SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1zef'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_1
(ADENOSINE DEAMINASE)		 1zef ALKALINE PHOSPHATASE
(Homo
sapiens) 		5 / 12 HIS A 320
HIS A 317
ASP A 273
HIS A 432
ASP A 316
 ZN  A 901 ( 3.3A)
PHE  A 802 (-4.0A)
None
ZN  A 901 ( 3.2A)
ZN  A 901 ( 1.9A)
 1.13A 1a4lA-1zefA:
undetectable		 1a4lA-1zefA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BU5_A_RBFA301_1
(PROTEIN (FLAVODOXIN))		 1zef ALKALINE PHOSPHATASE
(Homo
sapiens) 		4 / 7 THR A  48
THR A 355
GLY A  41
ASP A  42
 None
None
None
ZN  A 902 ( 2.1A)
 0.98A 1bu5A-1zefA:
undetectable		 1bu5A-1zefA:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BU5_B_RBFB302_1
(PROTEIN (FLAVODOXIN))		 1zef ALKALINE PHOSPHATASE
(Homo
sapiens) 		4 / 8 THR A  48
THR A 355
GLY A  41
ASP A  42
 None
None
None
ZN  A 902 ( 2.1A)
 1.02A 1bu5B-1zefA:
undetectable		 1bu5B-1zefA:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C8L_A_CFFA940_1
(PROTEIN (GLYCOGEN
PHOSPHORYLASE))		 1zef ALKALINE PHOSPHATASE
(Homo
sapiens) 		4 / 6 ASN A  84
PHE A 107
ALA A  94
GLY A  93
 None
PHE  A 802 (-4.4A)
None
SEP  A  92 ( 2.4A)
 1.03A 1c8lA-1zefA:
undetectable		 1c8lA-1zefA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_A_PPFA410_1
(PHOSPHONOACETATE
HYDROLASE)		 1zef ALKALINE PHOSPHATASE
(Homo
sapiens) 		4 / 5 ASP A 316
HIS A 320
HIS A 358
HIS A 432
 ZN  A 901 ( 1.9A)
ZN  A 901 ( 3.3A)
ZN  A 902 (-3.2A)
ZN  A 901 ( 3.2A)
 0.46A 1ei6A-1zefA:
15.4		 1ei6A-1zefA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_C_PPFC413_1
(PHOSPHONOACETATE
HYDROLASE)		 1zef ALKALINE PHOSPHATASE
(Homo
sapiens) 		5 / 8 ASP A  42
ASP A 316
HIS A 320
HIS A 358
HIS A 432
 ZN  A 902 ( 2.1A)
ZN  A 901 ( 1.9A)
ZN  A 901 ( 3.3A)
ZN  A 902 (-3.2A)
ZN  A 901 ( 3.2A)
 0.46A 1ei6C-1zefA:
15.4		 1ei6C-1zefA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_C_PPFC413_1
(PHOSPHONOACETATE
HYDROLASE)		 1zef ALKALINE PHOSPHATASE
(Homo
sapiens) 		4 / 8 ASP A  42
ASP A 316
HIS A 320
HIS A 360
 ZN  A 902 ( 2.1A)
ZN  A 901 ( 1.9A)
ZN  A 901 ( 3.3A)
None
 0.95A 1ei6C-1zefA:
15.4		 1ei6C-1zefA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GFZ_A_CFFA940_1
(GLYCOGEN
PHOSPHORYLASE)		 1zef ALKALINE PHOSPHATASE
(Homo
sapiens) 		4 / 6 ASN A  84
PHE A 107
ALA A  94
GLY A  93
 None
PHE  A 802 (-4.4A)
None
SEP  A  92 ( 2.4A)
 1.04A 1gfzA-1zefA:
undetectable		 1gfzA-1zefA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5Q_A_CFFA863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 1zef ALKALINE PHOSPHATASE
(Homo
sapiens) 		4 / 6 ASN A  84
PHE A 107
ALA A  94
GLY A  93
 None
PHE  A 802 (-4.4A)
None
SEP  A  92 ( 2.4A)
 0.98A 1l5qA-1zefA:
undetectable		 1l5qA-1zefA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5Q_B_CFFB1863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 1zef ALKALINE PHOSPHATASE
(Homo
sapiens) 		4 / 6 ASN A  84
PHE A 107
ALA A  94
GLY A  93
 None
PHE  A 802 (-4.4A)
None
SEP  A  92 ( 2.4A)
 0.98A 1l5qB-1zefA:
undetectable		 1l5qB-1zefA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7X_A_CFFA863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 1zef ALKALINE PHOSPHATASE
(Homo
sapiens) 		4 / 6 ASN A  84
PHE A 107
ALA A  94
GLY A  93
 None
PHE  A 802 (-4.4A)
None
SEP  A  92 ( 2.4A)
 0.99A 1l7xA-1zefA:
undetectable		 1l7xA-1zefA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7X_B_CFFB1863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 1zef ALKALINE PHOSPHATASE
(Homo
sapiens) 		4 / 6 ASN A  84
PHE A 107
ALA A  94
GLY A  93
 None
PHE  A 802 (-4.4A)
None
SEP  A  92 ( 2.4A)
 1.03A 1l7xB-1zefA:
undetectable		 1l7xB-1zefA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT2_A_SAMA301_1
(FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN)		 1zef ALKALINE PHOSPHATASE
(Homo
sapiens) 		3 / 3 THR A 355
GLU A 311
ASP A 273
 None
MG  A 903 (-2.6A)
None
 0.65A 1nt2A-1zefA:
1.5		 1nt2A-1zefA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW5_A_SAMA401_1
(MODIFICATION
METHYLASE RSRI)		 1zef ALKALINE PHOSPHATASE
(Homo
sapiens) 		3 / 3 ASP A 316
HIS A 153
ASP A 273
 ZN  A 901 ( 1.9A)
SEP  A  92 ( 4.5A)
None
 0.78A 1nw5A-1zefA:
undetectable		 1nw5A-1zefA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_A_TFPA204_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 1zef ALKALINE PHOSPHATASE
(Homo
sapiens) 		4 / 7 LEU A 190
MET A 133
VAL A 132
SER A 131
 None
 0.90A 1wrlA-1zefA:
undetectable
1wrlB-1zefA:
undetectable		 1wrlA-1zefA:
10.95
1wrlB-1zefA:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1zef ALKALINE PHOSPHATASE
(Homo
sapiens) 		3 / 3 HIS A 432
HIS A 320
HIS A 360
 ZN  A 901 ( 3.2A)
ZN  A 901 ( 3.3A)
None
 0.74A 2dyrA-1zefA:
undetectable		 2dyrA-1zefA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1zef ALKALINE PHOSPHATASE
(Homo
sapiens) 		3 / 3 HIS A 432
HIS A 320
HIS A 360
 ZN  A 901 ( 3.2A)
ZN  A 901 ( 3.3A)
None
 0.76A 2dyrN-1zefA:
undetectable		 2dyrN-1zefA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_A_CUA601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1zef ALKALINE PHOSPHATASE
(Homo
sapiens) 		3 / 3 HIS A 432
HIS A 320
HIS A 360
 ZN  A 901 ( 3.2A)
ZN  A 901 ( 3.3A)
None
 0.75A 2dysA-1zefA:
undetectable		 2dysA-1zefA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1zef ALKALINE PHOSPHATASE
(Homo
sapiens) 		3 / 3 HIS A 432
HIS A 320
HIS A 360
 ZN  A 901 ( 3.2A)
ZN  A 901 ( 3.3A)
None
 0.75A 2eilA-1zefA:
undetectable		 2eilA-1zefA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1zef ALKALINE PHOSPHATASE
(Homo
sapiens) 		3 / 3 HIS A 432
HIS A 320
HIS A 360
 ZN  A 901 ( 3.2A)
ZN  A 901 ( 3.3A)
None
 0.74A 2eimA-1zefA:
undetectable		 2eimA-1zefA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1zef ALKALINE PHOSPHATASE
(Homo
sapiens) 		3 / 3 HIS A 432
HIS A 320
HIS A 360
 ZN  A 901 ( 3.2A)
ZN  A 901 ( 3.3A)
None
 0.72A 2einN-1zefA:
undetectable		 2einN-1zefA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G78_A_REAA200_1
(CELLULAR RETINOIC
ACID-BINDING PROTEIN
2)		 1zef ALKALINE PHOSPHATASE
(Homo
sapiens) 		5 / 12 ALA A 433
THR A  95
VAL A  89
VAL A 437
LEU A  40
 None
SEP  A  92 ( 4.1A)
None
None
None
 1.12A 2g78A-1zefA:
undetectable		 2g78A-1zefA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M9Q_B_BEZB251_0
(SERINE PROTEASE
INHIBITOR
SERINE PROTEASE
SUBUNIT NS2B, SERINE
PROTEASE NS3)		 1zef ALKALINE PHOSPHATASE
(Homo
sapiens) 		5 / 9 LEU A 351
ILE A  38
ILE A 458
PHE A 307
ALA A 465
 None
 1.07A 2m9qA-1zefA:
undetectable		 2m9qA-1zefA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WKO_A_CUA154_0
(SUPEROXIDE DISMUTASE
[CU-ZN])		 1zef ALKALINE PHOSPHATASE
(Homo
sapiens) 		4 / 4 HIS A 432
HIS A 360
HIS A 320
HIS A 358
 ZN  A 901 ( 3.2A)
None
ZN  A 901 ( 3.3A)
ZN  A 902 (-3.2A)
 1.01A 2wkoA-1zefA:
undetectable		 2wkoA-1zefA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1zef ALKALINE PHOSPHATASE
(Homo
sapiens) 		3 / 3 HIS A 432
HIS A 320
HIS A 360
 ZN  A 901 ( 3.2A)
ZN  A 901 ( 3.3A)
None
 0.75A 2y69A-1zefA:
undetectable		 2y69A-1zefA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUL_A_SAMA376_1
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 1zef ALKALINE PHOSPHATASE
(Homo
sapiens) 		3 / 3 SER A 287
GLU A 339
ASP A  72
 None
 0.81A 2zulA-1zefA:
2.1		 2zulA-1zefA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1zef ALKALINE PHOSPHATASE
(Homo
sapiens) 		3 / 3 HIS A 432
HIS A 320
HIS A 360
 ZN  A 901 ( 3.2A)
ZN  A 901 ( 3.3A)
None
 0.72A 3abkA-1zefA:
undetectable		 3abkA-1zefA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1zef ALKALINE PHOSPHATASE
(Homo
sapiens) 		3 / 3 HIS A 432
HIS A 320
HIS A 360
 ZN  A 901 ( 3.2A)
ZN  A 901 ( 3.3A)
None
 0.71A 3abkN-1zefA:
undetectable		 3abkN-1zefA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1zef ALKALINE PHOSPHATASE
(Homo
sapiens) 		3 / 3 HIS A 432
HIS A 320
HIS A 360
 ZN  A 901 ( 3.2A)
ZN  A 901 ( 3.3A)
None
 0.77A 3ablA-1zefA:
undetectable		 3ablA-1zefA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1zef ALKALINE PHOSPHATASE
(Homo
sapiens) 		3 / 3 HIS A 432
HIS A 320
HIS A 360
 ZN  A 901 ( 3.2A)
ZN  A 901 ( 3.3A)
None
 0.76A 3abmA-1zefA:
undetectable		 3abmA-1zefA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1zef ALKALINE PHOSPHATASE
(Homo
sapiens) 		3 / 3 HIS A 432
HIS A 320
HIS A 360
 ZN  A 901 ( 3.2A)
ZN  A 901 ( 3.3A)
None
 0.72A 3ag1A-1zefA:
undetectable		 3ag1A-1zefA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1zef ALKALINE PHOSPHATASE
(Homo
sapiens) 		3 / 3 HIS A 432
HIS A 320
HIS A 360
 ZN  A 901 ( 3.2A)
ZN  A 901 ( 3.3A)
None
 0.73A 3ag1N-1zefA:
undetectable		 3ag1N-1zefA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1zef ALKALINE PHOSPHATASE
(Homo
sapiens) 		3 / 3 HIS A 432
HIS A 320
HIS A 360
 ZN  A 901 ( 3.2A)
ZN  A 901 ( 3.3A)
None
 0.72A 3ag2A-1zefA:
undetectable		 3ag2A-1zefA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1zef ALKALINE PHOSPHATASE
(Homo
sapiens) 		3 / 3 HIS A 432
HIS A 320
HIS A 360
 ZN  A 901 ( 3.2A)
ZN  A 901 ( 3.3A)
None
 0.74A 3ag2N-1zefA:
undetectable		 3ag2N-1zefA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1zef ALKALINE PHOSPHATASE
(Homo
sapiens) 		3 / 3 HIS A 432
HIS A 320
HIS A 360
 ZN  A 901 ( 3.2A)
ZN  A 901 ( 3.3A)
None
 0.74A 3ag3A-1zefA:
undetectable		 3ag3A-1zefA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1zef ALKALINE PHOSPHATASE
(Homo
sapiens) 		3 / 3 HIS A 432
HIS A 320
HIS A 360
 ZN  A 901 ( 3.2A)
ZN  A 901 ( 3.3A)
None
 0.74A 3ag3N-1zefA:
undetectable		 3ag3N-1zefA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1zef ALKALINE PHOSPHATASE
(Homo
sapiens) 		3 / 3 HIS A 432
HIS A 320
HIS A 360
 ZN  A 901 ( 3.2A)
ZN  A 901 ( 3.3A)
None
 0.73A 3ag4A-1zefA:
undetectable		 3ag4A-1zefA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1zef ALKALINE PHOSPHATASE
(Homo
sapiens) 		3 / 3 HIS A 432
HIS A 320
HIS A 360
 ZN  A 901 ( 3.2A)
ZN  A 901 ( 3.3A)
None
 0.76A 3ag4N-1zefA:
undetectable		 3ag4N-1zefA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1zef ALKALINE PHOSPHATASE
(Homo
sapiens) 		3 / 3 HIS A 432
HIS A 320
HIS A 360
 ZN  A 901 ( 3.2A)
ZN  A 901 ( 3.3A)
None
 0.75A 3asnA-1zefA:
undetectable		 3asnA-1zefA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1zef ALKALINE PHOSPHATASE
(Homo
sapiens) 		3 / 3 HIS A 432
HIS A 320
HIS A 360
 ZN  A 901 ( 3.2A)
ZN  A 901 ( 3.3A)
None
 0.75A 3asoA-1zefA:
undetectable		 3asoA-1zefA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BCR_A_AZZA940_1
(GLYCOGEN
PHOSPHORYLASE,
MUSCLE FORM)		 1zef ALKALINE PHOSPHATASE
(Homo
sapiens) 		4 / 5 ASN A  84
PHE A 107
ALA A  94
GLY A  93
 None
PHE  A 802 (-4.4A)
None
SEP  A  92 ( 2.4A)
 0.99A 3bcrA-1zefA:
undetectable		 3bcrA-1zefA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DD1_A_CFFA903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 1zef ALKALINE PHOSPHATASE
(Homo
sapiens) 		4 / 6 ASN A  84
PHE A 107
ALA A  94
GLY A  93
 None
PHE  A 802 (-4.4A)
None
SEP  A  92 ( 2.4A)
 1.01A 3dd1A-1zefA:
undetectable		 3dd1A-1zefA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DD1_B_CFFB903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 1zef ALKALINE PHOSPHATASE
(Homo
sapiens) 		4 / 6 ASN A  84
PHE A 107
ALA A  94
GLY A  93
 None
PHE  A 802 (-4.4A)
None
SEP  A  92 ( 2.4A)
 1.02A 3dd1B-1zefA:
undetectable		 3dd1B-1zefA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDS_A_CFFA904_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 1zef ALKALINE PHOSPHATASE
(Homo
sapiens) 		4 / 6 ASN A  84
PHE A 107
ALA A  94
GLY A  93
 None
PHE  A 802 (-4.4A)
None
SEP  A  92 ( 2.4A)
 1.00A 3ddsA-1zefA:
0.1		 3ddsA-1zefA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDS_B_CFFB903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 1zef ALKALINE PHOSPHATASE
(Homo
sapiens) 		4 / 6 ASN A  84
PHE A 107
ALA A  94
GLY A  93
 None
PHE  A 802 (-4.4A)
None
SEP  A  92 ( 2.4A)
 1.00A 3ddsB-1zefA:
undetectable		 3ddsB-1zefA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDW_A_CFFA903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 1zef ALKALINE PHOSPHATASE
(Homo
sapiens) 		4 / 6 ASN A  84
PHE A 107
ALA A  94
GLY A  93
 None
PHE  A 802 (-4.4A)
None
SEP  A  92 ( 2.4A)
 0.99A 3ddwA-1zefA:
0.8		 3ddwA-1zefA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDW_B_CFFB903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 1zef ALKALINE PHOSPHATASE
(Homo
sapiens) 		4 / 6 ASN A  84
PHE A 107
ALA A  94
GLY A  93
 None
PHE  A 802 (-4.4A)
None
SEP  A  92 ( 2.4A)
 1.00A 3ddwB-1zefA:
undetectable		 3ddwB-1zefA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMH_A_SAMA384_1
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 1zef ALKALINE PHOSPHATASE
(Homo
sapiens) 		3 / 3 SER A 287
GLU A 339
ASP A  72
 None
 0.79A 3dmhA-1zefA:
2.3		 3dmhA-1zefA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_C_CUC569_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1zef ALKALINE PHOSPHATASE
(Homo
sapiens) 		3 / 3 HIS A 432
HIS A 320
HIS A 360
 ZN  A 901 ( 3.2A)
ZN  A 901 ( 3.3A)
None
 0.75A 3dtuC-1zefA:
undetectable		 3dtuC-1zefA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_A_BCZA468_1
(NEURAMINIDASE)		 1zef ALKALINE PHOSPHATASE
(Homo
sapiens) 		3 / 3 ASP A 273
ARG A 314
ARG A 166
 None
None
SEP  A  92 (-2.9A)
 1.01A 3k37A-1zefA:
undetectable		 3k37A-1zefA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_B_GJZB506_1
(CHOLESTEROL
24-HYDROXYLASE)		 1zef ALKALINE PHOSPHATASE
(Homo
sapiens) 		4 / 6 ALA A  51
THR A  48
ALA A 327
THR A 331
 None
 1.08A 3mdrB-1zefA:
undetectable		 3mdrB-1zefA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NMU_F_SAMF228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 1zef ALKALINE PHOSPHATASE
(Homo
sapiens) 		5 / 12 GLU A 429
GLY A 318
GLU A 321
ALA A 324
ASP A 316
 PHE  A 802 ( 4.5A)
None
None
None
ZN  A 901 ( 1.9A)
 1.34A 3nmuA-1zefA:
undetectable
3nmuF-1zefA:
undetectable		 3nmuA-1zefA:
22.36
3nmuF-1zefA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_A_RITA600_2
(CYTOCHROME P450 3A4)		 1zef ALKALINE PHOSPHATASE
(Homo
sapiens) 		4 / 7 PHE A 334
ILE A 196
LEU A 100
THR A 149
 None
None
None
MG  A 903 ( 4.6A)
 1.10A 3nxuA-1zefA:
undetectable		 3nxuA-1zefA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S39_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1zef ALKALINE PHOSPHATASE
(Homo
sapiens) 		3 / 3 HIS A 432
HIS A 320
HIS A 360
 ZN  A 901 ( 3.2A)
ZN  A 901 ( 3.3A)
None
 0.79A 3s39A-1zefA:
undetectable		 3s39A-1zefA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3C_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1zef ALKALINE PHOSPHATASE
(Homo
sapiens) 		3 / 3 HIS A 432
HIS A 320
HIS A 360
 ZN  A 901 ( 3.2A)
ZN  A 901 ( 3.3A)
None
 0.80A 3s3cA-1zefA:
undetectable		 3s3cA-1zefA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3D_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1zef ALKALINE PHOSPHATASE
(Homo
sapiens) 		3 / 3 HIS A 432
HIS A 320
HIS A 360
 ZN  A 901 ( 3.2A)
ZN  A 901 ( 3.3A)
None
 0.76A 3s3dA-1zefA:
undetectable		 3s3dA-1zefA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1zef ALKALINE PHOSPHATASE
(Homo
sapiens) 		3 / 3 HIS A 432
HIS A 320
HIS A 360
 ZN  A 901 ( 3.2A)
ZN  A 901 ( 3.3A)
None
 0.76A 3wg7N-1zefA:
undetectable		 3wg7N-1zefA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_A_CUA604_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1zef ALKALINE PHOSPHATASE
(Homo
sapiens) 		3 / 3 HIS A 432
HIS A 320
HIS A 360
 ZN  A 901 ( 3.2A)
ZN  A 901 ( 3.3A)
None
 0.74A 3x2qA-1zefA:
0.0		 3x2qA-1zefA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_A_SHHA700_1
(HISTONE DEACETYLASE
8)		 1zef ALKALINE PHOSPHATASE
(Homo
sapiens) 		5 / 10 HIS A 317
HIS A 320
PRO A  90
HIS A 432
GLY A  43
 PHE  A 802 (-4.0A)
ZN  A 901 ( 3.3A)
None
ZN  A 901 ( 3.2A)
ZN  A 902 ( 4.9A)
 1.43A 4bz6A-1zefA:
2.6		 4bz6A-1zefA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_B_SHHB700_1
(HISTONE DEACETYLASE
8)		 1zef ALKALINE PHOSPHATASE
(Homo
sapiens) 		5 / 12 HIS A 317
HIS A 320
PRO A  90
HIS A 432
GLY A  43
 PHE  A 802 (-4.0A)
ZN  A 901 ( 3.3A)
None
ZN  A 901 ( 3.2A)
ZN  A 902 ( 4.9A)
 1.43A 4bz6A-1zefA:
2.9
4bz6B-1zefA:
2.9		 4bz6A-1zefA:
23.51
4bz6B-1zefA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_D_SHHD700_1
(HISTONE DEACETYLASE
8)		 1zef ALKALINE PHOSPHATASE
(Homo
sapiens) 		5 / 10 HIS A 317
HIS A 320
PRO A  90
HIS A 432
GLY A  43
 PHE  A 802 (-4.0A)
ZN  A 901 ( 3.3A)
None
ZN  A 901 ( 3.2A)
ZN  A 902 ( 4.9A)
 1.43A 4bz6D-1zefA:
2.3		 4bz6D-1zefA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_A_PXLA300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 1zef ALKALINE PHOSPHATASE
(Homo
sapiens) 		4 / 7 GLY A 312
ASP A  42
GLY A  41
HIS A 358
 None
ZN  A 902 ( 2.1A)
None
ZN  A 902 (-3.2A)
 0.86A 4c5nA-1zefA:
undetectable		 4c5nA-1zefA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_B_PXLB300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 1zef ALKALINE PHOSPHATASE
(Homo
sapiens) 		5 / 10 GLY A 312
ASP A  42
GLY A  41
HIS A 320
HIS A 358
 None
ZN  A 902 ( 2.1A)
None
ZN  A 901 ( 3.3A)
ZN  A 902 (-3.2A)
 1.03A 4c5nB-1zefA:
undetectable		 4c5nB-1zefA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ENH_A_FVXA602_1
(CHOLESTEROL
24-HYDROXYLASE)		 1zef ALKALINE PHOSPHATASE
(Homo
sapiens) 		5 / 12 LEU A  69
ALA A  51
THR A  48
ALA A 327
THR A 331
 None
 1.12A 4enhA-1zefA:
undetectable		 4enhA-1zefA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGF_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1zef ALKALINE PHOSPHATASE
(Homo
sapiens) 		4 / 5 THR A 149
THR A 147
THR A  95
HIS A 358
 MG  A 903 ( 4.6A)
None
SEP  A  92 ( 4.1A)
ZN  A 902 (-3.2A)
 1.31A 4pgfB-1zefA:
undetectable		 4pgfB-1zefA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_D_PARD500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 1zef ALKALINE PHOSPHATASE
(Homo
sapiens) 		4 / 8 SER A 363
SER A 322
GLU A 413
TYR A 388
 None
 1.18A 4qb9D-1zefA:
undetectable		 4qb9D-1zefA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZXI_A_GLYA1402_0
(TYROCIDINE
SYNTHETASE 3)		 1zef ALKALINE PHOSPHATASE
(Homo
sapiens) 		4 / 7 PHE A  39
ILE A 338
GLY A 342
THR A 292
 None
 1.13A 4zxiA-1zefA:
undetectable		 4zxiA-1zefA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1zef ALKALINE PHOSPHATASE
(Homo
sapiens) 		4 / 6 LYS A 275
GLU A 270
GLY A 202
GLY A 201
 None
CA  A 904 (-3.1A)
None
None
 0.94A 5a06D-1zefA:
undetectable		 5a06D-1zefA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1zef ALKALINE PHOSPHATASE
(Homo
sapiens) 		3 / 3 HIS A 432
HIS A 320
HIS A 360
 ZN  A 901 ( 3.2A)
ZN  A 901 ( 3.3A)
None
 0.74A 5b1aA-1zefA:
undetectable		 5b1aA-1zefA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1zef ALKALINE PHOSPHATASE
(Homo
sapiens) 		3 / 3 HIS A 432
HIS A 320
HIS A 360
 ZN  A 901 ( 3.2A)
ZN  A 901 ( 3.3A)
None
 0.77A 5b1aN-1zefA:
undetectable		 5b1aN-1zefA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1zef ALKALINE PHOSPHATASE
(Homo
sapiens) 		3 / 3 HIS A 432
HIS A 320
HIS A 360
 ZN  A 901 ( 3.2A)
ZN  A 901 ( 3.3A)
None
 0.71A 5b1bA-1zefA:
undetectable		 5b1bA-1zefA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1zef ALKALINE PHOSPHATASE
(Homo
sapiens) 		3 / 3 HIS A 432
HIS A 320
HIS A 360
 ZN  A 901 ( 3.2A)
ZN  A 901 ( 3.3A)
None
 0.74A 5b1bN-1zefA:
undetectable		 5b1bN-1zefA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1zef ALKALINE PHOSPHATASE
(Homo
sapiens) 		3 / 3 HIS A 432
HIS A 320
HIS A 360
 ZN  A 901 ( 3.2A)
ZN  A 901 ( 3.3A)
None
 0.70A 5b3sA-1zefA:
undetectable		 5b3sA-1zefA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1zef ALKALINE PHOSPHATASE
(Homo
sapiens) 		3 / 3 HIS A 432
HIS A 320
HIS A 360
 ZN  A 901 ( 3.2A)
ZN  A 901 ( 3.3A)
None
 0.73A 5b3sN-1zefA:
undetectable		 5b3sN-1zefA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CFS_A_TOYA203_1
(AAD(2''),GENTAMICIN
2''-NUCLEOTIDYLTRANS
FERASE,GENTAMICIN
RESISTANCE PROTEIN)		 1zef ALKALINE PHOSPHATASE
(Homo
sapiens) 		4 / 8 ASP A 357
ASP A  42
ILE A 110
ASP A  91
 ZN  A 902 (-2.3A)
ZN  A 902 ( 2.1A)
None
SEP  A  92 (-3.2A)
 0.95A 5cfsA-1zefA:
undetectable		 5cfsA-1zefA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0Y_A_FOLA201_0
(CONSERVED
HYPOTHETICAL
MEMBRANE PROTEIN)		 1zef ALKALINE PHOSPHATASE
(Homo
sapiens) 		5 / 12 LEU A 268
GLY A 272
ASP A 281
THR A 283
VAL A 247
 None
 1.44A 5d0yA-1zefA:
undetectable		 5d0yA-1zefA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_A_CUA601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1zef ALKALINE PHOSPHATASE
(Homo
sapiens) 		3 / 3 HIS A 432
HIS A 320
HIS A 360
 ZN  A 901 ( 3.2A)
ZN  A 901 ( 3.3A)
None
 0.73A 5iy5A-1zefA:
undetectable		 5iy5A-1zefA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_N_CUN602_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1zef ALKALINE PHOSPHATASE
(Homo
sapiens) 		3 / 3 HIS A 432
HIS A 320
HIS A 360
 ZN  A 901 ( 3.2A)
ZN  A 901 ( 3.3A)
None
 0.73A 5iy5N-1zefA:
undetectable		 5iy5N-1zefA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLC_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1zef ALKALINE PHOSPHATASE
(Homo
sapiens) 		5 / 12 ALA A 157
PHE A  74
GLY A 342
PHE A 307
THR A 147
 None
 1.27A 5jlcA-1zefA:
undetectable		 5jlcA-1zefA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 1zef ALKALINE PHOSPHATASE
(Homo
sapiens) 		5 / 12 ILE A 110
GLY A  93
PHE A 309
TYR A 160
ALA A 161
 None
SEP  A  92 ( 2.4A)
None
None
None
 1.09A 5n0oA-1zefA:
2.3		 5n0oA-1zefA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 1zef ALKALINE PHOSPHATASE
(Homo
sapiens) 		5 / 12 ILE A 110
GLY A  93
PHE A 309
TYR A 160
ALA A 161
 None
SEP  A  92 ( 2.4A)
None
None
None
 1.10A 5n0oB-1zefA:
2.5		 5n0oB-1zefA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 1zef ALKALINE PHOSPHATASE
(Homo
sapiens) 		5 / 12 ILE A 110
GLY A 158
VAL A 145
SER A 155
ALA A 154
 None
None
None
MG  A 903 (-2.1A)
SEP  A  92 ( 3.7A)
 1.16A 5n0oB-1zefA:
2.5		 5n0oB-1zefA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0R_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 1zef ALKALINE PHOSPHATASE
(Homo
sapiens) 		5 / 12 ILE A 110
GLY A  93
PHE A 309
TYR A 160
ALA A 161
 None
SEP  A  92 ( 2.4A)
None
None
None
 1.09A 5n0rA-1zefA:
2.3		 5n0rA-1zefA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 1zef ALKALINE PHOSPHATASE
(Homo
sapiens) 		5 / 12 ILE A 110
GLY A  93
PHE A 309
TYR A 160
ALA A 161
 None
SEP  A  92 ( 2.4A)
None
None
None
 1.09A 5n0wA-1zefA:
2.3		 5n0wA-1zefA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 1zef ALKALINE PHOSPHATASE
(Homo
sapiens) 		5 / 12 ILE A 110
GLY A  93
PHE A 309
TYR A 160
ALA A 161
 None
SEP  A  92 ( 2.4A)
None
None
None
 1.09A 5n0wB-1zefA:
2.4		 5n0wB-1zefA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 1zef ALKALINE PHOSPHATASE
(Homo
sapiens) 		5 / 12 ILE A 110
GLY A  93
PHE A 309
TYR A 160
ALA A 161
 None
SEP  A  92 ( 2.4A)
None
None
None
 1.10A 5n0xA-1zefA:
3.0		 5n0xA-1zefA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 1zef ALKALINE PHOSPHATASE
(Homo
sapiens) 		5 / 12 ILE A 110
GLY A  93
PHE A 309
TYR A 160
ALA A 161
 None
SEP  A  92 ( 2.4A)
None
None
None
 1.12A 5n0xB-1zefA:
2.3		 5n0xB-1zefA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNW_D_GCSD302_1
(25 KDA PROTEIN
ELICITOR)		 1zef ALKALINE PHOSPHATASE
(Homo
sapiens) 		5 / 7 ASP A  42
GLY A 313
ASP A 357
HIS A 320
ASP A 316
 ZN  A 902 ( 2.1A)
MG  A 903 ( 4.5A)
ZN  A 902 (-2.3A)
ZN  A 901 ( 3.3A)
ZN  A 901 ( 1.9A)
 1.47A 5nnwD-1zefA:
undetectable		 5nnwD-1zefA:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V5Z_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1zef ALKALINE PHOSPHATASE
(Homo
sapiens) 		3 / 3 GLY A 201
THR A  95
PRO A 156
 None
SEP  A  92 ( 4.1A)
None
 0.60A 5v5zA-1zefA:
undetectable		 5v5zA-1zefA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1zef ALKALINE PHOSPHATASE
(Homo
sapiens) 		3 / 3 HIS A 432
HIS A 320
HIS A 360
 ZN  A 901 ( 3.2A)
ZN  A 901 ( 3.3A)
None
 0.74A 5waua-1zefA:
undetectable		 5waua-1zefA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1zef ALKALINE PHOSPHATASE
(Homo
sapiens) 		3 / 3 HIS A 432
HIS A 320
HIS A 360
 ZN  A 901 ( 3.2A)
ZN  A 901 ( 3.3A)
None
 0.72A 5x19A-1zefA:
undetectable		 5x19A-1zefA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1zef ALKALINE PHOSPHATASE
(Homo
sapiens) 		3 / 3 HIS A 432
HIS A 320
HIS A 360
 ZN  A 901 ( 3.2A)
ZN  A 901 ( 3.3A)
None
 0.69A 5x19N-1zefA:
undetectable		 5x19N-1zefA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1zef ALKALINE PHOSPHATASE
(Homo
sapiens) 		3 / 3 HIS A 432
HIS A 320
HIS A 360
 ZN  A 901 ( 3.2A)
ZN  A 901 ( 3.3A)
None
 0.66A 5x1bN-1zefA:
undetectable		 5x1bN-1zefA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1zef ALKALINE PHOSPHATASE
(Homo
sapiens) 		3 / 3 HIS A 432
HIS A 320
HIS A 360
 ZN  A 901 ( 3.2A)
ZN  A 901 ( 3.3A)
None
 0.68A 5x1fN-1zefA:
undetectable		 5x1fN-1zefA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1zef ALKALINE PHOSPHATASE
(Homo
sapiens) 		3 / 3 HIS A 432
HIS A 320
HIS A 360
 ZN  A 901 ( 3.2A)
ZN  A 901 ( 3.3A)
None
 0.74A 5xdxA-1zefA:
undetectable		 5xdxA-1zefA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXL_B_SAMB401_0
(2-(3-AMINO-3-CARBOXY
PROPYL)HISTIDINE
SYNTHASE)		 1zef ALKALINE PHOSPHATASE
(Homo
sapiens) 		5 / 12 GLY A  93
SER A  80
GLN A 455
VAL A 437
ASP A 316
 SEP  A  92 ( 2.4A)
None
None
None
ZN  A 901 ( 1.9A)
 1.23A 6bxlB-1zefA:
undetectable		 6bxlB-1zefA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6J_D_ACTD404_0
(L-LYSINE
3-HYDROXYLASE)		 1zef ALKALINE PHOSPHATASE
(Homo
sapiens) 		4 / 6 GLN A 235
GLU A 236
TRP A 237
ALA A 239
 None
 1.21A 6f6jC-1zefA:
undetectable
6f6jD-1zefA:
undetectable		 6f6jC-1zefA:
22.29
6f6jD-1zefA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA806_0
(GEPHYRIN)		 1zef ALKALINE PHOSPHATASE
(Homo
sapiens) 		4 / 4 MET A  44
GLY A  43
HIS A 358
GLY A  45
 None
ZN  A 902 ( 4.9A)
ZN  A 902 (-3.2A)
None
 1.34A 6fgdA-1zefA:
undetectable		 6fgdA-1zefA:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GIQ_A_CUA601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1zef ALKALINE PHOSPHATASE
(Homo
sapiens) 		3 / 3 HIS A 432
HIS A 320
HIS A 360
 ZN  A 901 ( 3.2A)
ZN  A 901 ( 3.3A)
None
 0.73A 6giqa-1zefA:
undetectable		 6giqa-1zefA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_B_BO2B201_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-2)		 1zef ALKALINE PHOSPHATASE
(Homo
sapiens) 		5 / 12 THR A 109
THR A  97
ALA A  94
ALA A 116
THR A 123
 None
 1.25A 6hwdV-1zefA:
undetectable
6hwdb-1zefA:
undetectable		 6hwdV-1zefA:
11.24
6hwdb-1zefA:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_N_BO2N201_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-2)		 1zef ALKALINE PHOSPHATASE
(Homo
sapiens) 		5 / 12 THR A 109
THR A  97
ALA A  94
ALA A 116
THR A 123
 None
 1.25A 6hwdH-1zefA:
undetectable
6hwdN-1zefA:
undetectable		 6hwdH-1zefA:
11.24
6hwdN-1zefA:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_A_DCFA401_0
(ADENOSINE DEAMINASE)		 1zef ALKALINE PHOSPHATASE
(Homo
sapiens) 		5 / 12 ASP A 273
LEU A  40
ALA A 154
HIS A 358
ASP A 316
 None
None
SEP  A  92 ( 3.7A)
ZN  A 902 (-3.2A)
ZN  A 901 ( 1.9A)
 1.31A 6n91A-1zefA:
undetectable		 6n91A-1zefA:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_B_DCFB401_0
(ADENOSINE DEAMINASE)		 1zef ALKALINE PHOSPHATASE
(Homo
sapiens) 		5 / 12 ASP A 273
LEU A  40
ALA A 154
HIS A 358
ASP A 316
 None
None
SEP  A  92 ( 3.7A)
ZN  A 902 (-3.2A)
ZN  A 901 ( 1.9A)
 1.27A 6n91B-1zefA:
undetectable		 6n91B-1zefA:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_A_CUA601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1zef ALKALINE PHOSPHATASE
(Homo
sapiens) 		3 / 3 HIS A 432
HIS A 320
HIS A 360
 ZN  A 901 ( 3.2A)
ZN  A 901 ( 3.3A)
None
 0.76A 6nknA-1zefA:
undetectable		 6nknA-1zefA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_N_CUN602_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1zef ALKALINE PHOSPHATASE
(Homo
sapiens) 		3 / 3 HIS A 432
HIS A 320
HIS A 360
 ZN  A 901 ( 3.2A)
ZN  A 901 ( 3.3A)
None
 0.76A 6nknN-1zefA:
undetectable		 6nknN-1zefA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1zef ALKALINE PHOSPHATASE
(Homo
sapiens) 		3 / 3 HIS A 432
HIS A 320
HIS A 360
 ZN  A 901 ( 3.2A)
ZN  A 901 ( 3.3A)
None
 0.70A 6nmfA-1zefA:
undetectable		 6nmfA-1zefA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1zef ALKALINE PHOSPHATASE
(Homo
sapiens) 		3 / 3 HIS A 432
HIS A 320
HIS A 360
 ZN  A 901 ( 3.2A)
ZN  A 901 ( 3.3A)
None
 0.72A 6nmfN-1zefA:
undetectable		 6nmfN-1zefA:
22.80