SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1zk7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBY_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1zk7 MERCURIC REDUCTASE
(Pseudomonas
aeruginosa) 		6 / 12 ALA A 452
ALA A 451
GLN A 453
LEU A 434
ALA A 435
VAL A 356
 None
None
GOL  A3003 ( 3.8A)
None
None
None
 1.30A 1fbyA-1zk7A:
undetectable		 1fbyA-1zk7A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBY_B_9CRB1500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1zk7 MERCURIC REDUCTASE
(Pseudomonas
aeruginosa) 		6 / 12 ALA A 452
ALA A 451
GLN A 453
LEU A 434
ALA A 435
VAL A 356
 None
None
GOL  A3003 ( 3.8A)
None
None
None
 1.29A 1fbyB-1zk7A:
undetectable		 1fbyB-1zk7A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_A_9CRA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1zk7 MERCURIC REDUCTASE
(Pseudomonas
aeruginosa) 		6 / 12 ALA A 452
ALA A 451
GLN A 453
LEU A 434
ALA A 435
VAL A 356
 None
None
GOL  A3003 ( 3.8A)
None
None
None
 1.21A 1fm6A-1zk7A:
undetectable		 1fm6A-1zk7A:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IHI_A_IU5A326_1
(3-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE)		 1zk7 MERCURIC REDUCTASE
(Pseudomonas
aeruginosa) 		5 / 10 VAL A 181
VAL A 202
ILE A 231
GLU A 190
LEU A 210
 None
None
None
FAD  A 666 ( 4.7A)
None
 1.43A 1ihiA-1zk7A:
0.7		 1ihiA-1zk7A:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK9_C_2FAC308_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1zk7 MERCURIC REDUCTASE
(Pseudomonas
aeruginosa) 		5 / 11 SER A 359
GLY A 406
VAL A 356
GLU A 214
ILE A 425
 None
 1.26A 1pk9C-1zk7A:
undetectable		 1pk9C-1zk7A:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PW7_B_RABB646_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1zk7 MERCURIC REDUCTASE
(Pseudomonas
aeruginosa) 		5 / 9 SER A 359
GLY A 406
VAL A 356
GLU A 214
ILE A 425
 None
 1.33A 1pw7B-1zk7A:
undetectable		 1pw7B-1zk7A:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOB_A_PNNA1311_1
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 1zk7 MERCURIC REDUCTASE
(Pseudomonas
aeruginosa) 		3 / 3 ARG A 128
ARG A 118
ILE A  33
 None
 0.67A 1uobA-1zk7A:
undetectable		 1uobA-1zk7A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_A_ADNA252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1zk7 MERCURIC REDUCTASE
(Pseudomonas
aeruginosa) 		5 / 11 SER A 359
GLY A 406
VAL A 356
GLU A 214
ILE A 425
 None
 1.26A 1vhwA-1zk7A:
undetectable
1vhwD-1zk7A:
undetectable		 1vhwA-1zk7A:
19.49
1vhwD-1zk7A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_C_ADNC252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1zk7 MERCURIC REDUCTASE
(Pseudomonas
aeruginosa) 		5 / 11 SER A 359
GLY A 406
VAL A 356
GLU A 214
ILE A 425
 None
 1.29A 1vhwC-1zk7A:
undetectable
1vhwE-1zk7A:
undetectable		 1vhwC-1zk7A:
19.49
1vhwE-1zk7A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_D_ADND252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1zk7 MERCURIC REDUCTASE
(Pseudomonas
aeruginosa) 		5 / 11 SER A 359
GLY A 406
VAL A 356
GLU A 214
ILE A 425
 None
 1.28A 1vhwA-1zk7A:
undetectable
1vhwD-1zk7A:
undetectable		 1vhwA-1zk7A:
19.49
1vhwD-1zk7A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_E_ADNE252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1zk7 MERCURIC REDUCTASE
(Pseudomonas
aeruginosa) 		5 / 11 SER A 359
GLY A 406
VAL A 356
GLU A 214
ILE A 425
 None
 1.27A 1vhwC-1zk7A:
undetectable
1vhwE-1zk7A:
undetectable		 1vhwC-1zk7A:
19.49
1vhwE-1zk7A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_E_9CRE1500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1zk7 MERCURIC REDUCTASE
(Pseudomonas
aeruginosa) 		6 / 12 ALA A 452
ALA A 451
GLN A 453
LEU A 434
ALA A 435
VAL A 356
 None
None
GOL  A3003 ( 3.8A)
None
None
None
 1.41A 1xdkE-1zk7A:
undetectable		 1xdkE-1zk7A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XIU_A_9CRA201_1
(RXR-LIKE PROTEIN)		 1zk7 MERCURIC REDUCTASE
(Pseudomonas
aeruginosa) 		6 / 12 ALA A 452
ALA A 451
GLN A 453
LEU A 434
ALA A 435
VAL A 356
 None
None
GOL  A3003 ( 3.8A)
None
None
None
 1.30A 1xiuA-1zk7A:
undetectable		 1xiuA-1zk7A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_A_REAA502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1zk7 MERCURIC REDUCTASE
(Pseudomonas
aeruginosa) 		5 / 12 ALA A 452
ALA A 451
GLN A 453
LEU A 434
ALA A 435
 None
None
GOL  A3003 ( 3.8A)
None
None
 0.88A 2aclA-1zk7A:
undetectable
2aclE-1zk7A:
undetectable		 2aclA-1zk7A:
19.28
2aclE-1zk7A:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_C_REAC503_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1zk7 MERCURIC REDUCTASE
(Pseudomonas
aeruginosa) 		5 / 10 ALA A 452
ALA A 451
GLN A 453
ALA A 435
ILE A 418
 None
None
GOL  A3003 ( 3.8A)
None
None
 0.95A 2aclC-1zk7A:
undetectable		 2aclC-1zk7A:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_G_REAG501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1zk7 MERCURIC REDUCTASE
(Pseudomonas
aeruginosa) 		5 / 12 ALA A 452
ALA A 451
GLN A 453
LEU A 434
ALA A 435
 None
None
GOL  A3003 ( 3.8A)
None
None
 0.83A 2aclG-1zk7A:
undetectable		 2aclG-1zk7A:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_A_SAMA301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1zk7 MERCURIC REDUCTASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 125
GLU A  34
GLY A  11
ALA A 145
ALA A 307
 None
FAD  A 666 (-2.5A)
FAD  A 666 (-3.2A)
FAD  A 666 (-4.9A)
None
 1.06A 2bm9A-1zk7A:
4.1		 2bm9A-1zk7A:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_C_SAMC301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1zk7 MERCURIC REDUCTASE
(Pseudomonas
aeruginosa) 		5 / 12 GLU A  34
GLY A  11
ASN A 272
ALA A  16
ALA A  19
 FAD  A 666 (-2.5A)
FAD  A 666 (-3.2A)
SO4  A2002 (-3.8A)
None
None
 1.13A 2bm9C-1zk7A:
3.2		 2bm9C-1zk7A:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_D_SAMD301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1zk7 MERCURIC REDUCTASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 125
GLU A  34
GLY A  11
ALA A 145
ALA A 307
 None
FAD  A 666 (-2.5A)
FAD  A 666 (-3.2A)
FAD  A 666 (-4.9A)
None
 1.11A 2bm9D-1zk7A:
3.2		 2bm9D-1zk7A:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_A_SAMA301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1zk7 MERCURIC REDUCTASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 276
GLU A  34
GLY A  11
ALA A 145
ALA A 307
 None
FAD  A 666 (-2.5A)
FAD  A 666 (-3.2A)
FAD  A 666 (-4.9A)
None
 0.98A 2br4A-1zk7A:
3.3		 2br4A-1zk7A:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_B_SAMB301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1zk7 MERCURIC REDUCTASE
(Pseudomonas
aeruginosa) 		5 / 12 GLU A  34
GLY A  11
ASN A 272
ALA A  16
ALA A  19
 FAD  A 666 (-2.5A)
FAD  A 666 (-3.2A)
SO4  A2002 (-3.8A)
None
None
 1.09A 2br4B-1zk7A:
3.3		 2br4B-1zk7A:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_D_SAMD301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1zk7 MERCURIC REDUCTASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 276
GLU A  34
GLY A  11
ALA A 145
ALA A 307
 None
FAD  A 666 (-2.5A)
FAD  A 666 (-3.2A)
FAD  A 666 (-4.9A)
None
 1.02A 2br4D-1zk7A:
3.4		 2br4D-1zk7A:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_E_SAME301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1zk7 MERCURIC REDUCTASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 276
GLU A  34
GLY A  11
ALA A 145
ALA A 307
 None
FAD  A 666 (-2.5A)
FAD  A 666 (-3.2A)
FAD  A 666 (-4.9A)
None
 1.01A 2br4E-1zk7A:
3.4		 2br4E-1zk7A:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_F_SAMF301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1zk7 MERCURIC REDUCTASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 276
GLU A  34
GLY A  11
ALA A 145
ALA A 307
 None
FAD  A 666 (-2.5A)
FAD  A 666 (-3.2A)
FAD  A 666 (-4.9A)
None
 1.01A 2br4F-1zk7A:
3.4		 2br4F-1zk7A:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_B_GBNB914_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 1zk7 MERCURIC REDUCTASE
(Pseudomonas
aeruginosa) 		5 / 10 GLY A  14
GLY A 324
THR A 325
ALA A 322
ALA A 323
 FAD  A 666 (-3.9A)
None
SO4  A2001 (-4.6A)
SO4  A2001 (-3.4A)
None
 0.92A 2ej3B-1zk7A:
undetectable		 2ej3B-1zk7A:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_C_GBNC1414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 1zk7 MERCURIC REDUCTASE
(Pseudomonas
aeruginosa) 		5 / 8 GLY A  14
GLY A 324
THR A 325
ALA A 322
ALA A 323
 FAD  A 666 (-3.9A)
None
SO4  A2001 (-4.6A)
SO4  A2001 (-3.4A)
None
 0.94A 2ej3C-1zk7A:
1.4		 2ej3C-1zk7A:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_C_GBNC1414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 1zk7 MERCURIC REDUCTASE
(Pseudomonas
aeruginosa) 		5 / 8 GLY A 308
GLY A 324
THR A 325
ALA A 322
ALA A 323
 FAD  A 666 (-3.2A)
None
SO4  A2001 (-4.6A)
SO4  A2001 (-3.4A)
None
 1.43A 2ej3C-1zk7A:
1.4		 2ej3C-1zk7A:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6H_B_MXDB551_1
(PROSTACYCLIN
SYNTHASE)		 1zk7 MERCURIC REDUCTASE
(Pseudomonas
aeruginosa) 		4 / 6 ALA A 192
LEU A 191
ALA A 266
THR A 267
 None
 0.93A 3b6hB-1zk7A:
undetectable		 3b6hB-1zk7A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_A_V2HA602_0
(CYTOCHROME P450 2R1)		 1zk7 MERCURIC REDUCTASE
(Pseudomonas
aeruginosa) 		5 / 12 THR A 299
ALA A 277
VAL A 127
ILE A  10
THR A 126
 None
None
None
FAD  A 666 (-4.7A)
None
 1.25A 3dl9A-1zk7A:
undetectable		 3dl9A-1zk7A:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E00_A_9CRA7223_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1zk7 MERCURIC REDUCTASE
(Pseudomonas
aeruginosa) 		6 / 12 ALA A 452
ALA A 451
GLN A 453
ALA A 435
VAL A 356
ILE A 418
 None
None
GOL  A3003 ( 3.8A)
None
None
None
 1.18A 3e00A-1zk7A:
undetectable		 3e00A-1zk7A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FAL_A_REAA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1zk7 MERCURIC REDUCTASE
(Pseudomonas
aeruginosa) 		6 / 10 ALA A 452
ALA A 451
GLN A 453
ALA A 435
VAL A 356
ILE A 418
 None
None
GOL  A3003 ( 3.8A)
None
None
None
 1.13A 3falA-1zk7A:
undetectable		 3falA-1zk7A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FAL_C_REAC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1zk7 MERCURIC REDUCTASE
(Pseudomonas
aeruginosa) 		5 / 10 ALA A 452
ALA A 451
GLN A 453
LEU A 434
ALA A 435
 None
None
GOL  A3003 ( 3.8A)
None
None
 0.91A 3falC-1zk7A:
undetectable		 3falC-1zk7A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FC6_A_REAA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1zk7 MERCURIC REDUCTASE
(Pseudomonas
aeruginosa) 		5 / 11 ALA A 452
ALA A 451
GLN A 453
LEU A 434
ALA A 435
 None
None
GOL  A3003 ( 3.8A)
None
None
 0.95A 3fc6A-1zk7A:
undetectable		 3fc6A-1zk7A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FC6_C_REAC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1zk7 MERCURIC REDUCTASE
(Pseudomonas
aeruginosa) 		6 / 12 ALA A 452
ALA A 451
GLN A 453
LEU A 434
ALA A 435
VAL A 356
 None
None
GOL  A3003 ( 3.8A)
None
None
None
 1.25A 3fc6C-1zk7A:
undetectable		 3fc6C-1zk7A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_A_THHA642_1
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 1zk7 MERCURIC REDUCTASE
(Pseudomonas
aeruginosa) 		3 / 3 ASN A 330
ASP A 335
ARG A 426
 None
 0.84A 3k13A-1zk7A:
undetectable		 3k13A-1zk7A:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OAP_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1zk7 MERCURIC REDUCTASE
(Pseudomonas
aeruginosa) 		6 / 12 ALA A 452
ALA A 451
GLN A 453
LEU A 434
ALA A 435
VAL A 356
 None
None
GOL  A3003 ( 3.8A)
None
None
None
 1.26A 3oapA-1zk7A:
undetectable		 3oapA-1zk7A:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DUB_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT 9D7)		 1zk7 MERCURIC REDUCTASE
(Pseudomonas
aeruginosa) 		4 / 6 ALA A 421
GLY A 447
LEU A 417
VAL A 445
 None
 0.90A 4dubB-1zk7A:
undetectable		 4dubB-1zk7A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J14_A_X2NA602_1
(CHOLESTEROL
24-HYDROXYLASE)		 1zk7 MERCURIC REDUCTASE
(Pseudomonas
aeruginosa) 		5 / 10 ALA A 451
LEU A 448
ILE A 425
ALA A 422
ALA A 354
 None
 1.08A 4j14A-1zk7A:
undetectable		 4j14A-1zk7A:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NQA_H_9CRH501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1zk7 MERCURIC REDUCTASE
(Pseudomonas
aeruginosa) 		5 / 12 ALA A 452
ALA A 451
GLN A 453
LEU A 434
ALA A 435
 None
None
GOL  A3003 ( 3.8A)
None
None
 0.78A 4nqaH-1zk7A:
undetectable		 4nqaH-1zk7A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 1zk7 MERCURIC REDUCTASE
(Pseudomonas
aeruginosa) 		5 / 10 ALA A  19
THR A 325
ALA A 323
ALA A 327
GLY A  13
 None
SO4  A2001 (-4.6A)
None
None
FAD  A 666 (-3.4A)
 0.90A 4qvyK-1zk7A:
undetectable
4qvyL-1zk7A:
undetectable		 4qvyK-1zk7A:
19.27
4qvyL-1zk7A:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 1zk7 MERCURIC REDUCTASE
(Pseudomonas
aeruginosa) 		5 / 10 ALA A  19
THR A 325
ALA A 323
ALA A 327
GLY A  13
 None
SO4  A2001 (-4.6A)
None
None
FAD  A 666 (-3.4A)
 0.90A 4qvyY-1zk7A:
undetectable
4qvyZ-1zk7A:
undetectable		 4qvyY-1zk7A:
19.27
4qvyZ-1zk7A:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE5_A_OBNA1104_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 1zk7 MERCURIC REDUCTASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 462
GLU A 413
GLY A 447
ALA A 451
ASP A 388
 None
 1.27A 4xe5A-1zk7A:
undetectable		 4xe5A-1zk7A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1zk7 MERCURIC REDUCTASE
(Pseudomonas
aeruginosa) 		4 / 4 GLY A  36
LEU A 276
PHE A 119
ILE A  10
 FAD  A 666 ( 4.6A)
None
None
FAD  A 666 (-4.7A)
 0.90A 4xv2A-1zk7A:
undetectable		 4xv2A-1zk7A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPM_A_BO2A801_1
(LON PROTEASE)		 1zk7 MERCURIC REDUCTASE
(Pseudomonas
aeruginosa) 		5 / 12 ALA A 239
THR A 237
THR A 253
LEU A 251
THR A 203
 None
 1.03A 4ypmA-1zk7A:
undetectable		 4ypmA-1zk7A:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4F_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 1zk7 MERCURIC REDUCTASE
(Pseudomonas
aeruginosa) 		4 / 7 LEU A 170
PRO A  49
LEU A 191
GLU A 190
 None
None
None
FAD  A 666 ( 4.7A)
 1.07A 4z4fA-1zk7A:
undetectable		 4z4fA-1zk7A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_B_DB8B800_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 1zk7 MERCURIC REDUCTASE
(Pseudomonas
aeruginosa) 		5 / 10 ALA A 414
ILE A 418
GLY A 447
LEU A 448
ALA A 421
 None
 1.32A 5ajqB-1zk7A:
undetectable		 5ajqB-1zk7A:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB5_A_010A609_0
(HNL ISOENZYME 5)		 1zk7 MERCURIC REDUCTASE
(Pseudomonas
aeruginosa) 		5 / 11 ALA A 225
ALA A 221
VAL A 410
LEU A 189
VAL A 353
 None
 1.13A 5eb5A-1zk7A:
9.8		 5eb5A-1zk7A:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB5_B_010B607_0
(HNL ISOENZYME 5)		 1zk7 MERCURIC REDUCTASE
(Pseudomonas
aeruginosa) 		5 / 10 ALA A 225
ALA A 221
VAL A 410
LEU A 189
VAL A 353
 None
 1.21A 5eb5B-1zk7A:
10.6		 5eb5B-1zk7A:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_A_AC2A301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 1zk7 MERCURIC REDUCTASE
(Pseudomonas
aeruginosa) 		5 / 9 SER A 359
GLY A 406
VAL A 356
GLU A 214
ILE A 425
 None
 1.33A 5i3cA-1zk7A:
undetectable		 5i3cA-1zk7A:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K9D_A_CE9A402_0
(DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL)		 1zk7 MERCURIC REDUCTASE
(Pseudomonas
aeruginosa) 		5 / 12 ALA A 188
LEU A 191
ALA A 192
PHE A 195
PHE A 226
 None
 1.03A 5k9dA-1zk7A:
undetectable		 5k9dA-1zk7A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND7_B_TA1B601_2
(TUBULIN BETA-2B
CHAIN)		 1zk7 MERCURIC REDUCTASE
(Pseudomonas
aeruginosa) 		3 / 3 THR A  37
PRO A  49
ARG A  91
 None
 0.87A 5nd7B-1zk7A:
undetectable		 5nd7B-1zk7A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UAN_A_9CRA503_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1zk7 MERCURIC REDUCTASE
(Pseudomonas
aeruginosa) 		6 / 12 ALA A 452
ALA A 451
GLN A 453
LEU A 434
ALA A 435
VAL A 356
 None
None
GOL  A3003 ( 3.8A)
None
None
None
 1.22A 5uanA-1zk7A:
undetectable		 5uanA-1zk7A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Z_L_9CRL501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1zk7 MERCURIC REDUCTASE
(Pseudomonas
aeruginosa) 		5 / 12 ALA A 452
ALA A 451
GLN A 453
LEU A 434
ALA A 435
 None
None
GOL  A3003 ( 3.8A)
None
None
 0.86A 6a5zL-1zk7A:
undetectable		 6a5zL-1zk7A:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A60_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1zk7 MERCURIC REDUCTASE
(Pseudomonas
aeruginosa) 		5 / 12 ALA A 452
ALA A 451
GLN A 453
ALA A 435
ILE A 418
 None
None
GOL  A3003 ( 3.8A)
None
None
 1.01A 6a60D-1zk7A:
undetectable		 6a60D-1zk7A:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYC_A_1YNA502_2
(PROTEIN CYP51)		 1zk7 MERCURIC REDUCTASE
(Pseudomonas
aeruginosa) 		4 / 7 VAL A 380
PHE A 455
PHE A 439
LEU A 434
 None
 1.20A 6aycA-1zk7A:
undetectable		 6aycA-1zk7A:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA503_0
(ADENOSYLHOMOCYSTEINA
SE)		 1zk7 MERCURIC REDUCTASE
(Pseudomonas
aeruginosa) 		5 / 10 GLY A  11
GLY A  13
GLU A  34
THR A 146
ASN A 272
 FAD  A 666 (-3.2A)
FAD  A 666 (-3.4A)
FAD  A 666 (-2.5A)
FAD  A 666 (-3.8A)
SO4  A2002 (-3.8A)
 0.89A 6exiA-1zk7A:
4.1		 6exiA-1zk7A:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_B_ADNB503_1
(ADENOSYLHOMOCYSTEINA
SE)		 1zk7 MERCURIC REDUCTASE
(Pseudomonas
aeruginosa) 		5 / 10 GLY A  11
GLY A  13
GLU A  34
THR A 146
ASN A 272
 FAD  A 666 (-3.2A)
FAD  A 666 (-3.4A)
FAD  A 666 (-2.5A)
FAD  A 666 (-3.8A)
SO4  A2002 (-3.8A)
 0.93A 6exiB-1zk7A:
4.0		 6exiB-1zk7A:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_C_ADNC503_0
(ADENOSYLHOMOCYSTEINA
SE)		 1zk7 MERCURIC REDUCTASE
(Pseudomonas
aeruginosa) 		5 / 12 GLY A  11
GLY A  13
GLU A  34
THR A 146
ASN A 272
 FAD  A 666 (-3.2A)
FAD  A 666 (-3.4A)
FAD  A 666 (-2.5A)
FAD  A 666 (-3.8A)
SO4  A2002 (-3.8A)
 0.92A 6exiC-1zk7A:
3.8
6exiD-1zk7A:
4.0		 6exiC-1zk7A:
10.28
6exiD-1zk7A:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND503_0
(ADENOSYLHOMOCYSTEINA
SE)		 1zk7 MERCURIC REDUCTASE
(Pseudomonas
aeruginosa) 		5 / 12 GLY A  11
GLY A  13
GLU A  34
THR A 146
ASN A 272
 FAD  A 666 (-3.2A)
FAD  A 666 (-3.4A)
FAD  A 666 (-2.5A)
FAD  A 666 (-3.8A)
SO4  A2002 (-3.8A)
 0.89A 6exiC-1zk7A:
3.8
6exiD-1zk7A:
4.1		 6exiC-1zk7A:
10.28
6exiD-1zk7A:
10.28