SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1zgh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_A_ACTA3003_0
(BETA-CARBONIC
ANHYDRASE)		 1zgh METHIONYL-TRNA
FORMYLTRANSFERASE
(Ruminiclostridiu
m
thermocellum) 		4 / 8 ASP A 110
VAL A 161
HIS A  74
GLY A  84
 None
 0.89A 1ekjA-1zghA:
undetectable
1ekjB-1zghA:
undetectable		 1ekjA-1zghA:
22.66
1ekjB-1zghA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA156_1
(CALMODULIN)		 1zgh METHIONYL-TRNA
FORMYLTRANSFERASE
(Ruminiclostridiu
m
thermocellum) 		5 / 8 ILE A 136
LEU A 120
MET A  75
ILE A 100
ILE A 137
 None
None
None
UNX  A 244 ( 4.6A)
UNX  A 238 ( 4.0A)
 1.38A 1linA-1zghA:
undetectable		 1linA-1zghA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA131_0
(FATTY ACID-BINDING
PROTEIN)		 1zgh METHIONYL-TRNA
FORMYLTRANSFERASE
(Ruminiclostridiu
m
thermocellum) 		5 / 11 LEU A  78
ILE A  95
THR A  98
LEU A  90
PHE A 162
 None
 1.38A 1tw4A-1zghA:
undetectable		 1tw4A-1zghA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_2
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 1zgh METHIONYL-TRNA
FORMYLTRANSFERASE
(Ruminiclostridiu
m
thermocellum) 		4 / 6 PHE A  80
ARG A  82
GLN A 155
LEU A 145
 None
 1.19A 2nyrA-1zghA:
4.4		 2nyrA-1zghA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1zgh METHIONYL-TRNA
FORMYLTRANSFERASE
(Ruminiclostridiu
m
thermocellum) 		3 / 3 LEU A  87
PRO A  86
LEU A  90
 None
 0.55A 2po5B-1zghA:
3.3		 2po5B-1zghA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1zgh METHIONYL-TRNA
FORMYLTRANSFERASE
(Ruminiclostridiu
m
thermocellum) 		3 / 3 LEU A  87
PRO A  86
LEU A  90
 None
 0.56A 2po7B-1zghA:
undetectable		 2po7B-1zghA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XF3_A_J01A500_1
(ORF12)		 1zgh METHIONYL-TRNA
FORMYLTRANSFERASE
(Ruminiclostridiu
m
thermocellum) 		5 / 10 VAL A  72
ILE A 103
LEU A  90
LEU A  78
GLY A  81
 None
 0.95A 2xf3A-1zghA:
undetectable		 2xf3A-1zghA:
18.52