SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1zkl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JU6_C_LYAC315_1
(THYMIDYLATE SYNTHASE)		 1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A
(Homo
sapiens) 		5 / 10 ILE A 158
ASN A 365
PHE A 156
TYR A 227
ALA A 361
 None
IBM  A 503 ( 4.7A)
None
None
None
 1.24A 1ju6C-1zklA:
undetectable		 1ju6C-1zklA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S19_A_MC9A500_1
(VITAMIN D3 RECEPTOR)		 1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A
(Homo
sapiens) 		4 / 5 SER A 236
ARG A 350
HIS A 225
HIS A 181
 None
 1.32A 1s19A-1zklA:
0.0		 1s19A-1zklA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TBF_A_VIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A
(Homo
sapiens) 		5 / 9 TYR A 211
VAL A 380
LEU A 401
GLN A 413
PHE A 416
 IBM  A 503 (-4.6A)
IBM  A 503 (-4.7A)
None
IBM  A 503 (-3.0A)
IBM  A 503 (-3.4A)
 0.79A 1tbfA-1zklA:
38.5		 1tbfA-1zklA:
29.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_B_CHDB1130_0
(FATTY ACID-BINDING
PROTEIN)		 1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A
(Homo
sapiens) 		5 / 12 LEU A 194
LEU A 189
ILE A 201
THR A 251
HIS A 181
 None
 1.14A 1tw4B-1zklA:
0.0		 1tw4B-1zklA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDT_A_VIAA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A
(Homo
sapiens) 		6 / 12 TYR A 211
HIS A 212
VAL A 380
LEU A 401
GLN A 413
PHE A 416
 IBM  A 503 (-4.6A)
None
IBM  A 503 (-4.7A)
None
IBM  A 503 (-3.0A)
IBM  A 503 (-3.4A)
 0.79A 1udtA-1zklA:
35.3		 1udtA-1zklA:
28.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_A_CIAA1003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A
(Homo
sapiens) 		7 / 11 TYR A 211
VAL A 380
PHE A 384
LEU A 401
ILE A 409
GLN A 413
PHE A 416
 IBM  A 503 (-4.6A)
IBM  A 503 (-4.7A)
IBM  A 503 (-4.5A)
None
None
IBM  A 503 (-3.0A)
IBM  A 503 (-3.4A)
 0.88A 1uduA-1zklA:
34.1		 1uduA-1zklA:
28.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A
(Homo
sapiens) 		6 / 12 TYR A 211
VAL A 380
PHE A 384
LEU A 401
GLN A 413
PHE A 416
 IBM  A 503 (-4.6A)
IBM  A 503 (-4.7A)
IBM  A 503 (-4.5A)
None
IBM  A 503 (-3.0A)
IBM  A 503 (-3.4A)
 0.73A 1uduB-1zklA:
34.2		 1uduB-1zklA:
28.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UHO_A_VDNA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A
(Homo
sapiens) 		6 / 10 TYR A 211
HIS A 212
PHE A 384
GLN A 413
GLY A 415
PHE A 416
 IBM  A 503 (-4.6A)
None
IBM  A 503 (-4.5A)
IBM  A 503 (-3.0A)
None
IBM  A 503 (-3.4A)
 0.62A 1uhoA-1zklA:
35.2		 1uhoA-1zklA:
28.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UHO_A_VDNA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A
(Homo
sapiens) 		6 / 10 TYR A 211
HIS A 212
PHE A 384
LEU A 401
GLN A 413
PHE A 416
 IBM  A 503 (-4.6A)
None
IBM  A 503 (-4.5A)
None
IBM  A 503 (-3.0A)
IBM  A 503 (-3.4A)
 0.76A 1uhoA-1zklA:
35.2		 1uhoA-1zklA:
28.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UHO_A_VDNA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A
(Homo
sapiens) 		5 / 10 TYR A 211
HIS A 216
GLN A 413
GLY A 415
PHE A 416
 IBM  A 503 (-4.6A)
ZN  A 501 (-3.3A)
IBM  A 503 (-3.0A)
None
IBM  A 503 (-3.4A)
 1.43A 1uhoA-1zklA:
35.2		 1uhoA-1zklA:
28.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XLX_A_CIOA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A
(Homo
sapiens) 		6 / 12 TYR A 211
HIS A 212
HIS A 256
ASN A 365
GLN A 413
PHE A 416
 IBM  A 503 (-4.6A)
None
None
IBM  A 503 ( 4.7A)
IBM  A 503 (-3.0A)
IBM  A 503 (-3.4A)
 0.42A 1xlxA-1zklA:
45.3		 1xlxA-1zklA:
34.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XLX_B_CIOB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A
(Homo
sapiens) 		6 / 12 TYR A 211
HIS A 212
HIS A 256
PHE A 384
GLN A 413
PHE A 416
 IBM  A 503 (-4.6A)
None
None
IBM  A 503 (-4.5A)
IBM  A 503 (-3.0A)
IBM  A 503 (-3.4A)
 0.53A 1xlxB-1zklA:
45.1		 1xlxB-1zklA:
34.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XMU_A_ROFA101_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A
(Homo
sapiens) 		7 / 12 TYR A 211
HIS A 212
ASP A 362
PRO A 366
TRP A 376
PHE A 384
PHE A 416
 IBM  A 503 (-4.6A)
None
ZN  A 501 (-2.5A)
None
None
IBM  A 503 (-4.5A)
IBM  A 503 (-3.4A)
 0.34A 1xmuA-1zklA:
45.2		 1xmuA-1zklA:
34.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XMU_B_ROFB102_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A
(Homo
sapiens) 		6 / 12 TYR A 211
HIS A 212
ASP A 362
PRO A 366
TRP A 376
PHE A 384
 IBM  A 503 (-4.6A)
None
ZN  A 501 (-2.5A)
None
None
IBM  A 503 (-4.5A)
 0.24A 1xmuB-1zklA:
45.2		 1xmuB-1zklA:
34.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOM_A_CIOA603_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A
(Homo
sapiens) 		6 / 12 TYR A 211
HIS A 212
ASP A 362
PHE A 384
GLN A 413
PHE A 416
 IBM  A 503 (-4.6A)
None
ZN  A 501 (-2.5A)
IBM  A 503 (-4.5A)
IBM  A 503 (-3.0A)
IBM  A 503 (-3.4A)
 0.58A 1xomA-1zklA:
45.6		 1xomA-1zklA:
33.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOM_B_CIOB601_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A
(Homo
sapiens) 		5 / 12 TYR A 211
HIS A 212
PHE A 384
GLN A 413
PHE A 416
 IBM  A 503 (-4.6A)
None
IBM  A 503 (-4.5A)
IBM  A 503 (-3.0A)
IBM  A 503 (-3.4A)
 0.61A 1xomB-1zklA:
45.4		 1xomB-1zklA:
33.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOQ_A_ROFA502_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A
(Homo
sapiens) 		5 / 12 TYR A 211
HIS A 212
ASP A 362
PRO A 366
PHE A 416
 IBM  A 503 (-4.6A)
None
ZN  A 501 (-2.5A)
None
IBM  A 503 (-3.4A)
 0.37A 1xoqA-1zklA:
45.5		 1xoqA-1zklA:
33.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOQ_A_ROFA502_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A
(Homo
sapiens) 		3 / 3 ASN A 365
TRP A 376
GLN A 413
 IBM  A 503 ( 4.7A)
None
IBM  A 503 (-3.0A)
 0.20A 1xoqA-1zklA:
45.5		 1xoqA-1zklA:
33.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOQ_B_ROFB501_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A
(Homo
sapiens) 		6 / 12 TYR A 211
HIS A 212
ASP A 362
PRO A 366
TRP A 376
PHE A 416
 IBM  A 503 (-4.6A)
None
ZN  A 501 (-2.5A)
None
None
IBM  A 503 (-3.4A)
 0.36A 1xoqB-1zklA:
45.5		 1xoqB-1zklA:
33.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOS_A_VIAA1_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A
(Homo
sapiens) 		6 / 12 TYR A 211
HIS A 212
ASP A 362
PHE A 384
GLN A 413
PHE A 416
 IBM  A 503 (-4.6A)
None
ZN  A 501 (-2.5A)
IBM  A 503 (-4.5A)
IBM  A 503 (-3.0A)
IBM  A 503 (-3.4A)
 0.47A 1xosA-1zklA:
45.2		 1xosA-1zklA:
34.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOT_A_VDNA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A
(Homo
sapiens) 		5 / 12 TYR A 211
HIS A 212
SER A 399
GLN A 413
PHE A 416
 IBM  A 503 (-4.6A)
None
None
IBM  A 503 (-3.0A)
IBM  A 503 (-3.4A)
 0.87A 1xotA-1zklA:
45.3		 1xotA-1zklA:
34.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOT_B_VDNB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A
(Homo
sapiens) 		6 / 12 TYR A 211
HIS A 212
ASN A 365
SER A 399
GLN A 413
PHE A 416
 IBM  A 503 (-4.6A)
None
IBM  A 503 ( 4.7A)
None
IBM  A 503 (-3.0A)
IBM  A 503 (-3.4A)
 0.67A 1xotB-1zklA:
45.2		 1xotB-1zklA:
34.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A
(Homo
sapiens) 		6 / 12 TYR A 211
VAL A 380
PHE A 384
ILE A 409
GLN A 413
PHE A 416
 IBM  A 503 (-4.6A)
IBM  A 503 (-4.7A)
IBM  A 503 (-4.5A)
None
IBM  A 503 (-3.0A)
IBM  A 503 (-3.4A)
 0.82A 1xozA-1zklA:
38.4		 1xozA-1zklA:
29.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A
(Homo
sapiens) 		6 / 12 TYR A 211
VAL A 380
PHE A 384
LEU A 401
GLN A 413
PHE A 416
 IBM  A 503 (-4.6A)
IBM  A 503 (-4.7A)
IBM  A 503 (-4.5A)
None
IBM  A 503 (-3.0A)
IBM  A 503 (-3.4A)
 0.87A 1xozA-1zklA:
38.4		 1xozA-1zklA:
29.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XP0_A_VDNA201_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A
(Homo
sapiens) 		5 / 10 TYR A 211
VAL A 380
LEU A 401
GLN A 413
PHE A 416
 IBM  A 503 (-4.6A)
IBM  A 503 (-4.7A)
None
IBM  A 503 (-3.0A)
IBM  A 503 (-3.4A)
 0.85A 1xp0A-1zklA:
38.6		 1xp0A-1zklA:
29.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYO_A_LNLA1217_1
(LIPOPROTEIN LPPX)		 1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A
(Homo
sapiens) 		4 / 4 VAL A 151
LEU A 194
ILE A 184
LEU A 183
 None
 0.82A 2byoA-1zklA:
undetectable		 2byoA-1zklA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FT9_A_CHDA131_0
(FATTY ACID-BINDING
PROTEIN 2, LIVER)		 1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A
(Homo
sapiens) 		5 / 11 LEU A 298
ILE A 201
THR A 251
MET A 310
LEU A 183
 None
 1.21A 2ft9A-1zklA:
undetectable		 2ft9A-1zklA:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_A_VIAA901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A
(Homo
sapiens) 		7 / 11 TYR A 211
HIS A 212
VAL A 380
PHE A 384
ILE A 409
GLN A 413
PHE A 416
 IBM  A 503 (-4.6A)
None
IBM  A 503 (-4.7A)
IBM  A 503 (-4.5A)
None
IBM  A 503 (-3.0A)
IBM  A 503 (-3.4A)
 0.66A 2h42A-1zklA:
34.9		 2h42A-1zklA:
28.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_A_VIAA901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A
(Homo
sapiens) 		7 / 11 TYR A 211
HIS A 212
VAL A 380
PHE A 384
LEU A 401
GLN A 413
PHE A 416
 IBM  A 503 (-4.6A)
None
IBM  A 503 (-4.7A)
IBM  A 503 (-4.5A)
None
IBM  A 503 (-3.0A)
IBM  A 503 (-3.4A)
 0.81A 2h42A-1zklA:
34.9		 2h42A-1zklA:
28.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_B_VIAB902_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A
(Homo
sapiens) 		6 / 12 TYR A 211
HIS A 212
VAL A 380
ILE A 409
GLN A 413
PHE A 416
 IBM  A 503 (-4.6A)
None
IBM  A 503 (-4.7A)
None
IBM  A 503 (-3.0A)
IBM  A 503 (-3.4A)
 0.68A 2h42B-1zklA:
34.8		 2h42B-1zklA:
28.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_B_VIAB902_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A
(Homo
sapiens) 		5 / 12 TYR A 211
HIS A 212
VAL A 380
LEU A 401
GLN A 413
 IBM  A 503 (-4.6A)
None
IBM  A 503 (-4.7A)
None
IBM  A 503 (-3.0A)
 0.92A 2h42B-1zklA:
34.8		 2h42B-1zklA:
28.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_C_VIAC903_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A
(Homo
sapiens) 		5 / 12 TYR A 211
VAL A 380
ILE A 409
GLN A 413
PHE A 416
 IBM  A 503 (-4.6A)
IBM  A 503 (-4.7A)
None
IBM  A 503 (-3.0A)
IBM  A 503 (-3.4A)
 0.72A 2h42C-1zklA:
34.9		 2h42C-1zklA:
28.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_C_VIAC903_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A
(Homo
sapiens) 		5 / 12 TYR A 211
VAL A 380
PHE A 384
GLN A 413
PHE A 416
 IBM  A 503 (-4.6A)
IBM  A 503 (-4.7A)
IBM  A 503 (-4.5A)
IBM  A 503 (-3.0A)
IBM  A 503 (-3.4A)
 0.54A 2h42C-1zklA:
34.9		 2h42C-1zklA:
28.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_C_STIC600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A
(Homo
sapiens) 		4 / 6 LEU A 177
VAL A 290
ILE A 201
MET A 224
 None
 1.12A 2hyyC-1zklA:
undetectable		 2hyyC-1zklA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PIW_A_T3A932_1
(ANDROGEN RECEPTOR)		 1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A
(Homo
sapiens) 		4 / 6 LEU A 293
LYS A 193
MET A 310
ILE A 314
 None
 0.90A 2piwA-1zklA:
undetectable		 2piwA-1zklA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEY_A_EV1A1771_1
(CAMP AND
CAMP-INHIBITED CGMP
3', 5'-CYCLIC
PHOSPHODIESTERASE)		 1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A
(Homo
sapiens) 		6 / 12 TYR A 211
HIS A 212
GLU A 383
PHE A 384
GLN A 413
PHE A 416
 IBM  A 503 (-4.6A)
None
None
IBM  A 503 (-4.5A)
IBM  A 503 (-3.0A)
IBM  A 503 (-3.4A)
 0.74A 2weyA-1zklA:
36.9		 2weyA-1zklA:
28.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_E_GCSE710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A
(Homo
sapiens) 		4 / 8 HIS A 252
ASP A 362
ILE A 363
HIS A 216
 ZN  A 501 (-3.3A)
ZN  A 501 (-2.5A)
None
ZN  A 501 (-3.3A)
 1.07A 2xadA-1zklA:
undetectable		 2xadA-1zklA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_F_GCSF710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A
(Homo
sapiens) 		4 / 8 HIS A 252
ASP A 362
ILE A 363
HIS A 216
 ZN  A 501 (-3.3A)
ZN  A 501 (-2.5A)
None
ZN  A 501 (-3.3A)
 1.11A 2xadB-1zklA:
undetectable		 2xadB-1zklA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_G_GCSG710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A
(Homo
sapiens) 		4 / 8 HIS A 252
ASP A 362
ILE A 363
HIS A 216
 ZN  A 501 (-3.3A)
ZN  A 501 (-2.5A)
None
ZN  A 501 (-3.3A)
 1.09A 2xadC-1zklA:
undetectable		 2xadC-1zklA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_H_GCSH710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A
(Homo
sapiens) 		4 / 8 HIS A 252
ASP A 362
ILE A 363
HIS A 216
 ZN  A 501 (-3.3A)
ZN  A 501 (-2.5A)
None
ZN  A 501 (-3.3A)
 1.09A 2xadD-1zklA:
undetectable		 2xadD-1zklA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_D_VD3D2001_1
(VITAMIN D
HYDROXYLASE)		 1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A
(Homo
sapiens) 		5 / 12 LEU A 189
LEU A 244
MET A 310
ILE A 247
THR A 221
 None
 1.05A 3a50D-1zklA:
undetectable		 3a50D-1zklA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_A_VDNA1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A
(Homo
sapiens) 		7 / 12 TYR A 211
HIS A 212
VAL A 380
PHE A 384
ILE A 409
GLN A 413
PHE A 416
 IBM  A 503 (-4.6A)
None
IBM  A 503 (-4.7A)
IBM  A 503 (-4.5A)
None
IBM  A 503 (-3.0A)
IBM  A 503 (-3.4A)
 0.86A 3b2rA-1zklA:
30.7		 3b2rA-1zklA:
28.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_B_VDNB1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A
(Homo
sapiens) 		6 / 11 TYR A 211
HIS A 212
VAL A 380
ILE A 409
GLN A 413
PHE A 416
 IBM  A 503 (-4.6A)
None
IBM  A 503 (-4.7A)
None
IBM  A 503 (-3.0A)
IBM  A 503 (-3.4A)
 0.78A 3b2rB-1zklA:
30.6		 3b2rB-1zklA:
28.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZV_A_AZMA263_1
(CARBONIC ANHYDRASE
13)		 1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A
(Homo
sapiens) 		5 / 12 HIS A 216
HIS A 252
PHE A 416
THR A 321
VAL A 421
 ZN  A 501 (-3.3A)
ZN  A 501 (-3.3A)
IBM  A 503 (-3.4A)
None
None
 1.18A 3czvA-1zklA:
undetectable
3czvB-1zklA:
undetectable		 3czvA-1zklA:
19.72
3czvB-1zklA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ERD_A_DESA600_1
(ESTROGEN RECEPTOR
ALPHA)		 1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A
(Homo
sapiens) 		5 / 12 LEU A 246
ALA A 250
LEU A 198
LEU A 170
LEU A 173
 None
 0.97A 3erdA-1zklA:
undetectable		 3erdA-1zklA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_B_SAMB600_0
(PCZA361.24)		 1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A
(Homo
sapiens) 		5 / 12 LEU A 189
ASP A 204
MET A 200
GLY A 297
SER A 296
 None
 1.10A 3g2oB-1zklA:
undetectable		 3g2oB-1zklA:
20.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_A_ROFA901_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A
(Homo
sapiens) 		6 / 12 TYR A 211
HIS A 212
ASN A 365
PRO A 366
TRP A 376
PHE A 416
 IBM  A 503 (-4.6A)
None
IBM  A 503 ( 4.7A)
None
None
IBM  A 503 (-3.4A)
 0.42A 3g4lA-1zklA:
45.4		 3g4lA-1zklA:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_B_ROFB902_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A
(Homo
sapiens) 		6 / 12 TYR A 211
HIS A 212
ASP A 362
PRO A 366
TRP A 376
PHE A 416
 IBM  A 503 (-4.6A)
None
ZN  A 501 (-2.5A)
None
None
IBM  A 503 (-3.4A)
 0.44A 3g4lB-1zklA:
45.4		 3g4lB-1zklA:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_C_ROFC903_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A
(Homo
sapiens) 		6 / 12 TYR A 211
HIS A 212
ASP A 362
ASN A 365
PRO A 366
TRP A 376
 IBM  A 503 (-4.6A)
None
ZN  A 501 (-2.5A)
IBM  A 503 ( 4.7A)
None
None
 0.25A 3g4lC-1zklA:
45.3		 3g4lC-1zklA:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_D_ROFD904_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A
(Homo
sapiens) 		6 / 12 TYR A 211
HIS A 212
ASP A 362
PRO A 366
TRP A 376
GLN A 413
 IBM  A 503 (-4.6A)
None
ZN  A 501 (-2.5A)
None
None
IBM  A 503 (-3.0A)
 0.36A 3g4lD-1zklA:
45.1		 3g4lD-1zklA:
33.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HM1_A_J3ZA2_1
(ESTROGEN RECEPTOR)		 1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A
(Homo
sapiens) 		5 / 12 LEU A 246
ALA A 250
LEU A 198
LEU A 170
LEU A 173
 None
 1.06A 3hm1A-1zklA:
1.8		 3hm1A-1zklA:
23.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IAK_A_EV1A415_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A
(Homo
sapiens) 		5 / 9 TYR A 211
ASN A 365
PHE A 384
GLN A 413
PHE A 416
 IBM  A 503 (-4.6A)
IBM  A 503 ( 4.7A)
IBM  A 503 (-4.5A)
IBM  A 503 (-3.0A)
IBM  A 503 (-3.4A)
 0.53A 3iakA-1zklA:
44.9		 3iakA-1zklA:
33.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWQ_A_VIAA901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A
(Homo
sapiens) 		6 / 9 TYR A 211
HIS A 212
VAL A 380
GLN A 413
PHE A 416
VAL A 421
 IBM  A 503 (-4.6A)
None
IBM  A 503 (-4.7A)
IBM  A 503 (-3.0A)
IBM  A 503 (-3.4A)
None
 1.33A 3jwqA-1zklA:
38.1		 3jwqA-1zklA:
27.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWQ_B_VIAB901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A
(Homo
sapiens) 		6 / 11 TYR A 211
HIS A 212
ASN A 260
VAL A 380
GLN A 413
PHE A 416
 IBM  A 503 (-4.6A)
None
None
IBM  A 503 (-4.7A)
IBM  A 503 (-3.0A)
IBM  A 503 (-3.4A)
 0.82A 3jwqB-1zklA:
37.8
3jwqC-1zklA:
38.0		 3jwqB-1zklA:
27.69
3jwqC-1zklA:
27.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWQ_C_VIAC901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A
(Homo
sapiens) 		4 / 7 TYR A 211
HIS A 212
GLN A 413
PHE A 416
 IBM  A 503 (-4.6A)
None
IBM  A 503 (-3.0A)
IBM  A 503 (-3.4A)
 0.64A 3jwqC-1zklA:
38.0		 3jwqC-1zklA:
27.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWQ_D_VIAD901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A
(Homo
sapiens) 		5 / 11 TYR A 211
HIS A 212
PHE A 384
GLN A 413
PHE A 416
 IBM  A 503 (-4.6A)
None
IBM  A 503 (-4.5A)
IBM  A 503 (-3.0A)
IBM  A 503 (-3.4A)
 0.61A 3jwqA-1zklA:
38.1
3jwqD-1zklA:
37.7		 3jwqA-1zklA:
27.69
3jwqD-1zklA:
27.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QFX_A_CP6A602_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A
(Homo
sapiens) 		5 / 12 ALA A 250
ILE A 201
PHE A 178
SER A 296
THR A 221
 None
 1.06A 3qfxA-1zklA:
undetectable		 3qfxA-1zklA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QFX_B_CP6B702_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A
(Homo
sapiens) 		5 / 12 ALA A 250
ILE A 201
PHE A 178
SER A 296
THR A 221
 None
 1.04A 3qfxB-1zklA:
undetectable		 3qfxB-1zklA:
23.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TVX_A_PNXA902_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4A)		 1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A
(Homo
sapiens) 		5 / 9 TYR A 211
ASN A 365
PRO A 366
GLN A 413
PHE A 416
 IBM  A 503 (-4.6A)
IBM  A 503 ( 4.7A)
None
IBM  A 503 (-3.0A)
IBM  A 503 (-3.4A)
 0.56A 3tvxA-1zklA:
45.2		 3tvxA-1zklA:
33.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TVX_B_PNXB902_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4A)		 1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A
(Homo
sapiens) 		5 / 7 TYR A 211
ASN A 365
PHE A 384
GLN A 413
PHE A 416
 IBM  A 503 (-4.6A)
IBM  A 503 ( 4.7A)
IBM  A 503 (-4.5A)
IBM  A 503 (-3.0A)
IBM  A 503 (-3.4A)
 0.57A 3tvxB-1zklA:
45.1		 3tvxB-1zklA:
33.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A
(Homo
sapiens) 		4 / 8 ILE A 242
LEU A 246
VAL A 151
GLY A 152
 None
 0.85A 3w1wA-1zklA:
undetectable		 3w1wA-1zklA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_B_SAMB900_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A
(Homo
sapiens) 		4 / 4 ILE A 323
SER A 324
ASP A 253
ASP A 255
 IBM  A 503 ( 4.8A)
None
MG  A 502 ( 2.6A)
None
 1.48A 4krhB-1zklA:
undetectable		 4krhB-1zklA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_B_ADNB401_2
(ADENOSINE KINASE)		 1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A
(Homo
sapiens) 		4 / 5 LEU A 198
SER A 172
LEU A 177
LEU A 194
 None
 1.19A 4n09B-1zklA:
undetectable		 4n09B-1zklA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_D_ADND401_2
(ADENOSINE KINASE)		 1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A
(Homo
sapiens) 		4 / 5 LEU A 198
SER A 172
LEU A 177
LEU A 194
 None
 1.17A 4n09D-1zklA:
undetectable		 4n09D-1zklA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_B_LOCB502_1
(TUBULIN BETA CHAIN)		 1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A
(Homo
sapiens) 		5 / 12 LEU A 298
LEU A 292
LEU A 198
ALA A 250
ALA A 289
 None
 0.97A 4x20B-1zklA:
undetectable		 4x20B-1zklA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE3_A_CL6A502_1
(CYTOCHROME P-450)		 1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A
(Homo
sapiens) 		4 / 5 LEU A 243
ALA A 248
THR A 251
ILE A 201
 None
 0.89A 4xe3A-1zklA:
undetectable		 4xe3A-1zklA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE3_B_CL6B502_1
(CYTOCHROME P-450)		 1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A
(Homo
sapiens) 		4 / 5 LEU A 243
ALA A 248
THR A 251
ILE A 201
 None
 0.97A 4xe3B-1zklA:
undetectable		 4xe3B-1zklA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XTA_B_DIFB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A
(Homo
sapiens) 		4 / 8 ILE A 318
LEU A 170
LEU A 198
ILE A 247
 None
 0.99A 4xtaB-1zklA:
undetectable		 4xtaB-1zklA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZN7_A_DESA601_1
(ESTROGEN RECEPTOR)		 1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A
(Homo
sapiens) 		5 / 12 LEU A 246
ALA A 250
LEU A 198
LEU A 170
LEU A 173
 None
 0.94A 4zn7A-1zklA:
undetectable		 4zn7A-1zklA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEL_C_ACTC302_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A
(Homo
sapiens) 		4 / 6 HIS A 269
ASP A 255
HIS A 206
HIS A 284
 None
 0.96A 5nelB-1zklA:
undetectable
5nelC-1zklA:
undetectable		 5nelB-1zklA:
18.61
5nelC-1zklA:
18.61