SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1zit'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9Q_A_CHDA459_0
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 1zit TRANSCRIPTIONAL
REGULATOR (NTRC
FAMILY)
(Aquifex
aeolicus) 		4 / 6 ASP A  52
LEU A  51
VAL A  50
ILE A  49
 None
 0.96A 1s9qA-1zitA:
undetectable		 1s9qA-1zitA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_B_SAMB4001_0
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 1zit TRANSCRIPTIONAL
REGULATOR (NTRC
FAMILY)
(Aquifex
aeolicus) 		5 / 12 GLY A  60
GLY A  58
VAL A  78
ASN A  62
ILE A  67
 None
 0.89A 1zq9B-1zitA:
undetectable		 1zq9B-1zitA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBN_A_CAMA442_0
(CYTOCHROME P450-CAM)		 1zit TRANSCRIPTIONAL
REGULATOR (NTRC
FAMILY)
(Aquifex
aeolicus) 		4 / 7 VAL A 106
VAL A   6
ASP A   8
VAL A  50
 None
 0.93A 2qbnA-1zitA:
undetectable		 2qbnA-1zitA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X9G_A_LYAA1270_2
(PTERIDINE REDUCTASE)		 1zit TRANSCRIPTIONAL
REGULATOR (NTRC
FAMILY)
(Aquifex
aeolicus) 		3 / 3 MET A  55
VAL A   6
GLU A  11
 None
 0.85A 2x9gA-1zitA:
5.4		 2x9gA-1zitA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_D_TOPD200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 1zit TRANSCRIPTIONAL
REGULATOR (NTRC
FAMILY)
(Aquifex
aeolicus) 		5 / 9 ALA A 116
VAL A   4
ILE A  20
LEU A  17
PHE A 109
 None
 1.47A 3fl9D-1zitA:
undetectable		 3fl9D-1zitA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JZ0_B_CLYB900_1
(LINCOSAMIDE
NUCLEOTIDYLTRANSFERA
SE)		 1zit TRANSCRIPTIONAL
REGULATOR (NTRC
FAMILY)
(Aquifex
aeolicus) 		4 / 8 TYR A  26
PHE A  46
SER A  74
ILE A  67
 None
 1.05A 3jz0B-1zitA:
undetectable		 3jz0B-1zitA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_E_PARE500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 1zit TRANSCRIPTIONAL
REGULATOR (NTRC
FAMILY)
(Aquifex
aeolicus) 		5 / 12 LEU A 100
SER A 105
GLU A  10
ASP A  52
GLY A  81
 None
 1.26A 4qb9E-1zitA:
undetectable		 4qb9E-1zitA:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_D_PFLD410_1
(PROTON-GATED ION
CHANNEL)		 1zit TRANSCRIPTIONAL
REGULATOR (NTRC
FAMILY)
(Aquifex
aeolicus) 		5 / 9 PRO A  28
ILE A  20
VAL A   6
TYR A  26
ILE A 113
 None
 1.41A 5mzrD-1zitA:
undetectable		 5mzrD-1zitA:
18.02