SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1zel'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOF_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 1zel HYPOTHETICAL PROTEIN
RV2827C
(Mycobacterium
tuberculosis) 		4 / 5 LEU A  55
PRO A  48
ALA A  51
ILE A  52
 None
 1.03A 2aofB-1zelA:
undetectable		 2aofB-1zelA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_A_RALA600_1
(ESTROGEN RECEPTOR)		 1zel HYPOTHETICAL PROTEIN
RV2827C
(Mycobacterium
tuberculosis) 		5 / 12 THR A 189
ALA A 188
LEU A 234
LEU A 207
LEU A 220
 FMT  A 707 ( 4.6A)
None
None
None
None
 1.11A 2jfaA-1zelA:
undetectable		 2jfaA-1zelA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_B_RALB600_1
(ESTROGEN RECEPTOR)		 1zel HYPOTHETICAL PROTEIN
RV2827C
(Mycobacterium
tuberculosis) 		5 / 12 THR A 189
ALA A 188
LEU A 234
LEU A 207
LEU A 220
 FMT  A 707 ( 4.6A)
None
None
None
None
 1.15A 2qxsB-1zelA:
undetectable		 2qxsB-1zelA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APV_A_TP0A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 1zel HYPOTHETICAL PROTEIN
RV2827C
(Mycobacterium
tuberculosis) 		5 / 12 VAL A   1
PHE A  99
LEU A 175
ARG A  88
ALA A  92
 None
 1.38A 3apvA-1zelA:
undetectable		 3apvA-1zelA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APV_B_TP0B190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 1zel HYPOTHETICAL PROTEIN
RV2827C
(Mycobacterium
tuberculosis) 		5 / 12 VAL A   1
PHE A  99
LEU A 175
ARG A  88
ALA A  92
 None
 1.45A 3apvB-1zelA:
0.0		 3apvB-1zelA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APW_B_DP0B190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 1zel HYPOTHETICAL PROTEIN
RV2827C
(Mycobacterium
tuberculosis) 		5 / 12 VAL A   1
PHE A  99
LEU A 175
ARG A  88
ALA A  92
 None
 1.11A 3apwB-1zelA:
undetectable		 3apwB-1zelA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NY4_A_SMXA310_1
(BETA-LACTAMASE)		 1zel HYPOTHETICAL PROTEIN
RV2827C
(Mycobacterium
tuberculosis) 		5 / 8 LEU A 284
ARG A 230
ALA A 231
TRP A 197
GLY A 195
 None
 1.28A 3ny4A-1zelA:
undetectable		 3ny4A-1zelA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_B_RTZB1_1
(CYTOCHROME P450 2D6)		 1zel HYPOTHETICAL PROTEIN
RV2827C
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 289
PHE A 261
LEU A 284
GLY A 238
ASP A 282
 None
 1.13A 3tbgB-1zelA:
undetectable		 3tbgB-1zelA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_C_RTZC1_1
(CYTOCHROME P450 2D6)		 1zel HYPOTHETICAL PROTEIN
RV2827C
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 289
PHE A 261
LEU A 284
GLY A 238
ASP A 282
 None
 1.16A 3tbgC-1zelA:
undetectable		 3tbgC-1zelA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_D_RTZD1_1
(CYTOCHROME P450 2D6)		 1zel HYPOTHETICAL PROTEIN
RV2827C
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 289
PHE A 261
LEU A 284
GLY A 238
ASP A 282
 None
 1.14A 3tbgD-1zelA:
undetectable		 3tbgD-1zelA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_B_SAMB401_0
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 1zel HYPOTHETICAL PROTEIN
RV2827C
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 106
HIS A 109
GLY A 111
ALA A 209
PRO A 180
 None
None
None
NA  A 401 ( 4.2A)
None
 1.25A 3tm4B-1zelA:
undetectable		 3tm4B-1zelA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA501_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 1zel HYPOTHETICAL PROTEIN
RV2827C
(Mycobacterium
tuberculosis) 		4 / 5 TYR A 112
LEU A 110
LEU A 160
ARG A 157
 None
 1.35A 4em2A-1zelA:
2.5		 4em2A-1zelA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N49_A_SAMA601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 1zel HYPOTHETICAL PROTEIN
RV2827C
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 172
GLY A 179
PRO A 156
ILE A 187
LEU A 200
 None
 0.87A 4n49A-1zelA:
undetectable		 4n49A-1zelA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_B_MXMB807_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1zel HYPOTHETICAL PROTEIN
RV2827C
(Mycobacterium
tuberculosis) 		5 / 12 VAL A 285
LEU A 284
LEU A 200
TRP A 146
ALA A 188
 None
 1.07A 4o1zB-1zelA:
undetectable		 4o1zB-1zelA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_A_IPHA101_0
(INSULIN)		 1zel HYPOTHETICAL PROTEIN
RV2827C
(Mycobacterium
tuberculosis) 		5 / 10 CYH A 211
LEU A 184
LEU A 235
ALA A 231
LEU A 220
 None
 1.12A 4p65A-1zelA:
undetectable
4p65B-1zelA:
undetectable
4p65F-1zelA:
undetectable
4p65H-1zelA:
undetectable		 4p65A-1zelA:
4.48
4p65B-1zelA:
8.98
4p65F-1zelA:
8.98
4p65H-1zelA:
8.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PO0_A_NPSA602_1
(SERUM ALBUMIN)		 1zel HYPOTHETICAL PROTEIN
RV2827C
(Mycobacterium
tuberculosis) 		4 / 8 ALA A 231
GLY A 244
LEU A 247
LEU A 220
 None
 0.85A 4po0A-1zelA:
undetectable		 4po0A-1zelA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YIA_B_IMNB401_2
(THYROXINE-BINDING
GLOBULIN)		 1zel HYPOTHETICAL PROTEIN
RV2827C
(Mycobacterium
tuberculosis) 		3 / 3 LEU A 219
ARG A 218
ARG A 215
 None
None
FMT  A 712 (-4.8A)
 0.95A 4yiaB-1zelA:
undetectable		 4yiaB-1zelA:
8.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_NPSA603_1
(SERUM ALBUMIN)		 1zel HYPOTHETICAL PROTEIN
RV2827C
(Mycobacterium
tuberculosis) 		5 / 10 ALA A 106
LEU A 154
LEU A 183
ALA A 182
SER A 193
 None
 1.14A 4zbrA-1zelA:
undetectable		 4zbrA-1zelA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPU_A_IPHA101_0
(INSULIN, CHAIN A
INSULIN, CHAIN B)		 1zel HYPOTHETICAL PROTEIN
RV2827C
(Mycobacterium
tuberculosis) 		4 / 4 CYH A 211
LEU A 184
LEU A 235
ALA A 231
 None
 1.01A 5hpuA-1zelA:
undetectable
5hpuB-1zelA:
undetectable		 5hpuA-1zelA:
4.48
5hpuB-1zelA:
7.72