SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1zjy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 1zjy R-SPECIFIC ALCOHOL
DEHYDROGENASE
(Lactobacillus
brevis) 		5 / 12 TYR A 155
GLY A 145
ALA A 157
SER A 158
TYR A 189
 SS2  A1260 ( 4.2A)
None
None
None
None
 1.39A 1nbhD-1zjyA:
6.9		 1nbhD-1zjyA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 1zjy R-SPECIFIC ALCOHOL
DEHYDROGENASE
(Lactobacillus
brevis) 		5 / 12 TYR A 155
GLY A 145
ALA A 157
SER A 158
TYR A 189
 SS2  A1260 ( 4.2A)
None
None
None
None
 1.28A 1nbiC-1zjyA:
5.4		 1nbiC-1zjyA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 1zjy R-SPECIFIC ALCOHOL
DEHYDROGENASE
(Lactobacillus
brevis) 		5 / 12 TYR A 155
GLY A 145
ALA A 157
SER A 158
TYR A 189
 SS2  A1260 ( 4.2A)
None
None
None
None
 1.27A 1nbiD-1zjyA:
5.4		 1nbiD-1zjyA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PKV_A_RBFA100_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 1zjy R-SPECIFIC ALCOHOL
DEHYDROGENASE
(Lactobacillus
brevis) 		5 / 11 SER A 136
LEU A  86
THR A  12
THR A  36
ILE A  22
 None
 1.05A 1pkvA-1zjyA:
undetectable
1pkvB-1zjyA:
undetectable		 1pkvA-1zjyA:
18.15
1pkvB-1zjyA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHY_A_CLMA999_0
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)		 1zjy R-SPECIFIC ALCOHOL
DEHYDROGENASE
(Lactobacillus
brevis) 		5 / 12 VAL A 185
ILE A 138
ILE A  22
ILE A  18
VAL A 244
 None
None
None
NAI  A1270 (-3.6A)
None
 1.04A 1qhyA-1zjyA:
3.6		 1qhyA-1zjyA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_E_SAME301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1zjy R-SPECIFIC ALCOHOL
DEHYDROGENASE
(Lactobacillus
brevis) 		6 / 12 GLY A  13
ASP A  37
ARG A  38
ASP A  62
ASN A  89
ALA A  90
 NAI  A1270 (-2.9A)
NAI  A1270 (-2.9A)
NAI  A1270 (-4.6A)
NAI  A1270 (-3.1A)
NAI  A1270 (-3.0A)
NAI  A1270 (-3.2A)
 1.18A 2bm9E-1zjyA:
5.6		 2bm9E-1zjyA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_C_SAMC301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1zjy R-SPECIFIC ALCOHOL
DEHYDROGENASE
(Lactobacillus
brevis) 		5 / 12 GLY A  13
ARG A  38
ASP A  62
SER A  64
ALA A  90
 NAI  A1270 (-2.9A)
NAI  A1270 (-4.6A)
NAI  A1270 (-3.1A)
None
NAI  A1270 (-3.2A)
 1.06A 2br4C-1zjyA:
6.0		 2br4C-1zjyA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_B_9CRB501_1
(CYTOCHROME P450 2C8)		 1zjy R-SPECIFIC ALCOHOL
DEHYDROGENASE
(Lactobacillus
brevis) 		5 / 9 GLY A  51
SER A  49
VAL A  33
ILE A  11
VAL A  87
 None
 1.12A 2nnhB-1zjyA:
undetectable		 2nnhB-1zjyA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNI_A_MTKA501_2
(CYTOCHROME P450 2C8)		 1zjy R-SPECIFIC ALCOHOL
DEHYDROGENASE
(Lactobacillus
brevis) 		5 / 8 ILE A  22
ILE A  56
ASN A  88
VAL A  87
ALA A   9
 None
 1.26A 2nniA-1zjyA:
undetectable		 2nniA-1zjyA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_A_SAMA400_0
(UNCHARACTERIZED
PROTEIN TFU_2867)		 1zjy R-SPECIFIC ALCOHOL
DEHYDROGENASE
(Lactobacillus
brevis) 		5 / 12 ILE A  22
ALA A  21
GLY A  17
ILE A 222
GLY A  13
 None
None
NAI  A1270 (-3.9A)
None
NAI  A1270 (-2.9A)
 0.75A 2qe6A-1zjyA:
6.7		 2qe6A-1zjyA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_B_SAMB400_0
(UNCHARACTERIZED
PROTEIN TFU_2867)		 1zjy R-SPECIFIC ALCOHOL
DEHYDROGENASE
(Lactobacillus
brevis) 		5 / 12 ILE A  22
ALA A  21
GLY A  17
ILE A 222
GLY A  13
 None
None
NAI  A1270 (-3.9A)
None
NAI  A1270 (-2.9A)
 0.78A 2qe6B-1zjyA:
6.5		 2qe6B-1zjyA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W1B_A_DXCA2034_0
(ACRIFLAVIN
RESISTANCE PROTEIN B)		 1zjy R-SPECIFIC ALCOHOL
DEHYDROGENASE
(Lactobacillus
brevis) 		3 / 3 PHE A  26
SER A  84
LEU A  86
 None
 0.81A 2w1bA-1zjyA:
undetectable		 2w1bA-1zjyA:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BPX_A_SALA257_1
(TRANSCRIPTIONAL
REGULATOR)		 1zjy R-SPECIFIC ALCOHOL
DEHYDROGENASE
(Lactobacillus
brevis) 		4 / 8 ALA A 170
CYH A 173
THR A 121
ILE A 125
 None
 0.98A 3bpxA-1zjyA:
undetectable
3bpxB-1zjyA:
undetectable		 3bpxA-1zjyA:
20.08
3bpxB-1zjyA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NMU_J_SAMJ228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 1zjy R-SPECIFIC ALCOHOL
DEHYDROGENASE
(Lactobacillus
brevis) 		5 / 11 GLY A  13
ALA A  90
ILE A  11
ALA A  23
ASP A  37
 NAI  A1270 (-2.9A)
NAI  A1270 (-3.2A)
None
None
NAI  A1270 (-2.9A)
 1.08A 3nmuB-1zjyA:
undetectable
3nmuJ-1zjyA:
7.9		 3nmuB-1zjyA:
21.96
3nmuJ-1zjyA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_C_ACTC610_0
(GBAA_1210 PROTEIN)		 1zjy R-SPECIFIC ALCOHOL
DEHYDROGENASE
(Lactobacillus
brevis) 		3 / 3 ASN A 183
ALA A 237
ARG A 181
 None
 0.77A 3tj7C-1zjyA:
undetectable
3tj7D-1zjyA:
undetectable		 3tj7C-1zjyA:
19.61
3tj7D-1zjyA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UBO_B_ADNB353_2
(ADENOSINE KINASE)		 1zjy R-SPECIFIC ALCOHOL
DEHYDROGENASE
(Lactobacillus
brevis) 		4 / 5 SER A 142
ILE A  18
TYR A 155
GLY A 188
 NAI  A1270 ( 3.8A)
NAI  A1270 (-3.6A)
SS2  A1260 ( 4.2A)
None
 1.02A 3uboB-1zjyA:
6.5		 3uboB-1zjyA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0V_A_MIXA1301_1
(DNA TOPOISOMERASE
2-BETA)		 1zjy R-SPECIFIC ALCOHOL
DEHYDROGENASE
(Lactobacillus
brevis) 		4 / 7 ARG A 122
GLY A 124
ILE A 137
ASN A 139
 None
 0.96A 4g0vA-1zjyA:
2.1		 4g0vA-1zjyA:
16.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		 1zjy R-SPECIFIC ALCOHOL
DEHYDROGENASE
(Lactobacillus
brevis) 		4 / 7 ILE A 225
LEU A 229
HIS A 186
VAL A 243
 None
 0.73A 4g77A-1zjyA:
undetectable		 4g77A-1zjyA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_A_STRA604_1
(CYTOCHROME P450
21-HYDROXYLASE)		 1zjy R-SPECIFIC ALCOHOL
DEHYDROGENASE
(Lactobacillus
brevis) 		5 / 12 SER A  63
LEU A 109
ILE A  92
GLY A  91
VAL A 162
 NAI  A1270 (-3.9A)
None
NAI  A1270 (-4.6A)
NAI  A1270 (-3.9A)
None
 1.00A 4y8wA-1zjyA:
undetectable		 4y8wA-1zjyA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_B_STRB603_1
(CYTOCHROME P450
21-HYDROXYLASE)		 1zjy R-SPECIFIC ALCOHOL
DEHYDROGENASE
(Lactobacillus
brevis) 		5 / 12 ASP A  62
LEU A 109
ILE A  92
GLY A  91
VAL A 162
 NAI  A1270 (-3.1A)
None
NAI  A1270 (-4.6A)
NAI  A1270 (-3.9A)
None
 1.02A 4y8wB-1zjyA:
undetectable		 4y8wB-1zjyA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJ8_A_SUVA2001_2
(HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE)		 1zjy R-SPECIFIC ALCOHOL
DEHYDROGENASE
(Lactobacillus
brevis) 		4 / 6 ILE A 190
PRO A 219
ILE A  11
VAL A  87
 NAI  A1270 (-4.6A)
None
None
None
 1.01A 4zj8A-1zjyA:
5.3		 4zj8A-1zjyA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI2_A_BAXA801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1zjy R-SPECIFIC ALCOHOL
DEHYDROGENASE
(Lactobacillus
brevis) 		5 / 8 VAL A  87
ILE A  35
ILE A  22
ILE A  56
PHE A  80
 None
 1.04A 5hi2A-1zjyA:
undetectable		 5hi2A-1zjyA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0R_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 1zjy R-SPECIFIC ALCOHOL
DEHYDROGENASE
(Lactobacillus
brevis) 		4 / 4 SER A 168
ALA A 169
GLN A 126
THR A 121
 None
 1.31A 5n0rA-1zjyA:
2.0		 5n0rA-1zjyA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 1zjy R-SPECIFIC ALCOHOL
DEHYDROGENASE
(Lactobacillus
brevis) 		4 / 4 SER A 168
ALA A 169
GLN A 126
THR A 121
 None
 1.31A 5n0sA-1zjyA:
1.8		 5n0sA-1zjyA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 1zjy R-SPECIFIC ALCOHOL
DEHYDROGENASE
(Lactobacillus
brevis) 		4 / 5 SER A 168
ALA A 169
GLN A 126
THR A 121
 None
 1.27A 5n0tA-1zjyA:
undetectable		 5n0tA-1zjyA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 1zjy R-SPECIFIC ALCOHOL
DEHYDROGENASE
(Lactobacillus
brevis) 		4 / 4 SER A 168
ALA A 169
GLN A 126
THR A 121
 None
 1.34A 5n0xA-1zjyA:
2.1		 5n0xA-1zjyA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND2_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 1zjy R-SPECIFIC ALCOHOL
DEHYDROGENASE
(Lactobacillus
brevis) 		5 / 12 ASP A  67
GLU A  66
HIS A  61
ARG A 122
LEU A 123
 None
 1.42A 5nd2B-1zjyA:
7.0		 5nd2B-1zjyA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1zjy R-SPECIFIC ALCOHOL
DEHYDROGENASE
(Lactobacillus
brevis) 		3 / 3 ARG A 127
LEU A 123
PHE A 119
 None
 0.51A 6nknP-1zjyA:
undetectable		 6nknP-1zjyA:
18.55