SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1zk5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P2Y_A_NCTA440_1
(CYTOCHROME P450-CAM)		 1zk5 F17G ADHESIN SUBUNIT
(Escherichia
coli) 		4 / 7 LEU A  62
VAL A  60
GLY A 145
VAL A 122
 None
 0.78A 1p2yA-1zk5A:
undetectable		 1p2yA-1zk5A:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_A_8MOA501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 1zk5 F17G ADHESIN SUBUNIT
(Escherichia
coli) 		5 / 11 VAL A 139
PHE A 171
GLY A  75
ILE A 144
LEU A 168
 None
 1.06A 1z11A-1zk5A:
undetectable		 1z11A-1zk5A:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_B_8MOB501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 1zk5 F17G ADHESIN SUBUNIT
(Escherichia
coli) 		5 / 11 VAL A 139
PHE A 171
GLY A  75
ILE A 144
LEU A 168
 None
 1.06A 1z11B-1zk5A:
undetectable		 1z11B-1zk5A:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 1zk5 F17G ADHESIN SUBUNIT
(Escherichia
coli) 		4 / 8 ILE A 147
ASP A  61
GLY A 145
PHE A 166
 None
 0.91A 2tsrB-1zk5A:
undetectable		 2tsrB-1zk5A:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB2_A_IBPA3960_1
(LACTOTRANSFERRIN)		 1zk5 F17G ADHESIN SUBUNIT
(Escherichia
coli) 		4 / 4 GLY A  39
VAL A 124
GLY A  94
THR A  95
 None
 0.89A 3ib2A-1zk5A:
undetectable		 3ib2A-1zk5A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N62_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 1zk5 F17G ADHESIN SUBUNIT
(Escherichia
coli) 		3 / 3 GLY A 119
TRP A 109
VAL A  54
 NAG  A 301 (-3.6A)
NAG  A 301 (-3.9A)
None
 0.69A 3n62B-1zk5A:
undetectable		 3n62B-1zk5A:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N65_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 1zk5 F17G ADHESIN SUBUNIT
(Escherichia
coli) 		3 / 3 GLY A 119
TRP A 109
VAL A  54
 NAG  A 301 (-3.6A)
NAG  A 301 (-3.9A)
None
 0.68A 3n65B-1zk5A:
undetectable		 3n65B-1zk5A:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N66_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 1zk5 F17G ADHESIN SUBUNIT
(Escherichia
coli) 		3 / 3 GLY A 119
TRP A 109
VAL A  54
 NAG  A 301 (-3.6A)
NAG  A 301 (-3.9A)
None
 0.70A 3n66B-1zk5A:
undetectable		 3n66B-1zk5A:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9L_A_CAMA1419_0
(CYTOCHROME P450)		 1zk5 F17G ADHESIN SUBUNIT
(Escherichia
coli) 		5 / 12 ILE A  38
THR A 142
LEU A  62
GLY A  75
THR A  77
 None
 0.97A 4c9lA-1zk5A:
undetectable		 4c9lA-1zk5A:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9L_B_CAMB1419_0
(CYTOCHROME P450)		 1zk5 F17G ADHESIN SUBUNIT
(Escherichia
coli) 		5 / 12 ILE A  38
THR A 142
LEU A  62
GLY A  75
THR A  77
 None
 0.95A 4c9lB-1zk5A:
undetectable		 4c9lB-1zk5A:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9O_B_CAMB423_0
(CYTOCHROME P450)		 1zk5 F17G ADHESIN SUBUNIT
(Escherichia
coli) 		5 / 12 ILE A  38
THR A 142
LEU A  62
GLY A  75
THR A  77
 None
 0.94A 4c9oB-1zk5A:
undetectable		 4c9oB-1zk5A:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUO_B_ACTB804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1zk5 F17G ADHESIN SUBUNIT
(Escherichia
coli) 		3 / 3 GLY A 119
TRP A 109
VAL A  54
 NAG  A 301 (-3.6A)
NAG  A 301 (-3.9A)
None
 0.65A 5vuoB-1zk5A:
undetectable		 5vuoB-1zk5A:
18.23