SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1zgj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVT_A_FLPA125_1
(TRANSTHYRETIN)		 1zgj ISOFLAVANONE
4'-O-METHYLTRANSFERA
SE'
(Medicago
truncatula) 		4 / 8 LYS A 294
ALA A 260
LEU A 262
LEU A 238
 None
 0.76A 1dvtA-1zgjA:
undetectable
1dvtB-1zgjA:
undetectable		 1dvtA-1zgjA:
15.34
1dvtB-1zgjA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EA1_A_TPFA470_1
(CYTOCHROME P450
51-LIKE RV0764C)		 1zgj ISOFLAVANONE
4'-O-METHYLTRANSFERA
SE'
(Medicago
truncatula) 		4 / 8 PHE A 326
MET A 325
THR A 171
LEU A 163
 None
 1.28A 1ea1A-1zgjA:
undetectable		 1ea1A-1zgjA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F86_B_T44B528_1
(TRANSTHYRETIN
THR119MET VARIANT)		 1zgj ISOFLAVANONE
4'-O-METHYLTRANSFERA
SE'
(Medicago
truncatula) 		4 / 4 LYS A 280
LEU A 276
ALA A 343
LEU A 339
 None
 1.35A 1f86B-1zgjA:
undetectable		 1f86B-1zgjA:
14.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FPQ_A_SAMA1699_0
(ISOLIQUIRITIGENIN
2'-O-METHYLTRANSFERA
SE)		 1zgj ISOFLAVANONE
4'-O-METHYLTRANSFERA
SE'
(Medicago
truncatula) 		5 / 10 GLY A 207
ASP A 230
VAL A 234
ASP A 250
TRP A 270
 SAH  A3994 (-3.9A)
SAH  A3994 (-2.8A)
None
SAH  A3994 (-3.4A)
None
 0.39A 1fpqA-1zgjA:
23.1		 1fpqA-1zgjA:
33.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZZ_A_ACTA421_0
(ACLACINOMYCIN-10-HYD
ROXYLASE)		 1zgj ISOFLAVANONE
4'-O-METHYLTRANSFERA
SE'
(Medicago
truncatula) 		4 / 8 ASP A 205
GLY A 208
GLY A 211
GLY A 212
 SAH  A3994 ( 4.6A)
SAH  A3994 ( 4.3A)
None
None
 0.45A 1qzzA-1zgjA:
19.3		 1qzzA-1zgjA:
29.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZZ_A_SAMA635_0
(ACLACINOMYCIN-10-HYD
ROXYLASE)		 1zgj ISOFLAVANONE
4'-O-METHYLTRANSFERA
SE'
(Medicago
truncatula) 		5 / 12 GLY A 207
GLY A 208
GLY A 209
ASP A 250
TRP A 270
 SAH  A3994 (-3.9A)
SAH  A3994 ( 4.3A)
SAH  A3994 ( 4.0A)
SAH  A3994 (-3.4A)
None
 0.63A 1qzzA-1zgjA:
19.3		 1qzzA-1zgjA:
29.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDS_A_SAMA5635_0
(PROTEIN RDMB)		 1zgj ISOFLAVANONE
4'-O-METHYLTRANSFERA
SE'
(Medicago
truncatula) 		5 / 12 GLY A 207
GLY A 208
GLY A 209
ASP A 250
TRP A 270
 SAH  A3994 (-3.9A)
SAH  A3994 ( 4.3A)
SAH  A3994 ( 4.0A)
SAH  A3994 (-3.4A)
None
 0.45A 1xdsA-1zgjA:
9.6		 1xdsA-1zgjA:
29.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDS_B_SAMB9635_0
(PROTEIN RDMB)		 1zgj ISOFLAVANONE
4'-O-METHYLTRANSFERA
SE'
(Medicago
truncatula) 		5 / 12 GLY A 207
GLY A 208
GLY A 209
ASP A 250
TRP A 270
 SAH  A3994 (-3.9A)
SAH  A3994 ( 4.3A)
SAH  A3994 ( 4.0A)
SAH  A3994 (-3.4A)
None
 0.47A 1xdsB-1zgjA:
4.0		 1xdsB-1zgjA:
29.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8L_A_SAMA400_1
(HYPOTHETICAL PROTEIN
LMO1582)		 1zgj ISOFLAVANONE
4'-O-METHYLTRANSFERA
SE'
(Medicago
truncatula) 		4 / 4 THR A 214
THR A 210
ASP A 230
ASP A 250
 None
None
SAH  A3994 (-2.8A)
SAH  A3994 (-3.4A)
 1.32A 2f8lA-1zgjA:
10.6		 2f8lA-1zgjA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UYQ_A_SAMA1311_0
(HYPOTHETICAL PROTEIN
ML2640)		 1zgj ISOFLAVANONE
4'-O-METHYLTRANSFERA
SE'
(Medicago
truncatula) 		4 / 7 GLY A 209
ASP A 230
VAL A 234
ASP A 250
 SAH  A3994 ( 4.0A)
SAH  A3994 (-2.8A)
None
SAH  A3994 (-3.4A)
 0.65A 2uyqA-1zgjA:
9.9		 2uyqA-1zgjA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZSE_A_PAUA600_0
(PANTOTHENATE KINASE)		 1zgj ISOFLAVANONE
4'-O-METHYLTRANSFERA
SE'
(Medicago
truncatula) 		4 / 7 ARG A  76
PHE A  74
ILE A  70
ASN A  69
 None
 0.94A 2zseA-1zgjA:
2.4		 2zseA-1zgjA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGR_A_T27A556_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H
P51 RT)		 1zgj ISOFLAVANONE
4'-O-METHYLTRANSFERA
SE'
(Medicago
truncatula) 		5 / 11 LEU A 279
VAL A 295
TYR A 348
TRP A 336
LEU A 339
 None
 1.48A 3bgrA-1zgjA:
1.6
3bgrB-1zgjA:
0.4		 3bgrA-1zgjA:
19.55
3bgrB-1zgjA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDT_B_VORB506_1
(CHOLESTEROL
24-HYDROXYLASE)		 1zgj ISOFLAVANONE
4'-O-METHYLTRANSFERA
SE'
(Medicago
truncatula) 		5 / 11 LEU A 104
PHE A  84
ILE A  45
ALA A  36
ALA A  44
 None
 0.88A 3mdtB-1zgjA:
undetectable		 3mdtB-1zgjA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_C_SAMC300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1zgj ISOFLAVANONE
4'-O-METHYLTRANSFERA
SE'
(Medicago
truncatula) 		3 / 3 GLY A 209
ASP A 230
ASP A 250
 SAH  A3994 ( 4.0A)
SAH  A3994 (-2.8A)
SAH  A3994 (-3.4A)
 0.41A 3ou7C-1zgjA:
13.3		 3ou7C-1zgjA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_C_DSFC320_1
(GLR4197 PROTEIN)		 1zgj ISOFLAVANONE
4'-O-METHYLTRANSFERA
SE'
(Medicago
truncatula) 		4 / 8 ILE A 296
ILE A 298
VAL A 196
ILE A 353
 None
 0.80A 3p4wC-1zgjA:
undetectable		 3p4wC-1zgjA:
21.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PGH_A_SAMA401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 1zgj ISOFLAVANONE
4'-O-METHYLTRANSFERA
SE'
(Medicago
truncatula) 		7 / 11 GLY A 207
GLY A 208
ASP A 230
VAL A 234
ASP A 250
MET A 251
LYS A 264
 SAH  A3994 (-3.9A)
SAH  A3994 ( 4.3A)
SAH  A3994 (-2.8A)
None
SAH  A3994 (-3.4A)
SAH  A3994 (-3.6A)
SAH  A3994 (-2.7A)
 0.45A 4pghA-1zgjA:
32.5		 4pghA-1zgjA:
30.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PGH_A_SAMA401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 1zgj ISOFLAVANONE
4'-O-METHYLTRANSFERA
SE'
(Medicago
truncatula) 		7 / 11 GLY A 207
GLY A 208
THR A 214
ASP A 230
VAL A 234
ASP A 250
MET A 251
 SAH  A3994 (-3.9A)
SAH  A3994 ( 4.3A)
None
SAH  A3994 (-2.8A)
None
SAH  A3994 (-3.4A)
SAH  A3994 (-3.6A)
 1.37A 4pghA-1zgjA:
32.5		 4pghA-1zgjA:
30.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PGH_B_SAMB401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 1zgj ISOFLAVANONE
4'-O-METHYLTRANSFERA
SE'
(Medicago
truncatula) 		8 / 12 ASP A 205
GLY A 207
ASP A 230
ASP A 250
MET A 251
LYS A 264
ASP A 269
TRP A 270
 SAH  A3994 ( 4.6A)
SAH  A3994 (-3.9A)
SAH  A3994 (-2.8A)
SAH  A3994 (-3.4A)
SAH  A3994 (-3.6A)
SAH  A3994 (-2.7A)
None
None
 0.54A 4pghB-1zgjA:
32.1		 4pghB-1zgjA:
30.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PGH_C_SAMC401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 1zgj ISOFLAVANONE
4'-O-METHYLTRANSFERA
SE'
(Medicago
truncatula) 		8 / 11 GLY A 207
ASP A 230
VAL A 234
ASP A 250
MET A 251
LYS A 264
TRP A 265
TRP A 270
 SAH  A3994 (-3.9A)
SAH  A3994 (-2.8A)
None
SAH  A3994 (-3.4A)
SAH  A3994 (-3.6A)
SAH  A3994 (-2.7A)
None
None
 0.44A 4pghC-1zgjA:
33.9		 4pghC-1zgjA:
30.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PGH_C_SAMC401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 1zgj ISOFLAVANONE
4'-O-METHYLTRANSFERA
SE'
(Medicago
truncatula) 		5 / 11 GLY A 208
ASP A 230
VAL A 234
LYS A 264
TRP A 265
 SAH  A3994 ( 4.3A)
SAH  A3994 (-2.8A)
None
SAH  A3994 (-2.7A)
None
 1.39A 4pghC-1zgjA:
33.9		 4pghC-1zgjA:
30.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PGH_C_SAMC401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 1zgj ISOFLAVANONE
4'-O-METHYLTRANSFERA
SE'
(Medicago
truncatula) 		5 / 11 SER A 183
VAL A 234
MET A 251
TRP A 265
TRP A 270
 None
None
SAH  A3994 (-3.6A)
None
None
 1.05A 4pghC-1zgjA:
33.9		 4pghC-1zgjA:
30.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PGH_D_SAMD401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 1zgj ISOFLAVANONE
4'-O-METHYLTRANSFERA
SE'
(Medicago
truncatula) 		6 / 12 GLY A 207
GLY A 208
ASP A 230
ASP A 250
PHE A 252
LYS A 264
 SAH  A3994 (-3.9A)
SAH  A3994 ( 4.3A)
SAH  A3994 (-2.8A)
SAH  A3994 (-3.4A)
SAH  A3994 (-4.6A)
SAH  A3994 (-2.7A)
 0.92A 4pghD-1zgjA:
32.8		 4pghD-1zgjA:
30.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PGH_D_SAMD401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 1zgj ISOFLAVANONE
4'-O-METHYLTRANSFERA
SE'
(Medicago
truncatula) 		7 / 12 GLY A 207
GLY A 208
ASP A 230
MET A 251
PHE A 252
LYS A 264
TRP A 270
 SAH  A3994 (-3.9A)
SAH  A3994 ( 4.3A)
SAH  A3994 (-2.8A)
SAH  A3994 (-3.6A)
SAH  A3994 (-4.6A)
SAH  A3994 (-2.7A)
None
 0.76A 4pghD-1zgjA:
32.8		 4pghD-1zgjA:
30.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PGH_D_SAMD401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 1zgj ISOFLAVANONE
4'-O-METHYLTRANSFERA
SE'
(Medicago
truncatula) 		6 / 12 GLY A 207
GLY A 208
THR A 214
ASP A 230
ASP A 250
PHE A 252
 SAH  A3994 (-3.9A)
SAH  A3994 ( 4.3A)
None
SAH  A3994 (-2.8A)
SAH  A3994 (-3.4A)
SAH  A3994 (-4.6A)
 1.47A 4pghD-1zgjA:
32.8		 4pghD-1zgjA:
30.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PGH_D_SAMD401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 1zgj ISOFLAVANONE
4'-O-METHYLTRANSFERA
SE'
(Medicago
truncatula) 		6 / 12 GLY A 207
GLY A 208
THR A 214
ASP A 230
MET A 251
PHE A 252
 SAH  A3994 (-3.9A)
SAH  A3994 ( 4.3A)
None
SAH  A3994 (-2.8A)
SAH  A3994 (-3.6A)
SAH  A3994 (-4.6A)
 1.44A 4pghD-1zgjA:
32.8		 4pghD-1zgjA:
30.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PGH_D_SAMD401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 1zgj ISOFLAVANONE
4'-O-METHYLTRANSFERA
SE'
(Medicago
truncatula) 		5 / 12 GLY A 209
ASP A 230
MET A 251
PHE A 252
TRP A 270
 SAH  A3994 ( 4.0A)
SAH  A3994 (-2.8A)
SAH  A3994 (-3.6A)
SAH  A3994 (-4.6A)
None
 1.13A 4pghD-1zgjA:
32.8		 4pghD-1zgjA:
30.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGW_A_CTYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 1zgj ISOFLAVANONE
4'-O-METHYLTRANSFERA
SE'
(Medicago
truncatula) 		5 / 12 GLY A 208
ASP A 299
SER A 275
ILE A 278
MET A 251
 SAH  A3994 ( 4.3A)
None
None
None
SAH  A3994 (-3.6A)
 1.39A 5igwA-1zgjA:
undetectable		 5igwA-1zgjA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUR_E_PFLE406_1
(PROTON-GATED ION
CHANNEL)		 1zgj ISOFLAVANONE
4'-O-METHYLTRANSFERA
SE'
(Medicago
truncatula) 		5 / 10 TYR A 363
ILE A 350
ILE A 297
ILE A 296
ILE A 298
 None
 1.09A 5murE-1zgjA:
undetectable		 5murE-1zgjA:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJI_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 1zgj ISOFLAVANONE
4'-O-METHYLTRANSFERA
SE'
(Medicago
truncatula) 		5 / 10 PHE A 197
GLY A 199
ILE A 286
ALA A 260
LEU A 203
 None
 1.41A 5zjiA-1zgjA:
undetectable
5zjiJ-1zgjA:
undetectable		 5zjiA-1zgjA:
13.94
5zjiJ-1zgjA:
8.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6I0Y_A_TRPA3001_0
(23S RIBOSOMAL RNA
TRYPTOPHANASE OPERON
LEADER PEPTIDE)		 1zgj ISOFLAVANONE
4'-O-METHYLTRANSFERA
SE'
(Medicago
truncatula) 		3 / 3 TRP A 336
ILE A 300
ASP A 299
 None
 0.90A 6i0y7-1zgjA:
undetectable		 6i0y7-1zgjA:
5.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6I5Z_D_SAMD401_0
(O-METHYLTRANSFERASE
1)		 1zgj ISOFLAVANONE
4'-O-METHYLTRANSFERA
SE'
(Medicago
truncatula) 		9 / 11 GLY A 207
GLY A 209
ASP A 230
VAL A 234
ASP A 250
MET A 251
LYS A 264
TRP A 265
ASP A 269
 SAH  A3994 (-3.9A)
SAH  A3994 ( 4.0A)
SAH  A3994 (-2.8A)
None
SAH  A3994 (-3.4A)
SAH  A3994 (-3.6A)
SAH  A3994 (-2.7A)
None
None
 0.85A 6i5zD-1zgjA:
24.9		 6i5zD-1zgjA:
30.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6I5Z_D_SAMD401_0
(O-METHYLTRANSFERASE
1)		 1zgj ISOFLAVANONE
4'-O-METHYLTRANSFERA
SE'
(Medicago
truncatula) 		7 / 11 GLY A 208
ASP A 230
ASP A 250
MET A 251
LYS A 264
TRP A 265
ASP A 269
 SAH  A3994 ( 4.3A)
SAH  A3994 (-2.8A)
SAH  A3994 (-3.4A)
SAH  A3994 (-3.6A)
SAH  A3994 (-2.7A)
None
None
 0.84A 6i5zD-1zgjA:
24.9		 6i5zD-1zgjA:
30.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6I5Z_D_SAMD401_0
(O-METHYLTRANSFERASE
1)		 1zgj ISOFLAVANONE
4'-O-METHYLTRANSFERA
SE'
(Medicago
truncatula) 		9 / 11 SER A 183
GLY A 207
GLY A 209
ASP A 230
VAL A 234
ASP A 250
MET A 251
TRP A 265
ASP A 269
 None
SAH  A3994 (-3.9A)
SAH  A3994 ( 4.0A)
SAH  A3994 (-2.8A)
None
SAH  A3994 (-3.4A)
SAH  A3994 (-3.6A)
None
None
 0.99A 6i5zD-1zgjA:
24.9		 6i5zD-1zgjA:
30.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6I5Z_D_SAMD401_0
(O-METHYLTRANSFERASE
1)		 1zgj ISOFLAVANONE
4'-O-METHYLTRANSFERA
SE'
(Medicago
truncatula) 		7 / 11 SER A 183
GLY A 208
ASP A 230
ASP A 250
MET A 251
TRP A 265
ASP A 269
 None
SAH  A3994 ( 4.3A)
SAH  A3994 (-2.8A)
SAH  A3994 (-3.4A)
SAH  A3994 (-3.6A)
None
None
 1.23A 6i5zD-1zgjA:
24.9		 6i5zD-1zgjA:
30.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NJ9_K_SAMK500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 1zgj ISOFLAVANONE
4'-O-METHYLTRANSFERA
SE'
(Medicago
truncatula) 		5 / 12 ASP A 205
GLY A 207
GLY A 209
VAL A 213
ASP A 250
 SAH  A3994 ( 4.6A)
SAH  A3994 (-3.9A)
SAH  A3994 ( 4.0A)
SAH  A3994 (-4.7A)
SAH  A3994 (-3.4A)
 0.86A 6nj9K-1zgjA:
7.4		 6nj9K-1zgjA:
21.12