SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1zi0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9W_A_PAUA6001_0
(PANTOTHENATE KINASE)		 1zi0 DNA GYRASE SUBUNIT A
(Escherichia
coli) 		5 / 11 GLY A 821
ILE A 774
THR A 777
ARG A 779
THR A 748
 None
 1.29A 2f9wA-1zi0A:
undetectable
2f9wB-1zi0A:
undetectable		 2f9wA-1zi0A:
23.48
2f9wB-1zi0A:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WA2_A_SAMA1248_0
(NON-STRUCTURAL
PROTEIN 5)		 1zi0 DNA GYRASE SUBUNIT A
(Escherichia
coli) 		5 / 12 GLY A 751
GLY A 753
VAL A 833
THR A 799
ILE A 825
 None
 1.11A 2wa2A-1zi0A:
undetectable		 2wa2A-1zi0A:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DEU_B_SALB306_1
(TRANSCRIPTIONAL
REGULATOR SLYA)		 1zi0 DNA GYRASE SUBUNIT A
(Escherichia
coli) 		4 / 6 THR A 654
THR A 650
ILE A 674
LEU A 676
 None
 0.93A 3deuB-1zi0A:
undetectable		 3deuB-1zi0A:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_P_TRPP1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1zi0 DNA GYRASE SUBUNIT A
(Escherichia
coli) 		4 / 7 GLY A 785
VAL A 733
ILE A 774
GLN A 749
 None
 0.81A 3fi0P-1zi0A:
undetectable		 3fi0P-1zi0A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HDL_A_DXCA75_0
(PPCA)		 1zi0 DNA GYRASE SUBUNIT A
(Escherichia
coli) 		4 / 8 ILE A 619
ILE A 590
LYS A 671
GLY A 670
 None
 0.97A 4hdlA-1zi0A:
undetectable		 4hdlA-1zi0A:
11.62