SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1zi7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FML_A_RTLA401_0
(RETINOL DEHYDRATASE)		 1zi7 KES1 PROTEIN
(Saccharomyces
cerevisiae) 		5 / 12 TYR A  64
TYR A 194
LEU A  83
TYR A 265
ILE A 250
 None
 1.39A 1fmlA-1zi7A:
undetectable		 1fmlA-1zi7A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RTS_A_D16A309_1
(THYMIDYLATE SYNTHASE)		 1zi7 KES1 PROTEIN
(Saccharomyces
cerevisiae) 		4 / 8 PHE A 246
ILE A 231
GLY A 217
PHE A 233
 None
 0.77A 1rtsA-1zi7A:
undetectable		 1rtsA-1zi7A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XMU_A_ROFA101_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 1zi7 KES1 PROTEIN
(Saccharomyces
cerevisiae) 		5 / 12 LEU A  83
TRP A  88
ILE A  90
PHE A 246
PHE A 289
 None
 1.11A 1xmuA-1zi7A:
undetectable		 1xmuA-1zi7A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BB2_B_STRB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 1zi7 KES1 PROTEIN
(Saccharomyces
cerevisiae) 		5 / 11 SER A 193
THR A  92
PHE A  89
ILE A 221
SER A 219
 None
 1.48A 4bb2A-1zi7A:
0.0
4bb2B-1zi7A:
0.0		 4bb2A-1zi7A:
21.11
4bb2B-1zi7A:
6.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L3G_F_ACTF401_0
(METHYLAMINE
DEHYDROGENASE HEAVY
CHAIN)		 1zi7 KES1 PROTEIN
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 360
LEU A 311
GLU A 312
 None
 0.73A 4l3gF-1zi7A:
0.5		 4l3gF-1zi7A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PO0_A_NPSA602_1
(SERUM ALBUMIN)		 1zi7 KES1 PROTEIN
(Saccharomyces
cerevisiae) 		4 / 8 LYS A 262
ALA A 263
LYS A 247
GLU A 232
 None
None
SO4  A1103 (-3.3A)
SO4  A1103 ( 4.9A)
 0.77A 4po0A-1zi7A:
undetectable		 4po0A-1zi7A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_E_SPME202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 1zi7 KES1 PROTEIN
(Saccharomyces
cerevisiae) 		4 / 5 GLU A 350
GLU A 351
GLU A 349
GLU A 345
 None
 1.42A 4r87E-1zi7A:
0.0		 4r87E-1zi7A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_H_377H401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1zi7 KES1 PROTEIN
(Saccharomyces
cerevisiae) 		4 / 6 ASN A 125
GLU A  51
GLU A  55
PHE A  58
 None
 1.44A 4twdG-1zi7A:
undetectable
4twdH-1zi7A:
undetectable		 4twdG-1zi7A:
21.43
4twdH-1zi7A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_A_MZMA303_1
(ALPHA-CARBONIC
ANHYDRASE)		 1zi7 KES1 PROTEIN
(Saccharomyces
cerevisiae) 		5 / 12 ASP A 366
HIS A 418
HIS A 184
LEU A 385
ALA A 388
 None
 1.28A 4yhaA-1zi7A:
undetectable		 4yhaA-1zi7A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_B_MZMB303_1
(ALPHA-CARBONIC
ANHYDRASE)		 1zi7 KES1 PROTEIN
(Saccharomyces
cerevisiae) 		5 / 10 ASP A 366
HIS A 418
HIS A 184
LEU A 385
ALA A 388
 None
 1.17A 4yhaB-1zi7A:
undetectable		 4yhaB-1zi7A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H3A_A_D16A401_1
(ORF70)		 1zi7 KES1 PROTEIN
(Saccharomyces
cerevisiae) 		4 / 7 PHE A 246
ILE A 231
GLY A 217
PHE A 233
 None
 0.87A 5h3aA-1zi7A:
undetectable		 5h3aA-1zi7A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_A_ACTA612_0
(NADH DEHYDROGENASE,
PUTATIVE)		 1zi7 KES1 PROTEIN
(Saccharomyces
cerevisiae) 		3 / 3 LYS A 190
ASP A 191
ARG A  81
 None
 0.73A 5jwaA-1zi7A:
undetectable
5jwaH-1zi7A:
undetectable		 5jwaA-1zi7A:
22.20
5jwaH-1zi7A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_A_DAHA60_1
(PUTATIVE CYTOCHROME
C)		 1zi7 KES1 PROTEIN
(Saccharomyces
cerevisiae) 		4 / 6 HIS A 418
MET A 186
ASN A 165
LEU A 195
 None
 1.46A 5xdhA-1zi7A:
undetectable
5xdhC-1zi7A:
undetectable		 5xdhA-1zi7A:
11.85
5xdhC-1zi7A:
11.85