SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1zjc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QVT_A_PRLA311_0
(TRANSCRIPTIONAL
REGULATOR QACR)		 1zjc AMINOPEPTIDASE AMPS
(Staphylococcus
aureus) 		4 / 8 LEU A 349
GLU A 319
ILE A 386
TYR A 214
 None
CO  A 501 ( 2.6A)
None
None
 1.15A 1qvtA-1zjcA:
undetectable		 1qvtA-1zjcA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WU8_C_ADNC502_1
(HYPOTHETICAL PROTEIN
PH0463)		 1zjc AMINOPEPTIDASE AMPS
(Staphylococcus
aureus) 		4 / 7 ASN A 344
ARG A 180
HIS A 193
VAL A 254
 None
 1.36A 1wu8A-1zjcA:
undetectable
1wu8C-1zjcA:
undetectable		 1wu8A-1zjcA:
23.46
1wu8C-1zjcA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXP_A_P1ZA3001_1
(SERUM ALBUMIN)		 1zjc AMINOPEPTIDASE AMPS
(Staphylococcus
aureus) 		5 / 12 PHE A 341
TRP A 154
LEU A  15
ALA A  12
ILE A  43
 None
 1.16A 2bxpA-1zjcA:
undetectable		 2bxpA-1zjcA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0Y_A_SAMA300_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0657)		 1zjc AMINOPEPTIDASE AMPS
(Staphylococcus
aureus) 		5 / 9 GLY A 352
GLY A 313
ILE A 371
LEU A 375
ALA A 354
 None
 0.99A 2z0yA-1zjcA:
undetectable		 2z0yA-1zjcA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_A_NCAA192_0
(NICOTINAMIDASE)		 1zjc AMINOPEPTIDASE AMPS
(Staphylococcus
aureus) 		5 / 11 ASP A 383
GLU A 319
PHE A 255
HIS A 348
TYR A 355
 CO  A 502 ( 2.2A)
CO  A 501 ( 2.6A)
CO  A 501 ( 4.9A)
CO  A 501 (-3.4A)
CO  A 502 (-4.9A)
 1.50A 3o94A-1zjcA:
undetectable		 3o94A-1zjcA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_C_NCAC192_0
(NICOTINAMIDASE)		 1zjc AMINOPEPTIDASE AMPS
(Staphylococcus
aureus) 		5 / 11 ASP A 383
GLU A 319
PHE A 255
HIS A 348
TYR A 355
 CO  A 502 ( 2.2A)
CO  A 501 ( 2.6A)
CO  A 501 ( 4.9A)
CO  A 501 (-3.4A)
CO  A 502 (-4.9A)
 1.49A 3o94C-1zjcA:
undetectable		 3o94C-1zjcA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_D_NCAD192_0
(NICOTINAMIDASE)		 1zjc AMINOPEPTIDASE AMPS
(Staphylococcus
aureus) 		5 / 11 ASP A 383
GLU A 319
PHE A 255
HIS A 348
TYR A 355
 CO  A 502 ( 2.2A)
CO  A 501 ( 2.6A)
CO  A 501 ( 4.9A)
CO  A 501 (-3.4A)
CO  A 502 (-4.9A)
 1.49A 3o94D-1zjcA:
undetectable		 3o94D-1zjcA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_C_ACHC323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 1zjc AMINOPEPTIDASE AMPS
(Staphylococcus
aureus) 		4 / 8 GLU A 343
GLU A 319
TYR A 355
PHE A 255
 CO  A 503 (-2.2A)
CO  A 501 ( 2.6A)
CO  A 502 (-4.9A)
CO  A 501 ( 4.9A)
 1.13A 3rqwC-1zjcA:
undetectable
3rqwD-1zjcA:
undetectable		 3rqwC-1zjcA:
22.09
3rqwD-1zjcA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_J_ACHJ323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 1zjc AMINOPEPTIDASE AMPS
(Staphylococcus
aureus) 		4 / 8 GLU A 343
GLU A 319
TYR A 355
PHE A 255
 CO  A 503 (-2.2A)
CO  A 501 ( 2.6A)
CO  A 502 (-4.9A)
CO  A 501 ( 4.9A)
 1.14A 3rqwF-1zjcA:
undetectable
3rqwJ-1zjcA:
undetectable		 3rqwF-1zjcA:
22.09
3rqwJ-1zjcA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_C_SAMC401_1
(MNMC2)		 1zjc AMINOPEPTIDASE AMPS
(Staphylococcus
aureus) 		4 / 6 GLY A 277
ASP A  61
ASP A 109
GLU A  35
 None
 1.00A 3vywC-1zjcA:
undetectable		 3vywC-1zjcA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1zjc AMINOPEPTIDASE AMPS
(Staphylococcus
aureus) 		4 / 7 GLU A 343
GLU A 319
TYR A 355
PHE A 255
 CO  A 503 (-2.2A)
CO  A 501 ( 2.6A)
CO  A 502 (-4.9A)
CO  A 501 ( 4.9A)
 1.07A 4a97H-1zjcA:
undetectable		 4a97H-1zjcA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AMJ_B_CVDB1360_1
(BETA-1 ADRENERGIC
RECEPTOR)		 1zjc AMINOPEPTIDASE AMPS
(Staphylococcus
aureus) 		5 / 12 LEU A 225
SER A 327
SER A 330
PHE A 406
TYR A 214
 None
 1.49A 4amjB-1zjcA:
undetectable		 4amjB-1zjcA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_A_377A401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1zjc AMINOPEPTIDASE AMPS
(Staphylococcus
aureus) 		4 / 5 GLU A 343
GLU A 319
TYR A 355
PHE A 255
 CO  A 503 (-2.2A)
CO  A 501 ( 2.6A)
CO  A 502 (-4.9A)
CO  A 501 ( 4.9A)
 1.13A 4twdA-1zjcA:
0.0
4twdE-1zjcA:
0.0		 4twdA-1zjcA:
21.75
4twdE-1zjcA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_F_377F401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1zjc AMINOPEPTIDASE AMPS
(Staphylococcus
aureus) 		4 / 7 GLU A 343
GLU A 319
TYR A 355
PHE A 255
 CO  A 503 (-2.2A)
CO  A 501 ( 2.6A)
CO  A 502 (-4.9A)
CO  A 501 ( 4.9A)
 1.17A 4twdF-1zjcA:
undetectable
4twdJ-1zjcA:
undetectable		 4twdF-1zjcA:
21.75
4twdJ-1zjcA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_A_ACTA612_0
(NADH DEHYDROGENASE,
PUTATIVE)		 1zjc AMINOPEPTIDASE AMPS
(Staphylococcus
aureus) 		3 / 3 LYS A 170
ASP A 173
ARG A 332
 None
 0.89A 5jwaA-1zjcA:
undetectable
5jwaH-1zjcA:
undetectable		 5jwaA-1zjcA:
21.09
5jwaH-1zjcA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_F_Z80F401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1zjc AMINOPEPTIDASE AMPS
(Staphylococcus
aureus) 		5 / 10 ILE A 351
ILE A 308
PHE A 295
VAL A 382
ILE A 280
 None
 1.18A 5lg3F-1zjcA:
undetectable		 5lg3F-1zjcA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_G_Z80G401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1zjc AMINOPEPTIDASE AMPS
(Staphylococcus
aureus) 		5 / 10 ILE A 351
ILE A 308
PHE A 295
VAL A 382
ILE A 280
 None
 1.22A 5lg3G-1zjcA:
undetectable		 5lg3G-1zjcA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_H_Z80H401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1zjc AMINOPEPTIDASE AMPS
(Staphylococcus
aureus) 		5 / 10 ILE A 351
ILE A 308
PHE A 295
VAL A 382
ILE A 280
 None
 1.20A 5lg3H-1zjcA:
undetectable		 5lg3H-1zjcA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_J_Z80J401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1zjc AMINOPEPTIDASE AMPS
(Staphylococcus
aureus) 		5 / 12 ILE A 351
ILE A 308
PHE A 295
VAL A 382
ILE A 280
 None
 1.19A 5lg3J-1zjcA:
undetectable		 5lg3J-1zjcA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QSA615_1
(SERUM ALBUMIN)		 1zjc AMINOPEPTIDASE AMPS
(Staphylococcus
aureus) 		4 / 8 TYR A  11
VAL A 179
LEU A 103
ILE A 249
 None
 1.00A 5v0vA-1zjcA:
undetectable		 5v0vA-1zjcA:
21.61