SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1zkc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EFJ_A_37TA502_1
(3,7-DIMETHYLXANTHINE
METHYLTRANSFERASE)		 1zkc PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
LIKE 2
(Homo
sapiens) 		5 / 12 TYR A 316
LEU A 366
ILE A 330
ILE A 426
ILE A 428
 None
 1.36A 2efjA-1zkcA:
undetectable		 2efjA-1zkcA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJT_A_SAMA501_0
(N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE)		 1zkc PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
LIKE 2
(Homo
sapiens) 		5 / 12 LEU A 390
ALA A 388
ILE A 396
SER A 359
PHE A 381
 None
 1.24A 2ejtA-1zkcA:
undetectable		 2ejtA-1zkcA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD2_A_CHDA2_0
(FERROCHELATASE)		 1zkc PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
LIKE 2
(Homo
sapiens) 		4 / 8 MET A 410
LEU A 407
PRO A 422
SER A 415
 None
 1.07A 2qd2A-1zkcA:
undetectable		 2qd2A-1zkcA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD2_B_CHDB1_0
(FERROCHELATASE)		 1zkc PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
LIKE 2
(Homo
sapiens) 		5 / 10 MET A 410
LEU A 407
PRO A 422
SER A 415
GLY A 332
 None
 1.22A 2qd2B-1zkcA:
0.0		 2qd2B-1zkcA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_B_CHDB926_0
(FERROCHELATASE)		 1zkc PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
LIKE 2
(Homo
sapiens) 		5 / 10 MET A 410
LEU A 407
PRO A 422
SER A 415
GLY A 332
 None
 1.22A 2qd4B-1zkcA:
0.0		 2qd4B-1zkcA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_A_CHDA701_0
(FERROCHELATASE)		 1zkc PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
LIKE 2
(Homo
sapiens) 		4 / 8 MET A 410
LEU A 407
SER A 415
GLY A 332
 None
 1.08A 2qd5A-1zkcA:
undetectable		 2qd5A-1zkcA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_B_CHDB1103_0
(FERROCHELATASE)		 1zkc PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
LIKE 2
(Homo
sapiens) 		4 / 8 MET A 410
LEU A 407
SER A 415
GLY A 332
 None
 1.00A 2qd5B-1zkcA:
undetectable		 2qd5B-1zkcA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1373_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 1zkc PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
LIKE 2
(Homo
sapiens) 		4 / 8 PHE A 397
TYR A 438
PHE A 350
ASN A 376
 None
 1.16A 2wekA-1zkcA:
undetectable		 2wekA-1zkcA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1373_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 1zkc PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
LIKE 2
(Homo
sapiens) 		4 / 8 PHE A 397
TYR A 438
PHE A 350
ASN A 376
 None
 1.13A 2wekB-1zkcA:
undetectable		 2wekB-1zkcA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1zkc PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
LIKE 2
(Homo
sapiens) 		5 / 12 ASN A 292
THR A 432
VAL A 433
VAL A 406
LEU A 407
 None
 1.32A 3elzA-1zkcA:
undetectable		 3elzA-1zkcA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		 1zkc PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
LIKE 2
(Homo
sapiens) 		5 / 12 LEU A 366
GLY A 398
LEU A 293
ARG A 399
ILE A 382
 None
 1.05A 3gwvA-1zkcA:
undetectable		 3gwvA-1zkcA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCN_A_CHDA3_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1zkc PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
LIKE 2
(Homo
sapiens) 		4 / 7 MET A 410
LEU A 407
PRO A 422
SER A 415
 None
 1.02A 3hcnA-1zkcA:
undetectable		 3hcnA-1zkcA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCN_A_CHDA3_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1zkc PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
LIKE 2
(Homo
sapiens) 		4 / 7 MET A 410
LEU A 407
SER A 415
GLY A 332
 None
 1.06A 3hcnA-1zkcA:
undetectable		 3hcnA-1zkcA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCN_B_CHDB1_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1zkc PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
LIKE 2
(Homo
sapiens) 		5 / 9 MET A 410
LEU A 407
PRO A 422
SER A 415
GLY A 332
 None
 1.15A 3hcnB-1zkcA:
undetectable		 3hcnB-1zkcA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCO_A_CHDA4_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1zkc PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
LIKE 2
(Homo
sapiens) 		5 / 9 MET A 410
LEU A 407
PRO A 422
SER A 415
GLY A 332
 None
 1.14A 3hcoA-1zkcA:
0.0		 3hcoA-1zkcA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCO_B_CHDB924_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1zkc PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
LIKE 2
(Homo
sapiens) 		5 / 10 MET A 410
LEU A 407
PRO A 422
SER A 415
GLY A 332
 None
 1.14A 3hcoB-1zkcA:
0.0		 3hcoB-1zkcA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCP_B_CHDB1_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1zkc PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
LIKE 2
(Homo
sapiens) 		5 / 10 MET A 410
LEU A 407
PRO A 422
SER A 415
GLY A 332
 None
 1.20A 3hcpB-1zkcA:
undetectable		 3hcpB-1zkcA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SMT_A_ACTA1001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD3)		 1zkc PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
LIKE 2
(Homo
sapiens) 		4 / 5 LEU A 295
GLY A 398
PHE A 397
PHE A 307
 None
 1.17A 3smtA-1zkcA:
undetectable		 3smtA-1zkcA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KMM_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1zkc PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
LIKE 2
(Homo
sapiens) 		4 / 5 MET A 410
LEU A 407
PRO A 422
SER A 415
 None
 1.01A 4kmmB-1zkcA:
undetectable		 4kmmB-1zkcA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_D_AERD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1zkc PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
LIKE 2
(Homo
sapiens) 		5 / 12 LEU A 366
PHE A 307
ILE A 382
GLY A 332
THR A 319
 None
 1.14A 4nkvD-1zkcA:
undetectable		 4nkvD-1zkcA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOX_A_RFPA502_2
(PENTACHLOROPHENOL
4-MONOOXYGENASE)		 1zkc PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
LIKE 2
(Homo
sapiens) 		3 / 3 VAL A 401
ARG A 277
PRO A 437
 None
 0.78A 5koxA-1zkcA:
undetectable		 5koxA-1zkcA:
17.27