONYL
DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		8 / 10 ALA A   7
ASP A  27
LEU A  28
LYS A  32
ILE A  50
LEU A  54
ARG A  57
THR A 115
 None
None
SO4  A3486 ( 4.8A)
SO4  A3484 (-3.1A)
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
SO4  A3484 (-3.3A)
None
 0.66A 1tdrB-1zdrA:
24.2		 1tdrB-1zdrA:
40.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_A_BAXA1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		5 / 6 ILE A 137
VAL A 138
ILE A  95
ILE A  86
ASP A 110
 None
 0.95A 1uwhA-1zdrA:
undetectable		 1uwhA-1zdrA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_B_BAXB1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		5 / 6 ILE A 137
VAL A 138
ILE A  95
ILE A  86
ASP A 110
 None
 0.95A 1uwhB-1zdrA:
undetectable		 1uwhB-1zdrA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BL9_A_CP6A1240_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		8 / 12 ILE A   5
ALA A   7
LEU A  20
ASP A  27
PHE A  31
ILE A  50
ILE A  96
THR A 115
 None
None
None
None
SO4  A3486 (-4.1A)
SO4  A3486 ( 4.8A)
None
None
 0.51A 2bl9A-1zdrA:
20.2		 2bl9A-1zdrA:
24.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BLA_A_CP6A302_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		7 / 11 ILE A   5
ALA A   7
ASP A  27
PHE A  31
ILE A  50
ILE A  96
THR A 115
 None
None
None
SO4  A3486 (-4.1A)
SO4  A3486 ( 4.8A)
None
None
 0.53A 2blaA-1zdrA:
19.9		 2blaA-1zdrA:
25.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2CD2_A_FOLA307_0
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		8 / 12 ILE A   5
ALA A   7
LEU A  20
THR A  46
LEU A  54
ARG A  57
ILE A  96
THR A 115
 None
None
None
SO4  A3483 (-3.5A)
SO4  A3486 (-4.2A)
SO4  A3484 (-3.3A)
None
None
 0.62A 2cd2A-1zdrA:
19.6		 2cd2A-1zdrA:
34.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2D0K_A_FOLA1161_0
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		10 / 12 ILE A   5
ALA A   7
LEU A  28
PHE A  31
ILE A  50
LEU A  54
PRO A  55
ARG A  57
ILE A  96
THR A 115
 None
None
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.1A)
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
SO4  A3484 ( 4.4A)
SO4  A3484 (-3.3A)
None
None
 0.60A 2d0kA-1zdrA:
23.9		 2d0kA-1zdrA:
40.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2D0K_A_FOLA1161_0
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		7 / 12 ILE A   5
PHE A  31
LYS A  32
ILE A  50
LEU A  54
ARG A  57
ILE A  96
 None
SO4  A3486 (-4.1A)
SO4  A3484 (-3.1A)
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
SO4  A3484 (-3.3A)
None
 1.16A 2d0kA-1zdrA:
23.9		 2d0kA-1zdrA:
40.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2D0K_B_FOLB2161_0
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		10 / 12 ILE A   5
ALA A   7
LEU A  28
PHE A  31
THR A  46
ILE A  50
LEU A  54
ARG A  57
ILE A  96
THR A 115
 None
None
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.1A)
SO4  A3483 (-3.5A)
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
SO4  A3484 (-3.3A)
None
None
 0.55A 2d0kB-1zdrA:
23.9		 2d0kB-1zdrA:
40.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2DRC_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		9 / 12 ILE A   5
ALA A   7
ASP A  27
LEU A  28
LYS A  32
ILE A  50
LEU A  54
ARG A  57
ILE A  96
 None
None
None
SO4  A3486 ( 4.8A)
SO4  A3484 (-3.1A)
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
SO4  A3484 (-3.3A)
None
 0.63A 2drcA-1zdrA:
24.0		 2drcA-1zdrA:
39.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2DRC_B_MTXB161_1
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		10 / 12 ILE A   5
ALA A   7
ASP A  27
LEU A  28
LYS A  32
ILE A  50
LEU A  54
ARG A  57
ILE A  96
THR A 115
 None
None
None
SO4  A3486 ( 4.8A)
SO4  A3484 (-3.1A)
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
SO4  A3484 (-3.3A)
None
None
 0.64A 2drcB-1zdrA:
24.5		 2drcB-1zdrA:
39.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTT_C_H4BC1002_1
(HYPOTHETICAL PROTEIN
PH0634)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		4 / 6 TYR A  30
ASP A  27
PHE A  31
THR A  35
 None
None
SO4  A3486 (-4.1A)
None
 1.28A 2dttB-1zdrA:
undetectable
2dttC-1zdrA:
undetectable		 2dttB-1zdrA:
22.22
2dttC-1zdrA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_A_MTXA605_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		9 / 12 ALA A   7
LEU A  20
ASP A  27
LEU A  28
PHE A  31
THR A  46
ILE A  50
LEU A  54
ARG A  57
 None
None
None
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.1A)
SO4  A3483 (-3.5A)
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
SO4  A3484 (-3.3A)
 0.67A 2oipA-1zdrA:
20.6		 2oipA-1zdrA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_B_MTXB609_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		9 / 12 ALA A   7
LEU A  20
ASP A  27
LEU A  28
PHE A  31
THR A  46
LEU A  54
ARG A  57
THR A 115
 None
None
None
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.1A)
SO4  A3483 (-3.5A)
SO4  A3486 (-4.2A)
SO4  A3484 (-3.3A)
None
 0.54A 2oipB-1zdrA:
13.0		 2oipB-1zdrA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_C_MTXC613_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		9 / 12 ALA A   7
LEU A  20
ASP A  27
LEU A  28
PHE A  31
THR A  46
LEU A  54
ARG A  57
THR A 115
 None
None
None
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.1A)
SO4  A3483 (-3.5A)
SO4  A3486 (-4.2A)
SO4  A3484 (-3.3A)
None
 0.59A 2oipC-1zdrA:
20.4		 2oipC-1zdrA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_D_MTXD617_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		9 / 12 ALA A   7
LEU A  20
ASP A  27
LEU A  28
PHE A  31
THR A  46
ILE A  50
LEU A  54
ARG A  57
 None
None
None
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.1A)
SO4  A3483 (-3.5A)
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
SO4  A3484 (-3.3A)
 0.72A 2oipD-1zdrA:
20.9		 2oipD-1zdrA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_E_MTXE621_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		9 / 12 ALA A   7
LEU A  20
ASP A  27
LEU A  28
PHE A  31
THR A  46
ILE A  50
LEU A  54
ARG A  57
 None
None
None
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.1A)
SO4  A3483 (-3.5A)
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
SO4  A3484 (-3.3A)
 0.66A 2oipE-1zdrA:
20.1		 2oipE-1zdrA:
16.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QK8_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		6 / 12 ALA A   7
LEU A  28
LYS A  32
LEU A  54
PRO A  55
ARG A  57
 None
SO4  A3486 ( 4.8A)
SO4  A3484 (-3.1A)
SO4  A3486 (-4.2A)
SO4  A3484 ( 4.4A)
SO4  A3484 (-3.3A)
 0.57A 2qk8A-1zdrA:
25.4		 2qk8A-1zdrA:
52.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QK8_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		6 / 12 ALA A   7
LYS A  32
ILE A  50
LEU A  54
PRO A  55
ARG A  57
 None
SO4  A3484 (-3.1A)
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
SO4  A3484 ( 4.4A)
SO4  A3484 (-3.3A)
 0.60A 2qk8A-1zdrA:
25.4		 2qk8A-1zdrA:
52.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W3A_A_TOPA1190_1
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		6 / 11 ILE A   5
ALA A   7
PHE A  31
THR A  46
ILE A  50
THR A 115
 None
None
SO4  A3486 (-4.1A)
SO4  A3483 (-3.5A)
SO4  A3486 ( 4.8A)
None
 0.31A 2w3aA-1zdrA:
20.3		 2w3aA-1zdrA:
33.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W3A_B_TOPB1189_1
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		7 / 10 ILE A   5
ALA A   7
PHE A  31
THR A  46
ILE A  50
LEU A  54
THR A 115
 None
None
SO4  A3486 (-4.1A)
SO4  A3483 (-3.5A)
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
None
 0.55A 2w3aB-1zdrA:
20.4		 2w3aB-1zdrA:
33.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W3B_A_FOLA401_0
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		8 / 12 ILE A   5
ALA A   7
LEU A  20
PHE A  31
THR A  46
ILE A  50
LEU A  54
THR A 115
 None
None
None
SO4  A3486 (-4.1A)
SO4  A3483 (-3.5A)
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
None
 0.55A 2w3bA-1zdrA:
20.3		 2w3bA-1zdrA:
33.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W3B_B_FOLB401_0
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		7 / 12 ILE A   5
ALA A   7
LEU A  20
PHE A  31
ILE A  50
LEU A  54
THR A 115
 None
None
None
SO4  A3486 (-4.1A)
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
None
 0.53A 2w3bB-1zdrA:
20.2		 2w3bB-1zdrA:
33.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W3M_A_FOLA1188_0
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		7 / 12 ILE A   5
ALA A   7
LEU A  20
PHE A  31
ILE A  50
LEU A  54
THR A 115
 None
None
None
SO4  A3486 (-4.1A)
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
None
 0.53A 2w3mA-1zdrA:
20.1		 2w3mA-1zdrA:
33.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W3M_B_FOLB1188_0
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		7 / 12 ILE A   5
ALA A   7
LEU A  20
PHE A  31
LEU A  54
ARG A  57
THR A 115
 None
None
None
SO4  A3486 (-4.1A)
SO4  A3486 (-4.2A)
SO4  A3484 (-3.3A)
None
 0.41A 2w3mB-1zdrA:
20.2		 2w3mB-1zdrA:
33.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W3V_A_TOPA1169_1
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		6 / 12 ALA A   7
ASP A  27
LEU A  28
PHE A  31
ILE A  96
THR A 115
 None
None
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.1A)
None
None
 0.42A 2w3vA-1zdrA:
22.5		 2w3vA-1zdrA:
36.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W9G_A_TOPA1159_1
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		5 / 10 ALA A   7
LEU A  20
ASP A  27
ILE A  50
THR A 115
 None
None
None
SO4  A3486 ( 4.8A)
None
 0.72A 2w9gA-1zdrA:
26.1		 2w9gA-1zdrA:
49.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W9G_A_TOPA1159_1
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		5 / 10 ALA A   7
LEU A  20
ASP A  27
LEU A  28
THR A 115
 None
None
None
SO4  A3486 ( 4.8A)
None
 0.52A 2w9gA-1zdrA:
26.1		 2w9gA-1zdrA:
49.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W9H_A_TOPA1160_1
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		5 / 10 ALA A   7
LEU A  20
ASP A  27
ILE A  50
THR A 115
 None
None
None
SO4  A3486 ( 4.8A)
None
 0.73A 2w9hA-1zdrA:
26.3		 2w9hA-1zdrA:
49.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W9H_A_TOPA1160_1
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		5 / 10 ALA A   7
LEU A  20
ASP A  27
LEU A  28
THR A 115
 None
None
None
SO4  A3486 ( 4.8A)
None
 0.48A 2w9hA-1zdrA:
26.3		 2w9hA-1zdrA:
49.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W9S_A_TOPA1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		7 / 11 ILE A   5
ALA A   7
LEU A  20
ASP A  27
LEU A  28
ILE A  50
THR A 115
 None
None
None
None
SO4  A3486 ( 4.8A)
SO4  A3486 ( 4.8A)
None
 0.67A 2w9sA-1zdrA:
26.3		 2w9sA-1zdrA:
49.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W9S_B_TOPB1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		7 / 11 ILE A   5
ALA A   7
LEU A  20
ASP A  27
LEU A  28
ILE A  50
THR A 115
 None
None
None
None
SO4  A3486 ( 4.8A)
SO4  A3486 ( 4.8A)
None
 0.66A 2w9sB-1zdrA:
26.3		 2w9sB-1zdrA:
49.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W9S_C_TOPC1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		6 / 10 ILE A   5
ALA A   7
LEU A  20
ASP A  27
ILE A  50
THR A 115
 None
None
None
None
SO4  A3486 ( 4.8A)
None
 0.65A 2w9sC-1zdrA:
26.2		 2w9sC-1zdrA:
49.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W9S_D_TOPD1158_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		6 / 10 ILE A   5
ALA A   7
LEU A  20
ASP A  27
LEU A  28
THR A 115
 None
None
None
None
SO4  A3486 ( 4.8A)
None
 0.53A 2w9sD-1zdrA:
26.0		 2w9sD-1zdrA:
49.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W9S_E_TOPE1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		5 / 8 ILE A   5
ALA A   7
LEU A  20
ASP A  27
THR A 115
 None
 0.44A 2w9sE-1zdrA:
26.1		 2w9sE-1zdrA:
49.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W9S_F_TOPF1159_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		6 / 10 ILE A   5
ALA A   7
LEU A  20
ASP A  27
LEU A  28
THR A 115
 None
None
None
None
SO4  A3486 ( 4.8A)
None
 0.49A 2w9sF-1zdrA:
26.0		 2w9sF-1zdrA:
49.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZZA_A_FOLA164_0
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		8 / 12 ILE A   5
ALA A   7
LEU A  28
LYS A  32
ILE A  50
LEU A  54
ARG A  57
THR A 115
 None
None
SO4  A3486 ( 4.8A)
SO4  A3484 (-3.1A)
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
SO4  A3484 (-3.3A)
None
 0.63A 2zzaA-1zdrA:
25.0		 2zzaA-1zdrA:
46.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZZA_B_FOLB164_0
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		7 / 11 ILE A   5
ALA A   7
LEU A  28
LYS A  32
LEU A  54
ARG A  57
THR A 115
 None
None
SO4  A3486 ( 4.8A)
SO4  A3484 (-3.1A)
SO4  A3486 (-4.2A)
SO4  A3484 (-3.3A)
None
 0.83A 2zzaB-1zdrA:
24.9		 2zzaB-1zdrA:
46.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZZA_B_FOLB164_0
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		7 / 11 ILE A   5
ALA A   7
LYS A  32
ILE A  50
LEU A  54
ARG A  57
THR A 115
 None
None
SO4  A3484 (-3.1A)
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
SO4  A3484 (-3.3A)
None
 0.68A 2zzaB-1zdrA:
24.9		 2zzaB-1zdrA:
46.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BMC_A_FOLA270_0
(PTERIDINE REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		5 / 11 ARG A  12
SER A 131
PRO A 107
PRO A 128
GLU A 100
 None
 1.30A 3bmcA-1zdrA:
undetectable		 3bmcA-1zdrA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BMC_D_FOLD270_0
(PTERIDINE REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		5 / 12 ARG A  12
SER A 131
PRO A 107
PRO A 128
GLU A 100
 None
 1.30A 3bmcD-1zdrA:
undetectable		 3bmcD-1zdrA:
21.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CD2_A_MTXA307_1
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		6 / 12 ILE A   5
LEU A  20
LYS A  32
LEU A  54
ARG A  57
ILE A  96
 None
None
SO4  A3484 (-3.1A)
SO4  A3486 (-4.2A)
SO4  A3484 (-3.3A)
None
 0.55A 3cd2A-1zdrA:
19.4		 3cd2A-1zdrA:
34.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CL9_A_MTXA602_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE (DHFR-TS))		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		6 / 12 ALA A   7
ASP A  27
THR A  46
LEU A  54
PRO A  55
ARG A  57
 None
None
SO4  A3483 (-3.5A)
SO4  A3486 (-4.2A)
SO4  A3484 ( 4.4A)
SO4  A3484 (-3.3A)
 0.68A 3cl9A-1zdrA:
18.7		 3cl9A-1zdrA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_A_TMQA611_1
(DHFR-TS)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		6 / 11 ALA A   7
ASP A  27
ILE A  50
LEU A  54
ILE A  96
THR A 115
 None
None
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
None
None
 0.69A 3clbA-1zdrA:
18.8		 3clbA-1zdrA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_B_TMQB612_1
(DHFR-TS)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		6 / 12 ALA A   7
ASP A  27
PHE A  31
THR A  46
ILE A  50
ILE A  96
 None
None
SO4  A3486 (-4.1A)
SO4  A3483 (-3.5A)
SO4  A3486 ( 4.8A)
None
 0.70A 3clbB-1zdrA:
17.9		 3clbB-1zdrA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_C_TMQC613_1
(DHFR-TS)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		7 / 12 ALA A   7
ASP A  27
THR A  46
ILE A  50
LEU A  54
ILE A  96
THR A 115
 None
None
SO4  A3483 (-3.5A)
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
None
None
 0.70A 3clbC-1zdrA:
18.9		 3clbC-1zdrA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_D_TMQD614_1
(DHFR-TS)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		5 / 10 ALA A   7
ASP A  27
ILE A  50
ILE A  96
THR A 115
 None
None
SO4  A3486 ( 4.8A)
None
None
 0.51A 3clbD-1zdrA:
18.7		 3clbD-1zdrA:
17.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DAT_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		5 / 12 ALA A   7
LEU A  20
ILE A  50
LEU A  54
ARG A  57
 None
None
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
SO4  A3484 (-3.3A)
 0.63A 3datA-1zdrA:
25.7		 3datA-1zdrA:
52.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DAT_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		5 / 12 ALA A   7
LEU A  20
LEU A  28
LEU A  54
ARG A  57
 None
None
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
SO4  A3484 (-3.3A)
 0.64A 3datA-1zdrA:
25.7		 3datA-1zdrA:
52.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DAU_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		8 / 12 ILE A   5
ALA A   7
ASP A  27
ALA A  29
LYS A  32
ILE A  50
LEU A  54
ARG A  57
 None
None
None
None
SO4  A3484 (-3.1A)
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
SO4  A3484 (-3.3A)
 0.57A 3dauA-1zdrA:
25.3		 3dauA-1zdrA:
40.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DAU_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		8 / 12 ILE A   5
ALA A   7
ASP A  27
LEU A  28
ALA A  29
LYS A  32
LEU A  54
ARG A  57
 None
None
None
SO4  A3486 ( 4.8A)
None
SO4  A3484 (-3.1A)
SO4  A3486 (-4.2A)
SO4  A3484 (-3.3A)
 0.51A 3dauA-1zdrA:
25.3		 3dauA-1zdrA:
40.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DFR_A_MTXA164_1
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		7 / 12 ALA A   7
LEU A  20
ASP A  27
LEU A  28
LEU A  54
ARG A  57
THR A 115
 None
None
None
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
SO4  A3484 (-3.3A)
None
 0.64A 3dfrA-1zdrA:
23.9		 3dfrA-1zdrA:
38.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DRC_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		9 / 12 ILE A   5
ALA A   7
ASP A  27
LEU A  28
LYS A  32
ILE A  50
LEU A  54
ARG A  57
ILE A  96
 None
None
None
SO4  A3486 ( 4.8A)
SO4  A3484 (-3.1A)
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
SO4  A3484 (-3.3A)
None
 0.63A 3drcA-1zdrA:
24.0		 3drcA-1zdrA:
40.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DRC_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		10 / 12 ILE A   5
ALA A   7
ASP A  27
LEU A  28
LYS A  32
ILE A  50
LEU A  54
ARG A  57
ILE A  96
THR A 115
 None
None
None
SO4  A3486 ( 4.8A)
SO4  A3484 (-3.1A)
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
SO4  A3484 (-3.3A)
None
None
 0.61A 3drcB-1zdrA:
24.5		 3drcB-1zdrA:
40.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3EIG_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		5 / 12 ILE A   5
ALA A   7
LEU A  20
LEU A  54
ARG A  57
 None
None
None
SO4  A3486 (-4.2A)
SO4  A3484 (-3.3A)
 0.53A 3eigA-1zdrA:
19.7		 3eigA-1zdrA:
33.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FL9_E_TOPE200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		6 / 10 ALA A   7
LEU A  20
LEU A  28
ILE A  50
LEU A  54
THR A 115
 None
None
SO4  A3486 ( 4.8A)
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
None
 0.87A 3fl9E-1zdrA:
24.7		 3fl9E-1zdrA:
52.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FRB_X_TOPX300_1
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		5 / 11 ALA A   7
LEU A  20
ASP A  27
ILE A  50
THR A 115
 None
None
None
SO4  A3486 ( 4.8A)
None
 0.69A 3frbX-1zdrA:
26.1		 3frbX-1zdrA:
48.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FRB_X_TOPX300_1
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		5 / 11 ALA A   7
LEU A  20
ASP A  27
LEU A  28
THR A 115
 None
None
None
SO4  A3486 ( 4.8A)
None
 0.53A 3frbX-1zdrA:
26.1		 3frbX-1zdrA:
48.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FRE_X_TOPX300_1
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		5 / 9 ALA A   7
LEU A  20
ASP A  27
ILE A  50
THR A 115
 None
None
None
SO4  A3486 ( 4.8A)
None
 0.66A 3freX-1zdrA:
26.0		 3freX-1zdrA:
48.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FRE_X_TOPX300_1
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		5 / 9 ALA A   7
LEU A  20
ASP A  27
LEU A  28
THR A 115
 None
None
None
SO4  A3486 ( 4.8A)
None
 0.58A 3freX-1zdrA:
26.0		 3freX-1zdrA:
48.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_A_TMQA611_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		5 / 10 ALA A   7
ASP A  27
ILE A  50
LEU A  54
ILE A  96
 None
None
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
None
 0.72A 3hbbA-1zdrA:
18.8		 3hbbA-1zdrA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_C_TMQC613_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		6 / 11 ALA A   7
ASP A  27
ILE A  50
LEU A  54
ILE A  96
THR A 115
 None
None
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
None
None
 0.69A 3hbbC-1zdrA:
10.3		 3hbbC-1zdrA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_D_TMQD614_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		5 / 10 ALA A   7
ASP A  27
ILE A  50
ILE A  96
THR A 115
 None
None
SO4  A3486 ( 4.8A)
None
None
 0.49A 3hbbD-1zdrA:
18.8		 3hbbD-1zdrA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_A_MTXA605_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		9 / 12 ALA A   7
LEU A  20
ASP A  27
LEU A  28
PHE A  31
THR A  46
LEU A  54
ARG A  57
THR A 115
 None
None
None
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.1A)
SO4  A3483 (-3.5A)
SO4  A3486 (-4.2A)
SO4  A3484 (-3.3A)
None
 0.59A 3hj3A-1zdrA:
21.4		 3hj3A-1zdrA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_A_MTXA605_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		9 / 12 ALA A   7
LEU A  20
ASP A  27
PHE A  31
THR A  46
ILE A  50
LEU A  54
ARG A  57
THR A 115
 None
None
None
SO4  A3486 (-4.1A)
SO4  A3483 (-3.5A)
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
SO4  A3484 (-3.3A)
None
 0.76A 3hj3A-1zdrA:
21.4		 3hj3A-1zdrA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_B_MTXB609_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		9 / 12 ALA A   7
LEU A  20
ASP A  27
LEU A  28
PHE A  31
THR A  46
ILE A  50
LEU A  54
ARG A  57
 None
None
None
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.1A)
SO4  A3483 (-3.5A)
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
SO4  A3484 (-3.3A)
 0.72A 3hj3B-1zdrA:
21.4		 3hj3B-1zdrA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_C_MTXC613_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		9 / 12 ALA A   7
LEU A  20
ASP A  27
LEU A  28
PHE A  31
THR A  46
LEU A  54
ARG A  57
THR A 115
 None
None
None
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.1A)
SO4  A3483 (-3.5A)
SO4  A3486 (-4.2A)
SO4  A3484 (-3.3A)
None
 0.70A 3hj3C-1zdrA:
11.3		 3hj3C-1zdrA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_D_MTXD615_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		9 / 12 ALA A   7
LEU A  20
ASP A  27
LEU A  28
PHE A  31
THR A  46
ILE A  50
LEU A  54
ARG A  57
 None
None
None
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.1A)
SO4  A3483 (-3.5A)
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
SO4  A3484 (-3.3A)
 0.72A 3hj3D-1zdrA:
12.1		 3hj3D-1zdrA:
16.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IA4_A_MTXA164_1
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		5 / 12 ALA A   7
LEU A  28
LYS A  32
LEU A  54
ARG A  57
 None
SO4  A3486 ( 4.8A)
SO4  A3484 (-3.1A)
SO4  A3486 (-4.2A)
SO4  A3484 (-3.3A)
 0.72A 3ia4A-1zdrA:
25.1		 3ia4A-1zdrA:
46.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IA4_A_MTXA164_1
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		5 / 12 ALA A   7
LYS A  32
ILE A  50
LEU A  54
ARG A  57
 None
SO4  A3484 (-3.1A)
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
SO4  A3484 (-3.3A)
 0.62A 3ia4A-1zdrA:
25.1		 3ia4A-1zdrA:
46.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IA4_A_MTXA164_2
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		4 / 4 ILE A   5
PHE A  31
ILE A  96
THR A 115
 None
SO4  A3486 (-4.1A)
None
None
 0.28A 3ia4A-1zdrA:
25.1		 3ia4A-1zdrA:
46.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IA4_B_MTXB164_1
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		5 / 12 ILE A   5
ALA A   7
ILE A  50
LEU A  54
ARG A  57
 None
None
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
SO4  A3484 (-3.3A)
 0.47A 3ia4B-1zdrA:
25.0		 3ia4B-1zdrA:
46.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IA4_B_MTXB164_1
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		5 / 12 ILE A   5
ALA A   7
LEU A  28
LEU A  54
ARG A  57
 None
None
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
SO4  A3484 (-3.3A)
 0.56A 3ia4B-1zdrA:
25.0		 3ia4B-1zdrA:
46.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IA4_B_MTXB164_2
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		4 / 4 PHE A  31
LYS A  32
ILE A  96
THR A 115
 SO4  A3486 (-4.1A)
SO4  A3484 (-3.1A)
None
None
 0.39A 3ia4B-1zdrA:
25.0		 3ia4B-1zdrA:
46.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IA4_C_MTXC164_1
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		5 / 12 ALA A   7
LEU A  28
PHE A  31
LEU A  54
ARG A  57
 None
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.1A)
SO4  A3486 (-4.2A)
SO4  A3484 (-3.3A)
 0.57A 3ia4C-1zdrA:
25.0		 3ia4C-1zdrA:
46.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IA4_C_MTXC164_1
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		5 / 12 ALA A   7
LEU A  28
PHE A  31
LYS A  32
LEU A  54
 None
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.1A)
SO4  A3484 (-3.1A)
SO4  A3486 (-4.2A)
 0.79A 3ia4C-1zdrA:
25.0		 3ia4C-1zdrA:
46.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IA4_C_MTXC164_1
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		5 / 12 ALA A   7
PHE A  31
ILE A  50
LEU A  54
ARG A  57
 None
SO4  A3486 (-4.1A)
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
SO4  A3484 (-3.3A)
 0.53A 3ia4C-1zdrA:
25.0		 3ia4C-1zdrA:
46.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IA4_C_MTXC164_1
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		5 / 12 ALA A   7
PHE A  31
LYS A  32
ILE A  50
LEU A  54
 None
SO4  A3486 (-4.1A)
SO4  A3484 (-3.1A)
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
 0.77A 3ia4C-1zdrA:
25.0		 3ia4C-1zdrA:
46.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IA4_D_MTXD164_1
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		7 / 12 ILE A   5
ALA A   7
LEU A  28
PHE A  31
LYS A  32
LEU A  54
ARG A  57
 None
None
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.1A)
SO4  A3484 (-3.1A)
SO4  A3486 (-4.2A)
SO4  A3484 (-3.3A)
 0.52A 3ia4D-1zdrA:
25.0		 3ia4D-1zdrA:
46.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IA4_D_MTXD164_1
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		7 / 12 ILE A   5
ALA A   7
PHE A  31
LYS A  32
ILE A  50
LEU A  54
ARG A  57
 None
None
SO4  A3486 (-4.1A)
SO4  A3484 (-3.1A)
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
SO4  A3484 (-3.3A)
 0.47A 3ia4D-1zdrA:
25.0		 3ia4D-1zdrA:
46.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IX9_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		8 / 12 ILE A   5
ALA A   7
LEU A  20
LEU A  28
LYS A  32
LEU A  54
ARG A  57
THR A 115
 None
None
None
SO4  A3486 ( 4.8A)
SO4  A3484 (-3.1A)
SO4  A3486 (-4.2A)
SO4  A3484 (-3.3A)
None
 0.67A 3ix9A-1zdrA:
25.4		 3ix9A-1zdrA:
39.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IX9_B_MTXB200_1
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		8 / 12 ILE A   5
ALA A   7
LEU A  20
LEU A  28
LYS A  32
LEU A  54
ARG A  57
THR A 115
 None
None
None
SO4  A3486 ( 4.8A)
SO4  A3484 (-3.1A)
SO4  A3486 (-4.2A)
SO4  A3484 (-3.3A)
None
 0.66A 3ix9B-1zdrA:
25.5		 3ix9B-1zdrA:
39.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JW3_A_TOPA208_1
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		5 / 10 ALA A   7
ILE A  50
LEU A  54
ILE A  96
THR A 115
 None
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
None
None
 0.73A 3jw3A-1zdrA:
25.8		 3jw3A-1zdrA:
52.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JW3_A_TOPA208_1
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		5 / 10 ALA A   7
LEU A  28
LEU A  54
ILE A  96
THR A 115
 None
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
None
None
 0.88A 3jw3A-1zdrA:
25.8		 3jw3A-1zdrA:
52.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JW5_B_TOPB208_1
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		5 / 10 ALA A   7
LEU A  20
LEU A  28
LEU A  54
THR A 115
 None
None
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
None
 0.58A 3jw5B-1zdrA:
25.8		 3jw5B-1zdrA:
52.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JW5_B_TOPB208_1
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		5 / 10 ALA A   7
LEU A  28
ILE A  50
LEU A  54
THR A 115
 None
SO4  A3486 ( 4.8A)
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
None
 0.58A 3jw5B-1zdrA:
25.8		 3jw5B-1zdrA:
52.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		6 / 12 ALA A   7
ASP A  27
THR A  46
ILE A  50
LEU A  54
ARG A  57
 None
None
SO4  A3483 (-3.5A)
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
SO4  A3484 (-3.3A)
 0.85A 3k2hA-1zdrA:
21.2		 3k2hA-1zdrA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		5 / 12 ALA A   7
ASP A  27
ILE A  50
LEU A  54
ARG A  57
 None
None
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
SO4  A3484 (-3.3A)
 0.83A 3k2hB-1zdrA:
20.4		 3k2hB-1zdrA:
17.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N0H_A_TOPA187_1
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		7 / 11 ILE A   5
ALA A   7
PHE A  31
THR A  46
ILE A  50
LEU A  54
THR A 115
 None
None
SO4  A3486 (-4.1A)
SO4  A3483 (-3.5A)
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
None
 0.69A 3n0hA-1zdrA:
20.4		 3n0hA-1zdrA:
33.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_A_D16A520_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		5 / 12 ALA A   7
ASP A  27
THR A  46
ILE A  50
THR A 115
 None
None
SO4  A3483 (-3.5A)
SO4  A3486 ( 4.8A)
None
 0.38A 3nrrA-1zdrA:
20.6		 3nrrA-1zdrA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_B_D16B520_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		5 / 12 ALA A   7
ASP A  27
THR A  46
ILE A  50
THR A 115
 None
None
SO4  A3483 (-3.5A)
SO4  A3486 ( 4.8A)
None
 0.42A 3nrrB-1zdrA:
21.4		 3nrrB-1zdrA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_B_D16B520_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		5 / 12 ALA A   7
HIS A  23
ASP A  27
THR A  46
THR A 115
 None
None
None
SO4  A3483 (-3.5A)
None
 0.75A 3nrrB-1zdrA:
21.4		 3nrrB-1zdrA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QFX_A_CP6A602_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		6 / 12 ALA A   7
ASP A  27
PHE A  31
THR A  46
ILE A  96
THR A 115
 None
None
SO4  A3486 (-4.1A)
SO4  A3483 (-3.5A)
None
None
 0.32A 3qfxA-1zdrA:
19.2		 3qfxA-1zdrA:
27.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QFX_B_CP6B702_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		6 / 12 ALA A   7
ASP A  27
PHE A  31
THR A  46
ILE A  96
THR A 115
 None
None
SO4  A3486 (-4.1A)
SO4  A3483 (-3.5A)
None
None
 0.31A 3qfxB-1zdrA:
19.2		 3qfxB-1zdrA:
27.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QG2_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		6 / 10 ILE A   5
ALA A   7
ASP A  27
PHE A  31
ILE A  50
THR A 115
 None
None
None
SO4  A3486 (-4.1A)
SO4  A3486 ( 4.8A)
None
 0.35A 3qg2A-1zdrA:
20.4		 3qg2A-1zdrA:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QG2_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		6 / 11 ILE A   5
ALA A   7
ASP A  27
PHE A  31
ILE A  50
THR A 115
 None
None
None
SO4  A3486 (-4.1A)
SO4  A3486 ( 4.8A)
None
 0.31A 3qg2B-1zdrA:
20.4		 3qg2B-1zdrA:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGT_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		7 / 10 ILE A   5
ALA A   7
ASP A  27
PHE A  31
ILE A  50
ILE A  96
THR A 115
 None
None
None
SO4  A3486 (-4.1A)
SO4  A3486 ( 4.8A)
None
None
 0.47A 3qgtA-1zdrA:
20.6		 3qgtA-1zdrA:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGT_B_CP6B609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		7 / 10 ILE A   5
ALA A   7
ASP A  27
PHE A  31
ILE A  50
ILE A  96
THR A 115
 None
None
None
SO4  A3486 (-4.1A)
SO4  A3486 ( 4.8A)
None
None
 0.29A 3qgtB-1zdrA:
11.4		 3qgtB-1zdrA:
12.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QL0_A_FOLA160_0
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		9 / 12 ILE A   5
ALA A   7
LEU A  28
PHE A  31
LYS A  32
ILE A  50
LEU A  54
ARG A  57
THR A 115
 None
None
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.1A)
SO4  A3484 (-3.1A)
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
SO4  A3484 (-3.3A)
None
 0.55A 3ql0A-1zdrA:
25.0		 3ql0A-1zdrA:
40.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QL3_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		9 / 12 ILE A   5
ALA A   7
ASP A  27
LEU A  28
LYS A  32
ILE A  50
ARG A  57
ILE A  96
THR A 115
 None
None
None
SO4  A3486 ( 4.8A)
SO4  A3484 (-3.1A)
SO4  A3486 ( 4.8A)
SO4  A3484 (-3.3A)
None
None
 0.78A 3ql3A-1zdrA:
25.5		 3ql3A-1zdrA:
40.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3S3V_A_TOPA187_1
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		7 / 12 ILE A   5
ALA A   7
PHE A  31
THR A  46
ILE A  50
LEU A  54
THR A 115
 None
None
SO4  A3486 (-4.1A)
SO4  A3483 (-3.5A)
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
None
 0.72A 3s3vA-1zdrA:
20.3		 3s3vA-1zdrA:
34.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TQ8_A_TOPA2001_1
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		8 / 9 ILE A   5
ALA A   7
LEU A  20
ASP A  27
PHE A  31
ILE A  50
ILE A  96
THR A 115
 None
None
None
None
SO4  A3486 (-4.1A)
SO4  A3486 ( 4.8A)
None
None
 0.51A 3tq8A-1zdrA:
25.2		 3tq8A-1zdrA:
42.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TQ9_A_MTXA2001_1
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		11 / 12 ILE A   5
ALA A   7
LEU A  20
ASP A  27
LEU A  28
LYS A  32
ILE A  50
LEU A  54
ARG A  57
ILE A  96
THR A 115
 None
None
None
None
SO4  A3486 ( 4.8A)
SO4  A3484 (-3.1A)
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
SO4  A3484 (-3.3A)
None
None
 0.68A 3tq9A-1zdrA:
24.5		 3tq9A-1zdrA:
42.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TQB_A_FOLA2001_0
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		11 / 11 ALA A   7
LEU A  20
ASP A  27
LEU A  28
LYS A  32
THR A  46
ILE A  50
LEU A  54
ARG A  57
ILE A  96
THR A 115
 None
None
None
SO4  A3486 ( 4.8A)
SO4  A3484 (-3.1A)
SO4  A3483 (-3.5A)
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
SO4  A3484 (-3.3A)
None
None
 0.50A 3tqbA-1zdrA:
24.2		 3tqbA-1zdrA:
42.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UM5_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		7 / 10 ILE A   5
ASP A  27
PHE A  31
THR A  46
ILE A  50
ILE A  96
THR A 115
 None
None
SO4  A3486 (-4.1A)
SO4  A3483 (-3.5A)
SO4  A3486 ( 4.8A)
None
None
 0.42A 3um5A-1zdrA:
20.7		 3um5A-1zdrA:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UM5_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		7 / 10 ILE A   5
ASP A  27
PHE A  31
THR A  46
ILE A  50
ILE A  96
THR A 115
 None
None
SO4  A3486 (-4.1A)
SO4  A3483 (-3.5A)
SO4  A3486 ( 4.8A)
None
None
 0.41A 3um5B-1zdrA:
13.8		 3um5B-1zdrA:
12.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CD2_A_FOLA207_0
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		7 / 12 ILE A   5
ALA A   7
PHE A  31
LYS A  32
LEU A  54
ARG A  57
THR A 115
 None
None
SO4  A3486 (-4.1A)
SO4  A3484 (-3.1A)
SO4  A3486 (-4.2A)
SO4  A3484 (-3.3A)
None
 0.51A 4cd2A-1zdrA:
18.7		 4cd2A-1zdrA:
34.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CD2_A_FOLA207_0
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		7 / 12 ILE A   5
ALA A   7
PHE A  31
THR A  46
LEU A  54
ARG A  57
THR A 115
 None
None
SO4  A3486 (-4.1A)
SO4  A3483 (-3.5A)
SO4  A3486 (-4.2A)
SO4  A3484 (-3.3A)
None
 0.49A 4cd2A-1zdrA:
18.7		 4cd2A-1zdrA:
34.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DFR_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		9 / 12 ILE A   5
ALA A   7
ASP A  27
LEU A  28
LYS A  32
THR A  46
ILE A  50
LEU A  54
ARG A  57
 None
None
None
SO4  A3486 ( 4.8A)
SO4  A3484 (-3.1A)
SO4  A3483 (-3.5A)
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
SO4  A3484 (-3.3A)
 0.69A 4dfrA-1zdrA:
23.9		 4dfrA-1zdrA:
40.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DFR_B_MTXB162_1
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		9 / 12 ILE A   5
ALA A   7
ASP A  27
LEU A  28
LYS A  32
LEU A  54
ARG A  57
ILE A  96
THR A 115
 None
None
None
SO4  A3486 ( 4.8A)
SO4  A3484 (-3.1A)
SO4  A3486 (-4.2A)
SO4  A3484 (-3.3A)
None
None
 0.61A 4dfrB-1zdrA:
24.3		 4dfrB-1zdrA:
40.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DFR_B_MTXB162_1
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		9 / 12 ILE A   5
ALA A   7
ASP A  27
LYS A  32
ILE A  50
LEU A  54
ARG A  57
ILE A  96
THR A 115
 None
None
None
SO4  A3484 (-3.1A)
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
SO4  A3484 (-3.3A)
None
None
 0.66A 4dfrB-1zdrA:
24.3		 4dfrB-1zdrA:
40.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ECK_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		6 / 12 ALA A   7
LEU A  20
PHE A  31
LEU A  54
ARG A  57
THR A 115
 None
None
SO4  A3486 (-4.1A)
SO4  A3486 (-4.2A)
SO4  A3484 (-3.3A)
None
 0.73A 4eckA-1zdrA:
18.9		 4eckA-1zdrA:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ECK_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		7 / 12 ALA A   7
LEU A  20
ASP A  27
PHE A  31
LEU A  54
ARG A  57
THR A 115
 None
None
None
SO4  A3486 (-4.1A)
SO4  A3486 (-4.2A)
SO4  A3484 (-3.3A)
None
 0.78A 4eckB-1zdrA:
18.6		 4eckB-1zdrA:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		5 / 11 ALA A   7
ASP A  27
LEU A  54
ARG A  57
THR A 115
 None
None
SO4  A3486 (-4.2A)
SO4  A3484 (-3.3A)
None
 0.36A 4eilA-1zdrA:
20.1		 4eilA-1zdrA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		5 / 10 ALA A   7
ASP A  27
LEU A  54
ARG A  57
THR A 115
 None
None
SO4  A3486 (-4.2A)
SO4  A3484 (-3.3A)
None
 0.36A 4eilB-1zdrA:
20.5		 4eilB-1zdrA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_C_FOLC703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		5 / 11 ALA A   7
ASP A  27
LEU A  54
ARG A  57
THR A 115
 None
None
SO4  A3486 (-4.2A)
SO4  A3484 (-3.3A)
None
 0.37A 4eilC-1zdrA:
7.9		 4eilC-1zdrA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_E_FOLE703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		5 / 11 ALA A   7
ASP A  27
LEU A  54
ARG A  57
THR A 115
 None
None
SO4  A3486 (-4.2A)
SO4  A3484 (-3.3A)
None
 0.39A 4eilE-1zdrA:
20.6		 4eilE-1zdrA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_F_FOLF703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		5 / 9 ALA A   7
ASP A  27
LEU A  54
ARG A  57
THR A 115
 None
None
SO4  A3486 (-4.2A)
SO4  A3484 (-3.3A)
None
 0.36A 4eilF-1zdrA:
19.7		 4eilF-1zdrA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_G_FOLG703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		5 / 10 ALA A   7
ASP A  27
LEU A  54
ARG A  57
THR A 115
 None
None
SO4  A3486 (-4.2A)
SO4  A3484 (-3.3A)
None
 0.37A 4eilG-1zdrA:
7.9		 4eilG-1zdrA:
14.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EJ1_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		9 / 12 ILE A   5
ALA A   7
LEU A  28
PHE A  31
LYS A  32
THR A  46
ILE A  50
LEU A  54
ILE A  96
 None
None
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.1A)
SO4  A3484 (-3.1A)
SO4  A3483 (-3.5A)
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
None
 0.52A 4ej1A-1zdrA:
23.7		 4ej1A-1zdrA:
40.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EJ1_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		9 / 12 ILE A   5
ALA A   7
LEU A  28
PHE A  31
LYS A  32
THR A  46
ILE A  50
LEU A  54
THR A 115
 None
None
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.1A)
SO4  A3484 (-3.1A)
SO4  A3483 (-3.5A)
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
None
 0.51A 4ej1B-1zdrA:
23.8		 4ej1B-1zdrA:
40.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FHB_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		11 / 12 ILE A   5
ALA A   7
LEU A  28
PHE A  31
LYS A  32
THR A  46
ILE A  50
LEU A  54
ARG A  57
ILE A  96
THR A 115
 None
None
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.1A)
SO4  A3484 (-3.1A)
SO4  A3483 (-3.5A)
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
SO4  A3484 (-3.3A)
None
None
 0.57A 4fhbA-1zdrA:
24.4		 4fhbA-1zdrA:
40.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4G8Z_X_TOPX301_1
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		6 / 10 ILE A   5
ALA A   7
LEU A  20
PHE A  31
ILE A  96
THR A 115
 None
None
None
SO4  A3486 (-4.1A)
None
None
 0.46A 4g8zX-1zdrA:
19.7		 4g8zX-1zdrA:
33.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4GH8_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		7 / 12 ILE A   5
ALA A   7
ASP A  27
LEU A  28
ILE A  50
LEU A  54
ARG A  57
 None
None
None
SO4  A3486 ( 4.8A)
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
SO4  A3484 (-3.3A)
 0.68A 4gh8A-1zdrA:
24.6		 4gh8A-1zdrA:
39.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4GH8_A_MTXA201_2
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		3 / 3 LYS A  32
ILE A  96
THR A 115
 SO4  A3484 (-3.1A)
None
None
 0.38A 4gh8A-1zdrA:
24.6		 4gh8A-1zdrA:
39.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4GH8_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		7 / 12 ILE A   5
ALA A   7
ASP A  27
LEU A  28
LYS A  32
ILE A  50
ARG A  57
 None
None
None
SO4  A3486 ( 4.8A)
SO4  A3484 (-3.1A)
SO4  A3486 ( 4.8A)
SO4  A3484 (-3.3A)
 0.69A 4gh8B-1zdrA:
24.2		 4gh8B-1zdrA:
39.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4I13_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		9 / 12 ILE A   5
ALA A   7
LEU A  28
PHE A  31
LYS A  32
THR A  46
ILE A  50
LEU A  54
ILE A  96
 None
None
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.1A)
SO4  A3484 (-3.1A)
SO4  A3483 (-3.5A)
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
None
 0.48A 4i13A-1zdrA:
23.6		 4i13A-1zdrA:
40.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4I13_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		3 / 3 ASP A  27
ARG A  57
THR A 115
 None
SO4  A3484 (-3.3A)
None
 0.31A 4i13A-1zdrA:
23.6		 4i13A-1zdrA:
40.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4I1N_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		9 / 11 ILE A   5
ALA A   7
ASP A  27
LEU A  28
PHE A  31
LYS A  32
LEU A  54
ARG A  57
THR A 115
 None
None
None
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.1A)
SO4  A3484 (-3.1A)
SO4  A3486 (-4.2A)
SO4  A3484 (-3.3A)
None
 0.53A 4i1nA-1zdrA:
23.7		 4i1nA-1zdrA:
40.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KEB_B_FOLB202_0
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		8 / 12 ILE A   5
ALA A   7
LEU A  20
PHE A  31
THR A  46
ILE A  50
LEU A  54
THR A 115
 None
None
None
SO4  A3486 (-4.1A)
SO4  A3483 (-3.5A)
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
None
 0.52A 4kebB-1zdrA:
20.1		 4kebB-1zdrA:
33.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KFJ_B_FOLB202_0
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		7 / 12 ILE A   5
ALA A   7
LEU A  20
PHE A  31
ILE A  50
LEU A  54
THR A 115
 None
None
None
SO4  A3486 (-4.1A)
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
None
 0.55A 4kfjB-1zdrA:
20.3		 4kfjB-1zdrA:
33.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KJJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		6 / 12 ALA A  29
PHE A  31
LYS A  32
ILE A  50
LEU A  54
ILE A  40
 None
SO4  A3486 (-4.1A)
SO4  A3484 (-3.1A)
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
None
 1.10A 4kjjA-1zdrA:
24.1		 4kjjA-1zdrA:
40.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KJJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		9 / 12 ILE A   5
ALA A   7
ALA A  29
PHE A  31
LYS A  32
THR A  46
ILE A  50
LEU A  54
ILE A  96
 None
None
None
SO4  A3486 (-4.1A)
SO4  A3484 (-3.1A)
SO4  A3483 (-3.5A)
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
None
 0.45A 4kjjA-1zdrA:
24.1		 4kjjA-1zdrA:
40.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KJJ_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		4 / 4 ASP A  27
LEU A  28
ARG A  57
THR A 115
 None
SO4  A3486 ( 4.8A)
SO4  A3484 (-3.3A)
None
 0.58A 4kjjA-1zdrA:
24.1		 4kjjA-1zdrA:
40.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KJK_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		8 / 12 ILE A   5
ALA A   7
PHE A  31
LYS A  32
THR A  46
ILE A  50
LEU A  54
ILE A  96
 None
None
SO4  A3486 (-4.1A)
SO4  A3484 (-3.1A)
SO4  A3483 (-3.5A)
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
None
 0.58A 4kjkA-1zdrA:
25.0		 4kjkA-1zdrA:
40.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KJK_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		4 / 4 ASP A  27
LEU A  28
ARG A  57
THR A 115
 None
SO4  A3486 ( 4.8A)
SO4  A3484 (-3.3A)
None
 0.61A 4kjkA-1zdrA:
25.0		 4kjkA-1zdrA:
40.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KJL_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		9 / 12 ILE A   5
ALA A   7
PHE A  31
LYS A  32
THR A  46
ILE A  50
LEU A  54
ILE A  96
THR A 115
 None
None
SO4  A3486 (-4.1A)
SO4  A3484 (-3.1A)
SO4  A3483 (-3.5A)
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
None
None
 0.47A 4kjlA-1zdrA:
24.8		 4kjlA-1zdrA:
40.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KM0_A_CP6A201_1
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		7 / 10 ILE A   5
ALA A   7
ASP A  27
PHE A  31
THR A  46
ILE A  96
THR A 115
 None
None
None
SO4  A3486 (-4.1A)
SO4  A3483 (-3.5A)
None
None
 0.41A 4km0A-1zdrA:
21.5		 4km0A-1zdrA:
32.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KM0_B_CP6B201_1
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		7 / 12 ILE A   5
ALA A   7
ASP A  27
PHE A  31
THR A  46
ILE A  96
THR A 115
 None
None
None
SO4  A3486 (-4.1A)
SO4  A3483 (-3.5A)
None
None
 0.37A 4km0B-1zdrA:
21.9		 4km0B-1zdrA:
32.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KM2_A_TOPA202_1
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		7 / 12 ILE A   5
ALA A   7
ASP A  27
PHE A  31
THR A  46
ILE A  96
THR A 115
 None
None
None
SO4  A3486 (-4.1A)
SO4  A3483 (-3.5A)
None
None
 0.44A 4km2A-1zdrA:
22.2		 4km2A-1zdrA:
32.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KM2_A_TOPA202_1
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		7 / 12 ILE A   5
ALA A   7
ASP A  27
PHE A  31
THR A  46
LEU A  54
THR A 115
 None
None
None
SO4  A3486 (-4.1A)
SO4  A3483 (-3.5A)
SO4  A3486 (-4.2A)
None
 0.59A 4km2A-1zdrA:
22.2		 4km2A-1zdrA:
32.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KM2_B_TOPB202_1
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		7 / 12 ILE A   5
ALA A   7
ASP A  27
PHE A  31
LEU A  54
ILE A  96
THR A 115
 None
None
None
SO4  A3486 (-4.1A)
SO4  A3486 (-4.2A)
None
None
 0.41A 4km2B-1zdrA:
22.1		 4km2B-1zdrA:
32.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KM2_B_TOPB202_1
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		7 / 12 ILE A   5
ASP A  27
PHE A  31
THR A  46
LEU A  54
ILE A  96
THR A 115
 None
None
SO4  A3486 (-4.1A)
SO4  A3483 (-3.5A)
SO4  A3486 (-4.2A)
None
None
 0.50A 4km2B-1zdrA:
22.1		 4km2B-1zdrA:
32.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_A_MTXA603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		8 / 12 ALA A   7
LEU A  20
ASP A  27
LEU A  28
ILE A  50
LEU A  54
ARG A  57
THR A 115
 None
None
None
SO4  A3486 ( 4.8A)
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
SO4  A3484 (-3.3A)
None
 0.68A 4ky8A-1zdrA:
9.6		 4ky8A-1zdrA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_B_MTXB603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		8 / 12 ALA A   7
LEU A  20
ASP A  27
LEU A  28
ILE A  50
LEU A  54
ARG A  57
THR A 115
 None
None
None
SO4  A3486 ( 4.8A)
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
SO4  A3484 (-3.3A)
None
 0.66A 4ky8B-1zdrA:
15.3		 4ky8B-1zdrA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_C_MTXC603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		8 / 12 ALA A   7
LEU A  20
ASP A  27
LEU A  28
ILE A  50
LEU A  54
ARG A  57
THR A 115
 None
None
None
SO4  A3486 ( 4.8A)
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
SO4  A3484 (-3.3A)
None
 0.66A 4ky8C-1zdrA:
21.3		 4ky8C-1zdrA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_D_MTXD603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		8 / 12 ALA A   7
LEU A  20
ASP A  27
LEU A  28
ILE A  50
LEU A  54
ARG A  57
THR A 115
 None
None
None
SO4  A3486 ( 4.8A)
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
SO4  A3484 (-3.3A)
None
 0.70A 4ky8D-1zdrA:
17.9		 4ky8D-1zdrA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_E_MTXE603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		8 / 12 ALA A   7
LEU A  20
ASP A  27
LEU A  28
ILE A  50
LEU A  54
ARG A  57
THR A 115
 None
None
None
SO4  A3486 ( 4.8A)
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
SO4  A3484 (-3.3A)
None
 0.67A 4ky8E-1zdrA:
21.3		 4ky8E-1zdrA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		6 / 11 ALA A   7
ASP A  27
THR A  46
LEU A  54
ARG A  57
THR A 115
 None
None
SO4  A3483 (-3.5A)
SO4  A3486 (-4.2A)
SO4  A3484 (-3.3A)
None
 0.49A 4kyaA-1zdrA:
20.2		 4kyaA-1zdrA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		5 / 12 ALA A   7
ASP A  27
LEU A  54
ARG A  57
THR A 115
 None
None
SO4  A3486 (-4.2A)
SO4  A3484 (-3.3A)
None
 0.41A 4kyaB-1zdrA:
20.4		 4kyaB-1zdrA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_C_FOLC703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		5 / 10 ALA A   7
ASP A  27
LEU A  54
ARG A  57
THR A 115
 None
None
SO4  A3486 (-4.2A)
SO4  A3484 (-3.3A)
None
 0.46A 4kyaC-1zdrA:
14.7		 4kyaC-1zdrA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_D_FOLD703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		5 / 12 ALA A   7
ASP A  27
LEU A  54
ARG A  57
THR A 115
 None
None
SO4  A3486 (-4.2A)
SO4  A3484 (-3.3A)
None
 0.41A 4kyaD-1zdrA:
13.2		 4kyaD-1zdrA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_E_FOLE703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		6 / 11 ALA A   7
ASP A  27
THR A  46
LEU A  54
ARG A  57
THR A 115
 None
None
SO4  A3483 (-3.5A)
SO4  A3486 (-4.2A)
SO4  A3484 (-3.3A)
None
 0.50A 4kyaE-1zdrA:
20.1		 4kyaE-1zdrA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_F_FOLF703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		5 / 12 ALA A   7
ASP A  27
LEU A  54
ARG A  57
THR A 115
 None
None
SO4  A3486 (-4.2A)
SO4  A3484 (-3.3A)
None
 0.43A 4kyaF-1zdrA:
13.1		 4kyaF-1zdrA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_G_FOLG703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		6 / 11 ALA A   7
ASP A  27
THR A  46
LEU A  54
ARG A  57
THR A 115
 None
None
SO4  A3483 (-3.5A)
SO4  A3486 (-4.2A)
SO4  A3484 (-3.3A)
None
 0.49A 4kyaG-1zdrA:
20.1		 4kyaG-1zdrA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_H_FOLH703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		5 / 12 ALA A   7
ASP A  27
LEU A  54
ARG A  57
THR A 115
 None
None
SO4  A3486 (-4.2A)
SO4  A3484 (-3.3A)
None
 0.42A 4kyaH-1zdrA:
19.6		 4kyaH-1zdrA:
14.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M2X_A_TMQA202_1
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		6 / 12 ILE A   5
ALA A   7
ASP A  27
PHE A  31
LEU A  54
ILE A  96
 None
None
None
SO4  A3486 (-4.1A)
SO4  A3486 (-4.2A)
None
 0.43A 4m2xA-1zdrA:
22.0		 4m2xA-1zdrA:
34.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M2X_C_TMQC202_1
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		6 / 12 ILE A   5
ALA A   7
ASP A  27
LEU A  54
ILE A  96
THR A 115
 None
None
None
SO4  A3486 (-4.2A)
None
None
 0.37A 4m2xC-1zdrA:
7.6		 4m2xC-1zdrA:
34.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M2X_E_TMQE202_1
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		5 / 12 ILE A   5
ALA A   7
ASP A  27
LEU A  54
ILE A  96
 None
None
None
SO4  A3486 (-4.2A)
None
 0.43A 4m2xE-1zdrA:
7.5		 4m2xE-1zdrA:
34.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M2X_G_TMQG202_1
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		5 / 12 ILE A   5
ALA A   7
ASP A  27
ILE A  96
THR A 115
 None
 0.28A 4m2xG-1zdrA:
7.5		 4m2xG-1zdrA:
34.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M6K_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		8 / 12 ILE A   5
ALA A   7
LEU A  20
PHE A  31
THR A  46
ILE A  50
LEU A  54
THR A 115
 None
None
None
SO4  A3486 (-4.1A)
SO4  A3483 (-3.5A)
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
None
 0.53A 4m6kA-1zdrA:
20.4		 4m6kA-1zdrA:
33.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NX6_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		8 / 12 ALA A   7
LEU A  28
PHE A  31
LYS A  32
THR A  46
ILE A  50
LEU A  54
ILE A  96
 None
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.1A)
SO4  A3484 (-3.1A)
SO4  A3483 (-3.5A)
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
None
 0.77A 4nx6A-1zdrA:
25.4		 4nx6A-1zdrA:
40.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NX6_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		5 / 12 PHE A  31
LYS A  32
ILE A  50
LEU A  54
ILE A  40
 SO4  A3486 (-4.1A)
SO4  A3484 (-3.1A)
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
None
 1.03A 4nx6A-1zdrA:
25.4		 4nx6A-1zdrA:
40.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NX6_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		4 / 4 ILE A   5
ASP A  27
ARG A  57
THR A 115
 None
None
SO4  A3484 (-3.3A)
None
 0.37A 4nx6A-1zdrA:
25.4		 4nx6A-1zdrA:
40.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NX7_A_FOLA202_0
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		8 / 12 ALA A   7
LEU A  28
PHE A  31
LYS A  32
THR A  46
ILE A  50
LEU A  54
ILE A  96
 None
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.1A)
SO4  A3484 (-3.1A)
SO4  A3483 (-3.5A)
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
None
 0.84A 4nx7A-1zdrA:
25.3		 4nx7A-1zdrA:
40.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NX7_A_FOLA202_0
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		5 / 12 PHE A  31
LYS A  32
ILE A  50
LEU A  54
ILE A  40
 SO4  A3486 (-4.1A)
SO4  A3484 (-3.1A)
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
None
 1.00A 4nx7A-1zdrA:
25.3		 4nx7A-1zdrA:
40.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NX7_A_FOLA202_1
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		4 / 4 ILE A   5
ASP A  27
ARG A  57
THR A 115
 None
None
SO4  A3484 (-3.3A)
None
 0.38A 4nx7A-1zdrA:
25.3		 4nx7A-1zdrA:
40.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4P3Q_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		9 / 12 ILE A   5
ALA A   7
PHE A  31
LYS A  32
THR A  46
ILE A  50
LEU A  54
PRO A  55
ILE A  96
 None
None
SO4  A3486 (-4.1A)
SO4  A3484 (-3.1A)
SO4  A3483 (-3.5A)
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
SO4  A3484 ( 4.4A)
None
 0.89A 4p3qA-1zdrA:
25.4		 4p3qA-1zdrA:
40.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4P3Q_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		5 / 12 PHE A  31
LYS A  32
ILE A  50
LEU A  54
ILE A  40
 SO4  A3486 (-4.1A)
SO4  A3484 (-3.1A)
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
None
 1.05A 4p3qA-1zdrA:
25.4		 4p3qA-1zdrA:
40.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4P3Q_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		4 / 5 ASP A  27
LEU A  28
ARG A  57
THR A 115
 None
SO4  A3486 ( 4.8A)
SO4  A3484 (-3.3A)
None
 0.74A 4p3qA-1zdrA:
25.4		 4p3qA-1zdrA:
40.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4P3R_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		9 / 12 ILE A   5
ALA A   7
LEU A  28
PHE A  31
LYS A  32
THR A  46
ILE A  50
LEU A  54
ILE A  96
 None
None
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.1A)
SO4  A3484 (-3.1A)
SO4  A3483 (-3.5A)
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
None
 0.64A 4p3rA-1zdrA:
25.2		 4p3rA-1zdrA:
40.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4P3R_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		3 / 3 ASP A  27
ARG A  57
THR A 115
 None
SO4  A3484 (-3.3A)
None
 0.32A 4p3rA-1zdrA:
25.2		 4p3rA-1zdrA:
40.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4P66_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		9 / 11 ILE A   5
ALA A   7
ASP A  27
LEU A  28
LYS A  32
LEU A  54
ARG A  57
ILE A  96
THR A 115
 None
None
None
SO4  A3486 ( 4.8A)
SO4  A3484 (-3.1A)
SO4  A3486 (-4.2A)
SO4  A3484 (-3.3A)
None
None
 0.50A 4p66A-1zdrA:
25.6		 4p66A-1zdrA:
39.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4P68_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		8 / 11 ILE A   5
ASP A  27
PHE A  31
LYS A  32
ILE A  50
ARG A  57
ILE A  96
THR A 115
 None
None
SO4  A3486 (-4.1A)
SO4  A3484 (-3.1A)
SO4  A3486 ( 4.8A)
SO4  A3484 (-3.3A)
None
None
 0.45A 4p68A-1zdrA:
25.4		 4p68A-1zdrA:
39.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PSS_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		8 / 12 ILE A   5
ALA A   7
ALA A  29
PHE A  31
THR A  46
ILE A  50
LEU A  54
ILE A  96
 None
None
None
SO4  A3486 (-4.1A)
SO4  A3483 (-3.5A)
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
None
 0.51A 4pssA-1zdrA:
undetectable		 4pssA-1zdrA:
40.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PSS_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		8 / 12 ILE A   5
ALA A   7
LEU A  28
ALA A  29
PHE A  31
THR A  46
LEU A  54
ILE A  96
 None
None
SO4  A3486 ( 4.8A)
None
SO4  A3486 (-4.1A)
SO4  A3483 (-3.5A)
SO4  A3486 (-4.2A)
None
 0.50A 4pssA-1zdrA:
undetectable		 4pssA-1zdrA:
40.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PSS_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		4 / 4 ASP A  27
LYS A  32
ARG A  57
THR A 115
 None
SO4  A3484 (-3.1A)
SO4  A3484 (-3.3A)
None
 0.41A 4pssA-1zdrA:
undetectable		 4pssA-1zdrA:
40.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PST_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		9 / 12 ALA A   7
LEU A  28
PHE A  31
LYS A  32
THR A  46
ILE A  50
LEU A  54
ILE A  96
THR A 115
 None
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.1A)
SO4  A3484 (-3.1A)
SO4  A3483 (-3.5A)
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
None
None
 0.64A 4pstA-1zdrA:
undetectable		 4pstA-1zdrA:
40.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PST_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		3 / 3 ILE A   5
ASP A  27
ARG A  57
 None
None
SO4  A3484 (-3.3A)
 0.45A 4pstA-1zdrA:
undetectable		 4pstA-1zdrA:
40.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PSY_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		9 / 12 ILE A   5
ALA A   7
LEU A  28
ALA A  29
PHE A  31
LYS A  32
ILE A  50
LEU A  54
THR A 115
 None
None
SO4  A3486 ( 4.8A)
None
SO4  A3486 (-4.1A)
SO4  A3484 (-3.1A)
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
None
 0.48A 4psyA-1zdrA:
25.3		 4psyA-1zdrA:
40.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PTH_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		9 / 12 ILE A   5
ALA A   7
LYS A  32
THR A  46
ILE A  50
LEU A  54
ARG A  57
ILE A  96
THR A 115
 None
None
SO4  A3484 (-3.1A)
SO4  A3483 (-3.5A)
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
SO4  A3484 (-3.3A)
None
None
 0.64A 4pthA-1zdrA:
25.1		 4pthA-1zdrA:
40.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PTH_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		3 / 3 ASP A  27
LEU A  28
PHE A  31
 None
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.1A)
 0.41A 4pthA-1zdrA:
25.1		 4pthA-1zdrA:
40.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PTJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		9 / 12 ILE A   5
ALA A   7
LEU A  28
PHE A  31
THR A  46
ILE A  50
ARG A  57
ILE A  96
THR A 115
 None
None
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.1A)
SO4  A3483 (-3.5A)
SO4  A3486 ( 4.8A)
SO4  A3484 (-3.3A)
None
None
 0.52A 4ptjA-1zdrA:
25.3		 4ptjA-1zdrA:
40.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PTJ_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		3 / 3 ASP A  27
LYS A  32
LEU A  54
 None
SO4  A3484 (-3.1A)
SO4  A3486 (-4.2A)
 0.64A 4ptjA-1zdrA:
25.3		 4ptjA-1zdrA:
40.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_A_MTXA604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		8 / 12 ALA A   7
LEU A  20
ASP A  27
LEU A  28
ILE A  50
LEU A  54
ARG A  57
THR A 115
 None
None
None
SO4  A3486 ( 4.8A)
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
SO4  A3484 (-3.3A)
None
 0.63A 4q0dA-1zdrA:
21.1		 4q0dA-1zdrA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_B_MTXB604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		8 / 12 ALA A   7
LEU A  20
ASP A  27
LEU A  28
ILE A  50
LEU A  54
ARG A  57
THR A 115
 None
None
None
SO4  A3486 ( 4.8A)
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
SO4  A3484 (-3.3A)
None
 0.63A 4q0dB-1zdrA:
21.1		 4q0dB-1zdrA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_C_MTXC604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		7 / 12 ALA A   7
LEU A  20
ASP A  27
LEU A  28
LEU A  54
ARG A  57
THR A 115
 None
None
None
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
SO4  A3484 (-3.3A)
None
 0.48A 4q0dC-1zdrA:
21.1		 4q0dC-1zdrA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_D_MTXD604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		7 / 12 ALA A   7
LEU A  20
ASP A  27
LEU A  28
LEU A  54
ARG A  57
THR A 115
 None
None
None
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
SO4  A3484 (-3.3A)
None
 0.48A 4q0dD-1zdrA:
21.1		 4q0dD-1zdrA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_E_MTXE604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		8 / 12 ALA A   7
LEU A  20
ASP A  27
LEU A  28
ILE A  50
LEU A  54
ARG A  57
THR A 115
 None
None
None
SO4  A3486 ( 4.8A)
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
SO4  A3484 (-3.3A)
None
 0.63A 4q0dE-1zdrA:
21.2		 4q0dE-1zdrA:
16.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QI9_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		9 / 12 ILE A   5
ALA A   7
ASP A  27
LEU A  28
LYS A  32
ILE A  50
LEU A  54
ARG A  57
THR A 115
 None
None
None
SO4  A3486 ( 4.8A)
SO4  A3484 (-3.1A)
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
SO4  A3484 (-3.3A)
None
 0.58A 4qi9A-1zdrA:
22.1		 4qi9A-1zdrA:
43.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QI9_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		9 / 12 ILE A   5
ALA A   7
ASP A  27
LEU A  28
LYS A  32
ILE A  50
LEU A  54
ARG A  57
THR A 115
 None
None
None
SO4  A3486 ( 4.8A)
SO4  A3484 (-3.1A)
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
SO4  A3484 (-3.3A)
None
 0.57A 4qi9B-1zdrA:
22.6		 4qi9B-1zdrA:
43.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QI9_C_MTXC201_1
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		8 / 11 ILE A   5
ALA A   7
ASP A  27
LYS A  32
ILE A  50
LEU A  54
ARG A  57
THR A 115
 None
None
None
SO4  A3484 (-3.1A)
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
SO4  A3484 (-3.3A)
None
 0.63A 4qi9C-1zdrA:
21.6		 4qi9C-1zdrA:
43.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QLE_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		10 / 12 ILE A   5
ALA A   7
ASP A  27
LEU A  28
PHE A  31
LYS A  32
THR A  46
ILE A  50
LEU A  54
THR A 115
 None
None
None
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.1A)
SO4  A3484 (-3.1A)
SO4  A3483 (-3.5A)
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
None
 0.46A 4qleA-1zdrA:
24.4		 4qleA-1zdrA:
39.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QLE_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		9 / 11 ILE A   5
ALA A   7
ASP A  27
LEU A  28
LYS A  32
ILE A  50
LEU A  54
ARG A  57
THR A 115
 None
None
None
SO4  A3486 ( 4.8A)
SO4  A3484 (-3.1A)
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
SO4  A3484 (-3.3A)
None
 0.58A 4qleB-1zdrA:
24.4		 4qleB-1zdrA:
39.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QLF_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		10 / 11 ILE A   5
ALA A   7
ASP A  27
LEU A  28
PHE A  31
LYS A  32
ILE A  50
LEU A  54
ARG A  57
THR A 115
 None
None
None
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.1A)
SO4  A3484 (-3.1A)
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
SO4  A3484 (-3.3A)
None
 0.76A 4qlfA-1zdrA:
21.4		 4qlfA-1zdrA:
39.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QLG_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		10 / 12 ILE A   5
ALA A   7
ASP A  27
LEU A  28
PHE A  31
LYS A  32
ILE A  50
LEU A  54
ARG A  57
THR A 115
 None
None
None
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.1A)
SO4  A3484 (-3.1A)
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
SO4  A3484 (-3.3A)
None
 0.55A 4qlgA-1zdrA:
24.5		 4qlgA-1zdrA:
39.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QLG_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		11 / 12 ILE A   5
ALA A   7
ASP A  27
LEU A  28
PHE A  31
LYS A  32
THR A  46
ILE A  50
LEU A  54
ARG A  57
THR A 115
 None
None
None
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.1A)
SO4  A3484 (-3.1A)
SO4  A3483 (-3.5A)
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
SO4  A3484 (-3.3A)
None
 0.60A 4qlgB-1zdrA:
24.1		 4qlgB-1zdrA:
39.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RGC_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		10 / 12 ILE A   5
ALA A   7
ASP A  27
LEU A  28
PHE A  31
LYS A  32
ILE A  50
LEU A  54
ARG A  57
THR A 115
 None
None
None
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.1A)
SO4  A3484 (-3.1A)
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
SO4  A3484 (-3.3A)
None
 0.60A 4rgcA-1zdrA:
25.4		 4rgcA-1zdrA:
40.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X5F_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		10 / 12 ILE A   5
ALA A   7
LEU A  28
PHE A  31
LYS A  32
THR A  46
ILE A  50
LEU A  54
ARG A  57
THR A 115
 None
None
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.1A)
SO4  A3484 (-3.1A)
SO4  A3483 (-3.5A)
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
SO4  A3484 (-3.3A)
None
 0.63A 4x5fA-1zdrA:
24.3		 4x5fA-1zdrA:
40.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X5F_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		9 / 12 ILE A   5
ALA A   7
LEU A  28
PHE A  31
LYS A  32
THR A  46
ILE A  50
LEU A  54
ARG A  57
 None
None
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.1A)
SO4  A3484 (-3.1A)
SO4  A3483 (-3.5A)
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
SO4  A3484 (-3.3A)
 0.90A 4x5fB-1zdrA:
24.3		 4x5fB-1zdrA:
40.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X5F_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		9 / 12 ILE A   5
ALA A   7
LEU A  28
PHE A  31
THR A  46
ILE A  50
LEU A  54
ARG A  57
THR A 115
 None
None
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.1A)
SO4  A3483 (-3.5A)
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
SO4  A3484 (-3.3A)
None
 0.48A 4x5fB-1zdrA:
24.3		 4x5fB-1zdrA:
40.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X5G_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		10 / 12 ILE A   5
ALA A   7
ASP A  27
LEU A  28
PHE A  31
LYS A  32
THR A  46
ILE A  50
LEU A  54
THR A 115
 None
None
None
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.1A)
SO4  A3484 (-3.1A)
SO4  A3483 (-3.5A)
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
None
 0.61A 4x5gA-1zdrA:
24.3		 4x5gA-1zdrA:
40.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X5G_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		9 / 12 ILE A   5
ALA A   7
LEU A  28
LYS A  32
THR A  46
ILE A  50
LEU A  54
ARG A  57
ILE A  96
 None
None
SO4  A3486 ( 4.8A)
SO4  A3484 (-3.1A)
SO4  A3483 (-3.5A)
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
SO4  A3484 (-3.3A)
None
 0.90A 4x5gB-1zdrA:
24.4		 4x5gB-1zdrA:
40.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X5G_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		9 / 12 ILE A   5
ALA A   7
LEU A  28
THR A  46
ILE A  50
LEU A  54
ARG A  57
ILE A  96
THR A 115
 None
None
SO4  A3486 ( 4.8A)
SO4  A3483 (-3.5A)
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
SO4  A3484 (-3.3A)
None
None
 0.57A 4x5gB-1zdrA:
24.4		 4x5gB-1zdrA:
40.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X5H_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		9 / 12 ILE A   5
ALA A   7
LEU A  28
PHE A  31
LYS A  32
THR A  46
ILE A  50
LEU A  54
THR A 115
 None
None
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.1A)
SO4  A3484 (-3.1A)
SO4  A3483 (-3.5A)
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
None
 0.69A 4x5hA-1zdrA:
23.9		 4x5hA-1zdrA:
40.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X5I_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		9 / 12 ALA A   7
LEU A  28
PHE A  31
LYS A  32
THR A  46
ILE A  50
LEU A  54
ILE A  96
THR A 115
 None
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.1A)
SO4  A3484 (-3.1A)
SO4  A3483 (-3.5A)
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
None
None
 0.68A 4x5iA-1zdrA:
23.7		 4x5iA-1zdrA:
40.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X5I_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		9 / 12 ILE A   5
ALA A   7
LEU A  28
PHE A  31
THR A  46
ILE A  50
LEU A  54
ILE A  96
THR A 115
 None
None
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.1A)
SO4  A3483 (-3.5A)
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
None
None
 0.55A 4x5iA-1zdrA:
23.7		 4x5iA-1zdrA:
40.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X5I_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		6 / 12 LEU A  28
PHE A  31
LYS A  32
ILE A  50
LEU A  54
ILE A  40
 SO4  A3486 ( 4.8A)
SO4  A3486 (-4.1A)
SO4  A3484 (-3.1A)
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
None
 1.27A 4x5iA-1zdrA:
23.7		 4x5iA-1zdrA:
40.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X5J_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		9 / 12 ILE A   5
ALA A   7
LEU A  28
PHE A  31
LYS A  32
THR A  46
ILE A  50
ILE A  96
THR A 115
 None
None
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.1A)
SO4  A3484 (-3.1A)
SO4  A3483 (-3.5A)
SO4  A3486 ( 4.8A)
None
None
 0.56A 4x5jA-1zdrA:
23.7		 4x5jA-1zdrA:
40.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5E8Q_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		9 / 12 ILE A   5
ALA A   7
LEU A  28
PHE A  31
LYS A  32
THR A  46
ILE A  50
ILE A  96
THR A 115
 None
None
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.1A)
SO4  A3484 (-3.1A)
SO4  A3483 (-3.5A)
SO4  A3486 ( 4.8A)
None
None
 0.60A 5e8qA-1zdrA:
24.1		 5e8qA-1zdrA:
40.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5E8Q_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		3 / 3 ASP A  27
LEU A  54
ARG A  57
 None
SO4  A3486 (-4.2A)
SO4  A3484 (-3.3A)
 0.59A 5e8qA-1zdrA:
24.1		 5e8qA-1zdrA:
40.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5E8Q_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		9 / 12 ILE A   5
ALA A   7
LEU A  28
PHE A  31
LYS A  32
THR A  46
ILE A  50
LEU A  54
THR A 115
 None
None
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.1A)
SO4  A3484 (-3.1A)
SO4  A3483 (-3.5A)
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
None
 0.63A 5e8qB-1zdrA:
24.3		 5e8qB-1zdrA:
40.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EAJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		10 / 12 ILE A   5
ALA A   7
LEU A  28
PHE A  31
LYS A  32
THR A  46
ILE A  50
LEU A  54
ILE A  96
THR A 115
 None
None
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.1A)
SO4  A3484 (-3.1A)
SO4  A3483 (-3.5A)
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
None
None
 0.61A 5eajA-1zdrA:
24.2		 5eajA-1zdrA:
40.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EAJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		6 / 12 LEU A  28
PHE A  31
LYS A  32
ILE A  50
LEU A  54
ILE A  40
 SO4  A3486 ( 4.8A)
SO4  A3486 (-4.1A)
SO4  A3484 (-3.1A)
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
None
 1.31A 5eajA-1zdrA:
24.2		 5eajA-1zdrA:
40.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EAJ_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		10 / 12 ILE A   5
ALA A   7
LEU A  28
PHE A  31
LYS A  32
THR A  46
ILE A  50
LEU A  54
PRO A  55
THR A 115
 None
None
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.1A)
SO4  A3484 (-3.1A)
SO4  A3483 (-3.5A)
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
SO4  A3484 ( 4.4A)
None
 0.66A 5eajB-1zdrA:
24.4		 5eajB-1zdrA:
40.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI2_A_BAXA801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		5 / 8 ILE A 137
VAL A 138
ILE A  95
ILE A  86
ASP A 110
 None
 1.23A 5hi2A-1zdrA:
undetectable		 5hi2A-1zdrA:
20.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HI6_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		8 / 12 ILE A   5
ALA A   7
ASP A  27
LEU A  28
LYS A  32
LEU A  54
ARG A  57
THR A 115
 None
None
None
SO4  A3486 ( 4.8A)
SO4  A3484 (-3.1A)
SO4  A3486 (-4.2A)
SO4  A3484 (-3.3A)
None
 0.59A 5hi6A-1zdrA:
24.1		 5hi6A-1zdrA:
44.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HI6_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		8 / 12 ILE A   5
ALA A   7
ASP A  27
LYS A  32
ILE A  50
LEU A  54
ARG A  57
THR A 115
 None
None
None
SO4  A3484 (-3.1A)
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
SO4  A3484 (-3.3A)
None
 0.67A 5hi6A-1zdrA:
24.1		 5hi6A-1zdrA:
44.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HI6_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		9 / 12 ILE A   5
ALA A   7
ASP A  27
LEU A  28
LYS A  32
ILE A  50
LEU A  54
ARG A  57
THR A 115
 None
None
None
SO4  A3486 ( 4.8A)
SO4  A3484 (-3.1A)
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
SO4  A3484 (-3.3A)
None
 0.79A 5hi6B-1zdrA:
23.8		 5hi6B-1zdrA:
44.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UIH_A_8CVA201_1
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		6 / 8 ILE A   5
ALA A   7
ASP A  27
LEU A  28
ILE A  96
THR A 115
 None
None
None
SO4  A3486 ( 4.8A)
None
None
 0.32A 5uihA-1zdrA:
23.4		 5uihA-1zdrA:
31.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UJX_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		10 / 12 ILE A   5
ALA A   7
LEU A  28
PHE A  31
LYS A  32
THR A  46
ILE A  50
LEU A  54
ILE A  96
THR A 115
 None
None
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.1A)
SO4  A3484 (-3.1A)
SO4  A3483 (-3.5A)
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
None
None
 0.61A 5ujxA-1zdrA:
24.1		 5ujxA-1zdrA:
40.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UJX_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		10 / 12 ILE A   5
ALA A   7
LEU A  28
PHE A  31
LYS A  32
THR A  46
ILE A  50
LEU A  54
ARG A  57
THR A 115
 None
None
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.1A)
SO4  A3484 (-3.1A)
SO4  A3483 (-3.5A)
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
SO4  A3484 (-3.3A)
None
 0.63A 5ujxB-1zdrA:
24.3		 5ujxB-1zdrA:
40.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Z6F_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		9 / 12 ILE A   5
ALA A   7
LEU A  28
PHE A  31
LYS A  32
THR A  46
ILE A  50
ARG A  57
THR A 115
 None
None
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.1A)
SO4  A3484 (-3.1A)
SO4  A3483 (-3.5A)
SO4  A3486 ( 4.8A)
SO4  A3484 (-3.3A)
None
 0.46A 5z6fA-1zdrA:
25.3		 5z6fA-1zdrA:
40.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Z6J_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		9 / 12 ILE A   5
ALA A   7
LEU A  28
PHE A  31
LYS A  32
THR A  46
LEU A  54
ILE A  96
THR A 115
 None
None
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.1A)
SO4  A3484 (-3.1A)
SO4  A3483 (-3.5A)
SO4  A3486 (-4.2A)
None
None
 0.52A 5z6jA-1zdrA:
25.3		 5z6jA-1zdrA:
40.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Z6J_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		9 / 12 ILE A   5
ALA A   7
PHE A  31
LYS A  32
THR A  46
ILE A  50
LEU A  54
ILE A  96
THR A 115
 None
None
SO4  A3486 (-4.1A)
SO4  A3484 (-3.1A)
SO4  A3483 (-3.5A)
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
None
None
 0.49A 5z6jA-1zdrA:
25.3		 5z6jA-1zdrA:
40.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Z6K_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		9 / 12 ILE A   5
ALA A   7
LEU A  28
PHE A  31
LYS A  32
THR A  46
LEU A  54
ILE A  96
THR A 115
 None
None
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.1A)
SO4  A3484 (-3.1A)
SO4  A3483 (-3.5A)
SO4  A3486 (-4.2A)
None
None
 0.53A 5z6kA-1zdrA:
25.1		 5z6kA-1zdrA:
40.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Z6K_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		9 / 12 ILE A   5
ALA A   7
PHE A  31
LYS A  32
THR A  46
ILE A  50
LEU A  54
ILE A  96
THR A 115
 None
None
SO4  A3486 (-4.1A)
SO4  A3484 (-3.1A)
SO4  A3483 (-3.5A)
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
None
None
 0.54A 5z6kA-1zdrA:
25.1		 5z6kA-1zdrA:
40.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Z6L_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		8 / 9 ILE A   5
ALA A   7
ASP A  27
LEU A  28
LYS A  32
ILE A  50
PRO A  55
ARG A  57
 None
None
None
SO4  A3486 ( 4.8A)
SO4  A3484 (-3.1A)
SO4  A3486 ( 4.8A)
SO4  A3484 ( 4.4A)
SO4  A3484 (-3.3A)
 0.49A 5z6lA-1zdrA:
25.0		 5z6lA-1zdrA:
40.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Z6M_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		6 / 11 ALA A   7
ASP A  27
LEU A  28
PHE A  31
ILE A  96
THR A 115
 None
None
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.1A)
None
None
 0.95A 5z6mA-1zdrA:
24.3		 5z6mA-1zdrA:
40.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Z6M_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		6 / 11 ALA A   7
ASP A  27
LEU A  28
PHE A  31
LEU A  54
THR A 115
 None
None
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.1A)
SO4  A3486 (-4.2A)
None
 1.03A 5z6mA-1zdrA:
24.3		 5z6mA-1zdrA:
40.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Z6M_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		6 / 11 ILE A   5
ALA A   7
LEU A  28
PHE A  31
ILE A  96
THR A 115
 None
None
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.1A)
None
None
 0.63A 5z6mA-1zdrA:
24.3		 5z6mA-1zdrA:
40.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Z6M_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		6 / 11 ILE A   5
ALA A   7
LEU A  28
PHE A  31
LEU A  54
THR A 115
 None
None
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.1A)
SO4  A3486 (-4.2A)
None
 0.83A 5z6mA-1zdrA:
24.3		 5z6mA-1zdrA:
40.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AOG_A_CP6A704_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		5 / 10 ALA A   7
ASP A  27
PHE A  31
THR A  46
THR A 115
 None
None
SO4  A3486 (-4.1A)
SO4  A3483 (-3.5A)
None
 0.33A 6aogA-1zdrA:
20.0		 6aogA-1zdrA:
28.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AOG_B_CP6B704_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		5 / 10 ALA A   7
ASP A  27
PHE A  31
THR A  46
THR A 115
 None
None
SO4  A3486 (-4.1A)
SO4  A3483 (-3.5A)
None
 0.34A 6aogB-1zdrA:
20.1		 6aogB-1zdrA:
28.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
7DFR_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		9 / 12 ILE A   5
ALA A   7
PHE A  31
LYS A  32
THR A  46
ILE A  50
LEU A  54
ILE A  96
THR A 115
 None
None
SO4  A3486 (-4.1A)
SO4  A3484 (-3.1A)
SO4  A3483 (-3.5A)
SO4  A3486 ( 4.8A)
SO4  A3486 (-4.2A)
None
None
 0.56A 7dfrA-1zdrA:
25.1		 7dfrA-1zdrA:
40.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
7DFR_A_FOLA161_1
(DIHYDROFOLATE
REDUCTASE)		 1zdr DIHYDROFOLATE
REDUCTASE
(Geobacillus
stearothermophil
us) 		3 / 3 ASP A  27
LEU A  28
ARG A  57
 None
SO4  A3486 ( 4.8A)
SO4  A3484 (-3.3A)
 0.67A 7dfrA-1zdrA:
25.1		 7dfrA-1zdrA:
40.49