SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1zkd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DB1_A_VDXA428_1
(VITAMIN D NUCLEAR
RECEPTOR)		 1zkd DUF185
(Rhodopseudomonas
palustris) 		5 / 12 LEU A 363
LEU A 360
SER A  69
VAL A 349
LEU A 304
 None
 1.22A 1db1A-1zkdA:
undetectable		 1db1A-1zkdA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DB1_A_VDXA428_1
(VITAMIN D NUCLEAR
RECEPTOR)		 1zkd DUF185
(Rhodopseudomonas
palustris) 		5 / 12 LEU A 363
LEU A 360
VAL A 361
SER A  69
VAL A 349
 None
 1.11A 1db1A-1zkdA:
undetectable		 1db1A-1zkdA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE9_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 1zkd DUF185
(Rhodopseudomonas
palustris) 		5 / 12 LEU A 363
LEU A 360
VAL A 361
SER A  69
VAL A 349
 None
 1.18A 1ie9A-1zkdA:
undetectable		 1ie9A-1zkdA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG4_A_SAMA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 1zkd DUF185
(Rhodopseudomonas
palustris) 		4 / 8 GLU A  86
GLY A  88
GLU A 118
LEU A 123
 None
 0.59A 1jg4A-1zkdA:
7.2		 1jg4A-1zkdA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1zkd DUF185
(Rhodopseudomonas
palustris) 		4 / 6 GLY A 351
VAL A  72
ALA A 237
SER A 353
 None
 1.01A 1p6kA-1zkdA:
undetectable		 1p6kA-1zkdA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAO_A_SAMA245_0
(ERMC'
METHYLTRANSFERASE)		 1zkd DUF185
(Rhodopseudomonas
palustris) 		5 / 12 GLU A  86
GLY A  88
GLY A  90
ILE A 119
LEU A 123
 None
 0.64A 1qaoA-1zkdA:
9.1		 1qaoA-1zkdA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SH9_B_RITB301_2
(POL POLYPROTEIN)		 1zkd DUF185
(Rhodopseudomonas
palustris) 		5 / 10 GLY A 291
ILE A 227
ILE A 224
GLY A 284
ALA A 237
 None
 0.87A 1sh9B-1zkdA:
undetectable		 1sh9B-1zkdA:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOF_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 1zkd DUF185
(Rhodopseudomonas
palustris) 		4 / 5 LEU A 225
ASP A 221
ALA A 228
ILE A 224
 None
 0.78A 2aofB-1zkdA:
undetectable		 2aofB-1zkdA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOH_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 1zkd DUF185
(Rhodopseudomonas
palustris) 		4 / 5 LEU A 225
ASP A 221
ALA A 228
ILE A 224
 None
 0.70A 2aohB-1zkdA:
undetectable		 2aohB-1zkdA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LBD_A_REAA500_1
(RETINOIC ACID
RECEPTOR GAMMA)		 1zkd DUF185
(Rhodopseudomonas
palustris) 		5 / 12 PHE A 254
MET A  21
ILE A 179
PHE A 189
LEU A  31
 None
 1.29A 2lbdA-1zkdA:
undetectable		 2lbdA-1zkdA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMZ_B_ROCB401_1
(PROTEASE)		 1zkd DUF185
(Rhodopseudomonas
palustris) 		5 / 12 LEU A 225
ASP A 221
ASP A 279
ALA A 228
ILE A 224
 None
 0.87A 2nmzA-1zkdA:
undetectable		 2nmzA-1zkdA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1zkd DUF185
(Rhodopseudomonas
palustris) 		5 / 11 LEU A 102
LEU A 112
SER A 111
PRO A  79
VAL A  72
 None
 1.27A 2po5B-1zkdA:
3.1		 2po5B-1zkdA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RKF_A_AB1A501_2
(PROTEASE RETROPEPSIN)		 1zkd DUF185
(Rhodopseudomonas
palustris) 		5 / 12 LEU A 225
ASP A 221
ASP A 279
ALA A 228
ILE A 224
 None
 0.87A 2rkfB-1zkdA:
undetectable		 2rkfB-1zkdA:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W1B_A_DXCA2034_0
(ACRIFLAVIN
RESISTANCE PROTEIN B)		 1zkd DUF185
(Rhodopseudomonas
palustris) 		3 / 3 PHE A 303
SER A  71
LEU A  67
 None
 0.66A 2w1bA-1zkdA:
undetectable		 2w1bA-1zkdA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_D_H4BD3902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 1zkd DUF185
(Rhodopseudomonas
palustris) 		4 / 8 TRP A  24
PHE A 254
GLU A 176
ILE A 179
 None
 1.38A 3e7gC-1zkdA:
undetectable
3e7gD-1zkdA:
undetectable		 3e7gC-1zkdA:
22.03
3e7gD-1zkdA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GRY_A_SAMA300_0
(DIMETHYLADENOSINE
TRANSFERASE)		 1zkd DUF185
(Rhodopseudomonas
palustris) 		6 / 12 GLU A  86
GLY A  88
GLY A  90
GLU A 118
ILE A 119
LEU A 123
 None
 0.71A 3gryA-1zkdA:
10.1		 3gryA-1zkdA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQ7_B_DX2B271_1
(PTERIDINE REDUCTASE
1)		 1zkd DUF185
(Rhodopseudomonas
palustris) 		4 / 8 SER A 289
ASP A 221
LEU A 203
PRO A 204
 None
 1.14A 3jq7B-1zkdA:
4.6		 3jq7B-1zkdA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQ7_C_DX2C270_1
(PTERIDINE REDUCTASE
1)		 1zkd DUF185
(Rhodopseudomonas
palustris) 		4 / 8 SER A 289
ASP A 221
LEU A 203
PRO A 204
 None
 1.07A 3jq7C-1zkdA:
4.9		 3jq7C-1zkdA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUG_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1zkd DUF185
(Rhodopseudomonas
palustris) 		5 / 12 GLY A 296
VAL A 361
GLY A 284
ALA A 294
ALA A 228
 None
 1.10A 3sugA-1zkdA:
undetectable		 3sugA-1zkdA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEO_A_ACRA1001_2
(ALPHA-GLUCOSIDASE)		 1zkd DUF185
(Rhodopseudomonas
palustris) 		4 / 6 ILE A  87
ILE A 134
MET A  95
TRP A 139
 None
 0.78A 3weoA-1zkdA:
undetectable		 3weoA-1zkdA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_A_SAMA900_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 1zkd DUF185
(Rhodopseudomonas
palustris) 		5 / 12 PHE A 159
GLY A 351
GLY A 296
ARG A 293
ILE A 227
 None
 1.00A 4krhA-1zkdA:
10.9		 4krhA-1zkdA:
25.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_B_SAMB900_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 1zkd DUF185
(Rhodopseudomonas
palustris) 		5 / 12 PHE A 159
GLY A 351
GLY A 296
ARG A 293
ILE A 227
 None
 0.97A 4krhB-1zkdA:
11.3		 4krhB-1zkdA:
25.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UXQ_A_0LIA1752_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 1zkd DUF185
(Rhodopseudomonas
palustris) 		4 / 7 VAL A 231
ILE A 240
ARG A 306
ILE A 241
 None
 0.76A 4uxqA-1zkdA:
undetectable		 4uxqA-1zkdA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 1zkd DUF185
(Rhodopseudomonas
palustris) 		5 / 12 ILE A  87
HIS A 140
VAL A 146
ILE A 240
ALA A 155
 None
 0.94A 5n0sA-1zkdA:
undetectable		 5n0sA-1zkdA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 1zkd DUF185
(Rhodopseudomonas
palustris) 		5 / 12 ILE A  87
HIS A 140
VAL A 146
ILE A 240
ALA A 155
 None
 0.93A 5n0sB-1zkdA:
undetectable		 5n0sB-1zkdA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 1zkd DUF185
(Rhodopseudomonas
palustris) 		5 / 12 ILE A  87
HIS A 140
VAL A 146
ILE A 240
ALA A 155
 None
 0.98A 5n0tA-1zkdA:
undetectable		 5n0tA-1zkdA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 1zkd DUF185
(Rhodopseudomonas
palustris) 		5 / 12 ILE A  87
HIS A 140
VAL A 146
ILE A 240
ALA A 155
 None
 0.96A 5n0wB-1zkdA:
undetectable		 5n0wB-1zkdA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4I_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 1zkd DUF185
(Rhodopseudomonas
palustris) 		5 / 12 ILE A  87
HIS A 140
VAL A 146
ILE A 240
ALA A 155
 None
 0.96A 5n4iA-1zkdA:
undetectable		 5n4iA-1zkdA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_C_08JC602_1
(CYTOCHROME P450 3A4)		 1zkd DUF185
(Rhodopseudomonas
palustris) 		4 / 7 SER A  69
LEU A 102
ALA A  98
ILE A 134
 None
 0.96A 5te8C-1zkdA:
undetectable		 5te8C-1zkdA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 1zkd DUF185
(Rhodopseudomonas
palustris) 		4 / 7 THR A 336
PHE A 303
LEU A 307
SER A  69
 None
 1.04A 5uxcA-1zkdA:
undetectable		 5uxcA-1zkdA:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IFT_A_SAMA301_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A)		 1zkd DUF185
(Rhodopseudomonas
palustris) 		6 / 12 GLU A  86
ILE A  87
GLY A  88
GLY A  90
ILE A 119
LEU A 123
 None
 0.56A 6iftA-1zkdA:
8.1		 6iftA-1zkdA:
22.66