SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1zj9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FML_B_RTLB501_0
(RETINOL DEHYDRATASE)		 1zj9 PROBABLE
FERREDOXIN-DEPENDENT
NITRITE REDUCTASE
NIRA
(Mycobacterium
tuberculosis) 		5 / 12 ILE A 373
LEU A 403
LEU A 398
LEU A 358
ILE A 357
 None
 1.19A 1fmlB-1zj9A:
undetectable		 1fmlB-1zj9A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KF6_N_ACTN803_0
(FUMARATE REDUCTASE
FLAVOPROTEIN
FUMARATE REDUCTASE
IRON-SULFUR PROTEIN)		 1zj9 PROBABLE
FERREDOXIN-DEPENDENT
NITRITE REDUCTASE
NIRA
(Mycobacterium
tuberculosis) 		4 / 6 ARG A 286
GLY A 162
ASP A 163
TYR A  69
 None
None
None
SRM  A 569 (-3.4A)
 1.43A 1kf6M-1zj9A:
undetectable
1kf6N-1zj9A:
undetectable		 1kf6M-1zj9A:
22.14
1kf6N-1zj9A:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LHU_A_ESTA301_1
(SEX HORMONE-BINDING
GLOBULIN)		 1zj9 PROBABLE
FERREDOXIN-DEPENDENT
NITRITE REDUCTASE
NIRA
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 170
ASP A 217
SER A 177
ILE A 212
LEU A 239
 None
 1.24A 1lhuA-1zj9A:
undetectable		 1lhuA-1zj9A:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2201_1
(PROTEIN (METHIONINE
REPRESSOR))		 1zj9 PROBABLE
FERREDOXIN-DEPENDENT
NITRITE REDUCTASE
NIRA
(Mycobacterium
tuberculosis) 		4 / 4 HIS A 500
ALA A 543
PHE A 542
GLY A 499
 None
 1.15A 1mj2B-1zj9A:
undetectable		 1mj2B-1zj9A:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC1200_1
(PROTEIN (METHIONINE
REPRESSOR))		 1zj9 PROBABLE
FERREDOXIN-DEPENDENT
NITRITE REDUCTASE
NIRA
(Mycobacterium
tuberculosis) 		4 / 4 HIS A 500
ALA A 543
PHE A 542
GLY A 499
 None
 1.12A 1mj2D-1zj9A:
undetectable		 1mj2D-1zj9A:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_A_SAMA199_1
(METHIONINE REPRESSOR)		 1zj9 PROBABLE
FERREDOXIN-DEPENDENT
NITRITE REDUCTASE
NIRA
(Mycobacterium
tuberculosis) 		4 / 4 HIS A 500
ALA A 543
PHE A 542
GLY A 499
 None
 1.12A 1mjoB-1zj9A:
undetectable		 1mjoB-1zj9A:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_D_SAMD200_1
(METHIONINE REPRESSOR)		 1zj9 PROBABLE
FERREDOXIN-DEPENDENT
NITRITE REDUCTASE
NIRA
(Mycobacterium
tuberculosis) 		4 / 4 HIS A 500
ALA A 543
PHE A 542
GLY A 499
 None
 1.13A 1mjoD-1zj9A:
undetectable		 1mjoD-1zj9A:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_B_ADNB1502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1zj9 PROBABLE
FERREDOXIN-DEPENDENT
NITRITE REDUCTASE
NIRA
(Mycobacterium
tuberculosis) 		3 / 3 GLU A 491
GLU A 520
LEU A 437
 None
 0.72A 1v8bB-1zj9A:
undetectable		 1v8bB-1zj9A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AXN_A_EDTA737_0
(6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
PHOSPHATASE 3
(6PF-2-K/FRU-
2,6-P2ASE
BRAIN/PLACENTA-TYPE
ISOZYME) (IPFK-2)
[INCLUDES: 6-
PHOSPHOFRUCTO-2-KINA
SE (EC 2.7.1.105)
FRUCTOSE-2,6-BISPHO
SPHATASE (EC
3.1.3.46)])		 1zj9 PROBABLE
FERREDOXIN-DEPENDENT
NITRITE REDUCTASE
NIRA
(Mycobacterium
tuberculosis) 		5 / 12 PRO A 455
GLY A 498
ALA A 473
THR A 457
ARG A 541
 None
 1.46A 2axnA-1zj9A:
undetectable		 2axnA-1zj9A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IJ7_C_TPFC2471_1
(CYTOCHROME P450 121)		 1zj9 PROBABLE
FERREDOXIN-DEPENDENT
NITRITE REDUCTASE
NIRA
(Mycobacterium
tuberculosis) 		4 / 8 THR A 274
VAL A 243
ALA A 211
ARG A 130
 None
None
None
SRM  A 569 (-4.2A)
 1.16A 2ij7C-1zj9A:
undetectable		 2ij7C-1zj9A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1294_1
(FICOLIN-2)		 1zj9 PROBABLE
FERREDOXIN-DEPENDENT
NITRITE REDUCTASE
NIRA
(Mycobacterium
tuberculosis) 		5 / 9 VAL A 218
GLY A 170
SER A 171
LEU A 173
LEU A 384
 None
 1.43A 2j2pB-1zj9A:
0.0
2j2pC-1zj9A:
0.0		 2j2pB-1zj9A:
16.46
2j2pC-1zj9A:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_A_SAMA201_0
(UPF0066 PROTEIN
AF_0241)		 1zj9 PROBABLE
FERREDOXIN-DEPENDENT
NITRITE REDUCTASE
NIRA
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 343
ASP A 217
GLY A 103
LEU A 173
SER A 171
 None
 1.32A 2nv4A-1zj9A:
undetectable		 2nv4A-1zj9A:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_A_TOPA1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 1zj9 PROBABLE
FERREDOXIN-DEPENDENT
NITRITE REDUCTASE
NIRA
(Mycobacterium
tuberculosis) 		6 / 11 ILE A 383
ALA A 362
LEU A 358
LEU A 105
ILE A 373
ILE A 127
 None
 1.26A 2w9sA-1zj9A:
undetectable		 2w9sA-1zj9A:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_B_TOPB1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 1zj9 PROBABLE
FERREDOXIN-DEPENDENT
NITRITE REDUCTASE
NIRA
(Mycobacterium
tuberculosis) 		6 / 11 ILE A 383
ALA A 362
LEU A 358
LEU A 105
ILE A 373
ILE A 127
 None
 1.23A 2w9sB-1zj9A:
undetectable		 2w9sB-1zj9A:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1zj9 PROBABLE
FERREDOXIN-DEPENDENT
NITRITE REDUCTASE
NIRA
(Mycobacterium
tuberculosis) 		5 / 7 ARG A 509
LYS A 510
LEU A 511
GLN A 494
LEU A 554
 None
 1.49A 2zxwC-1zj9A:
undetectable
2zxwJ-1zj9A:
undetectable		 2zxwC-1zj9A:
17.61
2zxwJ-1zj9A:
5.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CKK_A_SAMA301_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 1zj9 PROBABLE
FERREDOXIN-DEPENDENT
NITRITE REDUCTASE
NIRA
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 462
ILE A 460
ALA A 468
LEU A 425
THR A  81
 SF4  A 556 (-3.1A)
None
None
SRM  A 569 (-4.2A)
None
 1.15A 3ckkA-1zj9A:
undetectable		 3ckkA-1zj9A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D20_A_017A201_1
(HIV-1 PROTEASE)		 1zj9 PROBABLE
FERREDOXIN-DEPENDENT
NITRITE REDUCTASE
NIRA
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 414
ALA A 347
GLY A 402
PRO A 439
VAL A 438
 None
 1.09A 3d20A-1zj9A:
undetectable		 3d20A-1zj9A:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL1_A_DR7A100_1
(PROTEASE)		 1zj9 PROBABLE
FERREDOXIN-DEPENDENT
NITRITE REDUCTASE
NIRA
(Mycobacterium
tuberculosis) 		5 / 11 LEU A 414
ALA A 347
GLY A 402
PRO A 439
VAL A 438
 None
 1.02A 3el1A-1zj9A:
undetectable		 3el1A-1zj9A:
11.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H9U_A_ADNA439_1
(ADENOSYLHOMOCYSTEINA
SE)		 1zj9 PROBABLE
FERREDOXIN-DEPENDENT
NITRITE REDUCTASE
NIRA
(Mycobacterium
tuberculosis) 		5 / 10 THR A 158
GLN A 156
THR A 157
LEU A  36
GLY A 197
 None
 1.49A 3h9uA-1zj9A:
undetectable		 3h9uA-1zj9A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H9U_B_ADNB438_1
(ADENOSYLHOMOCYSTEINA
SE)		 1zj9 PROBABLE
FERREDOXIN-DEPENDENT
NITRITE REDUCTASE
NIRA
(Mycobacterium
tuberculosis) 		5 / 10 THR A 158
GLN A 156
THR A 157
LEU A  36
GLY A 197
 None
 1.49A 3h9uB-1zj9A:
undetectable		 3h9uB-1zj9A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJO_A_EAAA211_1
(GLUTATHIONE
S-TRANSFERASE P)		 1zj9 PROBABLE
FERREDOXIN-DEPENDENT
NITRITE REDUCTASE
NIRA
(Mycobacterium
tuberculosis) 		4 / 8 VAL A 546
GLN A 494
ILE A 456
GLY A 498
 None
 0.53A 3hjoA-1zj9A:
undetectable		 3hjoA-1zj9A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9W_A_ACTA170_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 1zj9 PROBABLE
FERREDOXIN-DEPENDENT
NITRITE REDUCTASE
NIRA
(Mycobacterium
tuberculosis) 		3 / 3 SER A 354
GLY A 355
THR A 356
 None
 0.11A 3k9wA-1zj9A:
undetectable		 3k9wA-1zj9A:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_A_SAMA226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1zj9 PROBABLE
FERREDOXIN-DEPENDENT
NITRITE REDUCTASE
NIRA
(Mycobacterium
tuberculosis) 		6 / 12 ARG A 304
PRO A 233
GLY A 229
ALA A 259
GLY A 258
ILE A 228
 None
 1.23A 3ku1A-1zj9A:
undetectable		 3ku1A-1zj9A:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_C_SAMC226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1zj9 PROBABLE
FERREDOXIN-DEPENDENT
NITRITE REDUCTASE
NIRA
(Mycobacterium
tuberculosis) 		6 / 12 ARG A 304
PRO A 233
GLY A 229
ALA A 259
GLY A 258
ILE A 228
 None
 1.14A 3ku1C-1zj9A:
undetectable		 3ku1C-1zj9A:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_B_CGEB501_1
(CYTOCHROME P450 2B4)		 1zj9 PROBABLE
FERREDOXIN-DEPENDENT
NITRITE REDUCTASE
NIRA
(Mycobacterium
tuberculosis) 		4 / 8 ILE A 212
ALA A 271
THR A 274
VAL A 168
 None
 0.71A 3me6B-1zj9A:
undetectable		 3me6B-1zj9A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUG_A_SUEA1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 1zj9 PROBABLE
FERREDOXIN-DEPENDENT
NITRITE REDUCTASE
NIRA
(Mycobacterium
tuberculosis) 		4 / 5 GLN A  71
PHE A 422
TYR A 135
LEU A 425
 None
None
None
SRM  A 569 (-4.2A)
 1.45A 3sugA-1zj9A:
0.0		 3sugA-1zj9A:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_R_CLMR221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1zj9 PROBABLE
FERREDOXIN-DEPENDENT
NITRITE REDUCTASE
NIRA
(Mycobacterium
tuberculosis) 		5 / 10 SER A 275
PHE A 201
LEU A 316
VAL A 261
PHE A 227
 None
 1.36A 3u9fR-1zj9A:
undetectable		 3u9fR-1zj9A:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1004_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 1zj9 PROBABLE
FERREDOXIN-DEPENDENT
NITRITE REDUCTASE
NIRA
(Mycobacterium
tuberculosis) 		5 / 11 ALA A 549
GLY A 508
LEU A 554
GLY A 498
PHE A 542
 None
 1.03A 3zosA-1zj9A:
undetectable
3zosB-1zj9A:
undetectable		 3zosA-1zj9A:
20.35
3zosB-1zj9A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AX8_A_SAMA1474_1
(WBDD)		 1zj9 PROBABLE
FERREDOXIN-DEPENDENT
NITRITE REDUCTASE
NIRA
(Mycobacterium
tuberculosis) 		4 / 6 ARG A 433
ASP A 526
GLU A 446
LEU A 437
 None
 1.28A 4ax8A-1zj9A:
undetectable		 4ax8A-1zj9A:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_A_SAMA1281_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 1zj9 PROBABLE
FERREDOXIN-DEPENDENT
NITRITE REDUCTASE
NIRA
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 521
TYR A 524
GLY A 476
GLY A 499
GLY A 479
 None
 1.04A 4blvA-1zj9A:
undetectable		 4blvA-1zj9A:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYR_B_RITB301_1
(HIV-1 PROTEASE)		 1zj9 PROBABLE
FERREDOXIN-DEPENDENT
NITRITE REDUCTASE
NIRA
(Mycobacterium
tuberculosis) 		4 / 7 ASP A 399
VAL A 361
ILE A 349
THR A 356
 None
 0.79A 4eyrA-1zj9A:
undetectable		 4eyrA-1zj9A:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 1zj9 PROBABLE
FERREDOXIN-DEPENDENT
NITRITE REDUCTASE
NIRA
(Mycobacterium
tuberculosis) 		4 / 8 ASP A 183
ASP A 385
GLU A 189
GLU A 180
 None
 1.21A 4feuF-1zj9A:
undetectable		 4feuF-1zj9A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEX_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 1zj9 PROBABLE
FERREDOXIN-DEPENDENT
NITRITE REDUCTASE
NIRA
(Mycobacterium
tuberculosis) 		4 / 7 ASP A 183
ASP A 385
GLU A 189
GLU A 180
 None
 1.22A 4fexB-1zj9A:
undetectable		 4fexB-1zj9A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JEC_B_478B401_3
(HIV-1 PROTEASE)		 1zj9 PROBABLE
FERREDOXIN-DEPENDENT
NITRITE REDUCTASE
NIRA
(Mycobacterium
tuberculosis) 		3 / 3 ASP A 279
LEU A 294
VAL A 225
 None
 0.67A 4jecB-1zj9A:
undetectable		 4jecB-1zj9A:
11.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2V_A_BZ1A302_2
(CARBONIC ANHYDRASE 2)		 1zj9 PROBABLE
FERREDOXIN-DEPENDENT
NITRITE REDUCTASE
NIRA
(Mycobacterium
tuberculosis) 		3 / 3 HIS A 220
VAL A 273
LEU A 241
 None
 0.76A 4m2vA-1zj9A:
undetectable		 4m2vA-1zj9A:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PB1_A_RBVA501_1
(NUPC FAMILY PROTEIN)		 1zj9 PROBABLE
FERREDOXIN-DEPENDENT
NITRITE REDUCTASE
NIRA
(Mycobacterium
tuberculosis) 		5 / 12 GLN A 471
LEU A 501
ASN A 459
ASN A 461
SER A 466
 None
None
None
SF4  A 556 ( 4.9A)
None
 1.37A 4pb1A-1zj9A:
undetectable		 4pb1A-1zj9A:
25.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD5_A_GEOA501_1
(NUPC FAMILY PROTEIN)		 1zj9 PROBABLE
FERREDOXIN-DEPENDENT
NITRITE REDUCTASE
NIRA
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 244
VAL A 273
LEU A 241
PHE A 303
ILE A 300
 None
 1.18A 4pd5A-1zj9A:
undetectable		 4pd5A-1zj9A:
25.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD9_A_ADNA501_1
(NUPC FAMILY PROTEIN)		 1zj9 PROBABLE
FERREDOXIN-DEPENDENT
NITRITE REDUCTASE
NIRA
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 244
VAL A 273
LEU A 241
PHE A 303
ILE A 300
 None
 1.17A 4pd9A-1zj9A:
undetectable		 4pd9A-1zj9A:
25.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVL_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 1zj9 PROBABLE
FERREDOXIN-DEPENDENT
NITRITE REDUCTASE
NIRA
(Mycobacterium
tuberculosis) 		5 / 11 ALA A 226
THR A 210
ALA A 211
GLY A 244
ALA A 254
 None
 1.00A 4qvlK-1zj9A:
undetectable
4qvlL-1zj9A:
undetectable		 4qvlK-1zj9A:
18.23
4qvlL-1zj9A:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVL_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 1zj9 PROBABLE
FERREDOXIN-DEPENDENT
NITRITE REDUCTASE
NIRA
(Mycobacterium
tuberculosis) 		5 / 11 ALA A 226
THR A 210
ALA A 211
GLY A 244
ALA A 254
 None
 1.00A 4qvlY-1zj9A:
undetectable
4qvlZ-1zj9A:
undetectable		 4qvlY-1zj9A:
18.23
4qvlZ-1zj9A:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVM_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 1zj9 PROBABLE
FERREDOXIN-DEPENDENT
NITRITE REDUCTASE
NIRA
(Mycobacterium
tuberculosis) 		5 / 9 ALA A 226
THR A 210
ALA A 211
GLY A 244
ALA A 254
 None
 0.99A 4qvmK-1zj9A:
undetectable
4qvmL-1zj9A:
undetectable		 4qvmK-1zj9A:
18.23
4qvmL-1zj9A:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVM_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 1zj9 PROBABLE
FERREDOXIN-DEPENDENT
NITRITE REDUCTASE
NIRA
(Mycobacterium
tuberculosis) 		5 / 10 ALA A 226
THR A 210
ALA A 211
GLY A 244
ALA A 254
 None
 0.99A 4qvmY-1zj9A:
undetectable
4qvmZ-1zj9A:
undetectable		 4qvmY-1zj9A:
18.23
4qvmZ-1zj9A:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 1zj9 PROBABLE
FERREDOXIN-DEPENDENT
NITRITE REDUCTASE
NIRA
(Mycobacterium
tuberculosis) 		5 / 10 ALA A 226
THR A 210
ALA A 211
GLY A 244
ALA A 254
 None
 0.98A 4qvpK-1zj9A:
undetectable
4qvpL-1zj9A:
undetectable		 4qvpK-1zj9A:
18.41
4qvpL-1zj9A:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 1zj9 PROBABLE
FERREDOXIN-DEPENDENT
NITRITE REDUCTASE
NIRA
(Mycobacterium
tuberculosis) 		5 / 10 ALA A 226
THR A 210
ALA A 211
GLY A 244
ALA A 254
 None
 0.98A 4qvpY-1zj9A:
undetectable
4qvpZ-1zj9A:
undetectable		 4qvpY-1zj9A:
18.41
4qvpZ-1zj9A:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 1zj9 PROBABLE
FERREDOXIN-DEPENDENT
NITRITE REDUCTASE
NIRA
(Mycobacterium
tuberculosis) 		5 / 11 ALA A 226
THR A 210
ALA A 211
GLY A 244
ALA A 254
 None
 1.00A 4qw1K-1zj9A:
undetectable
4qw1L-1zj9A:
undetectable		 4qw1K-1zj9A:
18.23
4qw1L-1zj9A:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 1zj9 PROBABLE
FERREDOXIN-DEPENDENT
NITRITE REDUCTASE
NIRA
(Mycobacterium
tuberculosis) 		5 / 10 ALA A 226
THR A 210
ALA A 211
GLY A 244
ALA A 254
 None
 1.00A 4qw1Y-1zj9A:
undetectable
4qw1Z-1zj9A:
undetectable		 4qw1Y-1zj9A:
18.23
4qw1Z-1zj9A:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 1zj9 PROBABLE
FERREDOXIN-DEPENDENT
NITRITE REDUCTASE
NIRA
(Mycobacterium
tuberculosis) 		5 / 10 ALA A 226
THR A 210
ALA A 211
GLY A 244
ALA A 254
 None
 1.01A 4qw3K-1zj9A:
undetectable
4qw3L-1zj9A:
undetectable		 4qw3K-1zj9A:
18.23
4qw3L-1zj9A:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 1zj9 PROBABLE
FERREDOXIN-DEPENDENT
NITRITE REDUCTASE
NIRA
(Mycobacterium
tuberculosis) 		5 / 10 ALA A 226
THR A 210
ALA A 211
GLY A 244
ALA A 254
 None
 1.01A 4qw3Y-1zj9A:
undetectable
4qw3Z-1zj9A:
undetectable		 4qw3Y-1zj9A:
18.23
4qw3Z-1zj9A:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_B_LOCB502_2
(TUBULIN BETA CHAIN)		 1zj9 PROBABLE
FERREDOXIN-DEPENDENT
NITRITE REDUCTASE
NIRA
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 105
ALA A 109
LEU A 150
THR A 158
VAL A 133
 None
 1.00A 4x1iB-1zj9A:
undetectable		 4x1iB-1zj9A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1Y_B_LOCB502_1
(TUBULIN BETA CHAIN)		 1zj9 PROBABLE
FERREDOXIN-DEPENDENT
NITRITE REDUCTASE
NIRA
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 105
ALA A 109
LEU A 150
THR A 158
VAL A 133
 None
 0.96A 4x1yB-1zj9A:
undetectable		 4x1yB-1zj9A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_B_LOCB502_1
(TUBULIN BETA CHAIN)		 1zj9 PROBABLE
FERREDOXIN-DEPENDENT
NITRITE REDUCTASE
NIRA
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 105
ALA A 109
LEU A 150
THR A 158
VAL A 133
 None
 1.01A 4x20B-1zj9A:
1.6		 4x20B-1zj9A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDQ_A_BEZA306_0
(GLYCOSIDE HYDROLASE
FAMILY PROTEIN)		 1zj9 PROBABLE
FERREDOXIN-DEPENDENT
NITRITE REDUCTASE
NIRA
(Mycobacterium
tuberculosis) 		3 / 3 ARG A 256
ASP A 240
TRP A 242
 None
 0.87A 4xdqA-1zj9A:
undetectable		 4xdqA-1zj9A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 1zj9 PROBABLE
FERREDOXIN-DEPENDENT
NITRITE REDUCTASE
NIRA
(Mycobacterium
tuberculosis) 		5 / 11 ALA A 226
THR A 210
ALA A 211
GLY A 244
ALA A 254
 None
 1.00A 5bxnK-1zj9A:
undetectable
5bxnL-1zj9A:
undetectable		 5bxnK-1zj9A:
18.23
5bxnL-1zj9A:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 1zj9 PROBABLE
FERREDOXIN-DEPENDENT
NITRITE REDUCTASE
NIRA
(Mycobacterium
tuberculosis) 		5 / 11 ALA A 226
THR A 210
ALA A 211
GLY A 244
ALA A 254
 None
 1.00A 5bxnY-1zj9A:
undetectable
5bxnZ-1zj9A:
undetectable		 5bxnY-1zj9A:
18.23
5bxnZ-1zj9A:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 1zj9 PROBABLE
FERREDOXIN-DEPENDENT
NITRITE REDUCTASE
NIRA
(Mycobacterium
tuberculosis) 		5 / 9 ALA A 226
THR A 210
ALA A 211
GLY A 244
ALA A 254
 None
 1.00A 5d0xK-1zj9A:
undetectable
5d0xL-1zj9A:
undetectable		 5d0xK-1zj9A:
17.91
5d0xL-1zj9A:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 1zj9 PROBABLE
FERREDOXIN-DEPENDENT
NITRITE REDUCTASE
NIRA
(Mycobacterium
tuberculosis) 		5 / 9 ALA A 226
THR A 210
ALA A 211
GLY A 244
ALA A 254
 None
 1.00A 5d0xY-1zj9A:
undetectable
5d0xZ-1zj9A:
undetectable		 5d0xY-1zj9A:
17.91
5d0xZ-1zj9A:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_D_CVID301_1
(REGULATORY PROTEIN
TETR)		 1zj9 PROBABLE
FERREDOXIN-DEPENDENT
NITRITE REDUCTASE
NIRA
(Mycobacterium
tuberculosis) 		4 / 8 GLY A 479
GLU A 491
ILE A 460
GLN A 379
 None
None
None
SRM  A 569 (-3.9A)
 1.02A 5vlmD-1zj9A:
undetectable		 5vlmD-1zj9A:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_B_9SCB601_1
(SERUM ALBUMIN)		 1zj9 PROBABLE
FERREDOXIN-DEPENDENT
NITRITE REDUCTASE
NIRA
(Mycobacterium
tuberculosis) 		4 / 6 PHE A 227
TYR A 208
LEU A 307
SER A 275
 None
 1.28A 6a7pB-1zj9A:
undetectable		 6a7pB-1zj9A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DEB_B_MTXB303_1
(BIFUNCTIONAL PROTEIN
FOLD)		 1zj9 PROBABLE
FERREDOXIN-DEPENDENT
NITRITE REDUCTASE
NIRA
(Mycobacterium
tuberculosis) 		4 / 5 TYR A 378
LYS A 380
GLY A 498
ILE A 472
 None
 1.39A 6debB-1zj9A:
undetectable		 6debB-1zj9A:
8.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DEB_B_MTXB303_1
(BIFUNCTIONAL PROTEIN
FOLD)		 1zj9 PROBABLE
FERREDOXIN-DEPENDENT
NITRITE REDUCTASE
NIRA
(Mycobacterium
tuberculosis) 		4 / 5 TYR A 378
LYS A 380
GLY A 508
ILE A 472
 None
 1.48A 6debB-1zj9A:
undetectable		 6debB-1zj9A:
8.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_B_TA1B501_2
(TUBULIN BETA CHAIN)		 1zj9 PROBABLE
FERREDOXIN-DEPENDENT
NITRITE REDUCTASE
NIRA
(Mycobacterium
tuberculosis) 		4 / 5 LEU A 441
THR A 457
PRO A 407
ARG A 406
 None
 1.18A 6ew0B-1zj9A:
undetectable		 6ew0B-1zj9A:
8.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_D_TA1D501_2
(TUBULIN BETA CHAIN)		 1zj9 PROBABLE
FERREDOXIN-DEPENDENT
NITRITE REDUCTASE
NIRA
(Mycobacterium
tuberculosis) 		4 / 5 LEU A 441
THR A 457
PRO A 407
ARG A 406
 None
 1.18A 6ew0D-1zj9A:
undetectable		 6ew0D-1zj9A:
8.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_H_TA1H501_2
(TUBULIN BETA CHAIN)		 1zj9 PROBABLE
FERREDOXIN-DEPENDENT
NITRITE REDUCTASE
NIRA
(Mycobacterium
tuberculosis) 		4 / 5 LEU A 441
THR A 457
PRO A 407
ARG A 406
 None
 1.18A 6ew0H-1zj9A:
undetectable		 6ew0H-1zj9A:
8.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_I_TA1I501_2
(TUBULIN BETA CHAIN)		 1zj9 PROBABLE
FERREDOXIN-DEPENDENT
NITRITE REDUCTASE
NIRA
(Mycobacterium
tuberculosis) 		4 / 5 LEU A 441
THR A 457
PRO A 407
ARG A 406
 None
 1.18A 6ew0I-1zj9A:
undetectable		 6ew0I-1zj9A:
8.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_A_ACRA602_1
(-)		 1zj9 PROBABLE
FERREDOXIN-DEPENDENT
NITRITE REDUCTASE
NIRA
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 103
GLY A 102
VAL A 168
ARG A 374
PRO A 184
 None
 1.18A 6gneA-1zj9A:
2.3		 6gneA-1zj9A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		 1zj9 PROBABLE
FERREDOXIN-DEPENDENT
NITRITE REDUCTASE
NIRA
(Mycobacterium
tuberculosis) 		5 / 12 GLU A 221
GLY A 502
LEU A 501
GLY A 214
GLU A 180
 None
 1.10A 6gngB-1zj9A:
undetectable		 6gngB-1zj9A:
23.56