SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1zhg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3KKZ_B_SAMB302_0 (UNCHARACTERIZED PROTEIN Q5LES9)	1zhg	BETA HYDROXYACYL-ACYL CARRIER PROTEIN DEHYDRATASE (Plasmodium falciparum)	5 / 12	GLY A 119 GLY A 209 GLY A 211 ALA A 193 ASN A 194	None	0.97A	3kkzB-1zhgA: undetectable	3kkzB-1zhgA: 15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4H1N_A_CGEA505_1 (CYTOCHROME P450 2B4)	1zhg	BETA HYDROXYACYL-ACYL CARRIER PROTEIN DEHYDRATASE (Plasmodium falciparum)	5 / 11	ILE A 146 ILE A 219 LEU A 189 ALA A 193 VAL A 177	None	0.87A	4h1nA-1zhgA: undetectable	4h1nA-1zhgA: 13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4M2X_C_TMQC202_1 (DIHYDROFOLATE REDUCTASE)	1zhg	BETA HYDROXYACYL-ACYL CARRIER PROTEIN DEHYDRATASE (Plasmodium falciparum)	5 / 12	ILE A 221 ALA A 193 GLN A 151 LEU A 189 ILE A 219	None	1.01A	4m2xC-1zhgA: undetectable	4m2xC-1zhgA: 21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5DZK_Y_BEZY801_0 (ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 BEZ-LEU-LEU)	1zhg	BETA HYDROXYACYL-ACYL CARRIER PROTEIN DEHYDRATASE (Plasmodium falciparum)	4 / 5	PHE A 171 ILE A 221 GLY A 173 ILE A 146	None	0.88A	5dzkd-1zhgA: undetectable 5dzkk-1zhgA: undetectable 5dzky-1zhgA: undetectable	5dzkd-1zhgA: 25.82 5dzkk-1zhgA: 20.32 5dzky-1zhgA: 14.29

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3KKZ_B_SAMB302_0","UNCHARACTERIZED PROTEIN Q5LES9","1zhg","BETA HYDROXYACYL-ACYL CARRIER PROTEIN DEHYDRATASE","Plasmodium falciparum",5,"GLY A 119;GLY A 209;GLY A 211;ALA A 193;ASN A 194","None","0.97A","3kkzB-1zhgA:undetectable","3kkzB-1zhgA:15.73"],["4H1N_A_CGEA505_1","CYTOCHROME P450 2B4","1zhg","BETA HYDROXYACYL-ACYL CARRIER PROTEIN DEHYDRATASE","Plasmodium falciparum",5,"ILE A 146;ILE A 219;LEU A 189;ALA A 193;VAL A 177","None","0.87A","4h1nA-1zhgA:undetectable","4h1nA-1zhgA:13.90"],["4M2X_C_TMQC202_1","DIHYDROFOLATE REDUCTASE","1zhg","BETA HYDROXYACYL-ACYL CARRIER PROTEIN DEHYDRATASE","Plasmodium falciparum",5,"ILE A 221;ALA A 193;GLN A 151;LEU A 189;ILE A 219","None","1.01A","4m2xC-1zhgA:undetectable","4m2xC-1zhgA:21.25"],["5DZK_Y_BEZY801_0","ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1;ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2;BEZ-LEU-LEU","1zhg","BETA HYDROXYACYL-ACYL CARRIER PROTEIN DEHYDRATASE","Plasmodium falciparum",4,"PHE A 171;ILE A 221;GLY A 173;ILE A 146","None","0.88A","5dzkd-1zhgA:undetectable;5dzkk-1zhgA:undetectable;5dzky-1zhgA:undetectable","5dzkd-1zhgA:25.82;5dzkk-1zhgA:20.32;5dzky-1zhgA:14.29"]]