SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1zh8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GWR_A_ESTA600_1
(OESTROGEN RECEPTOR)		 1zh8 OXIDOREDUCTASE
(Thermotoga
maritima) 		5 / 10 LEU A 305
LEU A 308
ALA A 309
GLU A 312
LEU A 327
 None
 1.17A 1gwrA-1zh8A:
undetectable		 1gwrA-1zh8A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1503_0
(FERROCHELATASE)		 1zh8 OXIDOREDUCTASE
(Thermotoga
maritima) 		3 / 3 LEU A  78
PRO A  79
LEU A  82
 NAP  A 400 (-4.7A)
NAP  A 400 (-4.5A)
NAP  A 400 (-4.7A)
 0.55A 1hrkA-1zh8A:
3.9		 1hrkA-1zh8A:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_C_DESC500_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 1zh8 OXIDOREDUCTASE
(Thermotoga
maritima) 		5 / 12 LEU A 305
LEU A 308
ALA A 309
GLU A 312
LEU A 327
 None
 1.08A 1s9pC-1zh8A:
undetectable		 1s9pC-1zh8A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_D_SAMD301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1zh8 OXIDOREDUCTASE
(Thermotoga
maritima) 		3 / 3 LYS A 101
ASP A 211
ASP A 186
 NAP  A 400 (-3.2A)
NA  A 329 (-2.8A)
NAP  A 400 ( 4.7A)
 0.98A 2br4D-1zh8A:
3.0		 2br4D-1zh8A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYT_A_LEUA1301_0
(LEUCYL-TRNA
SYNTHETASE)		 1zh8 OXIDOREDUCTASE
(Thermotoga
maritima) 		4 / 7 ASP A 186
TYR A 240
TYR A 236
HIS A 191
 NAP  A 400 ( 4.7A)
None
None
None
 1.14A 2bytA-1zh8A:
undetectable		 2bytA-1zh8A:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYT_D_LEUD1601_0
(LEUCYL-TRNA
SYNTHETASE)		 1zh8 OXIDOREDUCTASE
(Thermotoga
maritima) 		4 / 7 ASP A 186
TYR A 240
TYR A 236
HIS A 191
 NAP  A 400 ( 4.7A)
None
None
None
 1.14A 2bytD-1zh8A:
undetectable		 2bytD-1zh8A:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1002_0
(ALDEHYDE
DEHYDROGENASE A)		 1zh8 OXIDOREDUCTASE
(Thermotoga
maritima) 		3 / 3 GLY A 299
ARG A 131
TYR A 125
 None
 0.71A 2opxA-1zh8A:
3.0		 2opxA-1zh8A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_B_CHDB1104_0
(FERROCHELATASE)		 1zh8 OXIDOREDUCTASE
(Thermotoga
maritima) 		3 / 3 LEU A  78
PRO A  79
LEU A  82
 NAP  A 400 (-4.7A)
NAP  A 400 (-4.5A)
NAP  A 400 (-4.7A)
 0.38A 2qd5B-1zh8A:
2.6		 2qd5B-1zh8A:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_A_SALA1302_1
(LYSR-TYPE REGULATORY
PROTEIN)		 1zh8 OXIDOREDUCTASE
(Thermotoga
maritima) 		5 / 11 ILE A  11
GLY A  10
PHE A 283
HIS A  22
ILE A  98
 None
 1.44A 2y7kA-1zh8A:
undetectable		 2y7kA-1zh8A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_B_SALB1304_1
(LYSR-TYPE REGULATORY
PROTEIN)		 1zh8 OXIDOREDUCTASE
(Thermotoga
maritima) 		5 / 10 ILE A  11
GLY A  10
PHE A 283
HIS A  22
ILE A  98
 None
 1.47A 2y7kB-1zh8A:
0.0		 2y7kB-1zh8A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7P_A_SALA1000_1
(LYSR-TYPE REGULATORY
PROTEIN)		 1zh8 OXIDOREDUCTASE
(Thermotoga
maritima) 		5 / 10 ILE A  11
GLY A  10
PHE A 283
HIS A  22
ILE A  98
 None
 1.43A 2y7pA-1zh8A:
undetectable		 2y7pA-1zh8A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_B_CELB1701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1zh8 OXIDOREDUCTASE
(Thermotoga
maritima) 		5 / 6 VAL A  71
LEU A 116
ILE A 126
ALA A  90
LEU A  66
 None
 1.39A 3kk6B-1zh8A:
undetectable		 3kk6B-1zh8A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LCV_B_SAMB301_0
(SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM)		 1zh8 OXIDOREDUCTASE
(Thermotoga
maritima) 		5 / 12 TYR A 125
ILE A  98
ASP A  75
LEU A  76
LEU A 116
 None
 1.33A 3lcvB-1zh8A:
3.7		 3lcvB-1zh8A:
25.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OLS_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)		 1zh8 OXIDOREDUCTASE
(Thermotoga
maritima) 		5 / 12 LEU A 305
LEU A 308
ALA A 309
GLU A 312
LEU A 327
 None
 1.09A 3olsA-1zh8A:
undetectable		 3olsA-1zh8A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1zh8 OXIDOREDUCTASE
(Thermotoga
maritima) 		3 / 3 LEU A  78
PRO A  79
LEU A  82
 NAP  A 400 (-4.7A)
NAP  A 400 (-4.5A)
NAP  A 400 (-4.7A)
 0.44A 3w1wB-1zh8A:
undetectable		 3w1wB-1zh8A:
24.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PXM_A_ESTA2000_1
(ESTROGEN RECEPTOR)		 1zh8 OXIDOREDUCTASE
(Thermotoga
maritima) 		5 / 12 LEU A 305
LEU A 308
ALA A 309
GLU A 312
LEU A 327
 None
 1.11A 4pxmA-1zh8A:
undetectable		 4pxmA-1zh8A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLC_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1zh8 OXIDOREDUCTASE
(Thermotoga
maritima) 		5 / 12 ALA A 147
PHE A 310
PHE A 226
THR A 251
MET A 154
 None
 1.33A 5jlcA-1zh8A:
undetectable		 5jlcA-1zh8A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_A_SAMA401_0
(PAVINE
N-METHYLTRANSFERASE)		 1zh8 OXIDOREDUCTASE
(Thermotoga
maritima) 		5 / 12 GLY A 110
THR A 109
ALA A 304
LEU A 305
ALA A 309
 None
 0.87A 5kpcA-1zh8A:
undetectable		 5kpcA-1zh8A:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_E_Z80E401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1zh8 OXIDOREDUCTASE
(Thermotoga
maritima) 		5 / 12 ILE A 257
ILE A 259
PHE A 136
ASN A 235
ALA A 194
 None
 0.91A 5lg3E-1zh8A:
undetectable		 5lg3E-1zh8A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_C_ADNC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 1zh8 OXIDOREDUCTASE
(Thermotoga
maritima) 		3 / 3 LEU A  66
GLY A  10
PHE A 286
 None
 0.64A 6exiC-1zh8A:
4.5		 6exiC-1zh8A:
13.17