SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1zl0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK7_B_ADNB1246_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1zl0 HYPOTHETICAL PROTEIN
PA5198
(Pseudomonas
aeruginosa) 		5 / 8 GLY A  49
VAL A  52
GLU A  53
GLU A  33
ILE A  21
 None
 1.19A 1pk7B-1zl0A:
undetectable		 1pk7B-1zl0A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SGU_B_MK1B2632_1
(POL POLYPROTEIN)		 1zl0 HYPOTHETICAL PROTEIN
PA5198
(Pseudomonas
aeruginosa) 		5 / 8 ALA A 137
GLY A 134
GLY A 113
ILE A 117
ALA A  19
 None
 1.07A 1sguA-1zl0A:
undetectable		 1sguA-1zl0A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_A_D16A566_2
(THYMIDYLATE SYNTHASE)		 1zl0 HYPOTHETICAL PROTEIN
PA5198
(Pseudomonas
aeruginosa) 		3 / 3 HIS A  71
ILE A  21
LEU A 120
 None
 0.59A 2kceA-1zl0A:
undetectable		 2kceA-1zl0A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEY_B_EV1B1771_1
(CAMP AND
CAMP-INHIBITED CGMP
3', 5'-CYCLIC
PHOSPHODIESTERASE)		 1zl0 HYPOTHETICAL PROTEIN
PA5198
(Pseudomonas
aeruginosa) 		4 / 8 LEU A  98
VAL A  82
ILE A 117
PHE A 124
 None
 0.89A 2weyB-1zl0A:
undetectable		 2weyB-1zl0A:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_A_CELA701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1zl0 HYPOTHETICAL PROTEIN
PA5198
(Pseudomonas
aeruginosa) 		4 / 6 VAL A  52
LEU A 158
ILE A  14
LEU A  32
 None
 0.87A 3kk6A-1zl0A:
undetectable		 3kk6A-1zl0A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_B_CELB1701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1zl0 HYPOTHETICAL PROTEIN
PA5198
(Pseudomonas
aeruginosa) 		4 / 6 VAL A  52
LEU A 158
ILE A  14
LEU A  32
 None
 0.89A 3kk6B-1zl0A:
undetectable		 3kk6B-1zl0A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O9M_B_BEZB999_0
(CHOLINESTERASE)		 1zl0 HYPOTHETICAL PROTEIN
PA5198
(Pseudomonas
aeruginosa) 		4 / 6 GLY A  87
GLY A  88
SER A 115
HIS A 285
 EDO  A1407 (-3.5A)
EDO  A1408 ( 3.4A)
TLA  A1401 ( 2.0A)
EDO  A1407 ( 3.9A)
 0.75A 3o9mB-1zl0A:
undetectable		 3o9mB-1zl0A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 1zl0 HYPOTHETICAL PROTEIN
PA5198
(Pseudomonas
aeruginosa) 		3 / 3 TYR A  89
LEU A  20
ARG A  86
 None
None
EDO  A1408 ( 3.7A)
 0.69A 3sufB-1zl0A:
undetectable		 3sufB-1zl0A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1005_1
(HEMOLYTIC LECTIN
CEL-III)		 1zl0 HYPOTHETICAL PROTEIN
PA5198
(Pseudomonas
aeruginosa) 		3 / 3 ASP A 116
GLY A  92
TYR A  89
 None
 0.81A 3w9tC-1zl0A:
undetectable		 3w9tC-1zl0A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY6_A_GNTA604_1
(ACETYLCHOLINESTERASE)		 1zl0 HYPOTHETICAL PROTEIN
PA5198
(Pseudomonas
aeruginosa) 		5 / 12 GLY A  87
GLY A  88
SER A  25
SER A 115
HIS A 285
 EDO  A1407 (-3.5A)
EDO  A1408 ( 3.4A)
None
TLA  A1401 ( 2.0A)
EDO  A1407 ( 3.9A)
 0.92A 4ey6A-1zl0A:
3.5		 4ey6A-1zl0A:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NC3_A_ERMA1202_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 1zl0 HYPOTHETICAL PROTEIN
PA5198
(Pseudomonas
aeruginosa) 		4 / 6 LEU A  32
GLN A  38
LEU A  39
GLU A  40
 None
 1.11A 4nc3A-1zl0A:
undetectable		 4nc3A-1zl0A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_B_VDYB201_2
(CDL2.2)		 1zl0 HYPOTHETICAL PROTEIN
PA5198
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 196
LEU A  98
TYR A 294
ALA A 131
LEU A 129
 None
 1.11A 5ienB-1zl0A:
undetectable		 5ienB-1zl0A:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEO_A_VDYA206_1
(CDL2.3A)		 1zl0 HYPOTHETICAL PROTEIN
PA5198
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 262
PHE A 266
LEU A 233
LEU A 214
PHE A 250
 None
 1.34A 5ieoA-1zl0A:
undetectable		 5ieoA-1zl0A:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WWS_B_SAMB501_0
(PUTATIVE
METHYLTRANSFERASE
NSUN6)		 1zl0 HYPOTHETICAL PROTEIN
PA5198
(Pseudomonas
aeruginosa) 		5 / 12 ALA A 131
PRO A 130
GLY A 128
ILE A 112
GLY A 191
 None
 1.21A 5wwsB-1zl0A:
undetectable		 5wwsB-1zl0A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EU9_B_REAB601_1
(RETINOIC ACID
RECEPTOR)		 1zl0 HYPOTHETICAL PROTEIN
PA5198
(Pseudomonas
aeruginosa) 		5 / 10 LEU A 230
SER A 229
PHE A 266
GLY A 248
GLY A 220
 None
GOL  A1402 (-2.6A)
None
None
None
 1.21A 6eu9B-1zl0A:
undetectable		 6eu9B-1zl0A:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_A_AM2A301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 1zl0 HYPOTHETICAL PROTEIN
PA5198
(Pseudomonas
aeruginosa) 		4 / 8 ASP A 116
GLU A 217
ASP A 218
GLU A 221
 None
None
K  A1417 ( 3.3A)
K  A1417 (-3.5A)
 1.14A 6mn4A-1zl0A:
0.1		 6mn4A-1zl0A:
26.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_E_LLLE301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 1zl0 HYPOTHETICAL PROTEIN
PA5198
(Pseudomonas
aeruginosa) 		4 / 7 GLU A 217
ASP A 218
CYH A 253
GLU A 221
 None
K  A1417 ( 3.3A)
None
K  A1417 (-3.5A)
 1.08A 6mn5E-1zl0A:
0.1		 6mn5E-1zl0A:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QXS_D_FOZD403_0
(THYMIDYLATE SYNTHASE)		 1zl0 HYPOTHETICAL PROTEIN
PA5198
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 188
LEU A 242
GLY A 243
ILE A 245
ALA A 270
 None
 1.33A 6qxsD-1zl0A:
undetectable		 6qxsD-1zl0A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QYA_B_FOZB401_0
(THYMIDYLATE SYNTHASE)		 1zl0 HYPOTHETICAL PROTEIN
PA5198
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 188
LEU A 242
GLY A 243
ILE A 245
ALA A 270
 None
 1.28A 6qyaB-1zl0A:
undetectable		 6qyaB-1zl0A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QYA_D_FOZD401_0
(THYMIDYLATE SYNTHASE)		 1zl0 HYPOTHETICAL PROTEIN
PA5198
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 188
LEU A 242
GLY A 243
ILE A 245
ALA A 270
 None
 1.27A 6qyaD-1zl0A:
undetectable		 6qyaD-1zl0A:
20.34