SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1zjk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AQ7_B_AG2B4_1
(TRYPSIN
AERUGINOSIN 98-B)		 1zjk MANNAN-BINDING
LECTIN SERINE
PROTEASE 2
(Homo
sapiens) 		5 / 8 HIS A 483
SER A 633
VAL A 653
GLY A 656
GLY A 667
 None
 0.58A 1aq7A-1zjkA:
29.3		 1aq7A-1zjkA:
26.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETR_H_MITH1_1
(EPSILON-THROMBIN)		 1zjk MANNAN-BINDING
LECTIN SERINE
PROTEASE 2
(Homo
sapiens) 		6 / 12 HIS A 483
SER A 633
VAL A 653
TRP A 655
GLY A 656
GLY A 667
 None
 0.68A 1etrH-1zjkA:
31.2		 1etrH-1zjkA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_E_CCSE47_0
(GLUTATHIONE
S-TRANSFERASE)		 1zjk MANNAN-BINDING
LECTIN SERINE
PROTEASE 2
(Homo
sapiens) 		4 / 7 THR A 670
LEU A 637
GLY A 635
LEU A 479
 None
 1.02A 1gtiE-1zjkA:
undetectable		 1gtiE-1zjkA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GXS_A_BEZA601_0
(P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
A
P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
B)		 1zjk MANNAN-BINDING
LECTIN SERINE
PROTEASE 2
(Homo
sapiens) 		4 / 7 GLY A 656
ASP A 532
HIS A 483
ALA A 481
 None
 0.99A 1gxsA-1zjkA:
undetectable
1gxsB-1zjkA:
undetectable		 1gxsA-1zjkA:
19.51
1gxsB-1zjkA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_C_MK1C402_2
(HIV-II PROTEASE)		 1zjk MANNAN-BINDING
LECTIN SERINE
PROTEASE 2
(Homo
sapiens) 		5 / 8 ALA A 468
GLY A 635
ILE A 652
ILE A 536
ILE A 462
 None
 0.95A 1hshD-1zjkA:
undetectable		 1hshD-1zjkA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_D_HISD450_0
(HISTIDYL-TRNA
SYNTHETASE)		 1zjk MANNAN-BINDING
LECTIN SERINE
PROTEASE 2
(Homo
sapiens) 		5 / 12 THR A 576
LEU A 581
GLY A 572
GLY A 631
ALA A 469
 None
 1.31A 1httD-1zjkA:
undetectable		 1httD-1zjkA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TNL_A_TPAA900_1
(TRYPSIN)		 1zjk MANNAN-BINDING
LECTIN SERINE
PROTEASE 2
(Homo
sapiens) 		4 / 6 SER A 633
VAL A 653
GLY A 656
GLY A 667
 None
 0.66A 1tnlA-1zjkA:
29.7		 1tnlA-1zjkA:
26.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8L_A_SAMA400_0
(HYPOTHETICAL PROTEIN
LMO1582)		 1zjk MANNAN-BINDING
LECTIN SERINE
PROTEASE 2
(Homo
sapiens) 		5 / 12 ALA A 636
GLY A 470
LEU A 472
VAL A 653
GLY A 651
 None
 1.15A 2f8lA-1zjkA:
undetectable		 2f8lA-1zjkA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXE_A_DR7A102_1
(POL PROTEIN)		 1zjk MANNAN-BINDING
LECTIN SERINE
PROTEASE 2
(Homo
sapiens) 		6 / 12 GLY A 667
ALA A 619
GLY A 650
GLY A 651
VAL A 588
ILE A 590
 None
 1.38A 2fxeA-1zjkA:
undetectable		 2fxeA-1zjkA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_A_SAMA1001_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 1zjk MANNAN-BINDING
LECTIN SERINE
PROTEASE 2
(Homo
sapiens) 		5 / 12 SER A 633
ALA A 484
ALA A 636
GLY A 572
GLY A 631
 None
 1.14A 2igtA-1zjkA:
undetectable		 2igtA-1zjkA:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_B_SAMB1002_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 1zjk MANNAN-BINDING
LECTIN SERINE
PROTEASE 2
(Homo
sapiens) 		5 / 12 SER A 633
ALA A 484
ALA A 636
GLY A 572
GLY A 631
 None
 1.14A 2igtB-1zjkA:
undetectable		 2igtB-1zjkA:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITZ_A_IREA2021_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 1zjk MANNAN-BINDING
LECTIN SERINE
PROTEASE 2
(Homo
sapiens) 		3 / 3 LEU A 505
LEU A 585
MET A 586
 None
 0.86A 2itzA-1zjkA:
undetectable		 2itzA-1zjkA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P16_A_GG2A298_1
(COAGULATION FACTOR X
(EC 3.4.21.6)
(STUART FACTOR)
(STUART-PROWER
FACTOR))		 1zjk MANNAN-BINDING
LECTIN SERINE
PROTEASE 2
(Homo
sapiens) 		5 / 12 VAL A 653
TRP A 655
GLY A 656
GLY A 667
TYR A 669
 None
 0.27A 2p16A-1zjkA:
30.2		 2p16A-1zjkA:
26.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_C_ACTC36_0
(GCN4 LEUCINE ZIPPER)		 1zjk MANNAN-BINDING
LECTIN SERINE
PROTEASE 2
(Homo
sapiens) 		5 / 10 TYR A 523
HIS A 520
ALA A 482
ALA A 534
TYR A 675
 None
 1.40A 2r2vC-1zjkA:
undetectable
2r2vF-1zjkA:
undetectable
2r2vG-1zjkA:
undetectable		 2r2vC-1zjkA:
11.07
2r2vF-1zjkA:
11.07
2r2vG-1zjkA:
11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W26_A_RIVA1001_1
(ACTIVATED FACTOR XA
HEAVY CHAIN)		 1zjk MANNAN-BINDING
LECTIN SERINE
PROTEASE 2
(Homo
sapiens) 		5 / 12 VAL A 653
TRP A 655
GLY A 656
GLY A 667
TYR A 669
 None
 0.23A 2w26A-1zjkA:
30.1		 2w26A-1zjkA:
26.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GY3_A_PNTA246_0
(CATIONIC TRYPSIN)		 1zjk MANNAN-BINDING
LECTIN SERINE
PROTEASE 2
(Homo
sapiens) 		5 / 11 HIS A 483
SER A 633
TRP A 655
GLY A 656
GLY A 667
 None
 0.63A 3gy3A-1zjkA:
28.8		 3gy3A-1zjkA:
26.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_D_URFD254_1
(URIDINE
PHOSPHORYLASE)		 1zjk MANNAN-BINDING
LECTIN SERINE
PROTEASE 2
(Homo
sapiens) 		4 / 6 GLY A 634
GLN A 459
ILE A 652
VAL A 653
 None
 1.12A 3kvvD-1zjkA:
undetectable		 3kvvD-1zjkA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RXF_A_4APA9_1
(CATIONIC TRYPSIN)		 1zjk MANNAN-BINDING
LECTIN SERINE
PROTEASE 2
(Homo
sapiens) 		5 / 6 SER A 633
VAL A 653
TRP A 655
GLY A 656
GLY A 667
 None
 0.65A 3rxfA-1zjkA:
13.0		 3rxfA-1zjkA:
26.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1475_0
(MJ0495-LIKE PROTEIN)		 1zjk MANNAN-BINDING
LECTIN SERINE
PROTEASE 2
(Homo
sapiens) 		4 / 8 ILE A 533
ASP A 532
ILE A 652
GLY A 470
 None
 0.85A 4ac9C-1zjkA:
2.9		 4ac9C-1zjkA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZT_A_SAMA1472_0
(METHYLTRANSFERASE
WBDD)		 1zjk MANNAN-BINDING
LECTIN SERINE
PROTEASE 2
(Homo
sapiens) 		5 / 12 GLY A 470
ALA A 636
ILE A 462
LEU A 472
VAL A 478
 None
 1.12A 4aztA-1zjkA:
undetectable		 4aztA-1zjkA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_A_OBNA1104_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 1zjk MANNAN-BINDING
LECTIN SERINE
PROTEASE 2
(Homo
sapiens) 		5 / 12 LEU A 575
GLY A 635
ALA A 469
PHE A 456
ARG A 439
 None
 1.16A 4hytA-1zjkA:
undetectable		 4hytA-1zjkA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_C_OBNC2004_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 1zjk MANNAN-BINDING
LECTIN SERINE
PROTEASE 2
(Homo
sapiens) 		5 / 12 LEU A 575
GLY A 635
ALA A 469
PHE A 456
ARG A 439
 None
 1.17A 4hytC-1zjkA:
undetectable		 4hytC-1zjkA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)		 1zjk MANNAN-BINDING
LECTIN SERINE
PROTEASE 2
(Homo
sapiens) 		5 / 12 LEU A 473
LEU A 472
LEU A 538
ILE A 679
ILE A 682
 None
 1.10A 4j24A-1zjkA:
undetectable		 4j24A-1zjkA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 1zjk MANNAN-BINDING
LECTIN SERINE
PROTEASE 2
(Homo
sapiens) 		5 / 12 LEU A 473
LEU A 472
LEU A 538
ILE A 679
ILE A 682
 None
 1.08A 4j24B-1zjkA:
undetectable		 4j24B-1zjkA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_2
(PROTEASE)		 1zjk MANNAN-BINDING
LECTIN SERINE
PROTEASE 2
(Homo
sapiens) 		5 / 12 ALA A 481
ILE A 652
GLY A 470
VAL A 517
ILE A 536
 None
 0.92A 4q5mA-1zjkA:
undetectable		 4q5mA-1zjkA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QDJ_A_SAMA301_0
(MAGNESIUM-PROTOPORPH
YRIN
O-METHYLTRANSFERASE)		 1zjk MANNAN-BINDING
LECTIN SERINE
PROTEASE 2
(Homo
sapiens) 		5 / 12 VAL A 672
GLY A 470
ILE A 533
LEU A 535
LEU A 472
 None
 1.05A 4qdjA-1zjkA:
undetectable		 4qdjA-1zjkA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		 1zjk MANNAN-BINDING
LECTIN SERINE
PROTEASE 2
(Homo
sapiens) 		5 / 12 HIS A 483
VAL A 653
TRP A 655
GLY A 656
GLY A 667
 None
 0.34A 4rn6B-1zjkA:
32.4		 4rn6B-1zjkA:
25.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_A_NOVA2000_1
(DNA GYRASE SUBUNIT B)		 1zjk MANNAN-BINDING
LECTIN SERINE
PROTEASE 2
(Homo
sapiens) 		5 / 12 GLU A 413
ASP A 415
ASP A 407
GLN A 393
ILE A 392
 None
 1.12A 4uroA-1zjkA:
undetectable		 4uroA-1zjkA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_B_NOVB2000_1
(DNA GYRASE SUBUNIT B)		 1zjk MANNAN-BINDING
LECTIN SERINE
PROTEASE 2
(Homo
sapiens) 		5 / 12 GLU A 413
ASP A 415
ASP A 407
GLN A 393
ILE A 392
 None
 1.14A 4uroB-1zjkA:
undetectable		 4uroB-1zjkA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UW0_A_SAMA1506_0
(WBDD)		 1zjk MANNAN-BINDING
LECTIN SERINE
PROTEASE 2
(Homo
sapiens) 		5 / 12 GLY A 470
ALA A 636
ILE A 462
LEU A 472
VAL A 478
 None
 1.08A 4uw0A-1zjkA:
undetectable		 4uw0A-1zjkA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODQ_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)		 1zjk MANNAN-BINDING
LECTIN SERINE
PROTEASE 2
(Homo
sapiens) 		3 / 3 HIS A 520
GLU A 521
TRP A 678
 None
 1.11A 5odqD-1zjkA:
undetectable		 5odqD-1zjkA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODR_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)		 1zjk MANNAN-BINDING
LECTIN SERINE
PROTEASE 2
(Homo
sapiens) 		3 / 3 HIS A 520
GLU A 521
TRP A 678
 None
 1.20A 5odrD-1zjkA:
undetectable		 5odrD-1zjkA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_D_HISD402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 1zjk MANNAN-BINDING
LECTIN SERINE
PROTEASE 2
(Homo
sapiens) 		4 / 8 GLY A 635
THR A 569
VAL A 638
LEU A 585
 None
 0.85A 6czmD-1zjkA:
undetectable
6czmF-1zjkA:
undetectable		 6czmD-1zjkA:
21.43
6czmF-1zjkA:
21.43