SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1zfj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A29_A_TFPA153_1
(CALMODULIN)		 1zfj INOSINE
MONOPHOSPHATE
DEHYDROGENASE
(Streptococcus
pyogenes) 		4 / 8 ILE A 252
LEU A 278
ALA A 239
VAL A 229
 None
 0.77A 1a29A-1zfjA:
undetectable		 1a29A-1zfjA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DG5_A_TOPA201_1
(DIHYDROFOLATE
REDUCTASE)		 1zfj INOSINE
MONOPHOSPHATE
DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 11 ALA A 113
ILE A 127
LEU A 200
PRO A 189
ILE A 122
 None
 1.16A 1dg5A-1zfjA:
undetectable		 1dg5A-1zfjA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4002_1
(SERUM ALBUMIN)		 1zfj INOSINE
MONOPHOSPHATE
DEHYDROGENASE
(Streptococcus
pyogenes) 		4 / 4 ARG A 290
ALA A 289
ALA A 333
GLU A 335
 None
 1.20A 1e7bA-1zfjA:
undetectable		 1e7bA-1zfjA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_U_TRPU81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1zfj INOSINE
MONOPHOSPHATE
DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 10 GLY A  58
THR A  50
THR A  57
ILE A  74
ALA A  66
 None
 1.12A 1gtnU-1zfjA:
undetectable
1gtnV-1zfjA:
undetectable		 1gtnU-1zfjA:
10.25
1gtnV-1zfjA:
10.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JR1_A_MOAA1332_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 1zfj INOSINE
MONOPHOSPHATE
DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 11 ASP A 253
ASN A 282
GLY A 305
CYH A 310
GLY A 392
 IMP  A 500 ( 4.7A)
IMP  A 500 ( 4.5A)
None
IMP  A 500 ( 3.2A)
IMP  A 500 (-2.9A)
 1.16A 1jr1A-1zfjA:
51.9		 1jr1A-1zfjA:
37.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JR1_A_MOAA1332_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 1zfj INOSINE
MONOPHOSPHATE
DEHYDROGENASE
(Streptococcus
pyogenes) 		6 / 11 ASP A 253
ASN A 282
GLY A 305
CYH A 310
THR A 312
GLY A 394
 IMP  A 500 ( 4.7A)
IMP  A 500 ( 4.5A)
None
IMP  A 500 ( 3.2A)
None
IMP  A 500 (-3.0A)
 0.59A 1jr1A-1zfjA:
51.9		 1jr1A-1zfjA:
37.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JR1_B_MOAB1333_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 1zfj INOSINE
MONOPHOSPHATE
DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 8 ASP A 253
ASN A 282
GLY A 305
THR A 312
GLY A 394
 IMP  A 500 ( 4.7A)
IMP  A 500 ( 4.5A)
None
None
IMP  A 500 (-3.0A)
 0.53A 1jr1B-1zfjA:
52.0		 1jr1B-1zfjA:
37.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LII_A_ADNA699_1
(ADENOSINE KINASE)		 1zfj INOSINE
MONOPHOSPHATE
DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 12 LEU A  44
GLY A 359
GLY A 360
THR A  36
LEU A  38
 None
 0.91A 1liiA-1zfjA:
2.1		 1liiA-1zfjA:
23.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ME7_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 1zfj INOSINE
MONOPHOSPHATE
DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 8 ASN A 282
ILE A 304
GLY A 305
CYH A 310
GLY A 394
 IMP  A 500 ( 4.5A)
None
None
IMP  A 500 ( 3.2A)
IMP  A 500 (-3.0A)
 0.43A 1me7A-1zfjA:
49.4		 1me7A-1zfjA:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ME7_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 1zfj INOSINE
MONOPHOSPHATE
DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 8 ASP A 253
ILE A 304
GLY A 305
CYH A 310
GLY A 394
 IMP  A 500 ( 4.7A)
None
None
IMP  A 500 ( 3.2A)
IMP  A 500 (-3.0A)
 0.62A 1me7A-1zfjA:
49.4		 1me7A-1zfjA:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MEH_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 1zfj INOSINE
MONOPHOSPHATE
DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 10 ASP A 253
ASN A 282
ILE A 304
GLY A 305
GLY A 392
 IMP  A 500 ( 4.7A)
IMP  A 500 ( 4.5A)
None
None
IMP  A 500 (-2.9A)
 1.04A 1mehA-1zfjA:
47.4		 1mehA-1zfjA:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MEH_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 1zfj INOSINE
MONOPHOSPHATE
DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 10 ASP A 253
ASN A 282
ILE A 304
GLY A 305
GLY A 394
 IMP  A 500 ( 4.7A)
IMP  A 500 ( 4.5A)
None
None
IMP  A 500 (-3.0A)
 0.62A 1mehA-1zfjA:
47.4		 1mehA-1zfjA:
33.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHS_A_CLMA888_0
(PROTEIN
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE))		 1zfj INOSINE
MONOPHOSPHATE
DEHYDROGENASE
(Streptococcus
pyogenes) 		4 / 5 PRO A 376
LYS A  60
MET A  61
ALA A  64
 None
 1.46A 1qhsA-1zfjA:
0.0		 1qhsA-1zfjA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_B_VIBB503_1
(YKOF)		 1zfj INOSINE
MONOPHOSPHATE
DEHYDROGENASE
(Streptococcus
pyogenes) 		4 / 7 ILE A 269
ILE A 266
LYS A 265
THR A 254
 None
 0.91A 1sbrB-1zfjA:
undetectable		 1sbrB-1zfjA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SGU_B_MK1B2632_1
(POL POLYPROTEIN)		 1zfj INOSINE
MONOPHOSPHATE
DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 8 ASP A  54
ILE A 309
GLY A 422
GLY A 394
ALA A  52
 None
None
IMP  A 500 (-3.1A)
IMP  A 500 (-3.0A)
None
 1.03A 1sguA-1zfjA:
undetectable		 1sguA-1zfjA:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_K_BO2K1402_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 1zfj INOSINE
MONOPHOSPHATE
DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 10 ALA A 284
THR A 285
ALA A 329
ALA A 325
GLY A 257
 None
 1.05A 2f16K-1zfjA:
undetectable
2f16L-1zfjA:
undetectable		 2f16K-1zfjA:
19.71
2f16L-1zfjA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_Y_BO2Y1403_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 1zfj INOSINE
MONOPHOSPHATE
DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 10 ALA A 284
THR A 285
ALA A 329
ALA A 325
GLY A 257
 None
 1.04A 2f16Y-1zfjA:
undetectable
2f16Z-1zfjA:
undetectable		 2f16Y-1zfjA:
19.71
2f16Z-1zfjA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_1
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 1zfj INOSINE
MONOPHOSPHATE
DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 12 THR A 339
ALA A 342
ALA A 355
ILE A 456
LEU A 441
 None
 1.08A 2nyrA-1zfjA:
undetectable		 2nyrA-1zfjA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VE3_B_REAB1445_1
(PUTATIVE CYTOCHROME
P450 120)		 1zfj INOSINE
MONOPHOSPHATE
DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 12 ALA A 289
THR A 324
VAL A 320
GLY A 319
PRO A 306
 None
 1.25A 2ve3B-1zfjA:
undetectable		 2ve3B-1zfjA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_A_VDYA6178_1
(VITAMIN D
HYDROXYLASE)		 1zfj INOSINE
MONOPHOSPHATE
DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 11 ILE A  48
ASN A 282
ILE A 346
PRO A  47
LEU A 356
 None
IMP  A 500 ( 4.5A)
None
None
None
 1.15A 3a51A-1zfjA:
undetectable		 3a51A-1zfjA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_C_VDYC6178_1
(VITAMIN D
HYDROXYLASE)		 1zfj INOSINE
MONOPHOSPHATE
DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 12 ILE A  48
ASN A 282
ILE A 346
PRO A  47
LEU A 356
 None
IMP  A 500 ( 4.5A)
None
None
None
 1.17A 3a51C-1zfjA:
undetectable		 3a51C-1zfjA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_D_VDYD6178_1
(VITAMIN D
HYDROXYLASE)		 1zfj INOSINE
MONOPHOSPHATE
DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 12 ILE A  48
ASN A 282
ILE A 346
PRO A  47
LEU A 356
 None
IMP  A 500 ( 4.5A)
None
None
None
 1.17A 3a51D-1zfjA:
undetectable		 3a51D-1zfjA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_E_VDYE6178_1
(VITAMIN D
HYDROXYLASE)		 1zfj INOSINE
MONOPHOSPHATE
DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 12 ILE A  48
ASN A 282
ILE A 346
PRO A  47
LEU A 356
 None
IMP  A 500 ( 4.5A)
None
None
None
 1.17A 3a51E-1zfjA:
undetectable		 3a51E-1zfjA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_A_V2HA602_0
(CYTOCHROME P450 2R1)		 1zfj INOSINE
MONOPHOSPHATE
DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 12 VAL A  73
ALA A 228
VAL A 299
VAL A  56
THR A  57
 None
 1.17A 3dl9A-1zfjA:
undetectable		 3dl9A-1zfjA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1zfj INOSINE
MONOPHOSPHATE
DEHYDROGENASE
(Streptococcus
pyogenes) 		3 / 3 ASN A  77
HIS A  75
VAL A  56
 None
 0.90A 3elzB-1zfjA:
undetectable		 3elzB-1zfjA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPB_A_SAMA1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 1zfj INOSINE
MONOPHOSPHATE
DEHYDROGENASE
(Streptococcus
pyogenes) 		6 / 12 ILE A 139
THR A 141
ASP A 144
THR A 160
ILE A 185
PRO A 189
 None
 1.04A 3kpbA-1zfjA:
15.6		 3kpbA-1zfjA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPB_A_SAMA1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 1zfj INOSINE
MONOPHOSPHATE
DEHYDROGENASE
(Streptococcus
pyogenes) 		6 / 12 THR A 202
ASP A 205
LYS A 208
ILE A 122
SER A 123
PRO A 126
 None
 1.36A 3kpbA-1zfjA:
15.6		 3kpbA-1zfjA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPB_C_SAMC1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 1zfj INOSINE
MONOPHOSPHATE
DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 12 ILE A 139
THR A 141
ASP A 144
ILE A 185
PRO A 189
 None
 1.24A 3kpbC-1zfjA:
15.9		 3kpbC-1zfjA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPB_C_SAMC1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 1zfj INOSINE
MONOPHOSPHATE
DEHYDROGENASE
(Streptococcus
pyogenes) 		6 / 12 ILE A 139
THR A 141
ASP A 144
THR A 160
ILE A 185
PRO A 189
 None
 0.98A 3kpbC-1zfjA:
15.9		 3kpbC-1zfjA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPB_C_SAMC1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 1zfj INOSINE
MONOPHOSPHATE
DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 12 THR A 202
ASP A 205
ILE A 122
SER A 123
PRO A 126
 None
 0.81A 3kpbC-1zfjA:
15.9		 3kpbC-1zfjA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPB_D_SAMD1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 1zfj INOSINE
MONOPHOSPHATE
DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 10 ILE A 139
THR A 141
ASP A 144
THR A 160
ILE A 185
 None
 0.90A 3kpbD-1zfjA:
15.8		 3kpbD-1zfjA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPC_A_SAMA1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 1zfj INOSINE
MONOPHOSPHATE
DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 11 ILE A 139
THR A 141
ASP A 144
THR A 160
PRO A 189
 None
 0.86A 3kpcA-1zfjA:
15.5		 3kpcA-1zfjA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_C_SAMC1000_1
(UNCHARACTERIZED
PROTEIN MJ0100)		 1zfj INOSINE
MONOPHOSPHATE
DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 12 ILE A 139
THR A 141
ASP A 144
THR A 160
PRO A 189
 None
 0.90A 3kpdC-1zfjA:
15.7		 3kpdC-1zfjA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_C_SAMC1000_1
(UNCHARACTERIZED
PROTEIN MJ0100)		 1zfj INOSINE
MONOPHOSPHATE
DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 12 THR A 202
ASP A 205
ILE A 122
VAL A 125
PRO A 126
 None
 0.70A 3kpdC-1zfjA:
15.7		 3kpdC-1zfjA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_C_SAMC1000_1
(UNCHARACTERIZED
PROTEIN MJ0100)		 1zfj INOSINE
MONOPHOSPHATE
DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 12 THR A 202
ILE A 122
SER A 123
VAL A 125
PRO A 126
 None
 1.01A 3kpdC-1zfjA:
15.7		 3kpdC-1zfjA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_B_FLPB701_1
(CYCLOOXYGENASE-2)		 1zfj INOSINE
MONOPHOSPHATE
DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 11 VAL A 353
LEU A 356
LEU A  20
GLY A 454
ALA A 453
 None
 1.26A 3pghB-1zfjA:
undetectable		 3pghB-1zfjA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEL_D_QELD2_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE [NMDA]
RECEPTOR SUBUNIT
EPSILON-2)		 1zfj INOSINE
MONOPHOSPHATE
DEHYDROGENASE
(Streptococcus
pyogenes) 		4 / 5 TYR A  13
THR A  14
PHE A  15
LEU A  19
 None
 1.46A 3qelC-1zfjA:
undetectable		 3qelC-1zfjA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9T_B_BEZB264_0
(ECHA1_1)		 1zfj INOSINE
MONOPHOSPHATE
DEHYDROGENASE
(Streptococcus
pyogenes) 		4 / 7 ILE A 341
LEU A  38
ALA A 226
ALA A 249
 None
 0.90A 3r9tB-1zfjA:
undetectable		 3r9tB-1zfjA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A202_2
(POL POLYPROTEIN)		 1zfj INOSINE
MONOPHOSPHATE
DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 9 GLY A  69
ALA A  68
GLY A  72
ILE A  49
VAL A 437
 None
 0.95A 3u7sB-1zfjA:
undetectable		 3u7sB-1zfjA:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		 1zfj INOSINE
MONOPHOSPHATE
DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 12 LEU A  44
GLY A 359
GLY A 360
THR A  36
LEU A  38
 None
 0.88A 4dc3B-1zfjA:
undetectable		 4dc3B-1zfjA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3A_A_ADNA500_2
(SUGAR KINASE PROTEIN)		 1zfj INOSINE
MONOPHOSPHATE
DEHYDROGENASE
(Streptococcus
pyogenes) 		4 / 4 SER A 308
TYR A 390
GLY A 344
PRO A 306
 IMP  A 500 (-2.6A)
IMP  A 500 (-4.5A)
IMP  A 500 ( 3.7A)
None
 1.46A 4e3aA-1zfjA:
1.8		 4e3aA-1zfjA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3A_A_ADNA500_2
(SUGAR KINASE PROTEIN)		 1zfj INOSINE
MONOPHOSPHATE
DEHYDROGENASE
(Streptococcus
pyogenes) 		4 / 4 SER A 308
TYR A 390
GLY A 345
PRO A 306
 IMP  A 500 (-2.6A)
IMP  A 500 (-4.5A)
IMP  A 500 (-4.0A)
None
 1.28A 4e3aA-1zfjA:
1.8		 4e3aA-1zfjA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ENH_A_FVXA602_1
(CHOLESTEROL
24-HYDROXYLASE)		 1zfj INOSINE
MONOPHOSPHATE
DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 12 LEU A 188
ILE A 201
ALA A 168
ALA A 176
THR A 175
 None
 1.08A 4enhA-1zfjA:
undetectable		 4enhA-1zfjA:
24.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FO4_A_MOAA502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 1zfj INOSINE
MONOPHOSPHATE
DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 8 ASN A 282
CYH A 310
THR A 312
MET A 393
GLY A 394
 IMP  A 500 ( 4.5A)
IMP  A 500 ( 3.2A)
None
None
IMP  A 500 (-3.0A)
 0.19A 4fo4A-1zfjA:
54.7		 4fo4A-1zfjA:
47.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FO4_A_MOAA502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 1zfj INOSINE
MONOPHOSPHATE
DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 8 ASP A 253
ASN A 282
THR A 312
MET A 393
GLY A 394
 IMP  A 500 ( 4.7A)
IMP  A 500 ( 4.5A)
None
None
IMP  A 500 (-3.0A)
 0.84A 4fo4A-1zfjA:
54.7		 4fo4A-1zfjA:
47.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FO4_B_MOAB502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 1zfj INOSINE
MONOPHOSPHATE
DEHYDROGENASE
(Streptococcus
pyogenes) 		6 / 8 ASN A 282
GLY A 305
CYH A 310
THR A 312
MET A 393
GLY A 394
 IMP  A 500 ( 4.5A)
None
IMP  A 500 ( 3.2A)
None
None
IMP  A 500 (-3.0A)
 0.24A 4fo4B-1zfjA:
51.0		 4fo4B-1zfjA:
47.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FXS_A_MOAA702_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 1zfj INOSINE
MONOPHOSPHATE
DEHYDROGENASE
(Streptococcus
pyogenes) 		7 / 9 ASP A 253
ASN A 282
ILE A 304
GLY A 305
CYH A 310
THR A 312
ASP A 343
 IMP  A 500 ( 4.7A)
IMP  A 500 ( 4.5A)
None
None
IMP  A 500 ( 3.2A)
None
IMP  A 500 (-2.8A)
 0.39A 4fxsA-1zfjA:
57.0		 4fxsA-1zfjA:
55.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QD3_A_5AEA201_1
(PEPTIDYL-TRNA
HYDROLASE)		 1zfj INOSINE
MONOPHOSPHATE
DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 9 LEU A 441
GLY A  69
HIS A 214
VAL A 437
SER A 434
 None
 1.05A 4qd3A-1zfjA:
undetectable		 4qd3A-1zfjA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1zfj INOSINE
MONOPHOSPHATE
DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 10 GLY A  58
THR A  50
THR A  57
ILE A  74
ALA A  66
 None
 1.16A 5eeyO-1zfjA:
undetectable
5eeyP-1zfjA:
undetectable		 5eeyO-1zfjA:
10.25
5eeyP-1zfjA:
10.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1zfj INOSINE
MONOPHOSPHATE
DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 10 GLY A  58
THR A  50
THR A  57
ILE A  74
ALA A  66
 None
 1.16A 5eezO-1zfjA:
undetectable
5eezP-1zfjA:
undetectable		 5eezO-1zfjA:
10.25
5eezP-1zfjA:
10.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1zfj INOSINE
MONOPHOSPHATE
DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 10 GLY A  58
THR A  50
THR A  57
ILE A  74
ALA A  66
 None
 1.16A 5ef0O-1zfjA:
undetectable
5ef0P-1zfjA:
undetectable		 5ef0O-1zfjA:
10.25
5ef0P-1zfjA:
10.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1zfj INOSINE
MONOPHOSPHATE
DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 10 GLY A  58
THR A  50
THR A  57
ILE A  74
ALA A  66
 None
 1.16A 5ef1O-1zfjA:
undetectable
5ef1P-1zfjA:
undetectable		 5ef1O-1zfjA:
10.25
5ef1P-1zfjA:
10.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1zfj INOSINE
MONOPHOSPHATE
DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 10 GLY A  58
THR A  50
THR A  57
ILE A  74
ALA A  66
 None
 1.16A 5ef2O-1zfjA:
undetectable
5ef2P-1zfjA:
undetectable		 5ef2O-1zfjA:
10.25
5ef2P-1zfjA:
10.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1zfj INOSINE
MONOPHOSPHATE
DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 10 GLY A  58
THR A  50
THR A  57
ILE A  74
ALA A  66
 None
 1.16A 5ef3O-1zfjA:
undetectable
5ef3P-1zfjA:
undetectable		 5ef3O-1zfjA:
10.25
5ef3P-1zfjA:
10.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA312_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 1zfj INOSINE
MONOPHOSPHATE
DEHYDROGENASE
(Streptococcus
pyogenes) 		3 / 3 ILE A 346
VAL A 363
PRO A  47
 None
 0.66A 5uunA-1zfjA:
undetectable		 5uunA-1zfjA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WWS_A_SAMA501_0
(PUTATIVE
METHYLTRANSFERASE
NSUN6)		 1zfj INOSINE
MONOPHOSPHATE
DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 12 ALA A  51
GLY A 344
GLY A  70
LEU A  42
LEU A  44
 IMP  A 500 (-3.4A)
IMP  A 500 ( 3.7A)
None
None
None
 1.13A 5wwsA-1zfjA:
undetectable		 5wwsA-1zfjA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA608_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 1zfj INOSINE
MONOPHOSPHATE
DEHYDROGENASE
(Streptococcus
pyogenes) 		3 / 3 GLY A 425
THR A 389
GLU A 380
 None
 0.60A 6b58A-1zfjA:
undetectable		 6b58A-1zfjA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBN_B_SAMB401_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1zfj INOSINE
MONOPHOSPHATE
DEHYDROGENASE
(Streptococcus
pyogenes) 		4 / 7 ALA A 295
ASP A 253
ILE A 252
ILE A 250
 None
IMP  A 500 ( 4.7A)
None
None
 0.96A 6fbnA-1zfjA:
undetectable		 6fbnA-1zfjA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FOS_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 1zfj INOSINE
MONOPHOSPHATE
DEHYDROGENASE
(Streptococcus
pyogenes) 		4 / 6 MET A 440
GLY A 350
ALA A 355
LEU A 356
 None
 0.96A 6fosA-1zfjA:
undetectable		 6fosA-1zfjA:
9.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		 1zfj INOSINE
MONOPHOSPHATE
DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 10 ALA A 295
LEU A 292
VAL A 297
ILE A 250
THR A 235
 None
 1.16A 6h1lA-1zfjA:
undetectable		 6h1lA-1zfjA:
23.77