SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1zkj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_C_ACTC3004_0
(BETA-CARBONIC
ANHYDRASE)		 1zkj EXTENDED-SPECTRUM
BETA-LACTAMASE
(Klebsiella
aerogenes) 		4 / 6 GLN A 121
TYR A 223
VAL A 213
GLY A 216
 None
None
ACY  A1402 (-4.0A)
None
 1.06A 1ekjC-1zkjA:
undetectable
1ekjD-1zkjA:
undetectable		 1ekjC-1zkjA:
21.11
1ekjD-1zkjA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_C_ACTC3007_0
(BETA-CARBONIC
ANHYDRASE)		 1zkj EXTENDED-SPECTRUM
BETA-LACTAMASE
(Klebsiella
aerogenes) 		4 / 6 VAL A 213
GLY A 216
GLN A 121
TYR A 223
 ACY  A1402 (-4.0A)
None
None
None
 1.13A 1ekjC-1zkjA:
undetectable
1ekjD-1zkjA:
undetectable		 1ekjC-1zkjA:
21.11
1ekjD-1zkjA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1501_0
(FERROCHELATASE)		 1zkj EXTENDED-SPECTRUM
BETA-LACTAMASE
(Klebsiella
aerogenes) 		5 / 12 LEU A 183
PHE A 235
LEU A 248
ILE A 225
VAL A  80
 None
 1.18A 1hrkA-1zkjA:
undetectable		 1hrkA-1zkjA:
22.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KVL_A_CLSA371_1
(BETA-LACTAMASE)		 1zkj EXTENDED-SPECTRUM
BETA-LACTAMASE
(Klebsiella
aerogenes) 		6 / 10 GLY A  64
GLN A 121
ASN A 153
TYR A 223
THR A 313
GLY A 314
 None
 1.21A 1kvlA-1zkjA:
53.5		 1kvlA-1zkjA:
42.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KVL_A_CLSA371_1
(BETA-LACTAMASE)		 1zkj EXTENDED-SPECTRUM
BETA-LACTAMASE
(Klebsiella
aerogenes) 		7 / 10 LEU A 120
GLN A 121
ASN A 153
TYR A 223
LYS A 312
THR A 313
GLY A 314
 None
 0.33A 1kvlA-1zkjA:
53.5		 1kvlA-1zkjA:
42.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KVL_A_CLSA371_1
(BETA-LACTAMASE)		 1zkj EXTENDED-SPECTRUM
BETA-LACTAMASE
(Klebsiella
aerogenes) 		6 / 10 LEU A 120
TYR A 151
ASN A 153
TYR A 223
THR A 313
GLY A 314
 None
 0.74A 1kvlA-1zkjA:
53.5		 1kvlA-1zkjA:
42.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC885_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 1zkj EXTENDED-SPECTRUM
BETA-LACTAMASE
(Klebsiella
aerogenes) 		4 / 8 ALA A 337
ASP A  14
ILE A  17
ILE A 353
 None
ZN  A 514 (-3.1A)
None
None
 0.93A 1p7lC-1zkjA:
undetectable		 1p7lC-1zkjA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC685_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 1zkj EXTENDED-SPECTRUM
BETA-LACTAMASE
(Klebsiella
aerogenes) 		4 / 8 ALA A 337
ASP A  14
ILE A  17
ILE A 353
 None
ZN  A 514 (-3.1A)
None
None
 0.93A 1rg9C-1zkjA:
undetectable		 1rg9C-1zkjA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X7P_A_SAMA301_0
(RRNA
METHYLTRANSFERASE)		 1zkj EXTENDED-SPECTRUM
BETA-LACTAMASE
(Klebsiella
aerogenes) 		6 / 11 THR A 316
GLY A 318
GLY A 203
ILE A  63
LEU A 336
ALA A 321
 ACY  A1402 (-4.3A)
None
None
None
None
None
 1.43A 1x7pA-1zkjA:
undetectable
1x7pB-1zkjA:
undetectable		 1x7pA-1zkjA:
23.63
1x7pB-1zkjA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_A_REAA502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1zkj EXTENDED-SPECTRUM
BETA-LACTAMASE
(Klebsiella
aerogenes) 		5 / 12 ALA A 163
ALA A 164
LEU A 174
ALA A  78
ILE A 225
 None
 0.91A 2aclA-1zkjA:
undetectable
2aclE-1zkjA:
undetectable		 2aclA-1zkjA:
22.01
2aclE-1zkjA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_E_REAE504_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1zkj EXTENDED-SPECTRUM
BETA-LACTAMASE
(Klebsiella
aerogenes) 		5 / 11 ALA A 163
ALA A 164
LEU A 174
ALA A  78
ILE A 225
 None
 0.97A 2aclE-1zkjA:
undetectable		 2aclE-1zkjA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HW2_A_RFPA1200_1
(RIFAMPIN ADP-RIBOSYL
TRANSFERASE)		 1zkj EXTENDED-SPECTRUM
BETA-LACTAMASE
(Klebsiella
aerogenes) 		5 / 12 ALA A 222
GLY A 224
MET A 175
LEU A 180
LEU A 183
 None
 0.85A 2hw2A-1zkjA:
undetectable		 2hw2A-1zkjA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q9R_A_BEZA203_0
(PROTEIN OF UNKNOWN
FUNCTION)		 1zkj EXTENDED-SPECTRUM
BETA-LACTAMASE
(Klebsiella
aerogenes) 		4 / 5 LEU A 283
GLY A 286
ILE A 343
ILE A 347
 None
 0.81A 2q9rA-1zkjA:
undetectable		 2q9rA-1zkjA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFS_A_J01A500_1
(ORF12)		 1zkj EXTENDED-SPECTRUM
BETA-LACTAMASE
(Klebsiella
aerogenes) 		4 / 8 HIS A  93
LEU A 167
GLY A  75
ALA A  78
 None
 0.65A 2xfsA-1zkjA:
14.1		 2xfsA-1zkjA:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_A_J01A1436_1
(ORF12)		 1zkj EXTENDED-SPECTRUM
BETA-LACTAMASE
(Klebsiella
aerogenes) 		4 / 8 HIS A  93
LEU A 167
GLY A  75
ALA A  78
 None
 0.64A 2xh9A-1zkjA:
14.1		 2xh9A-1zkjA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YDO_A_ADNA400_1
(ADENOSINE RECEPTOR
A2A)		 1zkj EXTENDED-SPECTRUM
BETA-LACTAMASE
(Klebsiella
aerogenes) 		5 / 12 LEU A  70
PHE A 235
MET A 185
LEU A 248
ILE A 252
 None
 1.46A 2ydoA-1zkjA:
0.0		 2ydoA-1zkjA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1zkj EXTENDED-SPECTRUM
BETA-LACTAMASE
(Klebsiella
aerogenes) 		5 / 12 ALA A 163
ALA A 164
LEU A 174
ALA A  78
ILE A 225
 None
 1.00A 3h0aA-1zkjA:
undetectable		 3h0aA-1zkjA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HUO_A_PNNA300_0
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 1zkj EXTENDED-SPECTRUM
BETA-LACTAMASE
(Klebsiella
aerogenes) 		5 / 12 LYS A  68
ASN A 153
LYS A 312
THR A 313
GLY A 314
 None
 0.44A 3huoA-1zkjA:
16.0		 3huoA-1zkjA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		 1zkj EXTENDED-SPECTRUM
BETA-LACTAMASE
(Klebsiella
aerogenes) 		6 / 12 SER A  65
LYS A  68
ASN A 153
GLY A 314
THR A 316
ARG A 346
 None
None
None
None
ACY  A1402 (-4.3A)
None
 1.07A 3mzeA-1zkjA:
15.0		 3mzeA-1zkjA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		 1zkj EXTENDED-SPECTRUM
BETA-LACTAMASE
(Klebsiella
aerogenes) 		6 / 12 SER A  65
LYS A  68
ASN A 153
THR A 313
GLY A 314
THR A 316
 None
None
None
None
None
ACY  A1402 (-4.3A)
 0.80A 3mzeA-1zkjA:
15.0		 3mzeA-1zkjA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_A_SAMA405_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1zkj EXTENDED-SPECTRUM
BETA-LACTAMASE
(Klebsiella
aerogenes) 		4 / 8 ALA A 337
ASP A  14
ILE A  17
ILE A 353
 None
ZN  A 514 (-3.1A)
None
None
 0.90A 4kttB-1zkjA:
undetectable		 4kttB-1zkjA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWV_A_BCZA513_1
(NEURAMINIDASE)		 1zkj EXTENDED-SPECTRUM
BETA-LACTAMASE
(Klebsiella
aerogenes) 		3 / 3 ARG A 339
GLU A 207
ARG A  49
 None
 0.86A 4mwvA-1zkjA:
undetectable		 4mwvA-1zkjA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_C_ADNC401_1
(ADENOSINE KINASE)		 1zkj EXTENDED-SPECTRUM
BETA-LACTAMASE
(Klebsiella
aerogenes) 		5 / 12 LEU A  97
GLY A 108
ALA A  90
LEU A 162
GLY A 146
 None
 0.94A 4n09C-1zkjA:
undetectable		 4n09C-1zkjA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_A_SAMA407_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1zkj EXTENDED-SPECTRUM
BETA-LACTAMASE
(Klebsiella
aerogenes) 		4 / 8 ALA A 337
ASP A  14
ILE A  17
ILE A 353
 None
ZN  A 514 (-3.1A)
None
None
 0.90A 4ndnB-1zkjA:
undetectable		 4ndnB-1zkjA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_C_SAMC405_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1zkj EXTENDED-SPECTRUM
BETA-LACTAMASE
(Klebsiella
aerogenes) 		4 / 8 ALA A 337
ASP A  14
ILE A  17
ILE A 353
 None
ZN  A 514 (-3.1A)
None
None
 0.92A 4ndnD-1zkjA:
undetectable		 4ndnD-1zkjA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_A_URFA302_1
(URIDINE
PHOSPHORYLASE)		 1zkj EXTENDED-SPECTRUM
BETA-LACTAMASE
(Klebsiella
aerogenes) 		4 / 7 THR A 313
GLN A 267
ARG A 149
ILE A 292
 None
 0.93A 4txnA-1zkjA:
undetectable		 4txnA-1zkjA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_B_URFB302_1
(URIDINE
PHOSPHORYLASE)		 1zkj EXTENDED-SPECTRUM
BETA-LACTAMASE
(Klebsiella
aerogenes) 		4 / 7 THR A 313
GLN A 267
ARG A 149
ILE A 292
 None
 0.91A 4txnB-1zkjA:
undetectable		 4txnB-1zkjA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_D_URFD302_1
(URIDINE
PHOSPHORYLASE)		 1zkj EXTENDED-SPECTRUM
BETA-LACTAMASE
(Klebsiella
aerogenes) 		4 / 7 THR A 313
GLN A 267
ARG A 149
ILE A 292
 None
 0.94A 4txnD-1zkjA:
undetectable		 4txnD-1zkjA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJE_A_TOYA202_1
(AADB)		 1zkj EXTENDED-SPECTRUM
BETA-LACTAMASE
(Klebsiella
aerogenes) 		4 / 8 ASP A 231
TYR A 189
ILE A 225
TYR A 200
 None
 1.00A 4xjeA-1zkjA:
undetectable		 4xjeA-1zkjA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_C_RBVC502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1zkj EXTENDED-SPECTRUM
BETA-LACTAMASE
(Klebsiella
aerogenes) 		3 / 3 THR A  69
HIS A 351
LEU A 309
 None
 0.83A 5axdC-1zkjA:
undetectable		 5axdC-1zkjA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KMF_A_6U9A1301_1
(ION TRANSPORT
PROTEIN)		 1zkj EXTENDED-SPECTRUM
BETA-LACTAMASE
(Klebsiella
aerogenes) 		4 / 6 THR A 106
GLY A 108
GLU A 109
PHE A 159
 None
 0.92A 5kmfA-1zkjA:
undetectable
5kmfC-1zkjA:
undetectable		 5kmfA-1zkjA:
22.31
5kmfC-1zkjA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L0Z_A_SAMA304_0
(PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY)		 1zkj EXTENDED-SPECTRUM
BETA-LACTAMASE
(Klebsiella
aerogenes) 		6 / 12 THR A 316
GLY A 318
GLY A 203
ILE A  63
LEU A 336
ALA A 321
 ACY  A1402 (-4.3A)
None
None
None
None
None
 1.39A 5l0zA-1zkjA:
undetectable		 5l0zA-1zkjA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8S_B_SAMB402_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 1zkj EXTENDED-SPECTRUM
BETA-LACTAMASE
(Klebsiella
aerogenes) 		4 / 8 ALA A 337
ASP A  14
ILE A  17
ILE A 353
 None
ZN  A 514 (-3.1A)
None
None
 0.90A 5t8sA-1zkjA:
undetectable		 5t8sA-1zkjA:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW9_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 1zkj EXTENDED-SPECTRUM
BETA-LACTAMASE
(Klebsiella
aerogenes) 		5 / 8 THR A 255
ALA A  72
GLY A 268
GLU A 272
SER A 273
 None
 1.41A 5vw9A-1zkjA:
undetectable		 5vw9A-1zkjA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XPR_A_K86A1201_1
(ENDOTHELIN B
RECEPTOR,ENDOLYSIN,E
NDOTHELIN B RECEPTOR)		 1zkj EXTENDED-SPECTRUM
BETA-LACTAMASE
(Klebsiella
aerogenes) 		5 / 12 LEU A 218
TRP A  96
LEU A 162
HIS A 161
ALA A  94
 None
ACY  A1403 (-4.1A)
None
ZN  A 508 (-3.2A)
ACY  A1403 ( 4.1A)
 1.43A 5xprA-1zkjA:
0.0		 5xprA-1zkjA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A60_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1zkj EXTENDED-SPECTRUM
BETA-LACTAMASE
(Klebsiella
aerogenes) 		5 / 12 ALA A 163
ALA A 164
LEU A 174
ALA A  78
ILE A 225
 None
 0.84A 6a60D-1zkjA:
undetectable		 6a60D-1zkjA:
12.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBN_B_SAMB401_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1zkj EXTENDED-SPECTRUM
BETA-LACTAMASE
(Klebsiella
aerogenes) 		4 / 7 ALA A 337
ASP A  14
ILE A  17
ILE A 353
 None
ZN  A 514 (-3.1A)
None
None
 0.90A 6fbnA-1zkjA:
undetectable		 6fbnA-1zkjA:
21.48