SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1zej'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_B_SAMB302_0
(HEMK PROTEIN)		 1zej 3-HYDROXYACYL-COA
DEHYDROGENASE
(Archaeoglobus
fulgidus) 		5 / 12 ILE A   6
GLY A   7
ILE A  15
VAL A  30
SER A  31
 None
 0.83A 1sg9B-1zejA:
6.3		 1sg9B-1zejA:
26.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SV9_A_DIFA701_1
(PHOSPHOLIPASE A2)		 1zej 3-HYDROXYACYL-COA
DEHYDROGENASE
(Archaeoglobus
fulgidus) 		4 / 8 LEU A  27
ALA A  20
ILE A  19
GLY A  14
 None
 0.79A 1sv9A-1zejA:
undetectable		 1sv9A-1zejA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TMX_A_BEZA881_0
(HYDROXYQUINOL
1,2-DIOXYGENASE)		 1zej 3-HYDROXYACYL-COA
DEHYDROGENASE
(Archaeoglobus
fulgidus) 		5 / 11 LEU A 209
GLY A 249
TYR A 264
ILE A 212
VAL A 216
 None
 1.44A 1tmxA-1zejA:
undetectable		 1tmxA-1zejA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_A_SAMA4000_0
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 1zej 3-HYDROXYACYL-COA
DEHYDROGENASE
(Archaeoglobus
fulgidus) 		5 / 12 GLY A 115
LEU A  91
LEU A 114
ILE A   6
MET A  11
 None
 1.13A 1zq9A-1zejA:
6.1		 1zq9A-1zejA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_A_TRPA602_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1zej 3-HYDROXYACYL-COA
DEHYDROGENASE
(Archaeoglobus
fulgidus) 		4 / 8 LEU A  80
ILE A 103
GLU A  71
ILE A   6
 None
 0.89A 2azxA-1zejA:
undetectable		 2azxA-1zejA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		 1zej 3-HYDROXYACYL-COA
DEHYDROGENASE
(Archaeoglobus
fulgidus) 		4 / 8 ILE A  19
ILE A  64
GLU A 145
VAL A 128
 None
 0.88A 3ua5A-1zejA:
undetectable		 3ua5A-1zejA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_B_8PRB603_1
(TRANSPORTER)		 1zej 3-HYDROXYACYL-COA
DEHYDROGENASE
(Archaeoglobus
fulgidus) 		5 / 12 VAL A  69
ALA A  68
VAL A   5
GLY A   9
THR A  75
 None
 1.24A 4mm4B-1zejA:
undetectable		 4mm4B-1zejA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB5_B_010B607_0
(HNL ISOENZYME 5)		 1zej 3-HYDROXYACYL-COA
DEHYDROGENASE
(Archaeoglobus
fulgidus) 		5 / 10 ALA A  18
ALA A  20
VAL A  25
VAL A   3
TRP A 118
 None
 1.05A 5eb5B-1zejA:
2.9		 5eb5B-1zejA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB5_B_010B607_0
(HNL ISOENZYME 5)		 1zej 3-HYDROXYACYL-COA
DEHYDROGENASE
(Archaeoglobus
fulgidus) 		5 / 10 ALA A  18
VAL A  25
LEU A 148
VAL A   3
TRP A 118
 None
 1.36A 5eb5B-1zejA:
2.9		 5eb5B-1zejA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_B_AC2B301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 1zej 3-HYDROXYACYL-COA
DEHYDROGENASE
(Archaeoglobus
fulgidus) 		5 / 10 GLY A 213
ALA A 220
VAL A 216
ASP A 210
ILE A 212
 None
 1.21A 5i3cB-1zejA:
undetectable		 5i3cB-1zejA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VIM_B_SAMB301_0
(METHYLTRANSFERASE)		 1zej 3-HYDROXYACYL-COA
DEHYDROGENASE
(Archaeoglobus
fulgidus) 		6 / 12 GLY A   7
GLY A  12
HIS A  23
VAL A 144
PHE A 143
ILE A  64
 None
 1.39A 5vimB-1zejA:
undetectable		 5vimB-1zejA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9M_A_NIOA401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 1zej 3-HYDROXYACYL-COA
DEHYDROGENASE
(Archaeoglobus
fulgidus) 		4 / 8 LEU A 148
VAL A 128
MET A  66
ILE A  15
 None
 0.67A 5y9mA-1zejA:
undetectable		 5y9mA-1zejA:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9M_X_NIOX401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 1zej 3-HYDROXYACYL-COA
DEHYDROGENASE
(Archaeoglobus
fulgidus) 		4 / 8 LEU A 148
VAL A 128
MET A  66
ILE A  15
 None
 0.67A 5y9mX-1zejA:
undetectable		 5y9mX-1zejA:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HCX_A_ZMRA519_1
(NEURAMINIDASE)		 1zej 3-HYDROXYACYL-COA
DEHYDROGENASE
(Archaeoglobus
fulgidus) 		3 / 3 TRP A 238
ILE A 256
GLU A 247
 None
 0.82A 6hcxA-1zejA:
undetectable		 6hcxA-1zejA:
13.99