SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1zip'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_4
(HIV-1 PROTEASE)		 1zip ADENYLATE KINASE
(Geobacillus
stearothermophil
us) 		4 / 4 GLY A  32
ASP A  84
GLY A   7
THR A  89
 AP5  A 218 (-3.6A)
MN  A 220 ( 4.3A)
None
None
 0.91A 1hxbB-1zipA:
undetectable		 1hxbB-1zipA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_C_BEZC505_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 1zip ADENYLATE KINASE
(Geobacillus
stearothermophil
us) 		4 / 6 TYR A  24
ILE A 111
PHE A 205
ARG A 209
 None
 1.50A 1oniA-1zipA:
undetectable
1oniC-1zipA:
undetectable		 1oniA-1zipA:
20.54
1oniC-1zipA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_2
(HIV-1 PROTEASE)		 1zip ADENYLATE KINASE
(Geobacillus
stearothermophil
us) 		4 / 4 GLY A  32
ASP A  84
GLY A   7
THR A  89
 AP5  A 218 (-3.6A)
MN  A 220 ( 4.3A)
None
None
 0.90A 3k4vC-1zipA:
undetectable		 3k4vC-1zipA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WXO_A_NIZA802_1
(CATALASE-PEROXIDASE)		 1zip ADENYLATE KINASE
(Geobacillus
stearothermophil
us) 		4 / 8 LEU A   5
ASN A   2
GLY A  80
ILE A  26
 None
 0.87A 3wxoA-1zipA:
undetectable		 3wxoA-1zipA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_A_ADNA501_1
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 1zip ADENYLATE KINASE
(Geobacillus
stearothermophil
us) 		5 / 12 VAL A  59
SER A  30
GLY A  32
ASP A  84
LYS A  13
 AP5  A 218 (-4.0A)
AP5  A 218 ( 4.6A)
AP5  A 218 (-3.6A)
MN  A 220 ( 4.3A)
AP5  A 218 (-3.0A)
 1.48A 4pevA-1zipA:
2.3		 4pevA-1zipA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_C_ADNC501_1
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 1zip ADENYLATE KINASE
(Geobacillus
stearothermophil
us) 		5 / 12 VAL A  59
SER A  30
GLY A  32
ASP A  84
LYS A  13
 AP5  A 218 (-4.0A)
AP5  A 218 ( 4.6A)
AP5  A 218 (-3.6A)
MN  A 220 ( 4.3A)
AP5  A 218 (-3.0A)
 1.43A 4pevC-1zipA:
undetectable		 4pevC-1zipA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA503_1
(ADENOSYLHOMOCYSTEINA
SE)		 1zip ADENYLATE KINASE
(Geobacillus
stearothermophil
us) 		3 / 3 LEU A 120
GLN A 117
LYS A  13
 None
None
AP5  A 218 (-3.0A)
 0.93A 6exiB-1zipA:
undetectable		 6exiB-1zipA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_B_ADNB503_0
(ADENOSYLHOMOCYSTEINA
SE)		 1zip ADENYLATE KINASE
(Geobacillus
stearothermophil
us) 		3 / 3 LEU A 120
GLN A 117
LYS A  13
 None
None
AP5  A 218 (-3.0A)
 0.90A 6exiA-1zipA:
undetectable		 6exiA-1zipA:
22.40