SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1zgz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A27_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE)
1zgz TORCAD OPERON
TRANSCRIPTIONAL
REGULATORY PROTEIN
TORR

(Escherichia
coli)
5 / 12 VAL A  90
GLY A  91
MET A  94
TYR A  99
GLU A  59
None
1.22A 1a27A-1zgzA:
7.3
1a27A-1zgzA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)
1zgz TORCAD OPERON
TRANSCRIPTIONAL
REGULATORY PROTEIN
TORR

(Escherichia
coli)
4 / 8 ARG A  17
LEU A 106
VAL A 113
VAL A  79
None
SO4  A 402 (-4.1A)
None
None
1.02A 2bdmA-1zgzA:
undetectable
2bdmA-1zgzA:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_C_478C200_1
(HIV-1 PROTEASE)
1zgz TORCAD OPERON
TRANSCRIPTIONAL
REGULATORY PROTEIN
TORR

(Escherichia
coli)
5 / 9 GLY A  95
ALA A  96
ASP A  98
GLY A  75
VAL A  74
None
0.94A 3oxvC-1zgzA:
undetectable
3oxvC-1zgzA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9L_B_CAMB1419_0
(CYTOCHROME P450)
1zgz TORCAD OPERON
TRANSCRIPTIONAL
REGULATORY PROTEIN
TORR

(Escherichia
coli)
5 / 12 ILE A  76
LEU A  56
GLY A  35
THR A  32
VAL A   6
None
1.06A 4c9lB-1zgzA:
undetectable
4c9lB-1zgzA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CCQ_A_ACTA1317_0
(THIOREDOXIN
REDUCTASE)
1zgz TORCAD OPERON
TRANSCRIPTIONAL
REGULATORY PROTEIN
TORR

(Escherichia
coli)
3 / 3 LEU A  68
GLU A  70
SER A  72
None
0.59A 4ccqA-1zgzA:
2.7
4ccqA-1zgzA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4B_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)
1zgz TORCAD OPERON
TRANSCRIPTIONAL
REGULATORY PROTEIN
TORR

(Escherichia
coli)
4 / 8 LEU A  49
VAL A 100
ASP A  98
VAL A  79
None
1.03A 4l4bA-1zgzA:
undetectable
4l4bA-1zgzA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OJ4_A_DIFA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)
1zgz TORCAD OPERON
TRANSCRIPTIONAL
REGULATORY PROTEIN
TORR

(Escherichia
coli)
4 / 8 LEU A  49
VAL A  74
ILE A  76
MET A  42
None
0.93A 4oj4A-1zgzA:
undetectable
4oj4A-1zgzA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CP4_A_CAMA422_0
(CYTOCHROME P450CAM)
1zgz TORCAD OPERON
TRANSCRIPTIONAL
REGULATORY PROTEIN
TORR

(Escherichia
coli)
4 / 8 LEU A  49
VAL A 100
ASP A  98
VAL A  79
None
1.02A 6cp4A-1zgzA:
undetectable
6cp4A-1zgzA:
17.53