SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1zgd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHI_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 1zgd CHALCONE REDUCTASE
(Medicago
sativa) 		5 / 11 ILE A  42
ALA A  40
LEU A  64
LEU A  82
ILE A  45
 None
 1.08A 1dhiB-1zgdA:
undetectable		 1dhiB-1zgdA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 1zgd CHALCONE REDUCTASE
(Medicago
sativa) 		5 / 12 ILE A  42
ALA A  40
LEU A  64
LEU A  82
ILE A  45
 None
 1.02A 1ra3A-1zgdA:
undetectable		 1ra3A-1zgdA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRC_B_MTXB161_1
(DIHYDROFOLATE
REDUCTASE)		 1zgd CHALCONE REDUCTASE
(Medicago
sativa) 		5 / 12 ILE A  42
ALA A  40
LEU A  64
LEU A  82
ILE A  45
 None
 1.06A 2drcB-1zgdA:
undetectable		 2drcB-1zgdA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0A_A_GLYA73_0
(NONSTRUCTURAL
PROTEIN 1)		 1zgd CHALCONE REDUCTASE
(Medicago
sativa) 		4 / 5 GLN A 196
ALA A 290
GLN A 291
ILE A 292
 None
 1.49A 2z0aA-1zgdA:
undetectable		 2z0aA-1zgdA:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDY_A_RBFA187_1
(LUMAZINE PROTEIN)		 1zgd CHALCONE REDUCTASE
(Medicago
sativa) 		5 / 12 SER A 264
ILE A  41
GLN A  47
ALA A  44
ASN A 273
 NAP  A 755 (-3.8A)
None
None
None
NAP  A 755 (-3.3A)
 1.19A 3ddyA-1zgdA:
undetectable		 3ddyA-1zgdA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_B_SAMB301_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 1zgd CHALCONE REDUCTASE
(Medicago
sativa) 		5 / 12 TYR A  58
ILE A 119
VAL A 165
ILE A 163
VAL A 147
 NAP  A 755 (-3.9A)
None
None
None
None
 1.24A 3fpjB-1zgdA:
undetectable		 3fpjB-1zgdA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_A_ADNA438_2
(ADENOSYLHOMOCYSTEINA
SE)		 1zgd CHALCONE REDUCTASE
(Medicago
sativa) 		4 / 4 GLN A  17
THR A  14
THR A 259
HIS A  51
 None
 1.31A 3g1uA-1zgdA:
undetectable		 3g1uA-1zgdA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GLQ_B_RABB602_2
(ADENOSYLHOMOCYSTEINA
SE)		 1zgd CHALCONE REDUCTASE
(Medicago
sativa) 		4 / 5 GLN A  17
THR A  14
THR A 259
HIS A  51
 None
 1.35A 3glqB-1zgdA:
undetectable		 3glqB-1zgdA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_A_ADNA500_2
(ADENOSYLHOMOCYSTEINA
SE)		 1zgd CHALCONE REDUCTASE
(Medicago
sativa) 		4 / 5 GLN A  17
THR A  14
THR A 259
HIS A  51
 None
 1.33A 3n58A-1zgdA:
undetectable		 3n58A-1zgdA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_G_CLMG221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1zgd CHALCONE REDUCTASE
(Medicago
sativa) 		5 / 12 SER A  27
SER A  86
LEU A 111
VAL A  84
ALA A  67
 NAP  A 755 (-4.9A)
None
None
None
None
 1.05A 3u9fG-1zgdA:
undetectable
3u9fH-1zgdA:
undetectable		 3u9fG-1zgdA:
20.70
3u9fH-1zgdA:
20.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UG8_A_IMNA2001_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 1zgd CHALCONE REDUCTASE
(Medicago
sativa) 		6 / 12 TYR A  58
TRP A  89
HIS A 120
ASN A 167
SER A 215
TYR A 310
 NAP  A 755 (-3.9A)
None
NAP  A 755 (-4.2A)
NAP  A 755 (-3.3A)
NAP  A 755 (-2.9A)
None
 0.91A 3ug8A-1zgdA:
39.9		 3ug8A-1zgdA:
38.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UGR_A_IMNA2001_2
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 1zgd CHALCONE REDUCTASE
(Medicago
sativa) 		4 / 7 TYR A  58
ASN A 167
GLU A 190
TYR A 310
 NAP  A 755 (-3.9A)
NAP  A 755 (-3.3A)
None
None
 1.01A 3ugrA-1zgdA:
39.9		 3ugrA-1zgdA:
38.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3V35_A_NTIA317_1
(ALDOSE REDUCTASE)		 1zgd CHALCONE REDUCTASE
(Medicago
sativa) 		4 / 8 TRP A  89
HIS A 120
TRP A 121
PHE A 132
 None
NAP  A 755 (-4.2A)
NAP  A 755 ( 4.3A)
None
 0.94A 3v35A-1zgdA:
41.0		 3v35A-1zgdA:
34.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9N_A_CAMA1419_0
(CYTOCHROME P450)		 1zgd CHALCONE REDUCTASE
(Medicago
sativa) 		4 / 8 THR A  54
LEU A 111
LEU A 109
GLY A  65
 None
 0.86A 4c9nA-1zgdA:
undetectable		 4c9nA-1zgdA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_C_ADNC501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 1zgd CHALCONE REDUCTASE
(Medicago
sativa) 		4 / 5 GLN A  17
THR A  14
THR A 259
HIS A  51
 None
 1.34A 4lvcC-1zgdA:
undetectable		 4lvcC-1zgdA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P66_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 1zgd CHALCONE REDUCTASE
(Medicago
sativa) 		5 / 11 ILE A  42
ALA A  40
LEU A  64
LEU A  82
ILE A  45
 None
 1.06A 4p66A-1zgdA:
undetectable		 4p66A-1zgdA:
19.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YVP_B_GBMB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)		 1zgd CHALCONE REDUCTASE
(Medicago
sativa) 		5 / 12 TYR A  58
TRP A  89
HIS A 120
ILE A 134
ASN A 167
 NAP  A 755 (-3.9A)
None
NAP  A 755 (-4.2A)
None
NAP  A 755 (-3.3A)
 1.16A 4yvpB-1zgdA:
40.4		 4yvpB-1zgdA:
39.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZGF_A_BEZA210_0
(UNCHARACTERIZED
PROTEIN)		 1zgd CHALCONE REDUCTASE
(Medicago
sativa) 		4 / 4 VAL A 228
ALA A 194
ASN A 295
GLN A 294
 None
 1.48A 4zgfA-1zgdA:
undetectable		 4zgfA-1zgdA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AOX_C_ACTC1001_0
(ALU JO CONSENSUS RNA
SIGNAL RECOGNITION
PARTICLE 14 KDA
PROTEIN)		 1zgd CHALCONE REDUCTASE
(Medicago
sativa) 		3 / 3 TYR A 117
THR A  85
THR A 160
 None
 0.77A 5aoxB-1zgdA:
undetectable		 5aoxB-1zgdA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AOX_F_ACTF1001_0
(ALU JO CONSENSUS RNA
SIGNAL RECOGNITION
PARTICLE 14 KDA
PROTEIN)		 1zgd CHALCONE REDUCTASE
(Medicago
sativa) 		3 / 3 TYR A 117
THR A  85
THR A 160
 None
 0.77A 5aoxE-1zgdA:
undetectable		 5aoxE-1zgdA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6APH_A_ADNA501_2
(ADENOSYLHOMOCYSTEINA
SE)		 1zgd CHALCONE REDUCTASE
(Medicago
sativa) 		4 / 5 GLN A  17
THR A  14
THR A 259
HIS A  51
 None
 1.32A 6aphA-1zgdA:
undetectable		 6aphA-1zgdA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_B_GMJB301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 1zgd CHALCONE REDUCTASE
(Medicago
sativa) 		4 / 6 TYR A 117
GLN A 188
GLU A  61
ALA A 101
 None
NAP  A 755 (-4.0A)
None
None
 1.26A 6djzB-1zgdA:
undetectable		 6djzB-1zgdA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_A_ADNA501_2
(-)		 1zgd CHALCONE REDUCTASE
(Medicago
sativa) 		4 / 5 GLN A  17
THR A  14
THR A 259
HIS A  51
 None
 1.36A 6gbnA-1zgdA:
undetectable		 6gbnA-1zgdA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_B_ADNB501_2
(-)		 1zgd CHALCONE REDUCTASE
(Medicago
sativa) 		4 / 5 GLN A  17
THR A  14
THR A 259
HIS A  51
 None
 1.36A 6gbnB-1zgdA:
undetectable		 6gbnB-1zgdA:
22.52