SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1zh4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKE_A_HSMA190_1
(NITROPHORIN 4)		 1zh4 KDP OPERON
TRANSCRIPTIONAL
REGULATORY PROTEIN
KDPE
(Escherichia
coli) 		3 / 3 ASP A   9
LEU A  53
LEU A  55
 MG  A 201 (-2.4A)
BEF  A 301 (-4.7A)
None
 0.77A 1ikeA-1zh4A:
undetectable		 1ikeA-1zh4A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_B_9CRB600_2
(RETINOIC ACID
RECEPTOR, BETA)		 1zh4 KDP OPERON
TRANSCRIPTIONAL
REGULATORY PROTEIN
KDPE
(Escherichia
coli) 		3 / 3 LEU A  51
PHE A  63
ARG A  44
 None
 0.88A 1xdkB-1zh4A:
undetectable		 1xdkB-1zh4A:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFX_A_VGHA9000_1
(TYROSINE-PROTEIN
KINASE RECEPTOR)		 1zh4 KDP OPERON
TRANSCRIPTIONAL
REGULATORY PROTEIN
KDPE
(Escherichia
coli) 		5 / 8 LEU A  67
GLY A  37
LEU A  34
GLY A  58
ASP A  59
 None
 1.43A 2yfxA-1zh4A:
undetectable		 2yfxA-1zh4A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UVV_A_T3A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 1zh4 KDP OPERON
TRANSCRIPTIONAL
REGULATORY PROTEIN
KDPE
(Escherichia
coli) 		5 / 12 MET A  26
ALA A  20
LEU A  17
LEU A 108
LEU A 112
 None
 1.13A 3uvvA-1zh4A:
undetectable		 3uvvA-1zh4A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRI_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 1zh4 KDP OPERON
TRANSCRIPTIONAL
REGULATORY PROTEIN
KDPE
(Escherichia
coli) 		4 / 5 LEU A  55
GLY A  60
ILE A  49
VAL A  75
 None
 0.84A 3wriA-1zh4A:
undetectable		 3wriA-1zh4A:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRI_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 1zh4 KDP OPERON
TRANSCRIPTIONAL
REGULATORY PROTEIN
KDPE
(Escherichia
coli) 		4 / 5 LEU A  55
GLY A  60
ILE A  49
VAL A  75
 None
 0.86A 3wriB-1zh4A:
undetectable		 3wriB-1zh4A:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP8_C_ASCC501_0
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)		 1zh4 KDP OPERON
TRANSCRIPTIONAL
REGULATORY PROTEIN
KDPE
(Escherichia
coli) 		5 / 12 LEU A 108
ILE A   6
ILE A 105
ALA A  20
PHE A  16
 None
 1.06A 4rp8C-1zh4A:
undetectable		 4rp8C-1zh4A:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIW_A_OAQA302_0
(SULFOTRANSFERASE)		 1zh4 KDP OPERON
TRANSCRIPTIONAL
REGULATORY PROTEIN
KDPE
(Escherichia
coli) 		5 / 12 ILE A  76
VAL A   7
LEU A 112
LEU A  17
LEU A  21
 None
 1.15A 5tiwA-1zh4A:
undetectable		 5tiwA-1zh4A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_B_CHDB401_0
(BILE SALT HYDROLASE)		 1zh4 KDP OPERON
TRANSCRIPTIONAL
REGULATORY PROTEIN
KDPE
(Escherichia
coli) 		5 / 10 LEU A  55
ILE A  13
LEU A  17
LEU A  48
LEU A   5
 None
 1.20A 5y7pB-1zh4A:
undetectable		 5y7pB-1zh4A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_H_CHDH401_0
(BILE SALT HYDROLASE)		 1zh4 KDP OPERON
TRANSCRIPTIONAL
REGULATORY PROTEIN
KDPE
(Escherichia
coli) 		5 / 10 LEU A  55
ILE A  13
LEU A  17
LEU A  48
LEU A   5
 None
 1.18A 5y7pH-1zh4A:
undetectable		 5y7pH-1zh4A:
16.67