SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1zem'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4F_A_ASRA140_0
(LYSOZYME C)		 1zem XYLITOL
DEHYDROGENASE
(Gluconobacter
oxydans) 		3 / 3 ASN A  18
ALA A  22
ASN A 235
 NAD  A2263 (-3.6A)
None
None
 0.79A 1n4fA-1zemA:
undetectable		 1n4fA-1zemA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_B_SAMB4001_0
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 1zem XYLITOL
DEHYDROGENASE
(Gluconobacter
oxydans) 		5 / 12 GLY A  14
GLY A  16
ASP A  64
VAL A  65
ILE A 115
 NAD  A2263 (-3.2A)
NAD  A2263 (-3.9A)
NAD  A2263 (-3.7A)
NAD  A2263 (-3.6A)
NAD  A2263 (-4.3A)
 0.77A 1zq9B-1zemA:
6.3		 1zq9B-1zemA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOH_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 1zem XYLITOL
DEHYDROGENASE
(Gluconobacter
oxydans) 		4 / 5 LEU A 167
GLY A  93
ALA A 163
ILE A 164
 None
NAD  A2263 (-3.6A)
None
None
 0.77A 2aohB-1zemA:
undetectable		 2aohB-1zemA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_E_SAME301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1zem XYLITOL
DEHYDROGENASE
(Gluconobacter
oxydans) 		5 / 12 GLY A  14
ASP A  38
ASP A  64
ASN A  91
ALA A  92
 NAD  A2263 (-3.2A)
NAD  A2263 (-2.6A)
NAD  A2263 (-3.7A)
NAD  A2263 (-3.2A)
NAD  A2263 (-3.6A)
 0.94A 2bm9E-1zemA:
5.2		 2bm9E-1zemA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_A_CHDA2_0
(FERROCHELATASE)		 1zem XYLITOL
DEHYDROGENASE
(Gluconobacter
oxydans) 		4 / 6 ARG A 230
PRO A 151
GLY A 188
MET A 145
 None
 1.45A 3aqiA-1zemA:
2.7		 3aqiA-1zemA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AY0_B_ADNB402_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 1zem XYLITOL
DEHYDROGENASE
(Gluconobacter
oxydans) 		5 / 10 GLY A  16
ASP A  38
ASN A  40
ASP A  64
VAL A  65
 NAD  A2263 (-3.9A)
NAD  A2263 (-2.6A)
None
NAD  A2263 (-3.7A)
NAD  A2263 (-3.6A)
 0.67A 3ay0B-1zemA:
6.6		 3ay0B-1zemA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJO_A_EAAA211_1
(GLUTATHIONE
S-TRANSFERASE P)		 1zem XYLITOL
DEHYDROGENASE
(Gluconobacter
oxydans) 		4 / 8 TYR A 157
VAL A 148
ILE A  19
GLY A 188
 NAD  A2263 (-4.4A)
None
NAD  A2263 (-3.8A)
None
 0.73A 3hjoA-1zemA:
undetectable		 3hjoA-1zemA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_M_TFPM201_1
(PROTEIN S100-A4)		 1zem XYLITOL
DEHYDROGENASE
(Gluconobacter
oxydans) 		4 / 7 GLY A 158
MET A 195
PHE A  98
GLY A  96
 None
NAD  A2263 ( 4.1A)
None
None
 0.97A 3ko0M-1zemA:
undetectable
3ko0P-1zemA:
undetectable		 3ko0M-1zemA:
13.74
3ko0P-1zemA:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_D_SAMD601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 1zem XYLITOL
DEHYDROGENASE
(Gluconobacter
oxydans) 		5 / 12 TYR A 157
GLY A  93
ILE A  19
GLY A  17
ARG A 198
 NAD  A2263 (-4.4A)
NAD  A2263 (-3.6A)
NAD  A2263 (-3.8A)
NAD  A2263 (-3.1A)
None
 1.07A 4obwD-1zemA:
6.6		 4obwD-1zemA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA
TYPE-5,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 1zem XYLITOL
DEHYDROGENASE
(Gluconobacter
oxydans) 		5 / 9 THR A  13
THR A 142
ALA A 143
ALA A 184
ALA A 120
 None
NAD  A2263 (-3.7A)
None
None
None
 1.10A 5l5zK-1zemA:
undetectable
5l5zL-1zemA:
undetectable		 5l5zK-1zemA:
21.48
5l5zL-1zemA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-5,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 1zem XYLITOL
DEHYDROGENASE
(Gluconobacter
oxydans) 		5 / 9 THR A  13
THR A 142
ALA A 143
ALA A 184
ALA A 120
 None
NAD  A2263 (-3.7A)
None
None
None
 1.10A 5l5zY-1zemA:
undetectable
5l5zZ-1zemA:
undetectable		 5l5zY-1zemA:
21.48
5l5zZ-1zemA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_K_6V8K305_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-5)		 1zem XYLITOL
DEHYDROGENASE
(Gluconobacter
oxydans) 		6 / 11 ALA A  24
THR A  23
VAL A  51
GLY A  17
GLY A  16
ALA A  15
 None
None
None
NAD  A2263 (-3.1A)
NAD  A2263 (-3.9A)
None
 1.42A 5lf7K-1zemA:
undetectable
5lf7L-1zemA:
undetectable		 5lf7K-1zemA:
22.14
5lf7L-1zemA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_Y_6V8Y306_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-5)		 1zem XYLITOL
DEHYDROGENASE
(Gluconobacter
oxydans) 		6 / 11 ALA A  24
THR A  23
VAL A  51
GLY A  17
GLY A  16
ALA A  15
 None
None
None
NAD  A2263 (-3.1A)
NAD  A2263 (-3.9A)
None
 1.41A 5lf7Y-1zemA:
undetectable
5lf7Z-1zemA:
undetectable		 5lf7Y-1zemA:
22.14
5lf7Z-1zemA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QPA613_1
(SERUM ALBUMIN)		 1zem XYLITOL
DEHYDROGENASE
(Gluconobacter
oxydans) 		4 / 8 ALA A 163
SER A 144
THR A 142
GLY A 158
 None
NAD  A2263 (-3.3A)
NAD  A2263 (-3.7A)
None
 0.76A 5v0vA-1zemA:
undetectable		 5v0vA-1zemA:
18.57